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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Chemical ID(s) = NCA

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Search Summary

This query matches 74 Structures.

Refinements

Structure Determination Methodology

experimental (74)

Scientific Name of Source Organism

	Homo sapiens (25)
	Mus musculus (3)
	Saccharomyces cerevisiae (3)
	Zea mays (3)
	Aplysia californica (2)
	Bos taurus (2)
	Chromobacterium violaceum (2)
	Escherichia coli (2)
	Momordica charantia (2)
	Mycobacterium tuberculosis (2)

More...

Taxonomy

	Eukaryota (47)
	Bacteria (28)
	Archaea (3)
	Eukaryota (eukaryotes) (3)
	Riboviria (1)
	other sequences (1)

Experimental Method

	X-RAY DIFFRACTION (70)
	ELECTRON MICROSCOPY (4)

Polymer Entity Type

	Protein (74)
	DNA (3)
	RNA (1)

Refinement Resolution (Å)

	0.5 - 1.0 (1)
	1.0 - 1.5 (13)
	1.5 - 2.0 (31)
	2.0 - 2.5 (17)
	2.5 - 3.0 (8)
	3.0 - 3.5 (3)
	3.5 - 4.0 (1)

Release Date

	1995 - 1999 (1)
	2000 - 2004 (3)
	2005 - 2009 (17)
	2010 - 2014 (11)
	2015 - 2019 (15)
	2020 - 2024 (27)

Enzyme Classification Name

	Transferases (34)
	Hydrolases (26)
	Oxidoreductases (10)
	Lyases (5)
	Isomerases (3)

Symmetry Type

	Asymmetric (43)
	Cyclic (32)
	Dihedral (2)

SCOP Classification

	Alpha and beta proteins (a/b) (25)
	Alpha and beta proteins (a+b) (12)
	Artifacts (5)
	All beta proteins (5)
	Membrane and cell surface proteins and peptides (1)

AllSelected

1 to 25 of 74 Structures

Page 1 of 3

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1DMA \| pdb_00001dma	Download File View File

DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH NICOTINAMIDE AND AMP

Li, M., Dyda, F., Benhar, I., Pastan, I., Davies, D.

(1995) Proc Natl Acad Sci U S A 92: 9308-9312

Released	1995-09-15
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Pseudomonas aeruginosa
Macromolecule	EXOTOXIN A (protein)
Unique Ligands	AMP, NCA

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1ISI \| pdb_00001isi	Download File View File

Crystal Structure Analysis of BST-1/CD157 complexed with ethenoNAD

Yamamoto-Katayama, S., Ariyoshi, M., Ishihara, K., Hirano, T., Jingami, H., Morikawa, K.

(2002) J Mol Biology 316: 711-723

Released	2002-03-13
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	bone marrow stromal cell antigen 1 (protein)
Unique Ligands	ENQ, NCA
Unique branched monosaccharides	NAG

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1ISM \| pdb_00001ism	Download File View File

Crystal Structure Analysis of BST-1/CD157 complexed with nicotinamide

Yamamoto-Katayama, S., Ariyoshi, M., Ishihara, K., Hirano, T., Jingami, H., Morikawa, K.

(2002) J Mol Biology 316: 711-723

Released	2002-03-13
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	bone marrow stromal cell antigen 1 (protein)
Unique Ligands	NCA
Unique branched monosaccharides	NAG

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1R15 \| pdb_00001r15	Download File View File

Aplysia ADP ribosyl cyclase with bound nicotinamide and R5P

Love, M.L., Szebenyi, D.M.E., Kriksunov, I.A., Thiel, D.J., Munshi, C., Graeff, R., Lee, H.C., Hao, Q.

(2004) Structure 12: 477-486

Released	2004-03-09
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Aplysia californica
Macromolecule	ADP-ribosyl cyclase (protein)
Unique Ligands	N, NCA

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1YC2 \| pdb_00001yc2	Download File View File

Sir2Af2-NAD-ADPribose-nicotinamide

Avalos, J.L., Bever, M.K., Wolberger, C.

(2005) Mol Cell 17: 855-868

Released	2005-03-29
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Archaeoglobus fulgidus
Macromolecule	NAD-dependent deacetylase 2 (protein)
Unique Ligands	2PE, APR, EDO, NAD, NCA, PG4, PGE, SO4, ZN

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1YC5 \| pdb_00001yc5	Download File View File

Sir2-p53 peptide-nicotinamide

Avalos, J.L., Bever, M.K., Wolberger, C.

(2005) Mol Cell 17: 855-868

Released	2005-04-26
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Homo sapiens Thermotoga maritima
Macromolecule	Cellular tumor antigen p53 peptide (protein) NAD-dependent deacetylase (protein)
Unique Ligands	NCA, ZN

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2A15 \| pdb_00002a15	Download File View File

X-ray Crystal Structure of RV0760 from Mycobacterium Tuberculosis at 1.68 Angstrom Resolution

Garen, C.R., Cherney, M.M., James, M.N.G., TB Structural Genomics Consortium (TBSGC)

(2008) Biochim Biophys Acta 1784: 1625-1632

Released	2005-10-11
Method	X-RAY DIFFRACTION 1.68 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	HYPOTHETICAL PROTEIN Rv0760c (protein)
Unique Ligands	NCA

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2C8A \| pdb_00002c8a	Download File View File

Structure of the wild-type C3bot1 Exoenzyme (Nicotinamide-bound state, crystal form I)

Stura, E.A., Menetrey, J., Flatau, G., Boquet, P., Menez, A.

(2008) Protein Sci 17: 878

Released	2007-02-27
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Clostridium botulinum
Macromolecule	MONO-ADP-RIBOSYLTRANSFERASE C3 (protein)
Unique Ligands	NCA, SO4

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2E5D \| pdb_00002e5d	Download File View File

Crystal structure of Human NMPRTase complexed with nicotinamide

Takahashi, R., Nakamura, S., Kobayashi, Y., Ohkubo, T.

(2010) J Biochem 147: 95-107

Released	2007-12-25
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Nicotinamide phosphoribosyltransferase (protein)
Unique Ligands	NCA

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2H4J \| pdb_00002h4j	Download File View File

Sir2-deacetylated peptide (from enzymatic turnover in crystal)

Hoff, K.G., Avalos, J.L., Sens, K., Wolberger, C.

(2006) Structure 14: 1231-1240

Released	2006-09-05
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens Thermotoga maritima
Macromolecule	Cellular tumor antigen p53 (protein) NAD-dependent deacetylase (protein)
Unique Ligands	NCA, OAD, ZN

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2HJH \| pdb_00002hjh	Download File View File

Crystal Structure of the Sir2 deacetylase

Hall, B.E., Ellenberger, T.E.

To be published

Released	2008-04-08
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	NAD-dependent histone deacetylase SIR2 (protein)
Unique Ligands	NCA, XYQ, ZN

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2OD9 \| pdb_00002od9	Download File View File

Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

Marmorstein, R., Sanders, B.D.

(2007) Mol Cell 25: 463-472

Released	2007-02-27
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	H4 peptide (protein) NAD-dependent deacetylase HST2 (protein)
Unique Ligands	A1R, NCA, ZN

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2OTV \| pdb_00002otv	Download File View File

Crystal structure of the complex formed between bovine trypsin and nicotinamide at 1.56 A resolution

Sinha, M., Singh, N., Sharma, S., Bhushan, A., Kaur, P., Singh, T.P.

To be published

Released	2007-02-27
Method	X-RAY DIFFRACTION 1.56 Å
Organisms	Bos taurus
Macromolecule	Cationic trypsin (protein)
Unique Ligands	CA, NCA, SO4

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2QHF \| pdb_00002qhf	Download File View File

Mycobacterium tuberculosis Chorismate synthase in complex with NCA

Bruning, M., Bourenkov, G.P., Strizhov, N.I., Bartunik, H.D.

To be published

Released	2008-07-15
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	Chorismate synthase (protein)
Unique Ligands	ACT, CL, NA, NCA, TRS

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2QQG \| pdb_00002qqg	Download File View File

Hst2 bound to ADP-HPD, acetyllated histone H4 and nicotinamide

Marmorstein, R., Sanders, B., Zhao, K., Slama, J.

(2007) Mol Cell 25: 463-472

Released	2007-10-09
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Saccharomyces cerevisiae Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Macromolecule	Histone H4 (protein) NAD-dependent deacetylase HST2 (protein)
Unique Ligands	A1R, NCA, ZN

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2R6V \| pdb_00002r6v	Download File View File

Crystal structure of FMN-binding protein (NP_142786.1) from Pyrococcus horikoshii at 1.35 A resolution

Joint Center for Structural Genomics (JCSG)

To be published

Released	2007-09-25
Method	X-RAY DIFFRACTION 1.25 Å
Organisms	Pyrococcus horikoshii OT3
Macromolecule	Uncharacterized protein PH0856 (protein)
Unique Ligands	EDO, FMN, NCA

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2R9J \| pdb_00002r9j	Download File View File

Ligand recognition in C-lobe: The crystal structure of the complex of lactoferrin C-lobe with nicotinamide at 2.5 A resolution

Mir, R., Vikram, G., Singh, N., Kumar, S., Sinha, M., Sharma, S., Kaur, P., Singh, T.P.

To be published

Released	2007-10-09
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Bos taurus
Macromolecule	Lactotransferrin' (protein)
Unique Ligands	CO3, FE, NAG, NCA, SO4, ZN
Unique branched monosaccharides	NAG

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2Z77 \| pdb_00002z77	Download File View File

X-ray crystal structure of RV0760c from Mycobacterium tuberculosis in complex with estradiol-17beta-hemisuccinate

Cherney, M.M., Garen, C.R., James, M.N.G., TB Structural Genomics Consortium (TBSGC)

(2008) Biochim Biophys Acta 1784: 1625-1632

Released	2007-09-18
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Mycobacterium tuberculosis H37Rv
Macromolecule	Putative steroid isomerase (protein)
Unique Ligands	ACT, HE7, NCA

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2ZB7 \| pdb_00002zb7	Download File View File

Crystal structure of human 15-ketoprostaglandin delta-13-reductase in complex with NADPH and nicotinamide

Wu, Y.H., Wang, A.H.J., Ko, T.P., Guo, R.T., Hu, S.M., Chuang, L.M.

(2008) Structure 16: 1714-1723

Released	2008-09-30
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Prostaglandin reductase 2 (protein)
Unique Ligands	NCA, NDP

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3DZG \| pdb_00003dzg	Download File View File

Crystal structure of human CD38 extracellular domain, ara-F-ribose-5'-phosphate/nicotinamide complex

Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.

(2008) Chem Biol 15: 1068-1078

Released	2008-11-04
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Homo sapiens
Macromolecule	ADP-ribosyl cyclase 1 (protein)
Unique Ligands	NCA, RF5

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3I9J \| pdb_00003i9j	Download File View File

Crystal structure of ADP ribosyl cyclase complexed with a substrate analog and a product nicotinamide

Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.

(2009) J Biological Chem 284: 27637-27645

Released	2009-07-28
Method	X-RAY DIFFRACTION 2.18 Å
Organisms	Aplysia californica
Macromolecule	ADP-ribosyl cyclase (protein)
Unique Ligands	AVV, NCA, NFD

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3NN0 \| pdb_00003nn0	Download File View File

Complex of 6-hydroxy-L-nicotine oxidase with nicotinamide

Kachalova, G.S., Bartunik, H.D.

(2010) J Mol Biology 396: 785-799

Released	2011-06-15
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Paenarthrobacter nicotinovorans
Macromolecule	6-hydroxy-L-nicotine oxidase (protein)
Unique Ligands	FAD, GP7, NCA