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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Dowson, C.G."

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Search Summary

This query matches 45 Structures.

Refinements

Structure Determination Methodology

experimental (45)

Scientific Name of Source Organism

	Pseudomonas aeruginosa PAO1 (19)
	Chlamydia trachomatis (4)
	Escherichia coli (4)
	Staphylococcus aureus (4)
	Escherichia coli K-12 (3)
	Homo sapiens (2)
	Streptococcus pneumoniae (2)
	synthetic construct (2)
	Acinetobacter baumannii (1)
	Burkholderia pseudomallei (1)

More...

Taxonomy

	Bacteria (43)
	Eukaryota (2)
	other sequences (2)

Experimental Method

X-RAY DIFFRACTION (45)

Polymer Entity Type

Protein (45)

Refinement Resolution (Å)

	1.0 - 1.5 (7)
	1.5 - 2.0 (23)
	2.0 - 2.5 (12)
	2.5 - 3.0 (3)

Release Date

	2010 - 2014 (2)
	2015 - 2019 (20)
	2020 - 2024 (23)

Enzyme Classification Name

	Hydrolases (27)
	Transferases (8)
	Ligases (8)

Symmetry Type

	Asymmetric (36)
	Cyclic (9)

SCOP Classification

	Multi-domain proteins (alpha and beta) (19)
	Artifacts (17)
	Alpha and beta proteins (a+b) (13)
	Alpha and beta proteins (a/b) (3)
	Small proteins (2)

AllSelected

1 to 25 of 45 Structures

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4C12 \| pdb_00004c12	Download File View File

X-ray Crystal Structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys and ADP

Fulop, V., Roper, D.I., Ruane, K.M., Barreteau, H., Boniface, A., Dementin, S., Blanot, D., Mengin-Lecreulx, D., Gobec, S., Dessen, A., Dowson, C.G., Lloyd, A.J.

(2013) J Biological Chem 288: 33439

Released	2013-10-02
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Staphylococcus aureus
Macromolecule	UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--L-LYSINE LIGASE (protein)
Unique Ligands	ADP, GOL, MG, UML

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4C13 \| pdb_00004c13	Download File View File

x-ray crystal structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys

Ruane, K.M., Roper, D.I., Fulop, V., Barreteau, H., Boniface, A., Dementin, S., Blanot, D., Mengin-Lecreulx, D., Gobec, S., Dessen, A., Dowson, C.G., Lloyd, A.J.

(2021) Nat Chem Biol

Released	2013-10-02
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Staphylococcus aureus
Macromolecule	UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--L-LYSINE LIGASE (protein)
Unique Ligands	CL, K, MG, PO4, UML

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4C5A \| pdb_00004c5a	Download File View File

The X-ray crystal structures of D-alanyl-D-alanine ligase in complex ADP and D-cycloserine phosphate

Batson, S., Majce, V., Lloyd, A.J., Rea, D., Fishwick, C.W.G., Simmons, K.J., Fulop, V., Roper, D.I.

(2017) Nat Commun 8: 1939-1939

Released	2015-01-21
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Escherichia coli K-12 synthetic construct
Macromolecule	D-ALANINE--D-ALANINE LIGASE (protein) PEPTIDE (protein)
Unique Ligands	ADP, DS0, GOL, MG

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4C5B \| pdb_00004c5b	Download File View File

The X-ray crystal structure of D-alanyl-D-alanine ligase in complex with ATP and D-ala-D-ala

Batson, S., Majce, V., Lloyd, A.J., Rea, D., Fishwick, C.W.G., Simmons, K.J., Fulop, V., Roper, D.I.

(2017) Nat Commun 8: 1939-1939

Released	2015-01-21
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Escherichia coli K-12
Macromolecule	D-ALANINE--D-ALANINE LIGASE (protein)
Unique Ligands	ADP, CO3, DAL, GOL, IMD, MG

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4C5C \| pdb_00004c5c	Download File View File

The X-ray crystal structure of D-alanyl-D-alanine ligase in complex with ADP and D-ala-D-ala

Batson, S., Majce, V., Lloyd, A.J., Rea, D., Fishwick, C.W.G., Simmons, K.J., Fulop, V., Roper, D.I.

(2017) Nat Commun 8: 1939-1939

Released	2015-01-21
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Escherichia coli K-12
Macromolecule	D-ALANINE--D-ALANINE LIGASE (protein)
Unique Ligands	ATP, DAL, GOL, MG

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5UFY \| pdb_00005ufy	Download File View File

Structure of Streptococcus pneumoniae peptidoglycan O-acetyltransferase A (OatA) C-terminal catalytic domain

Sychantha, D., Jones, C., Little, D.J., Moynihan, P.J., Robinson, H., Galley, N.F., Roper, D.I., Dowson, C.G., Howell, P.L., Clarke, A.J.

(2017) PLoS Pathog 13: e1006667-e1006667

Released	2017-10-25
Method	X-RAY DIFFRACTION 1.12 Å
Organisms	Streptococcus pneumoniae
Macromolecule	Acyltransferase (protein)
Unique Ligands	NA

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5UG1 \| pdb_00005ug1	Download File View File

Structure of Streptococcus pneumoniae peptidoglycan O-acetyltransferase A (OatA) C-terminal catalytic domain with methylsulfonyl adduct

Sychantha, D., Jones, C., Little, D.J., Moynihan, P.J., Robinson, H., Galley, N.F., Roper, D.I., Dowson, C.G., Howell, P.L., Clarke, A.J.

(2017) PLoS Pathog 13: e1006667-e1006667

Released	2017-10-25
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Streptococcus pneumoniae
Macromolecule	Acyltransferase (protein)
Unique Ligands	03S, NA

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6FTB \| pdb_00006ftb	Download File View File

Staphylococcus aureus monofunctional glycosyltransferase in complex with moenomycin

Punekar, A.S., Dowson, C.J., Roper, D.I.

(2018) Cell Surf 2: 54-66

Released	2018-06-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Staphylococcus aureus MW2
Macromolecule	Monofunctional glycosyltransferase (protein)
Unique Ligands	1QW, EDO, M0E, PO4

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6HR4 \| pdb_00006hr4	Download File View File

Apo form of penicillin-binding protein 3 from P. aeruginosa

Bellini, D., Dowson, C.G.

To be published

Released	2019-10-23
Method	X-RAY DIFFRACTION 1.19 Å
Organisms	Pseudomonas aeruginosa PAO1
Macromolecule	Peptidoglycan D,D-transpeptidase FtsI (protein)

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6HR6 \| pdb_00006hr6	Download File View File

Nitrocefin reacted with catalytic serine (Ser294) of penicillin-binding protein 3 from Pseudomonas aeruginosa

Bellini, D., Dowson, C.G.

To be published

Released	2019-10-23
Method	X-RAY DIFFRACTION 2.53 Å
Organisms	Pseudomonas aeruginosa PAO1
Macromolecule	Peptidoglycan D,D-transpeptidase FtsI (protein)
Unique Ligands	NEF

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6HR9 \| pdb_00006hr9	Download File View File

Nitrocefin acylation of both catalytic serines of the Y409 mutant of penicillin-binding protein 3 from P. aeruginosa

Bellini, D., Dowson, C.G.

To be published

Released	2019-10-23
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Pseudomonas aeruginosa PAO1
Macromolecule	Peptidoglycan D,D-transpeptidase FtsI (protein)
Unique Ligands	NEF

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6HZH \| pdb_00006hzh	Download File View File

Apo structure of TP domain from Chlamydia trachomatis penicillin-binding protein 3

Bellini, D., Koekemoer, L., Newman, H., Dowson, C.G.

To be published

Released	2019-11-20
Method	X-RAY DIFFRACTION 1.83 Å
Organisms	Chlamydia trachomatis
Macromolecule	Penicillin-binding protein (protein)

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6HZI \| pdb_00006hzi	Download File View File

Apo structure of TP domain from Burkholderia pseudomallei penicillin-binding protein 3

Bellini, D., Koekemoer, L., Newman, H., Dowson, C.G.

To be published

Released	2019-11-20
Method	X-RAY DIFFRACTION 2.29 Å
Organisms	Burkholderia pseudomallei
Macromolecule	Peptidoglycan D,D-transpeptidase FtsI (protein)

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6HZJ \| pdb_00006hzj	Download File View File

Apo structure of TP domain from clinical penicillin-resistant mutant Neisseria gonorrhoea strain 6140 Penicillin-Binding Protein 2 (PBP2)

Bellini, D., Koekemoer, L., Newman, H., Dowson, C.G.

(2019) J Mol Biology 431: 3501-3519

Released	2019-11-20
Method	X-RAY DIFFRACTION 1.43 Å
Organisms	Neisseria gonorrhoeae FA6140
Macromolecule	Probable peptidoglycan D,D-transpeptidase PenA (protein)

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6HZO \| pdb_00006hzo	Download File View File

Apo structure of TP domain from Haemophilus influenzae Penicillin-Binding Protein 3

Bellini, D., Koekemoer, L., Newman, H., Dowson, C.G.

(2019) J Mol Biology 431: 3501-3519

Released	2019-11-20
Method	X-RAY DIFFRACTION 2.44 Å
Organisms	Haemophilus influenzae
Macromolecule	FtsI (protein)

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6HZQ \| pdb_00006hzq	Download File View File

Apo structure of TP domain from Escherichia coli Penicillin-Binding Protein 3

Bellini, D., Koekemoer, L., Newman, H., Dowson, C.G.

(2019) J Mol Biology 431: 3501-3519

Released	2019-11-20
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Escherichia coli
Macromolecule	Peptidoglycan D,D-transpeptidase FtsI (protein)

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6HZR \| pdb_00006hzr	Download File View File

Apo structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3

Bellini, D., Dowson, C.G.

(2019) J Mol Biology 431: 3501-3519

Released	2019-11-20
Method	X-RAY DIFFRACTION 1.19 Å
Organisms	Pseudomonas aeruginosa PAO1
Macromolecule	Peptidoglycan D,D-transpeptidase FtsI (protein)

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6I1E \| pdb_00006i1e	Download File View File

Crystal structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 in complex with amoxicillin

Bellini, D., Dowson, C.G.

(2019) J Mol Biology 431: 3501-3519

Released	2019-11-20
Method	X-RAY DIFFRACTION 1.64 Å
Organisms	Pseudomonas aeruginosa
Macromolecule	Peptidoglycan D,D-transpeptidase FtsI (protein)
Unique Ligands	AXL

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6I1F \| pdb_00006i1f	Download File View File

Crystal structure of TP domain from Chlamydia trachomatis Penicillin-Binding Protein 3 in complex with amoxicillin

Bellini, D., Koekemoer, L., Newman, H., Dowson, C.G.

To be published

Released	2019-11-20
Method	X-RAY DIFFRACTION 1.89 Å
Organisms	Chlamydia trachomatis
Macromolecule	Penicillin-binding protein,Penicillin-binding protein (protein)
Unique Ligands	AXL

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6I1G \| pdb_00006i1g	Download File View File

Crystal structure of TP domain from Chlamydia trachomatis Penicillin-Binding Protein 3 in complex with piperacillin

Bellini, D., Koekemoer, L., Newman, H., Dowson, C.G.

To be published

Released	2019-11-20
Method	X-RAY DIFFRACTION 2.13 Å
Organisms	Chlamydia trachomatis
Macromolecule	Penicillin-binding protein,Penicillin-binding protein (protein)
Unique Ligands	JPP

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6I1H \| pdb_00006i1h	Download File View File

Crystal structure of TP domain from Chlamydia trachomatis Penicillin-Binding Protein 3 in complex with meropenem

Bellini, D., Koekemoer, L., Newman, H., Dowson, C.G.

To be published

Released	2019-11-20
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Chlamydia trachomatis
Macromolecule	Penicillin-binding protein,Penicillin-binding protein (protein)
Unique Ligands	MER

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6I1I \| pdb_00006i1i	Download File View File

Crystal structure of TP domain from Escherichia coli penicillin-binding protein 3 in complex with penicillin

Bellini, D., Koekemoer, L., Newman, H., Dowson, C.G.

(2019) J Mol Biology 431: 3501-3519

Released	2019-11-20
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Escherichia coli O157:H7
Macromolecule	Peptidoglycan D,D-transpeptidase FtsI,Peptidoglycan D,D-transpeptidase FtsI (protein)
Unique Ligands	JPP

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6R1M \| pdb_00006r1m	Download File View File

Crystal structure of E. coli seryl-tRNA synthetase complexed to seryl sulfamoyl adenosine

Salimraj, R., Cain, R., Roper, D.I.

(2019) J Med Chem 62: 9703-9717

Released	2020-01-22
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Escherichia coli
Macromolecule	Serine--tRNA ligase (protein)
Unique Ligands	EDO, PO4, SSA

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6R1N \| pdb_00006r1n	Download File View File

Crystal structure of S. aureus seryl-tRNA synthetase complexed to seryl sulfamoyl adenosine

Salimraj, R., Cain, R., Roper, D.I.

(2019) J Med Chem 62: 9703-9717

Released	2020-01-22
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Staphylococcus aureus
Macromolecule	Serine--tRNA ligase (protein)
Unique Ligands	EDO, MG, PEG, SSA

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6R1O \| pdb_00006r1o	Download File View File

Crystal structure of E. coli seryl-tRNA synthetase complexed to a seryl sulfamoyl adenosine derivative

Salimraj, R., Cain, R., Roper, D.I.

(2019) J Med Chem 62: 9703-9717

Released	2020-01-22
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Escherichia coli
Macromolecule	Serine--tRNA ligase (protein)
Unique Ligands	CL, DMS, EDO, JPE, SO4, TRS

1 to 25 of 45 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

4C12 | pdb_00004c12

4C13 | pdb_00004c13

4C5A | pdb_00004c5a

4C5B | pdb_00004c5b

4C5C | pdb_00004c5c

5UFY | pdb_00005ufy

5UG1 | pdb_00005ug1

6FTB | pdb_00006ftb

6HR4 | pdb_00006hr4

6HR6 | pdb_00006hr6

6HR9 | pdb_00006hr9

6HZH | pdb_00006hzh

6HZI | pdb_00006hzi

6HZJ | pdb_00006hzj

6HZO | pdb_00006hzo

6HZQ | pdb_00006hzq

6HZR | pdb_00006hzr

6I1E | pdb_00006i1e

6I1F | pdb_00006i1f

6I1G | pdb_00006i1g

6I1H | pdb_00006i1h

6I1I | pdb_00006i1i

6R1M | pdb_00006r1m

6R1N | pdb_00006r1n

6R1O | pdb_00006r1o