Phenylthiourea Binding to Human Tyrosinase-Related Protein 1
Lai, X., Wichers, H.J., Soler-Lopez, M., Dijkstra, B.W.(2020) Int J Mol Sci 
- DOI: https://doi.org/10.3390/ijms21030915
Experimental Data Snapshot
(2020) Int J Mol Sci 
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
5,6-dihydroxyindole-2-carboxylic acid oxidase | 446 | Homo sapiens | Mutation(s): 3  Gene Names: TYRP1, CAS2, TYRP, TYRRP EC: 1.14.18 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P17643 (Homo sapiens) Explore P17643  Go to UniProtKB:  P17643 | |||||
PHAROS:  P17643 GTEx:  ENSG00000107165  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P17643 | ||||
Glycosylation | |||||
Glycosylation Sites: 6 | Go to GlyGen: P17643-1 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 2 | |||||
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Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | E, H, P | 3 | N-Glycosylation | ||
Glycosylation Resources | |||||
GlyTouCan:  G21290RB GlyCosmos:  G21290RB GlyGen:  G21290RB |
Entity ID: 3 | |||||
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Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | F, G, J, L, N F, G, J, L, N, O, R, T | 2 | N-Glycosylation | ||
Glycosylation Resources | |||||
GlyTouCan:  G42666HT GlyCosmos:  G42666HT GlyGen:  G42666HT |
Entity ID: 4 | |||||
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Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
alpha-D-mannopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | I | 2 | N-Glycosylation | ||
Glycosylation Resources | |||||
GlyTouCan:  G87612PG GlyCosmos:  G87612PG GlyGen:  G87612PG |
Entity ID: 5 | |||||
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Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | K | 6 | N-Glycosylation | ||
Glycosylation Resources | |||||
GlyTouCan:  G64181RO GlyCosmos:  G64181RO GlyGen:  G64181RO |
Entity ID: 6 | |||||
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Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | M | 2 | N-Glycosylation | ||
Glycosylation Resources | |||||
GlyTouCan:  G86851RC GlyCosmos:  G86851RC GlyGen:  G86851RC |
Entity ID: 7 | |||||
---|---|---|---|---|---|
Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Q | 5 | N-Glycosylation | ||
Glycosylation Resources | |||||
GlyTouCan:  G26032DN GlyCosmos:  G26032DN GlyGen:  G26032DN |
Entity ID: 8 | |||||
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Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | S | 5 | N-Glycosylation | ||
Glycosylation Resources | |||||
GlyTouCan:  G21381MC GlyCosmos:  G21381MC GlyGen:  G21381MC |
Ligands 3 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
NAG Query on NAG | CA [auth C], DA [auth C], EA [auth C], U [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N | |||
URS Query on URS | FA [auth C], IA [auth D], V [auth A], Z [auth B] | N-PHENYLTHIOUREA C7 H8 N2 S FULZLIGZKMKICU-UHFFFAOYSA-N | |||
ZN Query on ZN | AA [auth B] BA [auth B] GA [auth C] HA [auth C] JA [auth D] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 90.081 | α = 90 |
b = 141.767 | β = 90 |
c = 191.73 | γ = 90 |
Software Name | Purpose |
---|---|
REFMAC | refinement |
PDB_EXTRACT | data extraction |
PHENIX | refinement |
SCALA | data scaling |
PHENIX | phasing |