RCSB PDB: Search

2IAE \| pdb_00002iae	Download File View File

Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.

Cho, U.S., Xu, W.

(2007) Nature 445: 53-57

Released	2006-12-26
Method	X-RAY DIFFRACTION 3.5 Å
Organisms	Homo sapiens Microcystis aeruginosa Mus musculus
Macromolecule	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) microcystin-LR (protein)
Unique Ligands	MN

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2IE3 \| pdb_00002ie3	Download File View File

Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins

Xing, Y., Xu, Y., Chen, Y., Jeffrey, P.D., Chao, Y., Shi, Y.

(2006) Cell 127: 341-353

Released	2006-11-07
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Cyanobacteriota Homo sapiens
Macromolecule	Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) microcystin LR (protein)
Unique Ligands	MN

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2IE4 \| pdb_00002ie4	Download File View File

Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid

Xing, Y., Xu, Y., Chen, Y., Jeffrey, P.D., Chao, Y., Shi, Y.

(2006) Cell 127: 341-353

Released	2006-11-07
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein)
Unique Ligands	MN, OKA

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2NPP \| pdb_00002npp	Download File View File

Structure of the Protein Phosphatase 2A Holoenzyme

Xu, Y., Chen, Y., Xing, Y., Chao, Y., Shi, Y.

(2006) Cell 127: 1239-1251

Released	2006-12-12
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Cyanobacteriota Homo sapiens
Macromolecule	Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) microcystin LR (protein)
Unique Ligands	MN

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2NYL \| pdb_00002nyl	Download File View File

Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated

Xing, Y., Xu, Y., Chen, Y., Chao, Y., Lin, Z., Shi, Y.

(2006) Cell 127: 1239-1251

Released	2006-12-12
Method	X-RAY DIFFRACTION 3.8 Å
Organisms	Cyanobacteriota Homo sapiens
Macromolecule	Protein phosphatase 2, regulatory subunit A (PR 65), alpha isoform (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) microcystin LR (protein)
Unique Ligands	MN

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2NYM \| pdb_00002nym	Download File View File

Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit

Chen, Y., Xing, Y., Xu, Y., Chao, Y., Lin, Z., Jeffrey, P.D., Shi, Y.

(2006) Cell 127: 1239-1251

Released	2006-12-12
Method	X-RAY DIFFRACTION 3.6 Å
Organisms	Cyanobacteriota Homo sapiens
Macromolecule	Protein phosphatase 2 (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) microcystin LR (protein)
Unique Ligands	MN

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2PF4 \| pdb_00002pf4	Download File View File

Crystal structure of the full-length simian virus 40 small t antigen complexed with the protein phosphatase 2A Aalpha subunit

Cho, U., Morrone, S., Xu, W.

(2007) PLoS Biol 5: e202-e202

Released	2007-08-07
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Betapolyomavirus macacae Mus musculus
Macromolecule	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Small T antigen (protein)
Unique Ligands	ZN

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2PKG \| pdb_00002pkg	Download File View File

Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40

Jeffrey, P.D., Shi, Y.

(2007) Nat Struct Mol Biol 14: 527-534

Released	2007-05-15
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Betapolyomavirus macacae Homo sapiens
Macromolecule	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Small T antigen (protein)
Unique Ligands	ZN

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3DW8 \| pdb_00003dw8	Download File View File

Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit

Xu, Y., Chen, Y., Zhang, P., Jeffrey, P.D., Shi, Y.

(2008) Mol Cell 31: 873-885

Released	2008-10-07
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Cyanobacteriota Homo sapiens
Macromolecule	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (protein) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) microcystin LR (protein)
Unique Ligands	MN

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3FGA \| pdb_00003fga	Download File View File

Structural Basis of PP2A and Sgo interaction

Xu, Z., Xu, W.

(2009) Mol Cell 35: 426-441

Released	2009-09-22
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens Microcystis aeruginosa Mus musculus
Macromolecule	MICROCYSTIN-LR (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) Shugoshin-like 1 (protein)
Unique Ligands	MN

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3K7V \| pdb_00003k7v	Download File View File

Protein phosphatase 2A core complex bound to dinophysistoxin-1

Jeffrey, P.D., Huhn, J., Shi, Y.

(2009) Chem Res Toxicol 22: 1782-1786

Released	2009-11-03
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein)
Unique Ligands	MN, SO4, XT1

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3K7W \| pdb_00003k7w	Download File View File

Protein phosphatase 2A core complex bound to dinophysistoxin-2

Jeffrey, P.D., Huhn, J., Shi, Y.

(2009) Chem Res Toxicol 22: 1782-1786

Released	2009-11-03
Method	X-RAY DIFFRACTION 2.96 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein)
Unique Ligands	MN, SO4, XT2

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4I5L \| pdb_00004i5l	Download File View File

Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation

Wlodarchak, N., Satyshur, K.A., Guo, F., Xing, Y.

(2013) Cell Res 23: 931-946

Released	2013-05-08
Method	X-RAY DIFFRACTION 2.43 Å
Organisms	Homo sapiens Microcystis aeruginosa
Macromolecule	Microcystin-LR (MCLR) bound form (protein) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha (protein) Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct (protein)
Unique Ligands	CA, MLI, MN, PEG

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4I5N \| pdb_00004i5n	Download File View File

Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation

Wlodarchak, N., Satyshur, K.A., Guo, F., Xing, Y.

(2013) Cell Res 23: 931-946

Released	2013-05-08
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens Microcystis aeruginosa
Macromolecule	Microcystin-LR (MCLR) bound form (protein) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha (protein) Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct (protein)
Unique Ligands	CA, MN

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5W0W \| pdb_00005w0w	Download File View File

Crystal structure of Protein Phosphatase 2A bound to TIPRL

Wu, C., Zheng, A., Li, J., Satyshur, K., Xing, Y.

(2017) Nat Commun 8: 2272-2272

Released	2018-01-17
Method	X-RAY DIFFRACTION 3.8 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) TIP41-like protein (protein)
Unique Ligands	MN

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6EF4 \| pdb_00006ef4	Download File View File

Crystal structure of mouse PP2A Aalpha P179R mutant

Wang, Z., Shen, G., Xu, W.

(2019) Cancer Res 79: 4242-4257

Released	2019-06-26
Method	X-RAY DIFFRACTION 3.4 Å
Organisms	Mus musculus
Macromolecule	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein)

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6IUR \| pdb_00006iur	Download File View File

A phosphatase complex STRN3-PP2Aa

Tang, Y., Zhou, Z.C.

(2020) Cancer Cell 38: 115-128.e9

Released	2019-12-04
Method	X-RAY DIFFRACTION 3.33 Å
Organisms	Homo sapiens
Macromolecule	PP2A scaffolding subunit (protein) Striatin-3 (protein)
Unique Ligands	TME

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6NTS \| pdb_00006nts	Download File View File

Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP)

Huang, W., Taylor, D.

(2020) Cell 181: 688-701.e16

Released	2020-05-06
Method	ELECTRON MICROSCOPY 3.63 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (protein) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein)
Unique Ligands	L2J, MN

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7K36 \| pdb_00007k36	Download File View File

Cryo-EM structure of STRIPAK complex

Jeong, B.-C., Bai, X.C.

(2021) Nat Struct Mol Biol 28: 290-299

Released	2021-03-10
Method	ELECTRON MICROSCOPY 3.3 Å
Organisms	Homo sapiens
Macromolecule	MOB-like protein phocein (protein) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) Striatin-3 (protein) Striatin-interacting protein 1 (protein)
Unique Ligands	IHP, MN, ZN

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7PKS \| pdb_00007pks	Download File View File

Structural basis of Integrator-mediated transcription regulation

Fianu, I., Chen, Y., Dienemann, C., Cramer, P.

(2021) Science 374: 883-887

Released	2021-12-08
Method	ELECTRON MICROSCOPY 3.6 Å
Organisms	Homo sapiens Human immunodeficiency virus 1 Sus scrofa domesticus
Macromolecule	Unique protein chains: 30 Unique nucleic acid chains: 3
Unique Ligands	MG, MN, ZN

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7SOY \| pdb_00007soy	Download File View File

The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex

Li, Y., Balakrishnan, V.K., Rowse, M., Novikova, I.V., Xing, Y.

(2022) Elife 11:

Released	2022-08-31
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Homo sapiens
Macromolecule	Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Protein phosphatase methylesterase 1 (protein) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein)

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7YCX \| pdb_00007ycx	Download File View File

The structure of INTAC-PEC complex

Zheng, H., Jin, Q., Wang, X., Qi, Y., Liu, W., Ren, Y., Zhao, D., Chen, F.X., Cheng, J., Chen, X., Xu, Y.

(2023) Protein Cell 14: 698-702

Released	2023-03-15
Method	ELECTRON MICROSCOPY 4.18 Å
Organisms	Homo sapiens Sus scrofa synthetic construct
Macromolecule	Unique protein chains: 31 Unique nucleic acid chains: 3
Unique Ligands	MG, MN, ZN

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8RBX \| pdb_00008rbx	Download File View File

Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex

Fianu, I., Ochmann, M., Walshe, J.L., Cramer, P.

(2024) Nature 629: 219-227

Released	2024-02-07
Method	ELECTRON MICROSCOPY 4.1 Å
Organisms	Homo sapiens Sus scrofa Trichoplusia ni synthetic construct
Macromolecule	Unique protein chains: 38 Unique nucleic acid chains: 3
Unique Ligands	MG, MN, ZN

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8RBZ \| pdb_00008rbz	Download File View File

Structure of Integrator-PP2A-SOSS-CTD post-termination complex

Fianu, I., Ochmann, M., Walshe, J.L., Cramer, P.

(2024) Nature 629: 219-227

Released	2024-02-07
Method	ELECTRON MICROSCOPY 3.7 Å
Organisms	Homo sapiens Sus scrofa Trichoplusia ni
Macromolecule	Unique protein chains: 21
Unique Ligands	MN, ZN

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8RC4 \| pdb_00008rc4	Download File View File

Structure of Integrator-PP2A complex

Fianu, I., Ochmann, M., Walshe, J.L., Cramer, P.

(2024) Nature 629: 219-227

Released	2024-02-07
Method	ELECTRON MICROSCOPY 3.1 Å
Organisms	Homo sapiens Trichoplusia ni
Macromolecule	Unique protein chains: 16
Unique Ligands	MN, ZN

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2IAE | pdb_00002iae

2IE3 | pdb_00002ie3

2IE4 | pdb_00002ie4

2NPP | pdb_00002npp

2NYL | pdb_00002nyl

2NYM | pdb_00002nym

2PF4 | pdb_00002pf4

2PKG | pdb_00002pkg

3DW8 | pdb_00003dw8

3FGA | pdb_00003fga

3K7V | pdb_00003k7v

3K7W | pdb_00003k7w

4I5L | pdb_00004i5l

4I5N | pdb_00004i5n

5W0W | pdb_00005w0w

6EF4 | pdb_00006ef4

6IUR | pdb_00006iur

6NTS | pdb_00006nts

7K36 | pdb_00007k36

7PKS | pdb_00007pks

7SOY | pdb_00007soy

7YCX | pdb_00007ycx

8RBX | pdb_00008rbx

8RBZ | pdb_00008rbz

8RC4 | pdb_00008rc4