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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 7.4.2.8

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Search Summary

This query matches 71 Structures.

Refinements

Structure Determination Methodology

experimental (71)

Scientific Name of Source Organism

	Shigella flexneri (17)
	Escherichia coli (11)
	Bacillus subtilis subsp. subtilis str. 168 (10)
	Geobacillus thermodenitrificans NG80-2 (9)
	Bacillus subtilis (8)
	Escherichia coli K-12 (4)
	Escherichia coli O127:H6 str. E2348/69 (4)
	Lama glama (4)
	Aequorea victoria (3)
	Vibrio cholerae (3)

More...

Taxonomy

	Bacteria (71)
	Eukaryota (5)
	Archaea (1)
	other sequences (1)

Experimental Method

	X-RAY DIFFRACTION (58)
	ELECTRON MICROSCOPY (11)
	SOLUTION NMR (2)

Polymer Entity Type

	Protein (71)
	RNA (1)

Refinement Resolution (Å)

	1.5 - 2.0 (4)
	2.0 - 2.5 (19)
	2.5 - 3.0 (23)
	3.0 - 3.5 (15)
	3.5 - 4.0 (4)
	4.0 - 4.5 (1)
	> 4.5 (3)

Release Date

	2000 - 2004 (10)
	2005 - 2009 (17)
	2010 - 2014 (5)
	2015 - 2019 (30)
	2020 - 2024 (4)
	2025 - 2029 (5)

Enzyme Classification Name

	Translocases (71)
	Hydrolases (8)

Membrane Protein Annotation

	PDBTM (11)
	MemProtMD (6)
	OPM (6)
	mpstruc (5)

Symmetry Type

	Asymmetric (55)
	Cyclic (17)
	Dihedral (5)

SCOP Classification

	Alpha and beta proteins (a/b) (10)
	All alpha proteins (7)
	Alpha and beta proteins (a+b) (4)
	Artifacts (6)
	Membrane and cell surface proteins and peptides (1)
	Small proteins (2)

AllSelected

1 to 25 of 71 Structures

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1M6N \| pdb_00001m6n	Download File View File

Crystal structure of the SecA translocation ATPase from Bacillus subtilis

Hunt, J.F., Weinkauf, S., Henry, L., Fak, J.J., McNicholas, P., Oliver, D.B., Deisenhofer, J.

(2002) Science 297: 2018-2026

Released	2002-09-20
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Bacillus subtilis
Macromolecule	Preprotein translocase secA (protein)
Unique Ligands	SO4

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1M74 \| pdb_00001m74	Download File View File

Crystal structure of Mg-ADP-bound SecA from Bacillus subtilis

Hunt, J.F., Weinkauf, S., Henry, L., Fak, J.J., McNicholas, P., Oliver, D.B., Deisenhofer, J.

(2002) Science 297: 2018-2026

Released	2002-09-20
Method	X-RAY DIFFRACTION 3 Å
Organisms	Bacillus subtilis
Macromolecule	Preprotein translocase secA (protein)
Unique Ligands	ADP, MG, SO4

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1NKT \| pdb_00001nkt	Download File View File

CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEX WITH ADPBS

Sharma, V., Arockiasamy, A., Ronning, D.R., Savva, C.G., Holzenburg, A., Braunstein, M., Jacobs Jr., W.R., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)

(2003) Proc Natl Acad Sci U S A 100: 2243-2248

Released	2003-03-04
Method	X-RAY DIFFRACTION 2.601 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	Preprotein translocase secA 1 subunit (protein)
Unique Ligands	ADP, MG

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1NL3 \| pdb_00001nl3	Download File View File

CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS in APO FORM

Sharma, V., Arockiasamy, A., Ronning, D.R., Savva, C.G., Holzenburg, A., Braunstein, M., Jacobs Jr., W.R., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)

(2003) Proc Natl Acad Sci U S A 100: 2243-2248

Released	2003-03-04
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	PREPROTEIN TRANSLOCASE SECA 1 SUBUNIT (protein)

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1OZB \| pdb_00001ozb	Download File View File

Crystal Structure of SecB complexed with SecA C-terminus

Zhou, J., Xu, Z.

(2003) Nat Struct Biol 10: 942-947

Released	2003-10-14
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Haemophilus influenzae
Macromolecule	Preprotein translocase secA subunit (protein) Protein-export protein secB (protein)
Unique Ligands	ZN

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1P9R \| pdb_00001p9r	Download File View File

Crystal Structure of Vibrio cholerae putative NTPase EpsE

Robien, M.A., Krumm, B.E., Sandkvist, M., Hol, W.G.J.

(2003) J Mol Biology 333: 657-674

Released	2003-10-14
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Vibrio cholerae
Macromolecule	General secretion pathway protein E (protein)
Unique Ligands	CL, ZN

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1P9W \| pdb_00001p9w	Download File View File

Crystal Structure of Vibrio cholerae putative NTPase EpsE

Robien, M.A., Krumm, B.E., Sandkvist, M., Hol, W.G.J.

(2003) J Mol Biology 333: 657-674

Released	2003-10-14
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Vibrio cholerae
Macromolecule	General secretion pathway protein E (protein)
Unique Ligands	ANP, ZN

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1TF2 \| pdb_00001tf2	Download File View File

Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis

Osborne, A.R., Clemons Jr., W.M., Rapoport, T.A.

(2004) Proc Natl Acad Sci U S A 101: 10937-10942

Released	2004-08-03
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Bacillus subtilis
Macromolecule	Preprotein translocase secA subunit (protein)
Unique Ligands	ADP, MG

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1TF5 \| pdb_00001tf5	Download File View File

Crystal structure of SecA in an open conformation from Bacillus Subtilis

Osborne, A.R., Clemons Jr., W.M., Rapoport, T.A.

(2004) Proc Natl Acad Sci U S A 101: 10937-10942

Released	2004-08-03
Method	X-RAY DIFFRACTION 2.18 Å
Organisms	Bacillus subtilis
Macromolecule	Preprotein translocase secA subunit (protein)

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1TM6 \| pdb_00001tm6	Download File View File

NMR Structure of the Free Zinc Binding C-terminal Domain of SecA

Matousek, W.M., Alexandrescu, A.T.

(2004) Biochim Biophys Acta 1702: 163-171

Released	2004-10-12
Method	SOLUTION NMR
Organisms	Escherichia coli
Macromolecule	Preprotein translocase secA subunit (protein)
Unique Ligands	ZN

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2BH1 \| pdb_00002bh1	Download File View File

X-ray structure of the general secretion pathway complex of the N- terminal domain of EpsE and the cytosolic domain of EpsL of Vibrio cholerae

Abendroth, J., Murphy, P.M., Mushtaq, A., Bagdasarian, M., Sandkvist, M., Hol, W.G.J.

(2005) J Mol Biology 348: 845

Released	2005-05-13
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Vibrio cholerae
Macromolecule	GENERAL SECRETION PATHWAY PROTEIN E, (protein) GENERAL SECRETION PATHWAY PROTEIN L (protein)
Unique Ligands	CA

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2D27 \| pdb_00002d27	Download File View File

Structure of the N-terminal domain of XpsE (crystal form I4122)

Chen, Y., Shiue, S.-J., Huang, C.-W., Chang, J.-L., Chien, Y.-L., Hu, N.-T., Chan, N.-L.

(2005) J Biological Chem 280: 42356-42363

Released	2005-09-20
Method	X-RAY DIFFRACTION 2.21 Å
Organisms	Xanthomonas campestris
Macromolecule	type II secretion ATPase XpsE (protein)

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2D28 \| pdb_00002d28	Download File View File

Structure of the N-terminal domain of XpsE (crystal form P43212)

Chen, Y., Shiue, S.-J., Huang, C.-W., Chang, J.-L., Chien, Y.-L., Hu, N.-T., Chan, N.-L.

(2005) J Biological Chem 280: 42356-42363

Released	2005-09-20
Method	X-RAY DIFFRACTION 2 Å
Organisms	Xanthomonas campestris
Macromolecule	type II secretion ATPase XpsE (protein)
Unique Ligands	CAC

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2FSF \| pdb_00002fsf	Download File View File

Escherichia coli SecA, the preprotein translocase dimeric ATPase

Papanikolau, Y., Petratos, K., Economou, A.

(2007) J Mol Biology 366: 1545-1557

Released	2007-01-16
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli
Macromolecule	Preprotein translocase secA subunit (protein)

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2FSG \| pdb_00002fsg	Download File View File

Complex SecA:ATP from Escherichia coli

Papanikolau, Y., Petratos, K., Economou, A.

(2007) J Mol Biology 366: 1545-1557

Released	2007-01-16
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Escherichia coli
Macromolecule	Preprotein translocase secA subunit (protein)
Unique Ligands	ATP

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2FSH \| pdb_00002fsh	Download File View File

Complex SecA:AMP-PNP from Escherichia coli

Papanikolau, Y., Petratos, K., Economou, A.

(2007) J Mol Biology 366: 1545-1557

Released	2007-01-16
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli
Macromolecule	Preprotein translocase secA subunit (protein)
Unique Ligands	ANP

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2FSI \| pdb_00002fsi	Download File View File

Complex SecA:ADP from Escherichia coli

Papanikolau, Y., Petratos, K., Economou, A.

(2007) J Mol Biology 366: 1545-1557

Released	2007-01-16
Method	X-RAY DIFFRACTION 2.11 Å
Organisms	Escherichia coli
Macromolecule	Preprotein translocase secA subunit (protein)
Unique Ligands	ADP

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2IBM \| pdb_00002ibm	Download File View File

A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA

Zimmer, J., Li, W., Rapoport, T.A.

(2006) J Mol Biology 364: 259-265

Released	2006-11-14
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Bacillus subtilis
Macromolecule	Preprotein translocase secA subunit (protein)
Unique Ligands	ADP

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2IPC \| pdb_00002ipc	Download File View File

Crystal structure of the translocation ATPase SecA from Thermus thermophilus reveals a parallel, head-to-head dimer

Vassylyev, D.G., Mori, H., Vassylyeva, M.N., Tsukazaki, T., Kimura, Y., Tahirov, T.H., Ito, K., RIKEN Structural Genomics/Proteomics Initiative (RSGI)

(2006) J Mol Biology 364: 248-258

Released	2006-11-28
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Thermus thermophilus HB8
Macromolecule	Preprotein translocase SecA subunit (protein)

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2OBL \| pdb_00002obl	Download File View File

Structural and biochemical analysis of a prototypical ATPase from the type III secretion system of pathogenic bacteria

Zarivach, R., Vuckovic, M., Deng, W., Finlay, B.B., Strynadka, N.C.J.

(2007) Nat Struct Mol Biol 14: 131-137

Released	2007-01-30
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Escherichia coli O127:H6 str. E2348/69
Macromolecule	EscN (protein)
Unique Ligands	ACT, CA, IMD

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2OBM \| pdb_00002obm	Download File View File

Structural and biochemical analysis of a prototypical ATPase from the type III secretion system of pathogenic bacteria

Zarivach, R., Vuckovic, M., Deng, W., Finlay, B.B., Strynadka, N.C.J.

(2007) Nat Struct Mol Biol 14: 131-137

Released	2007-01-30
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Escherichia coli O127:H6 str. E2348/69
Macromolecule	EscN (protein)
Unique Ligands	ADP, CA

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2VDA \| pdb_00002vda	Download File View File

Solution structure of the SecA-signal peptide complex

Gelis, I., Bonvin, A.M.J.J., Keramisanou, D., Koukaki, M., Gouridis, G., Karamanou, S., Economou, A., Kalodimos, C.G.

(2007) Cell 131: 756

Released	2007-11-27
Method	SOLUTION NMR
Organisms	Escherichia coli
Macromolecule	MALTOPORIN (protein) TRANSLOCASE SUBUNIT SECA (protein)

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3BXZ \| pdb_00003bxz	Download File View File

Crystal structure of the isolated DEAD motor domains from Escherichia coli SecA

Nithianantham, S., Namjoshi, S., Shilton, B.H.

(2008) J Mol Biology 383: 380-389

Released	2008-09-30
Method	X-RAY DIFFRACTION 3 Å
Organisms	Escherichia coli
Macromolecule	Preprotein translocase subunit secA (protein)
Unique Ligands	ADP, MG, SPD

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3DIN \| pdb_00003din	Download File View File

Crystal structure of the protein-translocation complex formed by the SecY channel and the SecA ATPase

Zimmer, J., Nam, Y., Rapoport, T.A.

(2008) Nature 455: 936-943

Released	2008-10-07
Method	X-RAY DIFFRACTION 4.5 Å
Organisms	Thermotoga maritima MSB8 Thermotoga sp. RQ2
Macromolecule	Preprotein translocase subunit SecG (protein) Preprotein translocase subunit SecY (protein) Preprotein translocase subunit secE (protein) Protein translocase subunit secA (protein)
Unique Ligands	ADP, BEF, MG

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3DL8 \| pdb_00003dl8	Download File View File

Structure of the complex of aquifex aeolicus SecYEG and bacillus subtilis SecA

Nam, Y., Zimmer, J., Rapoport, T.A.

(2008) Nature 455: 936-943

Released	2008-12-02
Method	X-RAY DIFFRACTION 7.5 Å
Organisms	Aquifex aeolicus Bacillus subtilis
Macromolecule	Preprotein translocase subunit secY (protein) Protein translocase subunit secA (protein) Protein-export membrane protein secG (protein) SecE (protein)

1 to 25 of 71 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1M6N | pdb_00001m6n

1M74 | pdb_00001m74

1NKT | pdb_00001nkt

1NL3 | pdb_00001nl3

1OZB | pdb_00001ozb

1P9R | pdb_00001p9r

1P9W | pdb_00001p9w

1TF2 | pdb_00001tf2

1TF5 | pdb_00001tf5

1TM6 | pdb_00001tm6

2BH1 | pdb_00002bh1

2D27 | pdb_00002d27

2D28 | pdb_00002d28

2FSF | pdb_00002fsf

2FSG | pdb_00002fsg

2FSH | pdb_00002fsh

2FSI | pdb_00002fsi

2IBM | pdb_00002ibm

2IPC | pdb_00002ipc

2OBL | pdb_00002obl

2OBM | pdb_00002obm

2VDA | pdb_00002vda

3BXZ | pdb_00003bxz

3DIN | pdb_00003din

3DL8 | pdb_00003dl8