RCSB PDB: Search

1NB8 \| pdb_00001nb8	Download File View File

Structure of the catalytic domain of USP7 (HAUSP)

Hu, M., Li, P., Li, M., Li, W., Yao, T., Wu, J.-W., Gu, W., Cohen, R.E., Shi, Y.

(2002) Cell 111: 1041-1054

Released	2003-01-07
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein)

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1NBF \| pdb_00001nbf	Download File View File

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

Hu, M., Li, P., Li, M., Li, W., Yao, T., Wu, J.-W., Gu, W., Cohen, R.E., Shi, Y.

(2002) Cell 111: 1041-1054

Released	2003-01-07
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin aldehyde (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)

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1X81 \| pdb_00001x81	Download File View File

Farnesyl transferase structure of Jansen compound

Li, Q., Claiborne, A., Li, T., Hasvold, L., Stoll, V.S., Muchmore, S., Jakob, C.G., Gu, W., Cohen, J., Hutchins, C., Frost, D., Rosenberg, S.H., Sham, H.L.

(2004) Bioorg Med Chem Lett 14: 5367-5370

Released	2004-12-21
Method	X-RAY DIFFRACTION 3.5 Å
Organisms	Rattus norvegicus
Macromolecule	Protein farnesyltransferase beta subunit (protein) Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (protein)
Unique Ligands	JAN, ZN

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3NX1 \| pdb_00003nx1	Download File View File

Crystal structure of Enterobacter sp. Px6-4 Ferulic Acid Decarboxylase

Gu, W., Yang, J.K., Lou, Z.Y., Meng, Z.H., Zhang, K.-Q.

(2011) PLoS One 6: e16262-e16262

Released	2011-02-16
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Enterobacter sp. Px6-4
Macromolecule	Ferulic acid decarboxylase (protein)

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3NX2 \| pdb_00003nx2	Download File View File

Enterobacter sp. Px6-4 Ferulic Acid Decarboxylase in complex with substrate analogues

Gu, W., Yang, J.K., Lou, Z.Y., Meng, Z.H., Zhang, K.-Q.

(2011) PLoS One 6: e16262-e16262

Released	2011-02-16
Method	X-RAY DIFFRACTION 2.01 Å
Organisms	Enterobacter sp. Px6-4
Macromolecule	Ferulic acid decarboxylase (protein)
Unique Ligands	FER

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6O0Q \| pdb_00006o0q	Download File View File

Crystal structure of the TIR domain from human SARM1 in complex with ribose

Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.

(2019) Science 365: 793-799

Released	2019-09-04
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Sterile alpha and TIR motif-containing protein 1 (protein)
Unique Ligands	BDR, CL

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6O0R \| pdb_00006o0r	Download File View File

Crystal structure of the TIR domain from human SARM1 in complex with glycerol

Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.

(2019) Science 365: 793-799

Released	2019-09-04
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Sterile alpha and TIR motif-containing protein 1 (protein)
Unique Ligands	GOL

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6O0S \| pdb_00006o0s	Download File View File

Crystal structure of the tandem SAM domains from human SARM1

Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.

(2019) Science 365: 793-799

Released	2019-09-04
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Sterile alpha and TIR motif-containing protein 1 (protein)

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6O0T \| pdb_00006o0t	Download File View File

Crystal structure of selenomethionine labelled tandem SAM domains (L446M:L505M:L523M mutant) from human SARM1

Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.

(2019) Science 365: 793-799

Released	2019-09-04
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Sterile alpha and TIR motif-containing protein 1 (protein)

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6O0U \| pdb_00006o0u	Download File View File

Crystal structure of the TIR domain H685A mutant from human SARM1

Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.

(2019) Science 365: 793-799

Released	2019-09-04
Method	X-RAY DIFFRACTION 3.03 Å
Organisms	Homo sapiens
Macromolecule	Sterile alpha and TIR motif-containing protein 1 (protein)

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6O0V \| pdb_00006o0v	Download File View File

Crystal structure of the TIR domain G601P mutant from human SARM1, crystal form 2

Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.

(2019) Science 365: 793-799

Released	2019-09-04
Method	X-RAY DIFFRACTION 2.07 Å
Organisms	Homo sapiens
Macromolecule	Sterile alpha and TIR motif-containing protein 1 (protein)
Unique Ligands	CL, MES

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6O0W \| pdb_00006o0w	Download File View File

Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 in complex with NADP+ and Bis-Tris

Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.

(2019) Science 365: 793-799

Released	2019-09-04
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Vitis rotundifolia
Macromolecule	TIR-NB-LRR type resistance protein RUN1 (protein)
Unique Ligands	A2P, BTB

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6O1B \| pdb_00006o1b	Download File View File

Crystal structure of the TIR domain G601P mutant from human SARM1, crystal form 1

Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.

(2019) Science 365: 793-799

Released	2019-09-04
Method	X-RAY DIFFRACTION 1.67 Å
Organisms	Homo sapiens
Macromolecule	Sterile alpha and TIR motif-containing protein 1 (protein)
Unique Ligands	MES

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6Y6D \| pdb_00006y6d	Download File View File

Tubulin-7-Aminonoscapine complex

Oliva, M.A., Prota, A.E., Rodriguez-Salarichs, J., Gu, W., Bennani, Y.L., Jimenez-Barbero, J., Canales, A., Steinmetz, M.O., Diaz, J.F.

(2020) J Med Chem 63: 8495-8501

Released	2020-07-22
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Bos taurus Gallus gallus Rattus norvegicus
Macromolecule	Stathmin-4 (protein) Tubulin alpha-1B chain (protein) Tubulin beta-2B chain (protein) Tubulin-Tyrosine Ligase (protein)
Unique Ligands	ACP, CA, GDP, GOL, GTP, MES, MG, OBQ

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7AHX \| pdb_00007ahx	Download File View File

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND D-ASPARTATE TENOFOVIR WITH BOUND MANGANESE

Gu, W., Martinez, S.E., Nguyen, H., Xu, H., Herdewijn, P., de Jonghe, S., Das, K.

(2021) J Med Chem 64: 782-796

Released	2021-01-13
Method	X-RAY DIFFRACTION 2.73 Å
Organisms	Homo sapiens Human immunodeficiency virus type 1 BH10
Macromolecule	Gag-Pol polyprotein (protein) DNA (5'-D(CPAPGPTPCPCPCPTPGPTPTPCPGPGP(MRG)CPGPCPCP(DDG))-3') (nucleic acid) DNA (5'-D(TPGPGPTPCPGPGPCPGPCPCPCPGPAPAPCPAPGPGPGPAPCPTPG)-3') (nucleic acid)
Unique Ligands	MN, REK

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7AID \| pdb_00007aid	Download File View File

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND D-ASPARTATE TENOFOVIR

Gu, W., Martinez, S.E., Nguyen, H., Xu, H., Herdewijn, P., de Jonghe, S., Das, K.

(2021) J Med Chem 64: 782-796

Released	2021-01-13
Method	X-RAY DIFFRACTION 3.15 Å
Organisms	Homo sapiens Human immunodeficiency virus type 1 BH10
Macromolecule	Gag-Pol polyprotein (protein) DNA (5'-D(CPAPGPTPCPCPCPTPGPTPTPCPGPGP(MRG)PCPGPCPCP(DDG))-3') (nucleic acid) DNA (5'-D(PGPGPTPCPGPGPCPGPCPCPCPGPAPAPCPAPGPGPGPAPCPTP*G)-3') (nucleic acid)
Unique Ligands	REK

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7AIF \| pdb_00007aif	Download File View File

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-GLUTAMATE TENOFOVIR WITH BOUND MANGANESE

Gu, W., Martinez, S.E., Nguyen, H., Xu, H., Herdewijn, P., de Jonghe, S., Das, K.

(2021) J Med Chem 64: 782-796

Released	2021-01-13
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Homo sapiens Human immunodeficiency virus type 1 BH10
Macromolecule	Gag-Pol polyprotein (protein) DNA (5'-D(CPAPGPTPCPCPCPTPGPTPTPCPGPGP(MRG)PCPGPCPCP(DDG))-3') (nucleic acid) DNA (5'-D(PGPGPTPCPGPGPCPGPCPCPCPGPAPAPCPAPGPGPGPAPCPTP*G)-3') (nucleic acid)
Unique Ligands	MN, RE5

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7AIG \| pdb_00007aig	Download File View File

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-GLUTAMATE TENOFOVIR

Gu, W., Martinez, S.E., Nguyen, H., Xu, H., Herdewijn, P., de Jonghe, S., Das, K.

(2021) J Med Chem 64: 782-796

Released	2021-01-13
Method	X-RAY DIFFRACTION 2.95 Å
Organisms	Homo sapiens Human immunodeficiency virus type 1 BH10
Macromolecule	Gag-Pol polyprotein (protein) DNA (5'-D(CPAPGPTPCPCPCPTPGPTPTPCPGPGP(MRG)PCPGPCPCP(DDG))-3') (nucleic acid) DNA (5'-D(PGPGPTPCPGPGPCPGPCPCPCPGPAPAPCPAPGPGPGPAPCPTP*G)-3') (nucleic acid)
Unique Ligands	RE5

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7AII \| pdb_00007aii	Download File View File

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-METHIONINE TENOFOVIR WITH BOUND MANGANESE

Gu, W., Martinez, S.E., Nguyen, H., Xu, H., Herdewijn, P., de Jonghe, S., Das, K.

(2021) J Med Chem 64: 782-796

Released	2021-01-13
Method	X-RAY DIFFRACTION 2.62 Å
Organisms	Homo sapiens Human immunodeficiency virus type 1 BH10
Macromolecule	Gag-Pol polyprotein (protein) DNA (5'-D(CPAPGPTPCPCPCPTPGPTPTPCPGPGP(MRG)PCPGPCPCP(DDG))-3') (nucleic acid) DNA (5'-D(PGPGPTPCPGPGPCPGPCPCPCPGPAPAPCPAPGPGPGPAPCPTP*G)-3') (nucleic acid)
Unique Ligands	MN, RFE

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7AIJ \| pdb_00007aij	Download File View File

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-METHIONINE TENOFOVIR

Gu, W., Martinez, S.E., Nguyen, H., Xu, H., Herdewijn, P., de Jonghe, S., Das, K.

(2021) J Med Chem 64: 782-796

Released	2021-01-13
Method	X-RAY DIFFRACTION 2.95 Å
Organisms	Homo sapiens Human immunodeficiency virus type 1 BH10
Macromolecule	Gag-Pol polyprotein (protein) DNA (5'-D(CPAPGPTPCPCPCPTPGPTPTPCPGPGP(MRG)PCPGPCPCP(DDG))-3') (nucleic acid) DNA (5'-D(PGPGPTPCPGPGPCPGPCPCPCPGPAPAPCPAPGPGPGPAPCPTP*G)-3') (nucleic acid)
Unique Ligands	RFE

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7KIH \| pdb_00007kih	Download File View File

Crystal structure of the mouse lipin-1 M-Lip domain

Gu, W., Airola, M.V.

(2021) Nat Commun 12: 4718-4718

Released	2021-07-07
Method	X-RAY DIFFRACTION 1.467 Å
Organisms	Mus musculus
Macromolecule	Isoform 2 of Phosphatidate phosphatase LPIN1 (protein)

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7KIL \| pdb_00007kil	Download File View File

Crystal structure of the mouse lipin-1 M-Lip domain with zinc

Gu, W., Airola, M.V.

(2021) Nat Commun 12: 4718-4718

Released	2021-07-07
Method	X-RAY DIFFRACTION 1.898 Å
Organisms	Mus musculus
Macromolecule	Isoform 2 of Phosphatidate phosphatase LPIN1 (protein)
Unique Ligands	CL, ZN

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7KIQ \| pdb_00007kiq	Download File View File

Crystal structure of the mouse lipin-2 M-Lip domain

Yang, J.W., Gu, W., Airola, M.V.

(2021) Nat Commun 12: 4718-4718

Released	2021-07-07
Method	X-RAY DIFFRACTION 2.523 Å
Organisms	Mus musculus
Macromolecule	Phosphatidate phosphatase LPIN2 (protein)
Unique Ligands	CA

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7LCY \| pdb_00007lcy	Download File View File

Crystal structure of the ligand-free ARM domain from Drosophila SARM1

Gu, W., Nanson, J.D., Luo, Z., McGuinness, H.Y., Manik, M.K., Jia, X., Ve, T., Kobe, B.

(2021) Neuron 109: 1118

Released	2021-03-10
Method	X-RAY DIFFRACTION 3.35 Å
Organisms	Drosophila melanogaster
Macromolecule	Isoform B of NAD(+) hydrolase sarm1 (protein)

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7LCZ \| pdb_00007lcz	Download File View File

Crystal structure of the ARM domain from Drosophila SARM1 in complex with NMN

Gu, W., Nanson, J.D., Luo, Z., Jia, X., Manik, M.K., Ve, T., Kobe, B.

(2021) Neuron 109: 1118

Released	2021-03-10
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Drosophila melanogaster
Macromolecule	Isoform B of NAD(+) hydrolase sarm1 (protein)
Unique Ligands	EDO, NA, NMN

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1NB8 | pdb_00001nb8

1NBF | pdb_00001nbf

1X81 | pdb_00001x81

3NX1 | pdb_00003nx1

3NX2 | pdb_00003nx2

6O0Q | pdb_00006o0q

6O0R | pdb_00006o0r

6O0S | pdb_00006o0s

6O0T | pdb_00006o0t

6O0U | pdb_00006o0u

6O0V | pdb_00006o0v

6O0W | pdb_00006o0w

6O1B | pdb_00006o1b

6Y6D | pdb_00006y6d

7AHX | pdb_00007ahx

7AID | pdb_00007aid

7AIF | pdb_00007aif

7AIG | pdb_00007aig

7AII | pdb_00007aii

7AIJ | pdb_00007aij

7KIH | pdb_00007kih

7KIL | pdb_00007kil

7KIQ | pdb_00007kiq

7LCY | pdb_00007lcy

7LCZ | pdb_00007lcz