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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Chan, J."

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Search Summary

This query matches 35 Structures.

Refinements

Structure Determination Methodology

experimental (35)

Scientific Name of Source Organism

	Homo sapiens (16)
	Aspergillus fumigatus Af293 (3)
	Bacteroides thetaiotaomicron VPI-5482 (2)
	Escherichia coli CFT073 (2)
	Escherichia coli K-12 (2)
	Mus musculus (2)
	Rhodococcus sp. MB1 'Bresler 1999 (2)
	Aspergillus fumigatus (1)
	Escherichia coli (1)
	HIV-1 06TG.HT043 (1)

More...

Taxonomy

	Eukaryota (23)
	Bacteria (11)
	Riboviria (1)

Experimental Method

X-RAY DIFFRACTION (35)

Polymer Entity Type

Protein (35)

Refinement Resolution (Å)

	1.0 - 1.5 (2)
	1.5 - 2.0 (9)
	2.0 - 2.5 (10)
	2.5 - 3.0 (13)
	3.0 - 3.5 (1)

Release Date

	2000 - 2004 (1)
	2005 - 2009 (1)
	2010 - 2014 (18)
	2015 - 2019 (10)
	2020 - 2024 (5)

Enzyme Classification Name

	Transferases (14)
	Hydrolases (10)

Membrane Protein Annotation

OPM (1)

Symmetry Type

	Asymmetric (23)
	Cyclic (12)
	Dihedral (1)

SCOP Classification

	Artifacts (7)
	All beta proteins (6)
	Alpha and beta proteins (a+b) (10)
	Alpha and beta proteins (a/b) (4)
	All alpha proteins (5)
	Small proteins (2)

AllSelected

1 to 25 of 35 Structures

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1N4K \| pdb_00001n4k	Download File View File

Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3

Bosanac, I., Alattia, J.R., Mal, T.K., Chan, J., Talarico, S., Tong, F.K., Tong, K.I., Yoshikawa, F., Furuichi, T., Iwai, M., Michikawa, T., Mikoshiba, K., Ikura, M.

(2002) Nature 420: 696-700

Released	2002-12-25
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Mus musculus
Macromolecule	Inositol 1,4,5-trisphosphate receptor type 1 (protein)
Unique Ligands	I3P

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2XCY \| pdb_00002xcy	Download File View File

Crystal structure of Aspergillus fumigatus sialidase

Telford, J.C., Yeung, J., Xu, G., Bennet, A., Moore, M.M., Taylor, G.L.

(2011) J Biological Chem 286: 10783

Released	2010-05-12
Method	X-RAY DIFFRACTION 1.84 Å
Organisms	Aspergillus fumigatus
Macromolecule	EXTRACELLULAR SIALIDASE/NEURAMINIDASE, PUTATIVE (protein)
Unique Ligands	CL, GOL

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2XZI \| pdb_00002xzi	Download File View File

THE ASPERGILLUS FUMIGATUS SIALIDASE IS A KDNASE: STRUCTURAL AND MECHANISTIC INSIGHTS

Telford, J.C., Yeung, J.H.F., Kiefel, M.J., Watts, A.G., Hader, S., Chan, J., Bennet, A.J., Moore, M.M., Taylor, G.L.

(2011) J Biological Chem 286: 10783

Released	2011-01-19
Method	X-RAY DIFFRACTION 1.45 Å
Organisms	Aspergillus fumigatus Af293
Macromolecule	EXTRACELLULAR SIALIDASE/NEURAMINIDASE, PUTATIVE (protein)
Unique Ligands	GOL, KDM, NA, NO2

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2XZJ \| pdb_00002xzj	Download File View File

THE ASPERGILLUS FUMIGATUS SIALIDASE IS A KDNASE: STRUCTURAL AND MECHANISTIC INSIGHTS

Telford, J.C., Yeung, J.H.F., Kiefel, M.J., Watts, A.G., Hader, S., Chan, J., Bennet, A.J., Moore, M.M., Taylor, G.L.

(2011) J Biological Chem 286: 10783

Released	2011-01-19
Method	X-RAY DIFFRACTION 1.84 Å
Organisms	Aspergillus fumigatus Af293
Macromolecule	EXTRACELLULAR SIALIDASE/NEURAMINIDASE, PUTATIVE (protein)
Unique Ligands	GOL, KFN, NA

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2XZK \| pdb_00002xzk	Download File View File

THE ASPERGILLUS FUMIGATUS SIALIDASE IS A KDNASE: STRUCTURAL AND MECHANISTIC INSIGHTS

Telford, J.C., Yeung, J.H.F., Kiefel, M.J., Watts, A.G., Hader, S., Chan, J., Bennet, A.J., Moore, M.M., Taylor, G.L.

(2011) J Biological Chem 286: 10783

Released	2011-01-19
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Aspergillus fumigatus Af293
Macromolecule	EXTRACELLULAR SIALIDASE/NEURAMINIDASE, PUTATIVE (protein)
Unique Ligands	CL, FKD, GOL, K99, NA, NO3

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3CIS \| pdb_00003cis	Download File View File

The Crystal Structure of Rv2623 from Mycobacterium tuberculosis

Bilder, P., Drumm, J., Mi, K., Chan, J., Almo, S.C.

To be published

Released	2009-03-17
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	Uncharacterized protein (protein)
Unique Ligands	ATP, MG

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3JRR \| pdb_00003jrr	Download File View File

Crystal structure of the ligand binding suppressor domain of type 3 inositol 1,4,5-trisphosphate receptor

Chan, J., Ishiyama, N., Ikura, M.

To be published

Released	2010-09-15
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mus musculus
Macromolecule	Inositol 1,4,5-trisphosphate receptor type 3 (protein)

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3PUH \| pdb_00003puh	Download File View File

Cocaine Esterase, wild-type biologically active dimer

Nance, M.R., Tesmer, J.J.G.

(2011) Mol Pharmacol 80: 1056-1065

Released	2011-09-21
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Rhodococcus sp. MB1 'Bresler 1999
Macromolecule	Cocaine esterase (protein)
Unique Ligands	GOL, SO4

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3PUI \| pdb_00003pui	Download File View File

Cocaine Esterase with mutations G4C, S10C

Nance, M.R., Tesmer, J.J.G.

(2011) Mol Pharmacol 80: 1056-1065

Released	2011-09-21
Method	X-RAY DIFFRACTION 1.53 Å
Organisms	Rhodococcus sp. MB1 'Bresler 1999
Macromolecule	Cocaine esterase (protein)
Unique Ligands	CL, NA

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3QS2 \| pdb_00003qs2	Download File View File

Crystal structure of the biofilm forming subunit of the E. coli common pilus: full length domain swapped dimer of EcpA

Garnett, J.A., Matthews, S.J.

(2012) Proc Natl Acad Sci U S A 109: 3950-3955

Released	2012-02-22
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Escherichia coli CFT073
Macromolecule	Fimbrillin matB homolog (protein)
Unique Ligands	IOD

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3QS3 \| pdb_00003qs3	Download File View File

Crystal structure of the biofilm forming subunit of the E. coli common pilus: donor strand complemented (DSC) EcpA

Garnett, J.A., Matthews, S.J.

(2012) Proc Natl Acad Sci U S A 109: 3950-3955

Released	2012-02-22
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Escherichia coli CFT073
Macromolecule	Fimbrillin matB homolog, EcpD (protein)
Unique Ligands	FLC

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3V01 \| pdb_00003v01	Download File View File

Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.

Heald, R., Jackson, P., Savy, P., Jones, M., Gancia, E., Burton, B., Newman, R., Boggs, J., Chan, E., Chan, J., Choo, E., Merchant, M., Ultsch, M., Wiesmann, C., Belvin, M., Price, S.

(2012) J Med Chem 55: 4594-4604

Released	2012-05-09
Method	X-RAY DIFFRACTION 2.705 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 1 (protein)
Unique Ligands	3V0, ATP, MG

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3V04 \| pdb_00003v04	Download File View File

Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.

Heald, R., Jackson, P., Savy, P., Jones, M., Gancia, E., Burton, B., Newman, R., Boggs, J., Chan, E., Chan, J., Choo, E., Merchant, M., Ultsch, M., Wiesmann, C., Belvin, M., Price, S.

(2012) J Med Chem 55: 4594-4604

Released	2012-05-09
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 1 (protein)
Unique Ligands	ATP, MG, V04

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3VOD \| pdb_00003vod	Download File View File

Crystal Structure of mutant MarR C80S from E.coli

Lou, H., Zhu, R., Hao, Z.

(2014) Nat Chem Biol 10: 21-28

Released	2013-03-06
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Escherichia coli K-12
Macromolecule	Multiple antibiotic resistance protein marR (protein)

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4AIS \| pdb_00004ais	Download File View File

A complex structure of BtGH84

He, Y., Davies, G.J.

(2012) J Biological Chem 287: 28882

Released	2012-06-20
Method	X-RAY DIFFRACTION 2 Å
Organisms	Bacteroides thetaiotaomicron VPI-5482
Macromolecule	O-GLCNACASE BT_4395 (protein)
Unique Ligands	GOA, GOL

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4AIU \| pdb_00004aiu	Download File View File

A complex structure of BtGH84

He, Y., Davies, G.J.

(2012) J Biological Chem 287: 28882

Released	2012-06-20
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Bacteroides thetaiotaomicron VPI-5482
Macromolecule	O-GLCNACASE BT_4395 (protein)
Unique Ligands	CA, GC3

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4JBA \| pdb_00004jba	Download File View File

Crystal Structure of the Oxidized Form of MarR from E.coli

Lou, H., Zhu, R., Hao, Z.

(2014) Nat Chem Biol 10: 21-28

Released	2013-10-16
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Escherichia coli K-12
Macromolecule	Multiple antibiotic resistance protein MarR (protein)

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4KZ0 \| pdb_00004kz0	Download File View File

Structure of PI3K gamma with Imidazopyridine inhibitors

Knapp, M.S., Elling, R.A.

(2013) Bioorg Med Chem Lett 23: 4652-4656

Released	2013-07-17
Method	X-RAY DIFFRACTION 2.87 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	1UJ, SO4

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4KZC \| pdb_00004kzc	Download File View File

Structure of PI3K gamma with Imidazopyridine inhibitors

Knapp, M.S., Elling, E.A.

(2013) Bioorg Med Chem Lett 23: 4652-4656

Released	2013-07-17
Method	X-RAY DIFFRACTION 3.25 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	1UK, SO4

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4LMN \| pdb_00004lmn	Download File View File

Crystal Structure of MEK1 kinase bound to GDC0973

Ultsch, M.H.

(2013) Nature 501: 232-236

Released	2013-08-07
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 1 (protein)
Unique Ligands	ANP, EUI, MG

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5BV7 \| pdb_00005bv7	Download File View File

Crystal structure of human LCAT (L4F, N5D) in complex with Fab of an agonistic antibody

Piper, D.E., Romanow, W.G., Thibault, S.T., Walker, N.P.C.

(2016) J Biological Chem 291: 2799-2811

Released	2015-12-16
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Homo sapiens
Macromolecule	27C3 heavy chain (protein) 27C3 light chain (protein) Fab1 heavy chain (protein) Fab1 light chain (protein) Phosphatidylcholine-sterol acyltransferase (protein)
Unique Ligands	NAG
Unique branched monosaccharides	MAN, NAG

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5DWR \| pdb_00005dwr	Download File View File

Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1,2 and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies

Bellamacina, C., Bussiere, D., Burger, M.

(2015) J Med Chem 58: 8373-8386

Released	2015-11-11
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	5H7

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5FI4 \| pdb_00005fi4	Download File View File

Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model

Elling, R.A., Knapp, M.S., Han, W., Daniel, L.M., Xy, Y., Burger, M.T., Ni, Z., Smith, A., Lan, J., Williams, T., Verhagen, J., Huh, K., Merritt, H., Chan, J., Kaufman, S., Voliva, C.F., Pecchi, S.

(2016) Bioorg Med Chem Lett 26: 742-746

Released	2016-02-03
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)
Unique Ligands	5XV, GOL