1MHU | pdb_00001mhu

THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1mhua_	Small proteins	Metallothionein	Metallothionein	Metallothionein	Metallothionein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Metallothionein	8026923	4003746	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Metallothionein	8039302	3001404	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Metallothio_4	e1mhuA1	A: few secondary structure elements	X: Metallothionein (From Topology)	H: Metallothionein (From Topology)	T: Metallothionein	F: Metallothio_4	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00131	Metallothionein (Metallothio)	Metallothionein		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CD7 METALLOTHIONEIN-2	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	cellular response to stimulus response to copper ion cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to chemical cellular process cellular response to copper ion response to peptide cellular response to interleukin-3 response to cytokine cellular response to cytokine stimulus response to interleukin-3 cellular response to stimulus response to copper ion cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to chemical cellular process cellular response to copper ion response to peptide cellular response to interleukin-3 response to cytokine cellular response to cytokine stimulus response to interleukin-3 detoxification of inorganic compound detoxification of copper ion detoxification stress response to copper ion response to toxic substance response to stress stress response to metal ion inorganic ion homeostasis homeostatic process intracellular copper ion homeostasis copper ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis response to zinc ion cellular response to zinc ion cellular response to erythropoietin response to erythropoietin regulation of biological process regulation of growth negative regulation of growth negative regulation of biological process biological regulation growth cellular response to cadmium ion response to cadmium ion intracellular zinc ion homeostasis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017854	Metallothionein domain superfamily	Homologous Superfamily
A	IPR018064	Metallothionein, vertebrate, metal binding site	Binding Site
A	IPR000006	Metallothionein, vertebrate	Family
A	IPR023587	Metallothionein domain superfamily, vertebrate	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P02795	Neoplasm Invasiveness adult acute respiratory distress syndrome diabetes mellitus urinary bladder cancer prostate cancer prostate intraepithelial neoplasia heart disease lung cancer ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia chronic renal failure syndrome gastric neoplasm hepatocellular carcinoma interstitial cystitis malignant colon neoplasm Neoplasm Invasiveness adult acute respiratory distress syndrome diabetes mellitus urinary bladder cancer prostate cancer prostate intraepithelial neoplasia heart disease lung cancer ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia chronic renal failure syndrome gastric neoplasm hepatocellular carcinoma interstitial cystitis malignant colon neoplasm medulloblastoma non-small cell lung carcinoma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous carcinoma cystic fibrosis endometriosis urinary bladder neoplasm glioblastoma hereditary diffuse gastric adenocarcinoma large cell medulloblastoma lung adenocarcinoma malignant mesothelioma myopathy osteosarcoma pancreatic intraductal papillary-mucinous neoplasm dermatomyositis ulcerative colitis gastric cancer inherited disease susceptibility

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.