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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 5.2.1.8

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Search Summary

This query matches 835 Structures.

Refinements

Structure Determination Methodology

experimental (835)

Scientific Name of Source Organism

	Homo sapiens (737)
	Mus musculus (53)
	Danio rerio (39)
	Sus scrofa (35)
	Saccharomyces cerevisiae (30)
	synthetic construct (19)
	Saccharomyces cerevisiae S288C (18)
	Arabidopsis thaliana (10)
	Tetrahymena thermophila (9)
	Xenopus laevis (9)

More...

Taxonomy

	Eukaryota (826)
	Eukaryota (eukaryotes) (64)
	other sequences (19)
	Varidnaviria (14)
	Archaea (3)
	Bacteria (2)
	Riboviria (2)
	Duplodnaviria (1)
	Riboviria (RNA viruses and viroids) (1)

Experimental Method

	X-RAY DIFFRACTION (681)
	ELECTRON MICROSCOPY (78)
	SOLUTION NMR (76)
	SOLUTION SCATTERING (1)

Polymer Entity Type

	Protein (835)
	DNA (74)
	RNA (13)

Refinement Resolution (Å)

	1.0 - 1.5 (47)
	1.5 - 2.0 (206)
	2.0 - 2.5 (268)
	2.5 - 3.0 (138)
	3.0 - 3.5 (39)
	3.5 - 4.0 (13)
	4.0 - 4.5 (8)
	> 4.5 (40)

Release Date

	1995 - 1999 (13)
	2000 - 2004 (46)
	2005 - 2009 (82)
	2010 - 2014 (130)
	2015 - 2019 (282)
	2020 - 2024 (273)
	2025 - 2029 (9)

Enzyme Classification Name

	Transferases (835)
	Hydrolases (46)
	Isomerases (26)
	Oxidoreductases (2)

Membrane Protein Annotation

OPM (2)

Symmetry Type

	Asymmetric (697)
	Cyclic (159)
	Dihedral (9)
	Octahedral (5)
	Tetrahedral (2)

SCOP Classification

	All alpha proteins (245)
	Alpha and beta proteins (a+b) (92)
	Artifacts (84)
	Small proteins (22)
	All beta proteins (8)
	Peptides (8)
	Alpha and beta proteins (a/b) (2)
	Designed proteins (1)

AllSelected

1 to 25 of 835 Structures

Page 1 of 34

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1BOB \| pdb_00001bob	Download File View File

HISTONE ACETYLTRANSFERASE HAT1 FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH ACETYL COENZYME A

Dutnall, R.N., Tafrov, S.T., Sternglanz, R., Ramakrishnan, V.

(1998) Cell 94: 427-438

Released	1999-04-20
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	HISTONE ACETYLTRANSFERASE (protein)
Unique Ligands	ACO, CA

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1C9B \| pdb_00001c9b	Download File View File

CRYSTAL STRUCTURE OF A HUMAN TBP CORE DOMAIN-HUMAN TFIIB CORE DOMAIN COMPLEX BOUND TO AN EXTENDED, MODIFIED ADENOVIRAL MAJOR LATE PROMOTER (ADMLP)

Tsai, F.T.F., Sigler, P.B.

(2000) EMBO J 19: 25-36

Released	2000-01-10
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Homo sapiens
Macromolecule	GENERAL TRANSCRIPTION FACTOR IIB (protein) TATA BOX BINDING PROTEIN (protein) ADMLP TATA-BOX DNA CONTAINING IIB RECOGNITION ELEMENT (nucleic acid)

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1CM0 \| pdb_00001cm0	Download File View File

CRYSTAL STRUCTURE OF THE PCAF/COENZYME-A COMPLEX

Clements, A., Rojas, J.R., Trievel, R.C., Wang, L., Berger, S.L., Marmorstein, R.

(1999) EMBO J 18: 3521-3532

Released	1999-07-06
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	P300/CBP ASSOCIATING FACTOR (protein)
Unique Ligands	COA

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1DL6 \| pdb_00001dl6	Download File View File

SOLUTION STRUCTURE OF HUMAN TFIIB N-TERMINAL DOMAIN

Chen, H.-T., Legault, P., Glushka, J., Omichinski, J.G., Scott, R.A.

(2000) Protein Sci 9: 1743-1752

Released	2000-10-18
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	TRANSCRIPTION FACTOR II B (TFIIB) (protein)
Unique Ligands	ZN

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1E6I \| pdb_00001e6i	Download File View File

Bromodomain from GCN5 complexed with acetylated H4 peptide

Owen, D.J., Travers, A.A., Evans, P.R.

(2000) EMBO J 19: 6141

Released	2000-11-24
Method	X-RAY DIFFRACTION 1.87 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	HISTONE H4 (protein) TRANSCRIPTIONAL ACTIVATOR GCN5 (protein)

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1EQF \| pdb_00001eqf	Download File View File

CRYSTAL STRUCTURE OF THE DOUBLE BROMODOMAIN MODULE FROM HUMAN TAFII250

Jacobson, R.H., Ladurner, A.G., King, D.S., Tjian, R.

(2000) Science 288: 1422-1425

Released	2000-06-07
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	RNA POLYMERASE II TRANSCRIPTION INITIATION FACTOR (protein)
Unique Ligands	SO4

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1F68 \| pdb_00001f68	Download File View File

NMR SOLUTION STRUCTURE OF THE BROMODOMAIN FROM HUMAN GCN5

Wright, P.E., Hudson, B.P., Dyson, H.J.

(2000) J Mol Biology 304: 355-370

Released	2000-12-13
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	HISTONE ACETYLTRANSFERASE (protein)

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1F81 \| pdb_00001f81	Download File View File

SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP

De Guzman, R.N., Liu, H.L., Martinez-Yamout, M., Dyson, H.J., Wright, P.E.

(2000) J Mol Biology 303: 243-253

Released	2000-10-18
Method	SOLUTION NMR
Organisms	Mus musculus
Macromolecule	CREB-BINDING PROTEIN (protein)
Unique Ligands	ZN

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1FM6 \| pdb_00001fm6	Download File View File

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND ROSIGLITAZONE AND CO-ACTIVATOR PEPTIDES.

Gampe Jr., R.T., Montana, V.G., Lambert, M.H., Miller, A.B., Bledsoe, R.K., Milburn, M.V., Kliewer, S.A., Willson, T.M., Xu, H.E.

(2000) Mol Cell 5: 545-555

Released	2001-02-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (protein) RETINOIC ACID RECEPTOR RXR-ALPHA (protein) STEROID RECEPTOR COACTIVATOR (protein)
Unique Ligands	9CR, BRL

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1FM9 \| pdb_00001fm9	Download File View File

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES.

Gampe Jr., R.T., Montana, V.G., Lambert, M.H., Miller, A.B., Bledsoe, R.K., Milburn, M.V., Kliewer, S.A., Willson, T.M., Xu, H.E.

(2000) Mol Cell 5: 545-555

Released	2001-02-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (protein) RETINOIC ACID RECEPTOR RXR-ALPHA (protein) STEROID RECEPTOR COACTIVATOR (protein)
Unique Ligands	570, 9CR

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1FY7 \| pdb_00001fy7	Download File View File

CRYSTAL STRUCTURE OF YEAST ESA1 HISTONE ACETYLTRANSFERASE DOMAIN COMPLEXED WITH COENZYME A

Yan, Y., Barlev, N.A., Haley, R.H., Berger, S.L., Marmorstein, R.

(2000) Mol Cell 6: 1195-1205

Released	2000-11-29
Method	X-RAY DIFFRACTION 2 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	ESA1 HISTONE ACETYLTRANSFERASE (protein)
Unique Ligands	COA, NA

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1JJS \| pdb_00001jjs	Download File View File

NMR Structure of IBiD, A Domain of CBP/p300

Lin, C.H., Hare, B.J., Wagner, G., Harrison, S.C., Maniatis, T., Fraenkel, E.

(2001) Mol Cell 8: 581-590

Released	2001-10-03
Method	SOLUTION NMR
Organisms	Mus musculus
Macromolecule	CREB-BINDING PROTEIN (protein)

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1JM4 \| pdb_00001jm4	Download File View File

NMR Structure of P/CAF Bromodomain in Complex with HIV-1 Tat Peptide

Mujtaba, S., He, Y., Zeng, L., Farooq, A., Carlson, J.E., Ott, M., Verdin, E., Zhou, M.-M.

(2002) Mol Cell 9: 575-586

Released	2002-07-17
Method	SOLUTION NMR
Organisms	Homo sapiens Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)
Macromolecule	HIV-1 Tat Peptide (protein) P300/CBP-associated Factor (protein)

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1JSP \| pdb_00001jsp	Download File View File

NMR Structure of CBP Bromodomain in complex with p53 peptide

He, Y., Mujtaba, S., Zeng, L., Yan, S., Zhou, M.-M.

(2004) Mol Cell 13: 251-263

Released	2002-08-17
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	CREB-BINDING PROTEIN (protein) tumor protein p53 (protein)

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1K4W \| pdb_00001k4w	Download File View File

X-ray structure of the orphan nuclear receptor ROR beta ligand-binding domain in the active conformation

Stehlin, C., Wurtz, J.M., Steinmetz, A., Greiner, E., Schuele, R., Moras, D., Renaud, J.P.

(2001) EMBO J 20: 5822-5831

Released	2002-04-09
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens Rattus norvegicus
Macromolecule	Nuclear receptor ROR-beta (protein) steroid receptor coactivator-1 (protein)
Unique Ligands	STE

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1K74 \| pdb_00001k74	Download File View File

The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.

Xu, H.E., Lambert, M.H., Montana, V.G., Moore, L.B., Collins, J.L., Oplinger, J.A., Kliewer, S.A., Gampe Jr., R.T., McKee, D.D., Moore, J.T., Willson, T.M.

(2001) Proc Natl Acad Sci U S A 98: 13919-13924

Released	2001-12-05
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Peroxisome proliferator activated receptor gamma (protein) Retinoic acid receptor RXR-alpha (protein) steroid receptor coactivator (protein)
Unique Ligands	544, 9CR

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1K7L \| pdb_00001k7l	Download File View File

The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide.

Xu, H.E., Lambert, M.H., Montana, V.G., Moore, L.B., Collins, J.L., Oplinger, J.A., Kliewer, S.A., Gampe Jr., R.T., McKee, D.D., Moore, J.T., Willson, T.M.

(2001) Proc Natl Acad Sci U S A 98: 13919-13924

Released	2001-12-05
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Peroxisome proliferator activated receptor alpha (protein) steroid receptor coactivator (protein)
Unique Ligands	544, YT3

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1KBH \| pdb_00001kbh	Download File View File

Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR

Demarest, S.J., Martinez-Yamout, M., Chung, J., Chen, H., Xu, W., Dyson, H.J., Evans, R.M., Wright, P.E.

(2002) Nature 415: 549-553

Released	2002-02-06
Method	SOLUTION NMR
Organisms	Homo sapiens Mus musculus
Macromolecule	CREB-BINDING PROTEIN (protein) nuclear receptor coactivator (protein)

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1KDX \| pdb_00001kdx	Download File View File

KIX DOMAIN OF MOUSE CBP (CREB BINDING PROTEIN) IN COMPLEX WITH PHOSPHORYLATED KINASE INDUCIBLE DOMAIN (PKID) OF RAT CREB (CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN), NMR 17 STRUCTURES

Radhakrishnan, I., Perez-Alvarado, G.C., Dyson, H.J., Wright, P.E.

(1997) Cell 91: 741-752

Released	1998-11-25
Method	SOLUTION NMR
Organisms	Mus musculus Rattus norvegicus
Macromolecule	CBP (protein) CREB (protein)

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1KV6 \| pdb_00001kv6	Download File View File

X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation

Greschik, H., Wurtz, J.-M., Sanglier, S., Bourguet, W., van Dorsselaer, A., Moras, D., Renaud, J.-P., Structural Proteomics in Europe (SPINE)

(2002) Mol Cell 9: 303-313

Released	2003-01-25
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	ESTROGEN-RELATED RECEPTOR GAMMA (protein) steroid receptor coactivator 1 (protein)

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1L3E \| pdb_00001l3e	Download File View File

NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex

Freedman, S.J., Sun, Z.J., Poy, F., Kung, A.L., Livingston, D.M., Wagner, G., Eck, M.J.

(2002) Proc Natl Acad Sci U S A 99: 5367-5372

Released	2002-04-24
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	hypoxia inducible factor-1 alpha subunit (protein) p300 protein (protein)
Unique Ligands	ZN

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1L8C \| pdb_00001l8c	Download File View File

STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE

Dames, S.A., Martinez-Yamout, M., De Guzman, R.N., Dyson, H.J., Wright, P.E.

(2002) Proc Natl Acad Sci U S A 99: 5271-5276

Released	2002-04-10
Method	SOLUTION NMR
Organisms	Homo sapiens Mus musculus
Macromolecule	CREB-binding protein (protein) Hypoxia-inducible factor 1 alpha (protein)
Unique Ligands	ZN

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1LIQ \| pdb_00001liq	Download File View File

Non-native Solution Structure of a fragment of the CH1 domain of CBP

Sharpe, B.K., Matthews, J.M., Kwan, A.H.Y., Newton, A., Gell, D.A., Crossley, M., Mackay, J.P.

(2002) Structure 10: 639-648

Released	2002-05-29
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	CREB Binding Protein (protein)
Unique Ligands	ZN

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1M1D \| pdb_00001m1d	Download File View File

TETRAHYMENA GCN5 WITH BOUND BISUBSTRATE ANALOG INHIBITOR

Poux, A.N., Cebrat, M., Kim, C.M., Cole, P.A., Marmorstein, R.

(2002) Proc Natl Acad Sci U S A 99: 14065-14070

Released	2002-10-30
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Tetrahymena thermophila
Macromolecule	HISTONE H3 (protein) TGCN5 HISTONE ACETYL TRANSFERASE (protein)