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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Stihle, M."

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Search Summary

This query matches 354 Structures.

Refinements

Structure Determination Methodology

experimental (354)

Scientific Name of Source Organism

	Rattus norvegicus (226)
	Homo sapiens (116)
	Mus musculus (13)
	Lama glama (7)
	Paenibacillus polymyxa (2)
	Tolypocladium inflatum (2)
	synthetic construct (2)
	unidentified (1)

Taxonomy

	Eukaryota (352)
	Eukaryota (eukaryotes) (5)
	Bacteria (2)
	other sequences (2)
	unclassified sequences (1)

Experimental Method

X-RAY DIFFRACTION (354)

Polymer Entity Type

Protein (354)

Refinement Resolution (Å)

	1.0 - 1.5 (35)
	1.5 - 2.0 (215)
	2.0 - 2.5 (88)
	2.5 - 3.0 (15)
	3.0 - 3.5 (1)

Release Date

	2000 - 2004 (4)
	2005 - 2009 (17)
	2010 - 2014 (59)
	2015 - 2019 (60)
	2020 - 2024 (214)

Enzyme Classification Name

	Hydrolases (291)
	Transferases (42)
	Isomerases (4)

Symmetry Type

	Asymmetric (343)
	Cyclic (16)

SCOP Classification

	All beta proteins (79)
	Alpha and beta proteins (a+b) (24)
	Alpha and beta proteins (a/b) (28)
	Small proteins (31)
	Artifacts (14)
	All alpha proteins (10)

AllSelected

1 to 25 of 354 Structures

Page 1 of 15

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1JR4 \| pdb_00001jr4	Download File View File

CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX

Ruf, A., Stihle, M.

(2001) Angew Chem Int Ed Engl 40: 4040-4042

Released	2002-08-10
Method	X-RAY DIFFRACTION 2.63 Å
Organisms	Rattus norvegicus
Macromolecule	CATECHOL O-METHYLTRANSFERASE, SOLUBLE FORM (protein)
Unique Ligands	CL4, MG

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1NU6 \| pdb_00001nu6	Download File View File

Crystal structure of human Dipeptidyl Peptidase IV (DPP-IV)

Hennig, M., Stihle, M., Thoma, R., Ruf, A.

(2003) Structure 11: 947-959

Released	2003-08-26
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase IV (protein)
Unique Ligands	HG, NAG

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1NU8 \| pdb_00001nu8	Download File View File

Crystal structure of human dipeptidyl peptidase IV (DPP-IV) in complex with Diprotin A (IPI)

Thoma, R., Loeffler, B., Stihle, M., Huber, W., Ruf, A., Hennig, M.

(2003) Structure 11: 947-959

Released	2003-08-26
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	3-mer peptide (protein) Dipeptidyl peptidase IV (protein)
Unique Ligands	NAG

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1RWQ \| pdb_00001rwq	Download File View File

Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-ylamine

Hennig, M., Thoma, R., Stihle, M.

(2004) Bioorg Med Chem Lett 14: 1491-1493

Released	2004-12-17
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase IV (protein)
Unique Ligands	5AP, NAG

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2BIT \| pdb_00002bit	Download File View File

Crystal structure of human cyclophilin D at 1.7 A resolution

Hennig, M., Thoma, R., Stihle, M., Schlatter, D.

(2005) Acta Crystallogr D Biol Crystallogr 61: 513-519

Released	2005-01-26
Method	X-RAY DIFFRACTION 1.71 Å
Organisms	Homo sapiens
Macromolecule	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (protein)

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2BIU \| pdb_00002biu	Download File View File

Crystal structure of human cyclophilin D at 1.7 A resolution, DMSO complex

Hennig, M., Thoma, R., Stihle, M., Schlatter, D.

(2005) Acta Crystallogr D Biol Crystallogr 61: 513-519

Released	2005-01-26
Method	X-RAY DIFFRACTION 1.71 Å
Organisms	Homo sapiens
Macromolecule	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (protein)
Unique Ligands	DMS

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2BOK \| pdb_00002bok	Download File View File

Factor Xa - cation

Morgenthaler, M., Schaerer, K., Paulini, R., Obst-Sander, U., Banner, D.W., Schlatter, D., Benz, J., Stihle, M., Diederich, F.

(2005) Angew Chem Int Ed Engl 44: 4400

Released	2005-06-16
Method	X-RAY DIFFRACTION 1.64 Å
Organisms	Homo sapiens
Macromolecule	COAGULATION FACTOR X (protein)
Unique Ligands	784, NA

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2DEB \| pdb_00002deb	Download File View File

Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221

Rufer, A.C., Thoma, R., Benz, J., Stihle, M., Gsell, B., De Roo, E., Banner, D.W., Mueller, F., Chomienne, O., Hennig, M.

(2006) Structure 14: 713-723

Released	2007-02-10
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Rattus norvegicus
Macromolecule	Carnitine O-palmitoyltransferase II, mitochondrial (protein)
Unique Ligands	BOG, COA, PLM

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2FVJ \| pdb_00002fvj	Download File View File

A novel anti-adipogenic partial agonist of peroxisome proliferator-activated receptor-gamma (PPARG) recruits pparg-coactivator-1 alpha (PGC1A) but potentiates insulin signaling in vitro

Benz, J., Burgermeister, E., Flament, A., Schnoebelen, A., Stihle, M., Gsell, B., Rufer, A., Ruf, A., Kuhn, B., Maerki, H.P., Mizrahi, J., Sebokova, E., Niesor, E., Meyer, M.

(2006) Mol Endocrinol 20: 809-830

Released	2006-05-16
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Homo sapiens
Macromolecule	Nuclear receptor coactivator 1 (protein) Peroxisome proliferator-activated receptor gamma (protein)
Unique Ligands	GOL, RO0

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2FW3 \| pdb_00002fw3	Download File View File

Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326

Rufer, A.C., Thoma, R., Benz, J., Stihle, M., Gsell, B., De Roo, E., Banner, D.W., Mueller, F., Chomienne, O., Hennig, M.

(2006) Structure 14: 713-723

Released	2007-02-01
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Rattus norvegicus
Macromolecule	Carnitine O-palmitoyltransferase II, mitochondrial (protein)
Unique Ligands	BUI

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2FYO \| pdb_00002fyo	Download File View File

Crystal structure of rat carnitine palmitoyltransferase 2 in space group P43212

Rufer, A.C., Thoma, R., Benz, J., Stihle, M., Gsell, B., De Roo, E., Banner, D.W., Mueller, F., Chomienne, O., Hennig, M.

(2006) Structure 14: 713-723

Released	2007-02-08
Method	X-RAY DIFFRACTION 2 Å
Organisms	Rattus norvegicus
Macromolecule	Carnitine O-palmitoyltransferase II, mitochondrial (protein)

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2JID \| pdb_00002jid	Download File View File

Human Dipeptidyl peptidase IV in complex with 1-(3,4-Dimethoxy-phenyl) -3-m-tolyl-piperidine-4-ylamine

Hennig, M., Stihle, M., Luebbers, T., Thoma, R.

(2007) Bioorg Med Chem Lett 17: 2966

Released	2008-05-27
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	DIPEPTIDYL PEPTIDASE 4 (protein)
Unique Ligands	GVB, NAG

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3FEI \| pdb_00003fei	Download File View File

Design and biological evaluation of novel, balanced dual PPARa/g agonists

Benz, J., Grether, U., Gsell, B., Binggeli, A., Hilpert, H., Maerki, H.P., Mohr, P., Ruf, A., Stihle, M., Schlatter, D.

(2009) ChemMedChem 4: 951-956

Released	2009-10-20
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Peptide motif 5 of Nuclear receptor coactivator 1 (protein) Peroxisome proliferator-activated receptor alpha (protein)
Unique Ligands	CTM

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3FEJ \| pdb_00003fej	Download File View File

Design and biological evaluation of novel, balanced dual PPARa/g agonists

Benz, J., Grether, U., Gsell, B., Binggeli, A., Hilpert, H., Kuhn, B., Maerki, H.P., Mohr, P., Ruf, A., Stihle, M.

(2009) ChemMedChem 4: 951-956

Released	2009-10-20
Method	X-RAY DIFFRACTION 2.01 Å
Organisms	Homo sapiens
Macromolecule	Peroxisome proliferator-activated receptor gamma (protein) peptide motif 3 of Nuclear receptor coactivator 1 (protein)
Unique Ligands	CTM

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3G8I \| pdb_00003g8i	Download File View File

Aleglitazar, a new, potent, and balanced PPAR alpha/gamma agonist for the treatment of type II diabetes

Benz, J., Bernardeau, A., Binggeli, A., Blum, D., Boehringer, M., Grether, U., Hilpert, H., Kuhn, B., Maerki, H.P., Meyer, M., Puentener, K., Raab, S., Ruf, A., Schlatter, D., Gsell, B., Stihle, M., Mohr, P.

(2009) Bioorg Med Chem Lett 19: 2468-2473

Released	2009-06-02
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Nuclear receptor coactivator 1 (protein) Peroxisome proliferator-activated receptor alpha (protein)
Unique Ligands	RO7

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3G9E \| pdb_00003g9e	Download File View File

Aleglitaar. a new. potent, and balanced dual ppara/g agonist for the treatment of type II diabetes

Ruf, A., Benz, J., Bernardeau, A., Binggeli, A., Blum, D., Boehringer, M., Grether, U., Hilpert, H., Kuhn, B., Maerki, H.P., Meyer, M., Puenterner, K., Raab, S., Schlatter, D., Gsell, B., Stihle, M., Mohr, P.

(2009) Bioorg Med Chem Lett 19: 2468-2473

Released	2009-06-02
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Nuclear receptor coactivator 1 (protein) Peroxisome proliferator-activated receptor gamma (protein)
Unique Ligands	RO7

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3H52 \| pdb_00003h52	Download File View File

Crystal structure of the antagonist form of human glucocorticoid receptor

Schoch, G.A., Benz, J., D'Arcy, B., Stihle, M., Burger, D., Thoma, R., Ruf, A.

(2010) J Mol Biology 395: 568-577

Released	2009-12-01
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Glucocorticoid receptor (protein) Nuclear receptor corepressor 1 (protein)
Unique Ligands	486, GOL

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3HVH \| pdb_00003hvh	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, N6-methyladenine-containing bisubstrate inhibitor

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2009) Angew Chem Int Ed Engl 48: 9092-9096

Released	2009-10-13
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	542, CL, CXS, MG, SO4

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3HVI \| pdb_00003hvi	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, N6-ethyladenine-containing bisubstrate inhibitor

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2009) Angew Chem Int Ed Engl 48: 9092-9096

Released	2009-10-13
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	619, CL, D1D, MG, NA

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3HVJ \| pdb_00003hvj	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, N6-propyladenine-containing bisubstrate inhibitor

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2009) Angew Chem Int Ed Engl 48: 9092-9096

Released	2009-10-13
Method	X-RAY DIFFRACTION 1.79 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	705, BTB, CL, MG

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3HVK \| pdb_00003hvk	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, purine-containing bisubstrate inhibitor - humanized form

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2009) Angew Chem Int Ed Engl 48: 9092-9096

Released	2009-10-13
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	719, CL, MG, NHE

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3KWF \| pdb_00003kwf	Download File View File

human DPP-IV with carmegliptin (S)-1-((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one

Hennig, M., Stihle, M., Thoma, R.

(2010) Bioorg Med Chem Lett 20: 1109-1113

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	B1Q, NAG

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3KWJ \| pdb_00003kwj	Download File View File

Structure of human DPP-IV with (2S,3S,11bS)-3-(3-Fluoromethyl-phenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine

Hennig, M., Stihle, M., Thoma, R.

(2010) Bioorg Med Chem Lett 20: 1106-1108

Released	2010-09-15
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 soluble form (protein)
Unique Ligands	23Q, NAG

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3MNE \| pdb_00003mne	Download File View File

Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by F608S mutation at 1.96A

Schoch, G.A., Seitz, T., Benz, J., Banner, D., Stihle, M., D'Arcy, B., Thoma, R., Sterner, R., Hennig, M., Ruf, A.

(2010) J Mol Biology 403: 562-577

Released	2010-09-15
Method	X-RAY DIFFRACTION 1.96 Å
Organisms	Mus musculus
Macromolecule	Glucocorticoid receptor (protein) Nuclear receptor coactivator 2 peptide (protein)
Unique Ligands	DEX, GOL

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3MNO \| pdb_00003mno	Download File View File

Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, F608S) mutations at 1.55A

Schoch, G.A., Seitz, T., Benz, J., Banner, D., Stihle, M., D'Arcy, B., Thoma, R., Sterner, R., Hennig, M., Ruf, A.

(2010) J Mol Biology 403: 562-577

Released	2010-09-15
Method	X-RAY DIFFRACTION 1.55 Å
Organisms	Mus musculus
Macromolecule	Glucocorticoid receptor (protein) Nuclear receptor coactivator 2 peptide (protein)
Unique Ligands	DEX, GOL, SCN

1 to 25 of 354 Structures

Page 1 of 15

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1JR4 | pdb_00001jr4

1NU6 | pdb_00001nu6

1NU8 | pdb_00001nu8

1RWQ | pdb_00001rwq

2BIT | pdb_00002bit

2BIU | pdb_00002biu

2BOK | pdb_00002bok

2DEB | pdb_00002deb

2FVJ | pdb_00002fvj

2FW3 | pdb_00002fw3

2FYO | pdb_00002fyo

2JID | pdb_00002jid

3FEI | pdb_00003fei

3FEJ | pdb_00003fej

3G8I | pdb_00003g8i

3G9E | pdb_00003g9e

3H52 | pdb_00003h52

3HVH | pdb_00003hvh

3HVI | pdb_00003hvi

3HVJ | pdb_00003hvj

3HVK | pdb_00003hvk

3KWF | pdb_00003kwf

3KWJ | pdb_00003kwj

3MNE | pdb_00003mne

3MNO | pdb_00003mno