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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 3.1.3.48

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Search Summary

This query matches 1,170 Structures.

Refinements

Structure Determination Methodology

experimental (1,170)

Scientific Name of Source Organism

	Homo sapiens (942)
	Mus musculus (58)
	Yersinia enterocolitica (19)
	Arabidopsis thaliana (16)
	Bos taurus (16)
	Rattus norvegicus (13)
	Saccharomyces cerevisiae (12)
	Yersinia pestis (12)
	Drosophila melanogaster (11)
	synthetic construct (10)

More...

Taxonomy

	Eukaryota (1,073)
	Bacteria (93)
	Eukaryota (eukaryotes) (18)
	other sequences (10)
	Archaea (6)
	Varidnaviria (6)
	Monodnaviria (5)
	Riboviria (2)
	Viruses incertae sedis (1)

Experimental Method

	X-RAY DIFFRACTION (1,094)
	SOLUTION NMR (62)
	ELECTRON MICROSCOPY (14)

Polymer Entity Type

	Protein (1,170)
	RNA (5)

Refinement Resolution (Å)

	1.0 - 1.5 (47)
	1.5 - 2.0 (507)
	2.0 - 2.5 (357)
	2.5 - 3.0 (133)
	3.0 - 3.5 (51)
	3.5 - 4.0 (8)
	4.0 - 4.5 (2)
	> 4.5 (3)

Release Date

	1990 - 1994 (10)
	1995 - 1999 (27)
	2000 - 2004 (98)
	2005 - 2009 (224)
	2010 - 2014 (162)
	2015 - 2019 (313)
	2020 - 2024 (335)
	2025 - 2029 (1)

Enzyme Classification Name

	Hydrolases (1,170)
	Transferases (43)
	Oxidoreductases (10)
	Isomerases (1)

Membrane Protein Annotation

	OPM (3)
	mpstruc (3)

Symmetry Type

	Asymmetric (1,085)
	Cyclic (95)
	Dihedral (9)
	Octahedral (1)

SCOP Classification

	Alpha and beta proteins (a/b) (638)
	Artifacts (127)
	All beta proteins (60)
	Alpha and beta proteins (a+b) (66)
	All alpha proteins (11)

AllSelected

1 to 25 of 1,170 Structures

Page 1 of 47

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1A5Y \| pdb_00001a5y	Download File View File

PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE

Pannifer, A.D.P., Flint, A.J., Tonks, N.K., Barford, D.

(1998) J Biological Chem 273: 10454-10462

Released	1998-06-17
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN TYROSINE PHOSPHATASE 1B (protein)

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1AAX \| pdb_00001aax	Download File View File

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES

Puius, Y.A., Zhao, Y., Sullivan, M., Lawrence, D., Almo, S.C., Zhang, Z.-Y.

(1997) Proc Natl Acad Sci U S A 94: 13420-13425

Released	1998-03-04
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN TYROSINE PHOSPHATASE 1B (protein)
Unique Ligands	BPM, MG

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1AYA \| pdb_00001aya	Download File View File

CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE

Lee, C.-H., Kuriyan, J.

(1994) Structure 2: 423-438

Released	1994-08-31
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Mus musculus
Macromolecule	PEPTIDE PDGFR-1009 (protein) PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) (protein)

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1AYB \| pdb_00001ayb	Download File View File

CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE

Lee, C.-H., Kuriyan, J.

(1994) Structure 2: 423-438

Released	1994-08-31
Method	X-RAY DIFFRACTION 3 Å
Organisms	Mus musculus
Macromolecule	PEPTIDE IRS-1-895 (protein) PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) (protein)

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1AYC \| pdb_00001ayc	Download File View File

CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE

Lee, C.-H., Kuriyan, J.

(1994) Structure 2: 423-438

Released	1994-08-31
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Mus musculus
Macromolecule	PEPTIDE PDGFR-740 (protein) PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) (protein)

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1AYD \| pdb_00001ayd	Download File View File

CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE

Lee, C.-H., Kuriyan, J.

(1994) Structure 2: 423-438

Released	1994-08-31
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Mus musculus
Macromolecule	PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) (protein)

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1BVH \| pdb_00001bvh	Download File View File

SOLUTION STRUCTURE OF A LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE

Logan, T.M., Zhou, M.-M., Nettesheim, D.G., Meadows, R.P., Van Etten, R.L., Fesik, S.W.

(1994) Biochemistry 33: 11087-11096

Released	1994-07-31
Method	SOLUTION NMR
Organisms	Bos taurus
Macromolecule	ACID PHOSPHATASE (protein)

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1BZC \| pdb_00001bzc	Download File View File

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI

Groves, M.R., Yao, Z.J., Jr Burke, T.R., Barford, D.

(1998) Biochemistry 37: 17773-17783

Released	1999-02-16
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) (protein)
Unique Ligands	TPI

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1BZH \| pdb_00001bzh	Download File View File

Cyclic peptide inhibitor of human PTP1B

Groves, M.R., Yao, Z.J., Burke Jr., T.R., Barford, D.

(1998) Biochemistry 37: 17773-17783

Released	1999-02-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR) (protein) PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B) (protein)

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1BZJ \| pdb_00001bzj	Download File View File

Human ptp1b complexed with tpicooh

Groves, M.R., Yao, Z.-J., Barford Jr., D.T.B.

(1998) Biochemistry 37: 17773-17783

Released	1999-02-16
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) (protein)
Unique Ligands	PIC

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1C0E \| pdb_00001c0e	Download File View File

Active Site S19A Mutant of Bovine Heart Phosphotyrosyl Phosphatase

Tabernero, L., Evans, B.N., Tishmack, P.A., Van Etten, R.L., Stauffacher, C.V.

(1999) Biochemistry 38: 11651-11658

Released	1999-09-28
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Bos taurus
Macromolecule	PROTEIN (TYROSINE PHOSPHATASE (ORTHOPHOSPHORIC MONOESTER PHOSPHOHYDROLASE)) (protein)
Unique Ligands	PO4

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1C25 \| pdb_00001c25	Download File View File

HUMAN CDC25A CATALYTIC DOMAIN

Fauman, E.B., Cogswell, J.P., Lovejoy, B., Rocque, W.J., Holmes, W., Montana, V.G., Piwnica-Worms, H., Rink, M.J., Saper, M.A.

(1998) Cell 93: 617-625

Released	1998-08-19
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	CDC25A (protein)

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1C83 \| pdb_00001c83	Download File View File

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID

Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.

(2000) J Biological Chem 275: 7101-7108

Released	2000-05-03
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) (protein)
Unique Ligands	OAI

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1C84 \| pdb_00001c84	Download File View File

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID

Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.

(2000) J Biological Chem 275: 7101-7108

Released	2000-05-03
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) (protein)
Unique Ligands	761

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1C85 \| pdb_00001c85	Download File View File

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID

Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.

(2000) J Biological Chem 275: 7101-7108

Released	2000-05-03
Method	X-RAY DIFFRACTION 2.72 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) (protein)
Unique Ligands	OBA

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1C86 \| pdb_00001c86	Download File View File

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID

Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.

(2000) J Biological Chem 275: 10300-10307

Released	2000-05-03
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) (protein)
Unique Ligands	OPA

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1C87 \| pdb_00001c87	Download File View File

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID

Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.

(2000) J Biological Chem 275: 10300-10307

Released	2000-05-03
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) (protein)
Unique Ligands	OPA

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1C88 \| pdb_00001c88	Download File View File

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID

Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.

(2000) J Biological Chem 275: 10300-10307

Released	2000-05-03
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) (protein)
Unique Ligands	OTA

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1CVI \| pdb_00001cvi	Download File View File

CRYSTAL STRUCTURE OF HUMAN PROSTATIC ACID PHOSPHATASE

Jakob, C.G., Lewinski, K., Kuciel, R., Ostrowski, W., Lebioda, L.

(2000) Prostate 42: 211-218

Released	1999-08-31
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Homo sapiens
Macromolecule	PROSTATIC ACID PHOSPHATASE (protein)
Unique Ligands	GLY, NAG
Unique branched monosaccharides	BMA, FUC, MAN, NAG

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1CWR \| pdb_00001cwr	Download File View File

HUMAN CDC25B CATALYTIC DOMAIN WITHOUT ION IN CATALYTIC SITE

Watenpaugh, K.D., Reynolds, R.A., Chidester, C.G.

(1999) J Mol Biology 293: 559-568

Released	2000-08-28
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (M-PHASE INDUCER PHOSPHATASE 2 (CDC25B)) (protein)
Unique Ligands	BME, SO4

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1CWS \| pdb_00001cws	Download File View File

HUMAN CDC25B CATALYTIC DOMAIN WITH TUNGSTATE

Watenpaugh, K.D., Reynolds, R.A., Chidester, C.G.

(1999) J Mol Biology 293: 559-568

Released	2000-08-30
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	CDC25 B-TYPE TYROSINE PHOSPHATASE (protein)
Unique Ligands	BME, CL, SO4, WO4

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1CWT \| pdb_00001cwt	Download File View File

HUMAN CDC25B CATALYTIC DOMAIN WITH METHYL MERCURY

Watenpaugh, K.D., Reynolds, R.A.

(1999) J Mol Biology 293: 559-568

Released	2000-08-30
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	CDC25 B-TYPE TYROSINE PHOSPHATASE (protein)
Unique Ligands	CL, MMC, SO4

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1D1P \| pdb_00001d1p	Download File View File

CRYSTAL STRUCTURE OF A YEAST LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LTP1)

Wang, S., Tabernero, L., Zhang, M., Harms, E., Van Etten, R.L., Stauffacher, C.V.

(2000) Biochemistry 39: 1903-1914

Released	2000-03-08
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	TYROSINE PHOSPHATASE (protein)
Unique Ligands	EPE

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1D1Q \| pdb_00001d1q	Download File View File

CRYSTAL STRUCTURE OF A YEAST LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LTP1) COMPLEXED WITH THE SUBSTRATE PNPP

Wang, S., Tabernero, L., Zhang, M., Harms, E., Van Etten, R.L., Staufacher, C.V.

(2000) Biochemistry 39: 1903-1914

Released	2000-03-08
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	TYROSINE PHOSPHATASE (E.C.3.1.3.48) (protein)
Unique Ligands	4NP, GOL, PO4

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1D2A \| pdb_00001d2a	Download File View File

CRYSTAL STRUCTURE OF A YEAST LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LTP1) COMPLEXED WITH THE ACTIVATOR ADENINE

Wang, S., Stauffacher, C.V., Van Etten, R.L.

(2000) Biochemistry 39: 1234-1242

Released	2000-03-01
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	TYROSINE PHOSPHATASE (protein)
Unique Ligands	ADE, CL, PO4

1 to 25 of 1,170 Structures

Page 1 of 47

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1A5Y | pdb_00001a5y

1AAX | pdb_00001aax

1AYA | pdb_00001aya

1AYB | pdb_00001ayb

1AYC | pdb_00001ayc

1AYD | pdb_00001ayd

1BVH | pdb_00001bvh

1BZC | pdb_00001bzc

1BZH | pdb_00001bzh

1BZJ | pdb_00001bzj

1C0E | pdb_00001c0e

1C25 | pdb_00001c25

1C83 | pdb_00001c83

1C84 | pdb_00001c84

1C85 | pdb_00001c85

1C86 | pdb_00001c86

1C87 | pdb_00001c87

1C88 | pdb_00001c88

1CVI | pdb_00001cvi

1CWR | pdb_00001cwr

1CWS | pdb_00001cws

1CWT | pdb_00001cwt

1D1P | pdb_00001d1p

1D1Q | pdb_00001d1q

1D2A | pdb_00001d2a