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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Sixma, T.K."

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Search Summary

This query matches 98 Structures.

Refinements

Structure Determination Methodology

experimental (98)

Scientific Name of Source Organism

	Homo sapiens (29)
	Escherichia coli (27)
	Aplysia californica (17)
	synthetic construct (13)
	Escherichia coli K-12 (9)
	Mus musculus (5)
	Lymnaea stagnalis (4)
	Bos taurus (2)
	Caenorhabditis elegans (2)
	Conus imperialis (2)

More...

Taxonomy

	Eukaryota (61)
	Bacteria (36)
	other sequences (13)

Experimental Method

	X-RAY DIFFRACTION (87)
	ELECTRON MICROSCOPY (9)
	SOLUTION NMR (2)

Polymer Entity Type

	Protein (97)
	DNA (22)
	RNA (2)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (12)
	2.0 - 2.5 (37)
	2.5 - 3.0 (21)
	3.0 - 3.5 (13)
	3.5 - 4.0 (5)
	4.0 - 4.5 (1)
	> 4.5 (6)

Release Date

	1990 - 1994 (4)
	1995 - 1999 (13)
	2000 - 2004 (15)
	2005 - 2009 (15)
	2010 - 2014 (23)
	2015 - 2019 (14)
	2020 - 2024 (13)
	2025 - 2029 (1)

Enzyme Classification Name

	Transferases (16)
	Hydrolases (15)
	Ligases (12)
	Lyases (1)

Symmetry Type

	Cyclic (47)
	Asymmetric (48)
	Dihedral (4)

SCOP Classification

	All beta proteins (27)
	Alpha and beta proteins (a+b) (33)
	Alpha and beta proteins (a/b) (11)
	All alpha proteins (14)
	Artifacts (2)
	Small proteins (3)

AllSelected

1 to 25 of 98 Structures

Page 1 of 4

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1B44 \| pdb_00001b44	Download File View File

CRYSTAL STRUCTURE OF THE B SUBUNIT OF HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY

Matkovic-Calogovic, D., Loregian, A., D'Acunto, M.R., Battistutta, R., Tossi, A., Palu, G., Zanotti, G.

(1999) J Biological Chem 274: 8764-8769

Released	1999-01-13
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Escherichia coli
Macromolecule	PROTEIN (B-POL SUBUNIT OF HEAT-LABILE ENTEROTOXIN) (protein)

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1DUH \| pdb_00001duh	Download File View File

CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN IV OF E. COLI 4.5S RNA

Jovine, L., Hainzl, T., Oubridge, C., Scott, W.G., Li, J., Sixma, T.K., Wonacott, A., Skarzynski, T., Nagai, K.

(2000) Structure 8: 527-540

Released	2000-05-08
Method	X-RAY DIFFRACTION 2.7 Å
Macromolecule	4.5S RNA DOMAIN IV (nucleic acid)
Unique Ligands	LU, MG, SO4

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1E3M \| pdb_00001e3m	Download File View File

The crystal structure of E. coli MutS binding to DNA with a G:T mismatch

Lamers, M.H., Perrakis, A., Enzlin, J.H., Winterwerp, H.H.K., De Wind, N., Sixma, T.K.

(2000) Nature 407: 711

Released	2000-11-01
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Escherichia coli
Macromolecule	DNA MISMATCH REPAIR PROTEIN MUTS (protein) 5'-D(APGPCPTPGPCPCPAPGPGPCPAPCPCPAP GPTPGPTPCPAPGPCPGPTPCPCPTPAPT)-3' (nucleic acid) 5'-D(APTPAPGPGPAPCPGPCPTPGPAPCPAPCP TPGPGPTPGPCPTPTPGPGPCPAPGPCPT)-3' (nucleic acid)
Unique Ligands	ADP, MG

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1EFI \| pdb_00001efi	Download File View File

HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH PARA-AMINOPHENYL-ALPHA-D-GALACTOPYRANOSIDE

Merritt, E.A., Hol, W.G.J.

(2001) Acta Crystallogr D Biol Crystallogr 57: 201-212

Released	2000-02-23
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Escherichia coli
Macromolecule	PROTEIN (HEAT-LABILE ENTEROTOXIN B CHAIN) (protein)
Unique Ligands	GAT

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1EMB \| pdb_00001emb	Download File View File

GREEN FLUORESCENT PROTEIN (GFP) FROM AEQUOREA VICTORIA, GLN 80 REPLACED WITH ARG

Brejc, K., Sixma, T.

(1997) Proc Natl Acad Sci U S A 94: 2306-2311

Released	1997-06-16
Method	X-RAY DIFFRACTION 2.13 Å
Organisms	Aequorea victoria
Macromolecule	GREEN FLUORESCENT PROTEIN (protein)

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1HC9 \| pdb_00001hc9	Download File View File

alpha-bungarotoxin complexed with high affinity peptide

Harel, M., Kasher, R., Sussman, J.L.

(2001) Neuron 32: 265

Released	2001-11-10
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Bungarus multicinctus synthetic construct
Macromolecule	ALPHA-BUNGAROTOXIN ISOFORM A31 (protein) ALPHA-BUNGAROTOXIN ISOFORM V31 (protein) PEPTIDE INHIBITOR (protein)
Unique Ligands	IOD

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1HTL \| pdb_00001htl	Download File View File

MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS

Merritt, E.A., Hol, W.G.J.

(1995) Nat Struct Biol 2: 269-272

Released	1995-04-20
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Escherichia coli
Macromolecule	HEAT-LABILE ENTEROTOXIN, SUBUNIT A (protein) HEAT-LABILE ENTEROTOXIN, SUBUNIT B (protein)

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1I9B \| pdb_00001i9b	Download File View File

X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP)

Brejc, K., van Dijk, W.J., Klaassen, R., Schuurmans, M., van der Oost, J., Smit, A.B., Sixma, T.K.

(2001) Nature 411: 269-276

Released	2001-05-16
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Lymnaea stagnalis
Macromolecule	ACETYLCHOLINE BINDING PROTEIN (protein)
Unique Ligands	CA, EPE

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1LT3 \| pdb_00001lt3	Download File View File

HEAT-LABILE ENTEROTOXIN DOUBLE MUTANT N40C/G166C

Van Den Akker, F., Hol, W.G.J.

(1997) Protein Sci 6: 2644-2649

Released	1997-07-07
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli
Macromolecule	HEAT-LABILE ENTEROTOXIN (protein)
Unique branched monosaccharides	BGC, GAL

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1LT4 \| pdb_00001lt4	Download File View File

HEAT-LABILE ENTEROTOXIN MUTANT S63K

Van Den Akker, F., Hol, W.G.J.

(1997) Protein Sci 6: 2650-2654

Released	1997-06-16
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli
Macromolecule	HEAT-LABILE ENTEROTOXIN (protein)
Unique branched monosaccharides	BGC, GAL

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1LT5 \| pdb_00001lt5	Download File View File

HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH THIODIGALACTOSIDE

Merritt, E.A., Hol, W.G.J.

(1997) Structure 5: 1485-1499

Released	1997-12-03
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Escherichia coli
Macromolecule	HEAT-LABILE ENTEROTOXIN (protein)
Unique branched monosaccharides	GAL, YIO

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1LT6 \| pdb_00001lt6	Download File View File

HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH METANITROPHENYLGALACTOSIDE

Merritt, E.A., Hol, W.G.J.

(1997) Structure 5: 1485-1499

Released	1997-12-03
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Escherichia coli
Macromolecule	HEAT-LABILE ENTEROTOXIN (protein)
Unique Ligands	GAA

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1LTA \| pdb_00001lta	Download File View File

2.2 ANGSTROMS CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN (LT) WITH BOUND GALACTOSE

Merritt, E.A., Sixma, T.K., Kalk, K.H., Van Zanten, B.A.M., Hol, W.G.J.

(1994) Mol Microbiol 13: 745-753

Released	1994-01-31
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Escherichia coli
Macromolecule	HEAT-LABILE ENTEROTOXIN, SUBUNIT A (protein) HEAT-LABILE ENTEROTOXIN, SUBUNIT B (protein)
Unique Ligands	GAL

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1LTB \| pdb_00001ltb	Download File View File

2.6 ANGSTROMS CRYSTAL STRUCTURE OF PARTIALLY-ACTIVATED E. COLI HEAT-LABILE ENTEROTOXIN (LT)

Merritt, E.A., Sixma, T.K., Hol, W.G.J.

(1994) FEBS Lett 337: 88-92

Released	1994-01-31
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Escherichia coli
Macromolecule	HEAT-LABILE ENTEROTOXIN, SUBUNIT A (protein) HEAT-LABILE ENTEROTOXIN, SUBUNIT B (protein)

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1LTG \| pdb_00001ltg	Download File View File

THE ARG7LYS MUTANT OF HEAT-LABILE ENTEROTOXIN EXHIBITS GREAT FLEXIBILITY OF ACTIVE SITE LOOP 47-56 OF THE A SUBUNIT

Van Den Akker, F., Hol, W.G.J.

(1995) Biochemistry 34: 10996-11004

Released	1995-09-15
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Escherichia coli
Macromolecule	HEAT-LABILE ENTEROTOXIN (protein)

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1LTR \| pdb_00001ltr	Download File View File

CRYSTAL STRUCTURE OF THE B SUBUNIT OF HUMAN HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY

Matkovic-Calogovic, D., Loreggian, A., Palu, G., Zanotti, G.

(1999) J Biological Chem 274: 8764-8769

Released	1999-02-09
Method	X-RAY DIFFRACTION 3.04 Å
Organisms	Escherichia coli
Macromolecule	HEAT-LABILE ENTEROTOXIN (protein)
Unique Ligands	SO4

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1LTS \| pdb_00001lts	Download File View File

REFINED STRUCTURE OF E. COLI HEAT LABILE ENTEROTOXIN, A CLOSE RELATIVE OF CHOLERA TOXIN

Sixma, T.K., Hol, W.G.J.

(1993) J Mol Biology 230: 890-918

Released	1994-01-31
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Escherichia coli
Macromolecule	HEAT-LABILE ENTEROTOXIN, SUBUNIT A (protein) HEAT-LABILE ENTEROTOXIN, SUBUNIT B (protein)

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1LTT \| pdb_00001ltt	Download File View File

LACTOSE BINDING TO HEAT-LABILE ENTEROTOXIN REVEALED BY X-RAY CRYSTALLOGRAPHY

Sixma, T.K., Hol, W.G.J.

(1992) Nature 355: 561-564

Released	1994-01-31
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Escherichia coli
Macromolecule	HEAT-LABILE ENTEROTOXIN, SUBUNIT A (protein) HEAT-LABILE ENTEROTOXIN, SUBUNIT B (protein)
Unique branched monosaccharides	BGC, GAL

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1NG9 \| pdb_00001ng9	Download File View File

E.coli MutS R697A: an ATPase-asymmetry mutant

Lamers, M.H., Winterwerp, H.H.K., Sixma, T.K.

(2003) EMBO J 22: 746-756

Released	2003-02-11
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Escherichia coli
Macromolecule	DNA mismatch repair protein MutS (protein) 5'-D(APGPCPTPGPCPCPAPGPGPCPAPCPCPAPGPTPGPTPCPAPGPCPGPTPCPCPTPAPT)-3' (nucleic acid) 5'-D(APTPAPGPGPAPCPGPCPTPGPAPCPAPCPTPGPGPTPGPCPTPTPGPGPCPAPGPCPT)-3' (nucleic acid)
Unique Ligands	ADP, MG

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1OH5 \| pdb_00001oh5	Download File View File

THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A C:A MISMATCH

Natrajan, G., Lamers, M.H., Enzlin, J.H., Winterwerp, H.H.K., Perrakis, A., Sixma, T.K.

(2003) Nucleic Acids Res 31: 4814

Released	2003-08-08
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Escherichia coli synthetic construct
Macromolecule	DNA MISMATCH REPAIR PROTEIN MUTS (protein) 5'-D(APGPCPTPGPCPCPAPCPGP CPAPCPCPAPGPTPGPTPCPAPGPCPGPTP CPCPTPAPT)-3' (nucleic acid) 5'-D(APTPAPGPGPAPCPGPCPTP GPAPCPAPCPTPGPGPTPGPCPAPTPGPGP CPAPGPCPT)-3' (nucleic acid)
Unique Ligands	ADP, MG

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1OH6 \| pdb_00001oh6	Download File View File

THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN A:A MISMATCH

Natrajan, G., Lamers, M.H., Enzlin, J.H., Winterwerp, H.H.K., Perrakis, A., Sixma, T.K.

(2003) Nucleic Acids Res 31: 4814

Released	2003-08-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Escherichia coli synthetic construct
Macromolecule	DNA MISMATCH REPAIR PROTEIN MUTS (protein) 5'-D(APGPCPTPGPCPCPAPAPGP CPAPCPCPAPGPTPGPTPCPAPGPCPGPTP CPCPTPAPT)-3' (nucleic acid) 5'-D(APTPAPGPGPAPCPGPCPTP GPAPCPAPCPTPGPGPTPGPCPAPTPGPGP CPAPGPCPT)-3' (nucleic acid)
Unique Ligands	ADP, MG

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1OH7 \| pdb_00001oh7	Download File View File

THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A G:G MISMATCH

Natrajan, G., Lamers, M.H., Enzlin, J.H., Winterwerp, H.H.K., Perrakis, A., Sixma, T.K.

(2003) Nucleic Acids Res 31: 4814

Released	2003-08-08
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Escherichia coli synthetic construct
Macromolecule	DNA MISMATCH REPAIR PROTEIN MUTS (protein) 5'-D(APGPCPTPGPCPCPAPGPGP CPAPCPCPAPGPTPGPTPCPAPGPCPGPTP CPCPTPAPT)-3' (nucleic acid) 5'-D(APTPAPGPGPAPCPGPCPTP GPAPCPAPCPTPGPGPTPGPCPGPTPGPGP CPAPGPCPT)-3' (nucleic acid)
Unique Ligands	ADP, MG

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1OH8 \| pdb_00001oh8	Download File View File

THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN UNPAIRED THYMIDINE

Natrajan, G., Lamers, M.H., Enzlin, J.H., Winterwerp, H.H.K., Perrakis, A., Sixma, T.K.

(2003) Nucleic Acids Res 31: 4814

Released	2003-08-08
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Escherichia coli synthetic construct
Macromolecule	DNA MISMATCH REPAIR PROTEIN MUTS (protein) 5'-D(APGPCPTPGPCPCPAPGPGP CPAPCPCPAPGPTPGPTPCPAPGPCPGPTPCPCP TPAPT)-3' (nucleic acid) 5'-D(APTPAPGPGPAPCPGPCPTP GPAPCPAPCPTPGPGPTPGPCPCPTPTPGPGPCP APGPCP*T)-3' (nucleic acid)
Unique Ligands	ADP, MG

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1TC3 \| pdb_00001tc3	Download File View File

TRANSPOSASE TC3A1-65 FROM CAENORHABDITIS ELEGANS

Van Pouderoyen, G., Ketting, R.F., Perrakis, A., Plasterk, R.H.A., Sixma, T.K.

(1997) EMBO J 16: 6044-6054

Released	1997-11-21
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Caenorhabditis elegans
Macromolecule	PROTEIN (TC3 TRANSPOSASE) (protein) DNA (5'-D(APGPGPGPGPGPGPGPTPCPCPTPAPTPAPGPA PAPCPTPT)-3') (nucleic acid) DNA (5'-D(APGPTPTPCPTPAPTPAPGPGPAPCPCPCPCPC PCPCP*T)-3') (nucleic acid)