RCSB PDB: Search

5O3L \| pdb_00005o3l	Download File View File

Paired helical filament in Alzheimer's disease brain

Fitzpatrick, A.W.P., Falcon, B., He, S., Murzin, A.G., Murshudov, G., Garringer, H.G., Crowther, R.A., Ghetti, B., Goedert, M., Scheres, S.H.W.

(2017) Nature 547: 185-190

Released	2017-07-26
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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5O3O \| pdb_00005o3o	Download File View File

Pronase-treated paired helical filament in Alzheimer's disease brain

Fitzpatrick, A.W.P., Falcon, B., He, S., Murzin, A.G., Murshudov, G., Garringer, H.G., Crowther, R.A., Ghetti, B., Goedert, M., Scheres, S.H.W.

(2017) Nature 547: 185-190

Released	2017-07-26
Method	ELECTRON MICROSCOPY 3.5 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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5O3T \| pdb_00005o3t	Download File View File

Straight filament in Alzheimer's disease brain

Fitzpatrick, A.W.P., Falcon, B., He, S., Murzin, A.G., Murshudov, G., Garringer, H.G., Crowther, R.A., Ghetti, B., Goedert, M., Scheres, S.H.W.

(2017) Nature 547: 185-190

Released	2017-07-26
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6GX5 \| pdb_00006gx5	Download File View File

Narrow Pick Filament from Pick's disease brain

Falcon, B., Zhang, W., Murzin, A.G., Murshudov, G., Garringer, H.J., Vidal, R., Crowther, R.A., Ghetti, B., Scheres, S.H.W., Goedert, M.

(2018) Nature 561: 137-140

Released	2018-09-12
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6HRE \| pdb_00006hre	Download File View File

Paired helical filament from sporadic Alzheimer's disease brain

Falcon, B., Zhang, W., Schweighauser, M., Murzin, A.G., Vidal, R., Garringer, H.J., Ghetti, B., Scheres, S.H.W., Goedert, M.

(2018) Acta Neuropathol 136: 699-708

Released	2018-10-10
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6HRF \| pdb_00006hrf	Download File View File

Straight filament from sporadic Alzheimer's disease brain

Falcon, B., Zhang, W., Schweighauser, M., Murzin, A.G., Vidal, R., Garringer, H.J., Ghetti, B., Scheres, S.H.W., Goedert, M.

(2018) Acta Neuropathol 136: 699-708

Released	2018-10-10
Method	ELECTRON MICROSCOPY 3.3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6NWP \| pdb_00006nwp	Download File View File

Chronic traumatic encephalopathy Type I Tau filament

Falcon, B., Zivanov, J., Zhang, W., Murzin, A.G., Garringer, H.J., Vidal, R., Crowther, R.A., Newell, K.L., Ghetti, B., Goedert, M., Scheres, H.W.

(2019) Nature 568: 420-423

Released	2019-03-27
Method	ELECTRON MICROSCOPY 2.3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6NWQ \| pdb_00006nwq	Download File View File

Chronic traumatic encephalopathy Type II Tau filament

Falcon, B., Zivanov, J., Zhang, W., Murzin, A.G., Garringer, H.J., Vidal, R., Crowther, R.A., Newell, K.L., Ghetti, B., Goedert, M., Scheres, H.W.

(2019) Nature 568: 420-423

Released	2019-03-27
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6QJH \| pdb_00006qjh	Download File View File

Cryo-EM structure of heparin-induced 2N4R tau snake filaments

Zhang, W., Falcon, B., Murzin, A.G., Fan, J., Crowther, R.A., Goedert, M., Scheres, S.H.W.

(2019) Elife 8:

Released	2019-02-20
Method	ELECTRON MICROSCOPY 3.3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6QJM \| pdb_00006qjm	Download File View File

Cryo-EM structure of heparin-induced 2N4R tau twister filaments

Zhang, W., Falcon, B., Murzin, A.G., Fan, J., Crowther, R.A., Goedert, M., Scheres, S.H.W.

(2019) Elife 8:

Released	2019-02-27
Method	ELECTRON MICROSCOPY 3.3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6QJP \| pdb_00006qjp	Download File View File

Cryo-EM structure of heparin-induced 2N4R tau jagged filaments

Zhang, W., Falcon, B., Murzin, A.G., Fan, J., Crowther, R.A., Goedert, M., Scheres, S.H.W.

(2019) Elife 8:

Released	2019-02-20
Method	ELECTRON MICROSCOPY 3.5 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6QJQ \| pdb_00006qjq	Download File View File

Cryo-EM structure of heparin-induced 2N3R tau filaments

Zhang, W., Falcon, B., Murzin, A.G., Fan, J., Crowther, R.A., Goedert, M., Scheres, S.H.W.

(2019) Elife 8:

Released	2019-02-20
Method	ELECTRON MICROSCOPY 3.7 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6TJO \| pdb_00006tjo	Download File View File

Cryo-EM structure of TypeI tau filaments extracted from the brains of individuals with Corticobasal degeneration

Zhang, W., Murzin, A.G., Falcon, B., Shi, Y., Goedert, M., Scheres, S.H.W.

(2020) Nature 580: 283-287

Released	2020-02-05
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6TJX \| pdb_00006tjx	Download File View File

Cryo-EM structure of TypeII tau filaments extracted from the brains of individuals with Corticobasal degeneration

Zhang, W., Murzin, A.G., Falcon, B., Shi, Y., Goedert, M., Scheres, S.H.W.

(2020) Nature 580: 283-287

Released	2020-02-05
Method	ELECTRON MICROSCOPY 3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6VI3 \| pdb_00006vi3	Download File View File

Straight Filament from Alzheimer's Disease Human Brain Tissue

Arakhamia, T., Lee, C.E., Carlomagno, Y., Duong, D.M., Kundinger, S.R., Wang, K., Williams, D., DeTure, M., Dickson, D.W., Cook, C.N., Seyfried, N.T., Petrucelli, L., Fitzpatrick, A.W.P.

(2020) Cell 180: 633-644.e12

Released	2020-04-15
Method	ELECTRON MICROSCOPY 3.3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)
Unique Ligands	GLY

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7NRQ \| pdb_00007nrq	Download File View File

Paired helical filament from primary age-related tauopathy brain

Shi, Y., Murzin, A.G., Falcon, B., Epstein, A., Machin, J., Tempest, P., Newell, K.L., Vidal, R., Garringer, H.J., Sahara, N., Higuchi, M., Ghetti, B., Jang, M., Scheres, S.H.W., Goedert, M.

(2021) Acta Neuropathol 141: 697-708

Released	2021-03-24
Method	ELECTRON MICROSCOPY 2.76 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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7NRS \| pdb_00007nrs	Download File View File

Conformation 1 of straight filament from primary age-related tauopathy brain

Shi, Y., Murzin, A.G., Falcon, B., Epstein, A., Machin, J., Tempest, P., Newell, K.L., Vidal, R., Garringer, H.J., Sahara, N., Higuchi, M., Ghetti, B., Jang, M., Scheres, S.H.W., Goedert, M.

(2021) Acta Neuropathol 141: 697-708

Released	2021-03-24
Method	ELECTRON MICROSCOPY 2.68 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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7NRT \| pdb_00007nrt	Download File View File

Conformation 2 of straight filament from primary age-related tauopathy brain

Shi, Y., Murzin, A.G., Falcon, B., Epstein, A., Machin, J., Tempest, P., Newell, K.L., Vidal, R., Garringer, H.J., Sahara, N., Higuchi, M., Ghetti, B., Jang, M., Scheres, S.H.W., Goedert, M.

(2021) Acta Neuropathol 141: 697-708

Released	2021-03-24
Method	ELECTRON MICROSCOPY 2.68 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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7NRV \| pdb_00007nrv	Download File View File

Paired helical filament from Alzheimer's disease with PET ligand APN-1607

Shi, Y., Murzin, A.G., Falcon, B., Epstein, A., Machin, J., Tempest, P., Newell, K.L., Vidal, R., Garringer, H.J., Sahara, N., Higuchi, M., Ghetti, B., Jang, M., Scheres, S.H.W., Goedert, M.

(2021) Acta Neuropathol 141: 697-708

Released	2021-03-24
Method	ELECTRON MICROSCOPY 3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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7NRX \| pdb_00007nrx	Download File View File

Straight filament from Alzheimer's disease with PET ligand APN-1607

Shi, Y., Murzin, A.G., Falcon, B., Epstein, A., Machin, J., Tempest, P., Newell, K.L., Vidal, R., Garringer, H.J., Sahara, N., Higuchi, M., Ghetti, B., Jang, M., Scheres, S.H.W., Goedert, M.

(2021) Acta Neuropathol 141: 697-708

Released	2021-03-24
Method	ELECTRON MICROSCOPY 3.55 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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7P65 \| pdb_00007p65	Download File View File

Progressive supranuclear palsy tau filament

Shi, Y., Zhang, W., Yang, Y., Murzin, A.G., Falcon, B., Kotecha, A., van Beers, M., Tarutani, A., Kametani, F., Garringer, H.J., Vidal, R., Hallinan, G.I., Lashley, T., Saito, Y., Murayama, S., Yoshida, M., Tanaka, H., Kakita, A., Ikeuchi, T., Robinson, A.C., Mann, D.M.A., Kovacs, G.G., Revesz, T., Ghetti, B., Hasegawa, M., Goedert, M., Scheres, S.H.W.

(2021) Nature 598: 359-363

Released	2021-09-15
Method	ELECTRON MICROSCOPY 2.7 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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7P66 \| pdb_00007p66	Download File View File

Globular glial tauopathy type 1 tau filament

Shi, Y., Zhang, W., Yang, Y., Murzin, A.G., Falcon, B., Kotecha, A., van Beers, M., Tarutani, A., Kametani, F., Garringer, H.J., Vidal, R., Hallinan, G.I., Lashley, T., Saito, Y., Murayama, S., Yoshida, M., Tanaka, H., Kakita, A., Ikeuchi, T., Robinson, A.C., Mann, D.M.A., Kovacs, G.G., Revesz, T., Ghetti, B., Hasegawa, M., Goedert, M., Scheres, S.H.W.

(2021) Nature 598: 359-363

Released	2021-09-15
Method	ELECTRON MICROSCOPY 3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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7P67 \| pdb_00007p67	Download File View File

Globular glial tauopathy type 2 tau filament

Shi, Y., Zhang, W., Yang, Y., Murzin, A.G., Falcon, B., Kotecha, A., van Beers, M., Tarutani, A., Kametani, F., Garringer, H.J., Vidal, R., Hallinan, G.I., Lashley, T., Saito, Y., Murayama, S., Yoshida, M., Tanaka, H., Kakita, A., Ikeuchi, T., Robinson, A.C., Mann, D.M.A., Kovacs, G.G., Revesz, T., Ghetti, B., Hasegawa, M., Goedert, M., Scheres, S.H.W.

(2021) Nature 598: 359-363

Released	2021-09-15
Method	ELECTRON MICROSCOPY 3.1 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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7P68 \| pdb_00007p68	Download File View File

Globular glial tauopathy type 3 tau filament

Shi, Y., Zhang, W., Yang, Y., Murzin, A.G., Falcon, B., Kotecha, A., van Beers, M., Tarutani, A., Kametani, F., Garringer, H.J., Vidal, R., Hallinan, G.I., Lashley, T., Saito, Y., Murayama, S., Yoshida, M., Tanaka, H., Kakita, A., Ikeuchi, T., Robinson, A.C., Mann, D.M.A., Kovacs, G.G., Revesz, T., Ghetti, B., Hasegawa, M., Goedert, M., Scheres, S.H.W.

(2021) Nature 598: 359-363

Released	2021-09-15
Method	ELECTRON MICROSCOPY 2.9 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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7P6A \| pdb_00007p6a	Download File View File

Limbic-predominant neuronal inclusion body 4R tauopathy type 1a tau filament

Shi, Y., Zhang, W., Yang, Y., Murzin, A.G., Falcon, B., Kotecha, A., van Beers, M., Tarutani, A., Kametani, F., Garringer, H.J., Vidal, R., Hallinan, G.I., Lashley, T., Saito, Y., Murayama, S., Yoshida, M., Tanaka, H., Kakita, A., Ikeuchi, T., Robinson, A.C., Mann, D.M.A., Kovacs, G.G., Revesz, T., Ghetti, B., Hasegawa, M., Goedert, M., Scheres, S.H.W.

(2021) Nature 598: 359-363

Released	2021-09-15
Method	ELECTRON MICROSCOPY 1.9 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Symmetry Type

5O3L | pdb_00005o3l

5O3O | pdb_00005o3o

5O3T | pdb_00005o3t

6GX5 | pdb_00006gx5

6HRE | pdb_00006hre

6HRF | pdb_00006hrf

6NWP | pdb_00006nwp

6NWQ | pdb_00006nwq

6QJH | pdb_00006qjh

6QJM | pdb_00006qjm

6QJP | pdb_00006qjp

6QJQ | pdb_00006qjq

6TJO | pdb_00006tjo

6TJX | pdb_00006tjx

6VI3 | pdb_00006vi3

7NRQ | pdb_00007nrq

7NRS | pdb_00007nrs

7NRT | pdb_00007nrt

7NRV | pdb_00007nrv

7NRX | pdb_00007nrx

7P65 | pdb_00007p65

7P66 | pdb_00007p66

7P67 | pdb_00007p67

7P68 | pdb_00007p68

7P6A | pdb_00007p6a