6VIL | pdb_00006vil

Crystal structure of mouse BAHCC1 BAH domain in complex with H3K27me3

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F [auth E]	BAH_1	e6vilE1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: BAH_1	ECOD (1.6)
A	BAH_1	e6vilA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: BAH_1	ECOD (1.6)
B	BAH_1	e6vilB1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: BAH_1	ECOD (1.6)
E [auth D]	BAH_1	e6vilD1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: BAH_1	ECOD (1.6)
G [auth F]	BAH_1	e6vilF1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: BAH_1	ECOD (1.6)
H [auth G]	BAH_1	e6vilG1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: BAH_1	ECOD (1.6)
I [auth H]	BAH_1	e6vilH1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: BAH_1	ECOD (1.6)
J [auth C]	BAH_1	e6vilC1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: BAH_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
F [auth E]	2.30.30.490	Mainly Beta	Roll	SH3 type barrels.	Bromo adjacent homology (BAH) domain	CATH (utative)
A	2.30.30.490	Mainly Beta	Roll	SH3 type barrels.	Bromo adjacent homology (BAH) domain	CATH (utative)
B	2.30.30.490	Mainly Beta	Roll	SH3 type barrels.	Bromo adjacent homology (BAH) domain	CATH (utative)
E [auth D]	2.30.30.490	Mainly Beta	Roll	SH3 type barrels.	Bromo adjacent homology (BAH) domain	CATH (utative)
G [auth F]	2.30.30.490	Mainly Beta	Roll	SH3 type barrels.	Bromo adjacent homology (BAH) domain	CATH (utative)
H [auth G]	2.30.30.490	Mainly Beta	Roll	SH3 type barrels.	Bromo adjacent homology (BAH) domain	CATH (utative)
I [auth H]	2.30.30.490	Mainly Beta	Roll	SH3 type barrels.	Bromo adjacent homology (BAH) domain	CATH (utative)
J [auth C]	2.30.30.490	Mainly Beta	Roll	SH3 type barrels.	Bromo adjacent homology (BAH) domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, E [auth D], F [auth E], G [auth F], A, B, E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth C]	PF01426	BAH domain (BAH)	BAH domain	This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, E [auth D], F [auth E], G [auth F], A, B, E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth C]	BAH and coiled-coil domain-containing protein 1	chromatin binding binding	behavior multicellular organismal process locomotory behavior developmental process cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular process system development behavior multicellular organismal process locomotory behavior developmental process cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular process system development cellular component organization chromatin organization cellular component organization or biogenesis	-
C [auth I], D [auth J], K [auth L], L [auth M]	Histone H3.1	DNA binding binding nucleic acid binding cell adhesion molecule binding cadherin binding protein binding protein heterodimerization activity protein dimerization activity structural molecule activity structural constituent of chromatin	protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization biosynthetic process protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process organelle organization telomere organization chromosome organization regulation of biosynthetic process regulation of biological process regulation of cellular process epigenetic regulation of gene expression biological regulation regulation of macromolecule metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of metabolic process	cellular anatomical structure membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex cellular anatomical structure membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle membraneless organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, E [auth D], F [auth E], G [auth F], A, B, E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth C]	IPR048924	BAHCC1-like, Tudor domain	Domain
A, B, E [auth D], F [auth E], G [auth F], A, B, E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth C]	IPR047411	BAH and coiled-coil domain-containing protein 1, Tudor domain	Domain
A, B, E [auth D], F [auth E], G [auth F], A, B, E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth C]	IPR052429	BAH domain-containing protein	Family
A, B, E [auth D], F [auth E], G [auth F], A, B, E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth C]	IPR043151	Bromo adjacent homology (BAH) domain superfamily	Homologous Superfamily
A, B, E [auth D], F [auth E], G [auth F], A, B, E [auth D], F [auth E], G [auth F], H [auth G], I [auth H], J [auth C]	IPR001025	Bromo adjacent homology (BAH) domain	Domain
C [auth I], D [auth J], K [auth L], L [auth M]	IPR009072	Histone-fold	Homologous Superfamily
C [auth I], D [auth J], K [auth L], L [auth M]	IPR007125	Histone H2A/H2B/H3	Domain
C [auth I], D [auth J], K [auth L], L [auth M]	IPR000164	Histone H3/CENP-A	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth I], D [auth J], K [auth L], L [auth M]	Pharos: P68431	lung carcinoma glioblastoma glioma large cell medulloblastoma malignant mesothelioma non-small cell lung carcinoma allergic rhinitis ovarian cancer autism spectrum disorder psoriasis cutaneous lupus erythematosus tuberculosis ependymoma gastric carcinoma Glioma of Brain, Familial lung carcinoma glioblastoma glioma large cell medulloblastoma malignant mesothelioma non-small cell lung carcinoma allergic rhinitis ovarian cancer autism spectrum disorder psoriasis cutaneous lupus erythematosus tuberculosis ependymoma gastric carcinoma Glioma of Brain, Familial hypertensive disorder lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm osteoarthritis astrocytoma (excluding glioblastoma) pancreatic intraductal papillary-mucinous carcinoma breast cancer spina bifida cystic fibrosis exocrine pancreatic carcinoma glioma susceptibility 1 invasive ductal breast carcinoma lung cancer malignant glioma medulloblastoma osteosarcoma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm breast carcinoma subependymoma ductal breast carcinoma in situ gastric cancer hepatocellular carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C [auth I], D [auth J], K [auth L], L [auth M]	M3L	Parent Component: LYS RESID: AA0074 PSI-MOD : N6,N6,N6-trimethyl-L-lysine MOD:00083

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.