5DWR | pdb_00005dwr

Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1,2 and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies

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Sequence of
     ​M​​A​​H​​H​​H​​H​​H​​H​​L​​E​     ​V​​L​​F​​Q​​G​​P​​L​​L​​S​​K​     ​I​​N​​S​​L​​A​​H​​L​​R​​A​​A​     ​P​​C​​N​​D​​L​​H​​A​​T​​K​​L​     ​A​​P​​G​​K​​E​​K​​E​​P​​L​​E​36   ​S​​Q​​Y​​Q​​V​​G​​P​​L​​L​​G​46   ​S​​G​​G​​F​​G​​S​​V​​Y​​S​​G​56   ​I​​R​​V​​S​​D​​N​​L​​P​​V​​A​66   ​I​​K​​H​​V​​E​​K​​D​​R​​I​​S​76   ​D​​W​​G​​E​​L​​P​​N​​G​​T​​R​86   ​V​​P​​M​​E​​V​​V​​L​​L​​K​​K​96   ​V​​S​​S​​G​​F​​S​​G​​V​​I​​R​106  ​L​​L​​D​​W​​F​​E​​R​​P​​D​​S​116  ​F​​V​​L​​I​​L​​E​​R​​P​​E​​P​126  ​V​​Q​​D​​L​​F​​D​​F​​I​​T​​E​136  ​R​​G​​A​​L​​Q​​E​​E​​L​​A​​R​146  ​S​​F​​F​​W​​Q​​V​​L​​E​​A​​V​156  ​R​​H​​C​​H​​N​​C​​G​​V​​L​​H​166  ​R​​D​​I​​K​​D​​E​​N​​I​​L​​I​176  ​D​​L​​N​​R​​G​​E​​L​​K​​L​​I​186  ​D​​F​​G​​S​​G​​A​​L​​L​​K​​D​196  ​T​​V​​Y​​T​​D​​F​​D​​G​​T​​R​206  ​V​​Y​​S​​P​​P​​E​​W​​I​​R​​Y​216  ​H​​R​​Y​​H​​G​​R​​S​​A​​A​​V​226  ​W​​S​​L​​G​​I​​L​​L​​Y​​D​​M​236  ​V​​C​​G​​D​​I​​P​​F​​E​​H​​D​246  ​E​​E​​I​​I​​R​​G​​Q​​V​​F​​F​256  ​R​​Q​​R​​V​​S​​SEP​​E​​C​​Q​​H​266  ​L​​I​​R​​W​​C​​L​​A​​L​​R​​P​276  ​S​​D​​R​​P​​T​​F​​E​​E​​I​​Q​286  ​N​​H​​P​​W​​M​​Q​​D​​V​​L​​L​296  ​P​​Q​​E​​T​​A​​E​​I​​H​​L​​H​306  ​S​​L​​S​​P​​G​​P​​S​​K​
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Asm Id
Dynamic Bonds

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