Download MendeleyA Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases
Sharma, M., Mangas-Sanchez, J., Turner, N.J., Grogan, G.(2018) ACS Catal
6EOD
Structure of Reductive Aminase from Aspergillus terreus in complex with NADPH
- PDB DOI: https://doi.org/10.2210/pdb6EOD/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Aspergillus terreus
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2017-10-09 Released: 2018-10-31
- Funding Organization(s): Biotechnology and Biological Sciences Research Council
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.20 Å
- R-Value Free: 0.236
- R-Value Work: 0.198
- R-Value Observed: 0.200
Starting Model: experimental
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This is version 1.2 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Reductive Aminase | 298 | Aspergillus terreus | Mutation(s): 0 Gene Names: ATEG_08501 |  | |
UniProt | |||||
Find proteins for Q0CCT3 (Aspergillus terreus (strain NIH 2624 / FGSC A1156)) Explore Q0CCT3 Go to UniProtKB: Q0CCT3 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q0CCT3 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAP Query on NAP | I [auth A], J [auth B], K [auth C] | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE C21 H28 N7 O17 P3 XJLXINKUBYWONI-NNYOXOHSSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.20 Å
- R-Value Free: 0.236
- R-Value Work: 0.198
- R-Value Observed: 0.200
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 75.977 | α = 90 |
| b = 85.552 | β = 90 |
| c = 355.423 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| xia2 | data reduction |
| XDS | data scaling |
| MOLREP | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2018-10-31 Deposition Author(s): Sharma, M., Mangas-Sanchez, J., Turner, N.J., Grogan, G.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Biotechnology and Biological Sciences Research Council | United Kingdom | BB/M006611/1 |
Revision History (Full details and data files)
- Version 1.0: 2018-10-31
Type: Initial release - Version 1.1: 2019-11-13
Changes: Data collection, Database references - Version 1.2: 2024-01-17
Changes: Data collection, Database references, Refinement description
