GLY

GLYCINE

Created:	1999-07-08
Last modified:	2024-09-27

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407 entries where GLY is found as a standalone ligand60 entries where GLY is covalently linked to polymer or other heterogen groups 222,727 entries where GLY is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	10
Chiral Atom Count	0
Bond Count	9
Aromatic Bond Count	0

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Chemical Component Summary
Name	GLYCINE
Systematic Name (OpenEye OEToolkits)	2-aminoethanoic acid
Formula	C₂ H₅ N O₂
Molecular Weight	75.067
Type	PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)CN
SMILES	CACTVS	3.341	NCC(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(=O)O)N
Canonical SMILES	CACTVS	3.341	NCC(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(C(=O)O)N
InChI	InChI	1.03	InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKey	InChI	1.03	DHMQDGOQFOQNFH-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB00145
Name	Glycine
Groups	approved vet_approved nutraceutical
Description	A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
Synonyms	Leimzucker Gly Aminoacetic acid Aminoethanoic acid Glyzin Glycin Glykokoll Glycine Glicina Aminoessigsäure Glycocoll
Brand Names	Smofkabiven Peripheral 2.75% Travas. Amino Acid InJ.W.elecw.25%dex 8.5% Freamine III 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II Olimel 3.3% E Aminosyn II with Electrolytes in Dextrose with Calcium Vamin N Aminosyn 8.5% Injection With Electrolytes Clinimix Aminosyn Nutrineal Pd4 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Aminosyn II 7% With 50% Dextrose Primene 10% Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Travasol Amino Acid Inj 8.5% Aminosyn II 7% M In 10% Dextrose(dual Chamber) Smofkabiven Electrolyte Free 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Glycine Irrigation 1.5% USP 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Olimel 7.6% 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminoderm Poudre HepatAmine Ph 12 Sterile Diluent for Flolan 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II 8.5% With 50% Dextrose Aminosyn II and Dextrose Plenamine 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Perikabiven 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Glycine Irrigation USP Aminosyn HF Aminosyn II In Dextrose Injection Aminosyn 3.5% M Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Antacid 2 Tablets 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II 8.5% Injection Primene 10%-liq IV Clinimix E Clinisol 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. RenAmin 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Olimel 5.7% 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Olimel 7.6% E 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Travasol E 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Vamin 18 Electrolyte-free Aminosyn-PF Olimel 5.7% E Premasol - sulfite-free (Amino Acid) Sterile Diluent for Flolan Injection 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Aminosyn 10% W Electrolytes Aminosyn Sulfite Free 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Glycine 1.5% Irrigation USP Sol Aminosyn-PF 10% Aminosyn II in Dextrose BANACOCica-aid Centella Peptide emulsion Primene Novamine Aminosyn 5% Aminosyn 8.5% Periolimel 2.5% E Travasol Inj Without Electrolytes 8.5% CAREDO Treating Gingivitis Toothpastes 100g Cicatrin Powder Travasol Inj Without Electrolytes 5.5% Travasol Amino Acid Inj 5.5% 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Travasol Renamin (amino Acids) Injection Smofkabiven Synthamin Olimel 4.4% CAREDO Repair Cracked Teeth Toothpastes 100g 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose ProSol 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Hepatasol Aminosyn-PF 7% ProcalAmine TrophAmine Aminosyn II 7% With 10% Dextrose Smofkabiven Extra Nitrogen Electrolyte Free FreAmine HBC Aminosyn II 5% Inj FreAmine III Aminosyn II 10% With Electrolytes 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Smofkabiven Extra Nitrogen 20% Prosol Aminosyn II with Electrolytes Essepna Olimel 4.4% E 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn II 7% Injection Aminosyn 7% Kabiven Glycine
Indication	Supplemental glycine may have antispastic activity. Very early findings suggest it may also have antipsychotic activity as well as antioxidant and anti-inflammatory activities.
Categories	Amino Acids Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Dietary Supplements Glycine Agents Irrigating Solutions Neurotransmitter Agents Proteinogenic Amino Acids Supplements
ATC-Code	B05CX03
CAS number	56-40-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	MWPGNAWRAALFWVPRGRRAQSALAQLRGILEGELEGIRGAGTWKSERVI...	unknown	substrate
5-aminolevulinate synthase, nonspecific, mitochondrial	MESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALST...	unknown	substrate
5-aminolevulinate synthase, erythroid-specific, mitochondrial	MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQ...	unknown	substrate
Glycine--tRNA ligase	MPSPRPVLLRGARAALLLLLPPRLLARPSLLLRRSLSAASCPPISLPAAA...	unknown	substrate
Glutamate receptor ionotropic, NMDA 2A	MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERE...	unknown	antagonist
Bile acid-CoA:amino acid N-acyltransferase	MIQLTATPVSALVDEPVHIRATGLIPFQMVSFQASLEDENGDMFYSQAHY...	unknown	substrate
N-arachidonyl glycine receptor	MITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCT...	unknown	substrate
Glutathione synthetase	MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPF...	unknown	substrate
Glutamate receptor ionotropic, NMDA 2C	MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARL...	unknown	agonist
Serine hydroxymethyltransferase	MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLS...	unknown	product of
Glycine N-acyltransferase	MMLPLQGAQMLQMLEKSLRKSLPASLKVYGTVFHINHGNPFNLKAVVDKW...	unknown	substrate
Serine hydroxymethyltransferase, mitochondrial	MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLS...	unknown	product of
Glycine N-acyltransferase-like protein 2	MLVLHNSQKLQILYKSLEKSIPESIKVYGAIFNIKDKNPFNMEVLVDAWP...	unknown	substrate
Glycine N-acyltransferase-like protein 1	MILLNNSHKLLALYKSLARSIPESLKVYGSVYHINHGNPFNMEVLVDSWP...	unknown	substrate
Alanine--glyoxylate aminotransferase 2, mitochondrial	MTLIWRHLLRPLCLVTSAPRILEMHPFLSLGTSRTSVTKLSLHTKPRMPP...	unknown	product of
Peroxisomal sarcosine oxidase	MAAQKDLWDAIVIGAGIQGCFTAYHLAKHRKRILLLEQFFLPHSRGSSHG...	unknown	product of
Glutamate receptor ionotropic, NMDA 3B	MEFVRALWLGLALALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLAR...	unknown	substrate
Glycine receptor subunit alpha-1	MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTS...	unknown	ligand
Serine--pyruvate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown	substrate
Glycine receptor subunit beta	MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLAR...	unknown	ligand
Serine hydroxymethyltransferase, cytosolic	MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLEL...	unknown	product of
Glycine receptor subunit alpha-3	MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKL...	unknown	ligand
Glycine receptor subunit alpha-2	MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDK...	unknown	ligand
Glycine N-methyltransferase	MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLL...	unknown	substrate
Glycine amidinotransferase, mitochondrial	MLRVRCLRGGSRGAEAVHYIGSRLGRTLTGWVQRTFQSTQAATASSRNSC...	unknown	substrate
Aminomethyltransferase, mitochondrial	MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMV...	unknown	substrate
Glycine dehydrogenase [decarboxylating], mitochondrial	MQSCARAWGLRLGRGVGGGRRLAGGSGPCWAPRSRDSSSGGGDSAAAGAS...	unknown	substrate
Dihydrolipoyl dehydrogenase, mitochondrial	MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSG...	unknown	substrate
Glycine cleavage system H protein, mitochondrial	MALRVVRSVRALLCTLRAVPSPAAPCPPRPWQLGVGAVRTLRTGPALLSV...	unknown	substrate
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Proton-coupled amino acid transporter 1	MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWF...	unknown	substrate
Vesicular inhibitory amino acid transporter	MATLLRSKLSNVATSVSNKSQAKMSGMFARMGFQAATDEEAVGFAHCDDL...	unknown	substrate
Sodium- and chloride-dependent glycine transporter 2	MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPR...	unknown	substrate
Sodium- and chloride-dependent glycine transporter 1	MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPS...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682