RCSB PDB: Search

3SMQ \| pdb_00003smq	Download File View File

Crystal structure of protein arginine methyltransferase 3

Dobrovetsky, E., Dong, A., Walker, J.R., Siarheyeva, A., Senisterra, G., Wasney, G.A., Smil, D., Bolshan, Y., Nguyen, K.T., Allali-Hassani, A., Hajian, T., Poda, G., Bountra, C., Weigelt, J., Edwards, A.M., Al-Awar, R., Brown, P.J., Schapira, M., Arrowsmith, C.H., Vedadi, M., Structural Genomics Consortium (SGC)

(2012) Structure 20: 1425-1435

Released	2011-08-31
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Protein arginine N-methyltransferase 3 (protein)
Unique Ligands	CL, TDU, UNX

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3SMR \| pdb_00003smr	Download File View File

Crystal structure of human WD repeat domain 5 with compound

Dong, A., Dombrovski, L., Wasney, G.A., Tempel, W., Senisterra, G., Bolshan, Y., Smil, D., Nguyen, K.T., Hajian, T., Poda, G., Al-Awar, R., Bountra, C., Weigelt, J., Edwards, A.M., Brown, P.J., Schapira, M., Arrowsmith, C.H., Vedadi, M., Wu, H., Structural Genomics Consortium (SGC)

(2013) Biochem J 449: 151-159

Released	2011-08-31
Method	X-RAY DIFFRACTION 1.82 Å
Organisms	Homo sapiens
Macromolecule	WD repeat-containing protein 5 (protein)
Unique Ligands	EDO, NP7, UNX

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3SMS \| pdb_00003sms	Download File View File

Human Pantothenate kinase 3 in complex with a pantothenate analog

Mottaghi, K., Tempel, W., Hong, B., Smil, D., Bolshan, Y., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)

To be published

Released	2011-07-13
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Pantothenate kinase 3 (protein)
Unique Ligands	ADP, RNH, UNX

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3SX0 \| pdb_00003sx0	Download File View File

Crystal structure of Dot1l in complex with a brominated SAH analog

Yu, W., Tempel, W., Smil, D., Schapira, M., Li, Y., Vedadi, M., Nguyen, K.T., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Brown, P.J., Structural Genomics Consortium (SGC)

(2013) Bioorg Med Chem 21: 1787-1794

Released	2011-07-27
Method	X-RAY DIFFRACTION 2.28 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-79 specific (protein)
Unique Ligands	SO4, SX0, UNX

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3UR4 \| pdb_00003ur4	Download File View File

Crystal structure of human WD repeat domain 5 with compound

Dong, A., Dombrovski, L., Senisterra, G., Wernimont, A., Wasney, G.A., Allali Hassani, A., Nguyen, K.T., Smil, D., Bolshan, Y., Hajian, T., Poda, G., Chau, I., Al-Awar, R., Bountra, C., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Brown, P., Schapira, M., Vedadi, M., Wu, H., Structural Genomics Consortium (SGC)

(2013) Biochem J 449: 151-159

Released	2011-12-14
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	WD repeat-containing protein 5 (protein)
Unique Ligands	0BW, CL, EDO, SO4, UNX

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3UWP \| pdb_00003uwp	Download File View File

Crystal structure of Dot1l in complex with 5-iodotubercidin

Yu, W., Tempel, W., Smil, D., Schapira, M., Li, Y., Vedadi, M., Nguyen, K.T., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Brown, P.J., Structural Genomics Consortium (SGC)

(2012) Nat Commun 3: 1288-1288

Released	2012-03-14
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-79 specific (protein)
Unique Ligands	5ID, IOD, NA, UNX

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4F7W \| pdb_00004f7w	Download File View File

Crystal structure of Klebsiella pneumoniae pantothenate kinase in complex with N-pentylpantothenamide

Li, B., Tempel, W., Smil, D., Bolshan, Y., Hong, B.S., Park, H.W., Structural Genomics Consortium (SGC)

(2013) Proteins 81: 1466-1472

Released	2013-04-10
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Klebsiella pneumoniae 342
Macromolecule	Pantothenate kinase (protein)
Unique Ligands	ADP, PN4, UNX

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4GI7 \| pdb_00004gi7	Download File View File

Crystal structure of Klebsiella pneumoniae pantothenate kinase in complex with a pantothenate analogue

Li, B., Tempel, W., Smil, D., Bolshan, Y., Hong, B.S., Park, H.W., Structural Genomics Consortium (SGC)

(2013) Proteins 81: 1466-1472

Released	2013-04-10
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Klebsiella pneumoniae 342
Macromolecule	Pantothenate kinase (protein)
Unique Ligands	0JR, ADP, UNX

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4HSG \| pdb_00004hsg	Download File View File

Crystal structure of human PRMT3 in complex with an allosteric inhibitor (PRMT3- KTD)

Dobrovetsky, E., Dong, A., Liu, F., Li, F., Tempel, W., Siarheyeva, A., Hajian, T., Smil, D., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Schapira, M., Jin, J., Vedadi, M., Structural Genomics Consortium (SGC)

(2013) J Med Chem 56: 2110-2124

Released	2012-12-05
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	PRMT3 protein (protein)
Unique Ligands	KTD, UNX

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4IA9 \| pdb_00004ia9	Download File View File

Crystal structure of human WD REPEAT DOMAIN 5 in complex with 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide

Dong, A., Dombrovski, L., Bolshan, Y., Getlik, M., Tempel, W., Kuznetsova, E., Wasney, G.A., Hajian, T., Poda, G., Nguyen, K.T., Schapira, M., Brown, P.J., Al-awar, R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Smil, D., Vedadi, M., Wu, H., Structural Genomics Consortium (SGC)

(2013) ACS Med Chem Lett 4: 353-357

Released	2012-12-26
Method	X-RAY DIFFRACTION 1.66 Å
Organisms	Homo sapiens
Macromolecule	WD repeat-containing protein 5 (protein)
Unique Ligands	EDO, IA9, UNX

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4NB4 \| pdb_00004nb4	Download File View File

Pantothenamide-bound Pantothenate kinase from Staphylococcus aureus

Hughes, S.J., Antoshchenko, T., Smil, D., Park, H.W.

(2014) Proteins 82: 1542-1548

Released	2014-03-05
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Staphylococcus aureus subsp. aureus MRSA252
Macromolecule	Type II pantothenate kinase (protein)
Unique Ligands	ADP, MG, SH3

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4NE2 \| pdb_00004ne2	Download File View File

Pantothenamide-bound Pantothenate Kinase from Klebsiella pneumoniae

Hughes, S.J., Antoshchenko, T., Kim, K.P., Smil, D., Park, H.W.

(2014) Proteins 82: 1542-1548

Released	2014-02-26
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Klebsiella pneumoniae 342
Macromolecule	Pantothenate kinase (protein)
Unique Ligands	ADP, MG, SH2

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4QL1 \| pdb_00004ql1	Download File View File

Crystal structure of human WDR5 in complex with compound OICR-9429

Dong, A., Dombrovski, L., Walker, J.R., Getlik, M., Kuznetsova, E., Smil, D., Barsyte, D., Li, F., Poda, G., Senisterra, G., Marcellus, R., Al-Awar, R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Schapira, M., Vedadi, M., Wu, H., Structural Genomics Consortium (SGC)

(2015) Nat Chem Biol 11: 571-578

Released	2014-12-17
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	WD repeat-containing protein 5 (protein)
Unique Ligands	35Q, EDO, GOL, UNX

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4QPP \| pdb_00004qpp	Download File View File

The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound DS-421 (2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE

Dong, A., Zeng, H., Smil, D., Walker, J.R., He, H., Eram, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)

To be published

Released	2014-08-20
Method	X-RAY DIFFRACTION 2.52 Å
Organisms	Homo sapiens
Macromolecule	POLY-UNK (protein) Protein arginine N-methyltransferase 6 (protein)
Unique Ligands	36S, SAH

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4QQE \| pdb_00004qqe	Download File View File

Crystal structure of WDR5, WD repeat domain 5 in complex with compound SGC-DS-MT-0345

Dong, A., Dombrovski, L., Wernimont, A., Smil, D., Getlik, M., Senisterra, G., Poda, G., Al-Awar, R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Schapira, M., Vedadi, M., Wu, H., Structural Genomics Consortium (SGC)

To be published

Released	2014-07-30
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	WD repeat-containing protein 5 (protein)
Unique Ligands	37F, CL, EDO, UNX

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4QQN \| pdb_00004qqn	Download File View File

Protein arginine methyltransferase 3 in complex with compound MTV044246

Dong, A., Dobrovetsky, E., Tempel, W., He, H., Zhao, K., Smil, D., Landon, M., Luo, X., Chen, Z., Dai, M., Yu, Z., Lin, Y., Zhang, H., Zhao, K., Schapira, M., Brown, P.J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Structural Genomics Consortium (SGC)

(2018) J Med Chem 61: 1204-1217

Released	2014-09-17
Method	X-RAY DIFFRACTION 2.08 Å
Organisms	Homo sapiens
Macromolecule	PRMT3 protein (protein)
Unique Ligands	3BQ, CL, GOL, UNX

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4RYL \| pdb_00004ryl	Download File View File

Human Protein Arginine Methyltransferase 3 in complex with 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea

Dong, A., Dobrovetsky, E., Kaniskan, H.U., Szewczyk, M., Yu, Z., Eram, M.S., Yang, X., Schmidt, K., Luo, X., Dai, M., He, F., Zang, I., Lin, Y., Kennedy, S., Li, F., Tempel, W., Smil, D., Min, S.J., Landon, M., Lin-Jones, J., Huang, X.P., Roth, B.L., Schapira, M., Atadja, P., Barsyte-Lovejoy, D., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Brown, P.J., Zhao, K., Jin, J., Vedadi, M., Structural Genomics Consortium (SGC)

(2015) Angew Chem Int Ed Engl 54: 5166-5170

Released	2015-02-25
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PRMT3 protein (protein)
Unique Ligands	3ZG, UNX

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5EAL \| pdb_00005eal	Download File View File

Crystal structure of human WDR5 in complex with compound 9h

DONG, A., DOMBROVSKI, L., SMIL, D., GETLIK, M., BOLSHAN, Y., WALKER, J.R., SENISTERRA, G., PODA, G., AL-AWAR, R., SCHAPIRA, M., VEDADI, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)

To be published

Released	2015-11-04
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	WD repeat-containing protein 5 (protein)
Unique Ligands	5ML, CL, EDO, GOL, UNX

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5EAM \| pdb_00005eam	Download File View File

Crystal structure of human WDR5 in complex with compound 9o

DONG, A., DOMBROVSKI, L., SMIL, D., GETLIK, M., BOLSHAN, Y., WALKER, J.R., SENISTERRA, G., PODA, G., AL-AWAR, R., SCHAPIRA, M., VEDADI, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)

(2016) J Med Chem 59: 2478-2496

Released	2015-11-04
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	WD repeat-containing protein 5 (protein)
Unique Ligands	5MN, BTB, EDO, SO4, UNX

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5EAP \| pdb_00005eap	Download File View File

Crystal structure of human WDR5 in complex with compound 9e

DONG, A., DOMBROVSKI, L., SMIL, D., GETLIK, M., BOLSHAN, Y., WALKER, J.R., SENISTERRA, G., PODA, G., AL-AWAR, R., SCHAPIRA, M., VEDADI, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)

(2016) J Med Chem 59: 2478-2496

Released	2015-11-04
Method	X-RAY DIFFRACTION 1.73 Å
Organisms	Homo sapiens
Macromolecule	WD repeat-containing protein 5 (protein)
Unique Ligands	5MO, CL, EDO, GOL, UNX

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5EAR \| pdb_00005ear	Download File View File

Crystal structure of human WDR5 in complex with compound 9d

DONG, A., DOMBROVSKI, L., SMIL, D., GETLIK, M., BOLSHAN, Y., WALKER, J.R., SENISTERRA, G., PODA, G., AL-AWAR, R., SCHAPIRA, M., VEDADI, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)

(2016) J Med Chem 59: 2478-2496

Released	2015-11-04
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	WD repeat-containing protein 5 (protein)
Unique Ligands	5MQ, EDO, SO4, UNX

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5S75 \| pdb_00005s75	Download File View File

XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010913a

Williams, E.P., Adamson, R.J., Smil, D., Krojer, T., Burgess-Brown, N., von Delft, F., Bountra, C., Bullock, A.N.

To be published

Released	2021-06-23
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Homo sapiens
Macromolecule	Activin receptor type-1 (protein)
Unique Ligands	DMS, EDO, HUH, LU8, SO4, SRT

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5S76 \| pdb_00005s76	Download File View File

XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010916a

Williams, E.P., Adamson, R.J., Smil, D., Krojer, T., Burgess-Brown, N., von Delft, F., Bountra, C., Bullock, A.N.

To be published

Released	2021-06-23
Method	X-RAY DIFFRACTION 1.31 Å
Organisms	Homo sapiens
Macromolecule	Activin receptor type-1 (protein)
Unique Ligands	02A, DMS, EDO, LU8, SO4, TLA

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5S77 \| pdb_00005s77	Download File View File

XChem group deposition -- Crystal Structure of human ACVR1 in complex with XS035133b

Williams, E.P., Adamson, R.J., Smil, D., Krojer, T., Burgess-Brown, N., von Delft, F., Bountra, C., Bullock, A.N.

To be published

Released	2021-06-23
Method	X-RAY DIFFRACTION 1.31 Å
Organisms	Homo sapiens
Macromolecule	Activin receptor type-1 (protein)
Unique Ligands	BAQ, DMS, EDO, LU8, SO4, TLA

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5S78 \| pdb_00005s78	Download File View File

XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010934a

Williams, E.P., Adamson, R.J., Smil, D., Krojer, T., Burgess-Brown, N., von Delft, F., Bountra, C., Bullock, A.N.

To be published

Released	2021-06-23
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Homo sapiens
Macromolecule	Activin receptor type-1 (protein)
Unique Ligands	DMS, EDO, LU8, SO4, XGV

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

3SMQ | pdb_00003smq

3SMR | pdb_00003smr

3SMS | pdb_00003sms

3SX0 | pdb_00003sx0

3UR4 | pdb_00003ur4

3UWP | pdb_00003uwp

4F7W | pdb_00004f7w

4GI7 | pdb_00004gi7

4HSG | pdb_00004hsg

4IA9 | pdb_00004ia9

4NB4 | pdb_00004nb4

4NE2 | pdb_00004ne2

4QL1 | pdb_00004ql1

4QPP | pdb_00004qpp

4QQE | pdb_00004qqe

4QQN | pdb_00004qqn

4RYL | pdb_00004ryl

5EAL | pdb_00005eal

5EAM | pdb_00005eam

5EAP | pdb_00005eap

5EAR | pdb_00005ear

5S75 | pdb_00005s75

5S76 | pdb_00005s76

5S77 | pdb_00005s77

5S78 | pdb_00005s78