LYS

LYSINE

Created:	1999-07-08
Last modified:	2024-09-27

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187 entries where LYS is found as a standalone ligand67 entries where LYS is covalently linked to polymer or other heterogen groups 226,490 entries where LYS is found in a polymer sequence

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Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

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Chemical Component Summary
Name	LYSINE
Systematic Name (OpenEye OEToolkits)	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCCC[NH3+]
SMILES	CACTVS	3.341	N[CH](CCCC[NH3+])C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCCC[NH3+])C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	InChI	1.03	KDXKERNSBIXSRK-YFKPBYRVSA-O

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00123
Name	Lysine
Groups	nutraceutical approved
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	(S)-2,6-diaminohexanoic acid (S)-α,ε-diaminocaproic acid L-lys L-Lysine Lysina Lysinum Lysine dihydrate Lysine acetate Lysine LYS Lysine hydrochloride L-Lysin L-2,6-Diaminocaproic acid Lysine monohydrate 6-ammonio-L-norleucine (S)-lysine Lysine acid
Brand Names	Aminosyn 10% W Electrolytes Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn II Aminosyn-PF 10% 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Clinimix Olimel 5.7% E Travasol Inj Without Electrolytes 5.5% Kabiven Plenamine 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Smofkabiven Extra Nitrogen Primene Smofkabiven Nutrineal Pd4 Primene 10%-liq IV Essepna Aminosyn 8.5% Aminosyn II 7% Injection Aminosyn II with Electrolytes RenAmin Periolimel 2.5% E 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Vamin N Primene 10% Aminosyn-PF 7% Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Travasol Amino Acid Inj 8.5% Hepatasol Clinisol Aminosyn 5% Olimel 5.7% Aminosyn II 5% Inj Nephramine Liq IV 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Travasol Amino Acid Inj 5.5% TrophAmine Aminosyn II In Dextrose Injection Perikabiven 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn II and Dextrose Aminosyn RF Injection Aminosyn-PF NephrAmine Travasol E Olimel 4.4% E 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Aminosyn 8.5% Injection With Electrolytes Olimel 7.6% E 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Xyzmune 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn Sulfite Free Aminosyn RF 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Novamine FreAmine III Aminosyn HF Aminosyn 3.5% M FreAmine HBC 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 20% Prosol 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn II 7% M In 10% Dextrose(dual Chamber) Aminosyn Synthamin 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Renamin (amino Acids) Injection Vamin 18 Electrolyte-free 4.25%travasol Amino Acid InJ.W.elecw.5%dex. HepatAmine Lysakare Aminosyn II 10% With Electrolytes Aminosyn II 7% With 10% Dextrose Aminosyn II 8.5% Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Olimel 7.6% Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn II 8.5% With 50% Dextrose Smofkabiven Electrolyte Free Olimel 3.3% E 8.5% Freamine III 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn II 7% With 50% Dextrose Effervescent Potassium Chloride 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Travasol Imubolic 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix ProcalAmine 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Clinimix E Travasol Inj Without Electrolytes 8.5% Premasol - sulfite-free (Amino Acid) Olimel 4.4% Aminosyn II in Dextrose 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn 7% ProSol
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682