TRS

2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL

Created: 1999-07-08
Last modified:  2020-06-05

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Chemical Details

Formal Charge1
Atom Count20
Chiral Atom Count0
Bond Count19
Aromatic Bond Count0
2D diagram of TRS
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Chemical Component Summary

Name2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
SynonymsTRIS BUFFER
Systematic Name (OpenEye OEToolkits)[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]azanium
FormulaC4 H12 N O3
Molecular Weight122.143
TypeNON-POLYMER

Chemical Descriptors

TypeProgram Version Descriptor
SMILESACDLabs10.04OCC([NH3+])(CO)CO
SMILESCACTVS3.341[NH3+]C(CO)(CO)CO
SMILESOpenEye OEToolkits1.5.0C(C(CO)(CO)[NH3+])O
Canonical SMILESCACTVS3.341 [NH3+]C(CO)(CO)CO
Canonical SMILESOpenEye OEToolkits1.5.0 C(C(CO)(CO)[NH3+])O
InChIInChI1.03 InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2/p+1
InChIKeyInChI1.03 LENZDBCJOHFCAS-UHFFFAOYSA-O

Drug Info: DrugBank

DrugBank IDDB03754 
NameTromethamine
Groups approved
DescriptionAn organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)
Synonyms
  • 1,1,1-tris(hydroxymethyl)methanamine
  • Tris(hydroxymethyl)aminomethane
  • aminotris(hydroxymethyl)methane
  • Trometamol
  • Tris
Brand Names
  • Tham Solution 36mg/ml
  • Sooryehan Hyo Fermented Sun Block
  • Tham
IndicationFor the prevention and correction of metabolic acidosis.
Categories
  • Alcohols
  • Blood and Blood Forming Organs
  • Blood Substitutes and Perfusion Solutions
  • Buffers
  • Compounds used in a research, industrial, or household setting
ATC-Code
  • B05XX02
  • B05BB03
CAS number77-86-1

Drug Targets

NameTarget SequencePharmacological ActionActions
Amyloid beta A4 proteinMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNG...unknowninhibitor
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 3777159, 88088752
ChEBI CHEBI:46097
CCDC/CSD DUBXII, CUFSII, GEXRUW, LULKIP, WIYXEH, KORSAL01, POPNAJ, BUZGAE, UREWAQ, TRISHC11, GOLWIN, TUDPIR01, RUVNEC, GADYUI, PIPLOS, TERLIO, PIPMUZ, PEHDEN, TUDPIR, PIPMEJ, XUMLUP, GICHUW, VATVAP, HISMAZ, TEQCAW, PIPLUY, VIPXUQ, PIPMOT, PIPMAF, EDALEC, CIKQIY, SAFXAA, CUYBIJ, PIPLIM, COZBAX, TRISHC10, DOPYUE, RUVNEC01, GADXUH, EPAXAX, ITUXED, CUWSIZ
COD 2221989, 2229955, 2233157