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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Weeks, S.D."

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Search Summary

This query matches 92 Structures.

Refinements

Structure Determination Methodology

experimental (92)

Scientific Name of Source Organism

	Neisseria gonorrhoeae (31)
	Homo sapiens (25)
	Vicugna pacos (7)
	Klebsiella pneumoniae (6)
	Escherichia coli BL21(DE3) (5)
	Thermus thermophilus (4)
	Escherichia coli K-12 (3)
	Pseudomonas aeruginosa (3)
	Trypanosoma brucei gambiense (3)
	Actinoplanes teichomyceticus (2)

More...

Taxonomy

	Bacteria (61)
	Eukaryota (31)
	Riboviria (2)

Experimental Method

X-RAY DIFFRACTION (92)

Polymer Entity Type

Protein (92)

Refinement Resolution (Å)

	0.5 - 1.0 (1)
	1.5 - 2.0 (19)
	2.0 - 2.5 (52)
	2.5 - 3.0 (14)
	3.0 - 3.5 (5)
	> 4.5 (1)

Release Date

	2005 - 2009 (2)
	2010 - 2014 (9)
	2015 - 2019 (27)
	2020 - 2024 (54)

Enzyme Classification Name

	Ligases (65)
	Hydrolases (8)

Symmetry Type

	Asymmetric (57)
	Cyclic (35)
	Dihedral (2)
	Tetrahedral (1)

SCOP Classification

	Alpha and beta proteins (a+b) (6)
	Artifacts (6)
	All beta proteins (8)
	Multi-domain proteins (alpha and beta) (4)
	Alpha and beta proteins (a/b) (3)

AllSelected

1 to 25 of 92 Structures

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3H7P \| pdb_00003h7p	Download File View File

Crystal structure of K63-linked di-ubiquitin

Weeks, S.D., Grasty, K.C., Hernandez-Cuebas, L., Loll, P.J.

(2009) Proteins 77: 753-759

Released	2009-09-22
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin (protein)
Unique Ligands	CD

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3H7S \| pdb_00003h7s	Download File View File

Crystal structures of K63-linked di- and tri-ubiquitin reveal a highly extended chain architecture

Weeks, S.D., Grasty, K.C., Hernandez-Cuebas, L., Loll, P.J.

(2009) Proteins 77: 753-759

Released	2009-09-22
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin (protein)
Unique Ligands	ZN

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3O65 \| pdb_00003o65	Download File View File

Crystal structure of a Josephin-ubiquitin complex: Evolutionary restraints on ataxin-3 deubiquitinating activity

Weeks, S.D., Grasty, K.C., Hernandez-Cuebas, L., Loll, P.J.

(2011) J Biological Chem 286: 4555-4565

Released	2010-11-24
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Putative ataxin-3-like protein (protein) Ubiquitin (protein)
Unique Ligands	NA

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3RUL \| pdb_00003rul	Download File View File

New strategy to analyze structures of glycopeptide-target complexes

Economou, N.J., Nahoum, V., Weeks, S.D., Grasty, K.C., Loll, P.J.

(2012) J Am Chem Soc 134: 4637-4645

Released	2012-06-06
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Dalbavancin (protein) Ubiquitin (protein)
Unique Ligands	CL, M12, MAN, N1L, TLA

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3RUM \| pdb_00003rum	Download File View File

New strategy to analyze structures of glycopeptide antibiotic-target complexes

Economou, N.J., Weeks, S.D., Grasty, K.C., Nahoum, V., Loll, P.J.

(2012) J Am Chem Soc 134: 4637-4645

Released	2012-06-06
Method	X-RAY DIFFRACTION 1.851 Å
Organisms	Amycolatopsis lurida Escherichia coli K-12
Macromolecule	Maltose-binding periplasmic protein (protein) Ristocetin (protein)
Unique Ligands	IPA, MAN, RST, SO4
Unique branched monosaccharides	BGC, BXY, GLC, MAN, RAM

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3VFJ \| pdb_00003vfj	Download File View File

The structure of monodechloro-teicoplanin in complex with its ligand, using MBP as a ligand carrier

Economou, N.J., Weeks, S.D., Grasty, K.C., Loll, P.J.

(2013) Acta Crystallogr D Biol Crystallogr 69: 520-533

Released	2013-01-09
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Actinoplanes teichomyceticus Escherichia coli K-12
Macromolecule	Maltose-binding periplasmic protein, C-terminal fused by Cys-Lys-D-Ala-D-Ala (protein) MonodeChloro- Teicoplanin A2-2 (protein)
Unique Ligands	ACT, CAC, GCS, MAN, NAG, T55, ZN

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3VFK \| pdb_00003vfk	Download File View File

The structure of monodechloro-teicoplanin in complex with its ligand, using ubiquitin as a ligand carrier

Economou, N.J., Weeks, S.D., Grasty, K.C., Loll, P.J.

(2013) Acta Crystallogr D Biol Crystallogr 69: 520-533

Released	2013-01-09
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Actinoplanes teichomyceticus Homo sapiens
Macromolecule	MonodeChloro- Teicoplanin A2-2 (protein) ubiquitin, C-terminal fused by Cys-Lys-D-Ala-D-Ala (protein)
Unique Ligands	GCS, MAN, NAG, T55

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4G2U \| pdb_00004g2u	Download File View File

Crystal Structure Analysis of Ostertagia ostertagi ASP-1

Weeks, S.D., Borloo, J., Geldhof, P., Vercruysse, J., Strelkov, S.V.

(2013) Acta Crystallogr D Biol Crystallogr 69: 493-503

Released	2013-03-27
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Ostertagia ostertagi
Macromolecule	Ancylostoma-secreted protein-like protein (protein)
Unique Ligands	NAG, SO4

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4G9S \| pdb_00004g9s	Download File View File

Crystal structure of Escherichia coli PliG in complex with Atlantic salmon g-type lysozyme

Leysen, S., Vanderkelen, L., Weeks, S.D., Michiels, C.W., Strelkov, S.V.

(2013) Cell Mol Life Sci 70: 1113-1122

Released	2012-11-07
Method	X-RAY DIFFRACTION 0.95 Å
Organisms	Escherichia coli Salmo salar
Macromolecule	Goose-type lysozyme (protein) Inhibitor of g-type lysozyme (protein)
Unique Ligands	CL, FLC

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4JUS \| pdb_00004jus	Download File View File

Crystal structure of a fragment of Human HSPB6

Weeks, S.D., Baranova, E.V., Beelen, S., Heirbaut, M., Gusev, N.B., Strelkov, S.V.

(2014) J Struct Biol 185: 342-354

Released	2014-02-05
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Heat shock protein beta-6 (protein)
Unique Ligands	GOL

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4JUT \| pdb_00004jut	Download File View File

Crystal structure of a mutant fragment of Human HSPB6

Weeks, S.D., Baranova, E.V., Beelen, S., Heirbaut, M., Gusev, N.B., Strelkov, S.V.

(2014) J Struct Biol 185: 342-354

Released	2014-02-05
Method	X-RAY DIFFRACTION 2.196 Å
Organisms	Homo sapiens
Macromolecule	Heat shock protein beta-6 (protein)
Unique Ligands	GOL

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5HVF \| pdb_00005hvf	Download File View File

Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-i83)

Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.

(2016) J Thromb Haemost 14: 1629-1638

Released	2016-06-22
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Homo sapiens Vicugna pacos
Macromolecule	Carboxypeptidase B2 (protein) VHH-i83 (protein)
Unique Ligands	FLC, NAG, ZN
Unique branched monosaccharides	BMA, MAN, NAG

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5HVG \| pdb_00005hvg	Download File View File

Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-a204)

Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.

(2016) J Thromb Haemost 14: 1629-1638

Released	2016-06-22
Method	X-RAY DIFFRACTION 3.05 Å
Organisms	Homo sapiens Vicugna pacos
Macromolecule	Carboxypeptidase B2 (protein) VHH-a204 (protein)
Unique Ligands	ACT, NAG, ZN
Unique branched monosaccharides	BMA, MAN, NAG

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5HVH \| pdb_00005hvh	Download File View File

Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies

Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.

(2016) J Thromb Haemost 14: 1629-1638

Released	2016-06-22
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens Vicugna pacos
Macromolecule	Carboxypeptidase B2 (protein) VHH-a204 (protein) VHH-i83 (protein)
Unique Ligands	NAG, ZN
Unique branched monosaccharides	NAG

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5LTW \| pdb_00005ltw	Download File View File

Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6

Sluchanko, N.N., Beelen, S., Kulikova, A.A., Weeks, S.D., Antson, A.A., Gusev, N.B., Strelkov, S.V.

(2017) Structure 25: 305-316

Released	2017-02-01
Method	X-RAY DIFFRACTION 4.5 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 protein sigma (protein) Heat shock protein beta-6 (protein)
Unique Ligands	NI, TRS

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5LU1 \| pdb_00005lu1	Download File View File

Human 14-3-3 sigma CLU3 mutant complexed with short HSPB6 phosphopeptide

Sluchanko, N.N., Beelen, S., Kulikova, A.A., Weeks, S.D., Antson, A.A., Gusev, N.B., Strelkov, S.V.

(2017) Structure 25: 305-316

Released	2017-02-01
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 protein sigma (protein) Heat shock protein beta-6 (protein)
Unique Ligands	TRS

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5LU2 \| pdb_00005lu2	Download File View File

Human 14-3-3 sigma complexed with long HSPB6 phosphopeptide

Sluchanko, N.N., Beelen, S., Kulikova, A.A., Weeks, S.D., Antson, A.A., Gusev, N.B., Strelkov, S.V.

(2017) Structure 25: 305-316

Released	2017-02-01
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 protein sigma (protein) Heat shock protein beta-6 (protein)

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5LUM \| pdb_00005lum	Download File View File

Alpha-crystallin domain of human HSPB6 patched with its N-terminal peptide

Sluchanko, N.N., Beelen, S., Kulikova, A.A., Weeks, S.D., Antson, A.A., Gusev, N.B., Strelkov, S.V.

(2017) Structure 25: 305-316

Released	2017-02-01
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Heat shock protein beta-6 (protein)
Unique Ligands	SO4

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6FPC \| pdb_00006fpc	Download File View File

Structure of the PRO-PRO endopeptidase (PPEP-2) from Paenibacillus alvei

Weeks, S.D., Klychnikov, O.I., Hensbergen, P.J., Strelkov, S.V.

(2018) J Biological Chem 293: 11154-11165

Released	2018-05-30
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Paenibacillus alvei
Macromolecule	PRO-PRO endopeptidase (protein)
Unique Ligands	CD, SO4, ZN

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6GWN \| pdb_00006gwn	Download File View File

Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)

Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J.

(2020) J Thromb Haemost 18: 681-692

Released	2020-01-01
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens Vicugna pacos
Macromolecule	Plasminogen activator inhibitor 1 (protein) VHH-2g-42 (protein) VHH-2w-64 (protein)

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6GWP \| pdb_00006gwp	Download File View File

Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)

Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J.

(2020) J Thromb Haemost 18: 681-692

Released	2020-01-01
Method	X-RAY DIFFRACTION 2.28 Å
Organisms	Homo sapiens Vicugna pacos
Macromolecule	Plasminogen Activator Inhibitor-1 (protein) VHH-2g-42 (protein) VHH-2w-64 (protein)

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6GWQ \| pdb_00006gwq	Download File View File

Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with an Inhibitory Nanobody (VHH-2g-42)

Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J.

(2020) J Thromb Haemost 18: 681-692

Released	2020-01-01
Method	X-RAY DIFFRACTION 2.32 Å
Organisms	Homo sapiens Vicugna pacos
Macromolecule	Plasminogen Activator Inhibitor-1 (protein) VHH-2g-42 (protein)

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6H9X \| pdb_00006h9x	Download File View File

Klebsiella pneumoniae Seryl-tRNA Synthetase in Complex with the Intermediate Analog 5'-O-(N-(L-Seryl)-Sulfamoyl)Adenosine

Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.

(2019) Eur J Med Chem 174: 252-264

Released	2019-05-15
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Klebsiella pneumoniae
Macromolecule	Serine--tRNA ligase (protein)
Unique Ligands	CA, EDO, SSA

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6HB5 \| pdb_00006hb5	Download File View File

Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-cytidine

De Graef, S., Pang, L., Strelkov, S.V., Weeks, S.D.

(2019) Eur J Med Chem 173: 154-166

Released	2019-04-17
Method	X-RAY DIFFRACTION 1.88 Å
Organisms	Escherichia coli BL21(DE3)
Macromolecule	Tyrosine--tRNA ligase (protein)
Unique Ligands	CL, EDO, YSC

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6HB6 \| pdb_00006hb6	Download File View File

Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-uridine

De Graef, S., Pang, L., Strelkov, S.V., Weeks, S.D.

(2019) Eur J Med Chem 173: 154-166

Released	2019-04-17
Method	X-RAY DIFFRACTION 1.92 Å
Organisms	Escherichia coli BL21(DE3)
Macromolecule	Tyrosine--tRNA ligase (protein)
Unique Ligands	CL, EDO, YSU

1 to 25 of 92 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

3H7P | pdb_00003h7p

3H7S | pdb_00003h7s

3O65 | pdb_00003o65

3RUL | pdb_00003rul

3RUM | pdb_00003rum

3VFJ | pdb_00003vfj

3VFK | pdb_00003vfk

4G2U | pdb_00004g2u

4G9S | pdb_00004g9s

4JUS | pdb_00004jus

4JUT | pdb_00004jut

5HVF | pdb_00005hvf

5HVG | pdb_00005hvg

5HVH | pdb_00005hvh

5LTW | pdb_00005ltw

5LU1 | pdb_00005lu1

5LU2 | pdb_00005lu2

5LUM | pdb_00005lum

6FPC | pdb_00006fpc

6GWN | pdb_00006gwn

6GWP | pdb_00006gwp

6GWQ | pdb_00006gwq

6H9X | pdb_00006h9x

6HB5 | pdb_00006hb5

6HB6 | pdb_00006hb6