6K6U

Crystal structure of human YTHDC2 YTH domain.

(2019) Biochem Biophys Res Commun 518: 678-684

• PubMed: 31472957 Search on PubMed
• DOI: https://doi.org/10.1016/j.bbrc.2019.08.107
• Primary Citation of Related Structures:  
  6K6U


• PubMed Abstract: 
  

  N ⁶ -methyladenosine (m ⁶ A) "readers" play an important role in mRNA functions and metabolism. YTHDC2, as one of the m ⁶ A readers, controls fertileness through decreasing associated mRNA abundance and enhancing the translation efficiency of related mRNA via binding the targeted m ⁶ A RNA. However, how YTH domain of YTHDC2 recognize m ⁶ A RNA is still unknown. In this study, we determined the crystal structure of human YTHDC2 YTH domain, which adopts similar architecture to other solved YTH domain structures. YTHDC2 contains a conserved m ⁶ A binding pocket, and similar RNA binding surface shared by YTHDC1.

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Organizational Affiliation: 

Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, 230027, Hefei, China.