Download MendeleyA novel human obesity and sensory deficit syndrome resulting from a mutation in the TUB gene
Boutboul, S., Carroll, K.J., Basdevant, A., Gomez, C., Nandrot, E., Clement, K., Shapiro, L., Abitbol, M.To be published.
1S31 | pdb_00001s31
Crystal Structure Analysis of the human Tub protein (isoform a) spanning residues 289 through 561
- PDB DOI: https://doi.org/10.2210/pdb1S31/pdb
- Classification: SIGNALING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Membrane Protein: Yes OPM
- Deposited: 2004-01-12 Released: 2005-01-25
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.70 Å
- R-Value Free: 0.226 (Depositor), 0.230 (DCC)
- R-Value Work: 0.181 (Depositor), 0.190 (DCC)
- R-Value Observed: 0.184 (Depositor)
Starting Model: experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 1.4 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| tubby isoform a | 273 | Homo sapiens | Mutation(s): 0 Gene Names: tub Membrane Entity: Yes |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P50607 (Homo sapiens) Explore P50607 Go to UniProtKB: P50607 | |||||
PHAROS: P50607 GTEx: ENSG00000166402 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P50607 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PGE Query on PGE | B [auth A] | TRIETHYLENE GLYCOL C6 H14 O4 ZIBGPFATKBEMQZ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.70 Å
- R-Value Free: 0.226 (Depositor), 0.230 (DCC)
- R-Value Work: 0.181 (Depositor), 0.190 (DCC)
- R-Value Observed: 0.184 (Depositor)
Space Group: I 2 3
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 149.981 | α = 90 |
| b = 149.981 | β = 90 |
| c = 149.981 | γ = 90 |
| Software Name | Purpose |
|---|---|
| DENZO | data reduction |
| SCALEPACK | data scaling |
| AMoRE | phasing |
| REFMAC | refinement |
Entry History
Deposition Data
- Released Date: 2005-01-25 Deposition Author(s): Boutboul, S., Carroll, K.J., Basdevant, A., Gomez, C., Nandrot, E., Clement, K., Shapiro, L., Abitbol, M.
Revision History (Full details and data files)
- Version 1.0: 2005-01-25
Type: Initial release - Version 1.1: 2008-04-29
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Advisory, Derived calculations, Version format compliance - Version 1.3: 2017-10-11
Changes: Refinement description - Version 1.4: 2023-08-23
Changes: Data collection, Database references, Derived calculations, Refinement description
