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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Caroe, E."

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Search Summary

This query matches 123 Structures.

Refinements

Structure Determination Methodology

experimental (123)

Scientific Name of Source Organism

	synthetic construct (57)
	Streptococcus pyogenes (33)
	Homo sapiens (17)
	Enterococcus italicus DSM 15952 (12)
	Thermus thermophilus HB8 (9)
	Severe acute respiratory syndrome coronavirus 2 (7)
	Thermoanaerobacter brockii subsp. finnii Ako-1 (7)
	Drosophila melanogaster (6)
	Scytonema hofmannii (6)
	Streptococcus pyogenes serotype M1 (6)

More...

Taxonomy

	Bacteria (93)
	other sequences (57)
	Eukaryota (28)
	Riboviria (8)
	Archaea (1)
	Varidnaviria (1)

Experimental Method

	X-RAY DIFFRACTION (90)
	ELECTRON MICROSCOPY (33)

Polymer Entity Type

	Protein (123)
	RNA (75)
	DNA (55)
	NA-hybrid (3)

Refinement Resolution (Å)

	1.0 - 1.5 (5)
	1.5 - 2.0 (15)
	2.0 - 2.5 (31)
	2.5 - 3.0 (38)
	3.0 - 3.5 (27)
	3.5 - 4.0 (5)
	4.0 - 4.5 (2)

Release Date

	2000 - 2004 (1)
	2005 - 2009 (5)
	2010 - 2014 (24)
	2015 - 2019 (23)
	2020 - 2024 (56)
	2025 - 2029 (14)

Enzyme Classification Name

	Hydrolases (71)
	Transferases (21)
	Lyases (4)
	Ligases (2)
	Isomerases (1)
	Oxidoreductases (1)

Symmetry Type

	Asymmetric (96)
	Cyclic (26)
	Helical (1)

SCOP Classification

	Alpha and beta proteins (a+b) (5)
	Artifacts (4)
	All alpha proteins (2)
	Alpha and beta proteins (a/b) (2)
	Multi-domain proteins (alpha and beta) (1)
	All beta proteins (1)

AllSelected

1 to 25 of 123 Structures

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1W3B \| pdb_00001w3b	Download File View File

The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.

Jinek, M., Rehwinkel, J., Lazarus, B.D., Izaurralde, E., Hanover, J.A., Conti, E.

(2004) Nat Struct Mol Biol 11: 1001

Released	2004-09-09
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Homo sapiens
Macromolecule	UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 (protein)
Unique Ligands	CA

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2J0A \| pdb_00002j0a	Download File View File

Structure of the catalytic domain of mouse Manic Fringe

Jinek, M., Chen, Y.-W., Clausen, H., Cohen, S.M., Conti, E.

(2006) Nat Struct Mol Biol 13: 945

Released	2006-09-04
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Mus musculus
Macromolecule	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE (protein)
Unique Ligands	K, SO4

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2J0B \| pdb_00002j0b	Download File View File

Structure of the catalytic domain of mouse Manic Fringe in complex with UDP and manganese

Jinek, M., Chen, Y.-W., Clausen, H., Cohen, S.M., Conti, E.

(2006) Nat Struct Mol Biol 13: 945

Released	2006-09-04
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Mus musculus
Macromolecule	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE (protein)
Unique Ligands	K, MN, SO4, UDP

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2VXG \| pdb_00002vxg	Download File View File

Crystal structure of the conserved C-terminal region of Ge-1

Jinek, M., Eulalio, A., Lingel, A., Helms, S., Conti, E., Izaurralde, E.

(2008) RNA 14: 1991

Released	2008-09-09
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Drosophila melanogaster
Macromolecule	CG6181-PA, ISOFORM A (protein)

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2X04 \| pdb_00002x04	Download File View File

Crystal structure of the PABC-TNRC6C complex

Jinek, M., Fabian, M.R., Coyle, S.M., Sonenberg, N., Doudna, J.A.

(2010) Nat Struct Mol Biol 17: 238

Released	2010-01-19
Method	X-RAY DIFFRACTION 1.49 Å
Organisms	Homo sapiens
Macromolecule	POLYADENYLATE-BINDING PROTEIN 1 (protein) TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN (protein)
Unique Ligands	SO4

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2XLI \| pdb_00002xli	Download File View File

Crystal structure of the Csy4-crRNA complex, monoclinic form

Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.

(2010) Science 329: 1355

Released	2010-09-22
Method	X-RAY DIFFRACTION 2.33 Å
Organisms	Pseudomonas aeruginosa UCBPP-PA14
Macromolecule	CSY4 ENDORIBONUCLEASE (protein) 5'-R(CPUPGPCPCPGPUPAPUPAPGPGPCPADGC)-3' (nucleic acid)

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2XLJ \| pdb_00002xlj	Download File View File

Crystal structure of the Csy4-crRNA complex, hexagonal form

Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.

(2010) Science 329: 1355

Released	2010-09-22
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Pseudomonas aeruginosa UCBPP-PA14
Macromolecule	CSY4 ENDORIBONUCLEASE (protein) 5'-R(CPUPGPCPCPGPUPAPUPAPGPGPCPADGC)-3' (nucleic acid)

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2XLK \| pdb_00002xlk	Download File View File

Crystal structure of the Csy4-crRNA complex, orthorhombic form

Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.

(2010) Science 329: 1355

Released	2010-09-22
Method	X-RAY DIFFRACTION 1.805 Å
Organisms	Pseudomonas aeruginosa UCBPP-PA14
Macromolecule	CSY4 ENDORIBONUCLEASE (protein) 5'-R(CPUPGPCPCPGPUPAPUPAPGPGPCPADGC)-3' (nucleic acid)

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2Y35 \| pdb_00002y35	Download File View File

Crystal structure of Xrn1-substrate complex

Jinek, M., Coyle, S.M., Doudna, J.A.

(2011) Mol Cell 41: 600

Released	2011-03-16
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Drosophila melanogaster synthetic construct
Macromolecule	LD22664P (protein) DT11 (5'-D(TPTPTPTPTPTPTPTPTPTP*TP)-3' (nucleic acid)
Unique Ligands	MG

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2Y8W \| pdb_00002y8w	Download File View File

Structure of CRISPR endoribonuclease Cse3 bound to 20 nt RNA

Sashital, D.G., Jinek, M., Doudna, J.A.

(2011) Nat Struct Mol Biol 18: 680

Released	2011-05-18
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Thermus thermophilus HB8
Macromolecule	CSE3 (protein) 5'-R(UPCPCPCPCPAPCPGPCPGPUPGPUPGP GPGPDGPAPUPG)-3' (nucleic acid)

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2Y8Y \| pdb_00002y8y	Download File View File

Structure B of CRISPR endoribonuclease Cse3 bound to 19 nt RNA

Sashital, D.G., Jinek, M., Doudna, J.A.

(2011) Nat Struct Mol Biol 18: 680

Released	2011-05-18
Method	X-RAY DIFFRACTION 1.44 Å
Organisms	Thermus thermophilus HB8
Macromolecule	CSE3 (protein) 5'-R(UPCPCPCPCPAPCPGPCPGPUPGPUPGP GPGPDGPAP*U)-3' (nucleic acid)

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2Y9H \| pdb_00002y9h	Download File View File

Structure A of CRISPR endoribonuclease Cse3 bound to 19 nt RNA

Sashital, D.G., Jinek, M., Doudna, J.A.

(2011) Nat Struct Mol Biol 18: 680

Released	2011-05-18
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Thermus thermophilus HB8
Macromolecule	CSE3 (protein) 5'-R(UPCPCPCPCPAPCPGPCPGPUPGPUPGP GPGPDGPAP*UP)-3' (nucleic acid)

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3IBV \| pdb_00003ibv	Download File View File

Karyopherin cytosolic state

Cook, A.G., Fukuhara, N., Jinek, M., Conti, E.

(2009) Nature 461: 60-65

Released	2009-08-25
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Schizosaccharomyces pombe
Macromolecule	Exportin-T (protein)
Unique Ligands	CA

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3ICQ \| pdb_00003icq	Download File View File

Karyopherin nuclear state

Cook, A.G., Fukuhara, N., Jinek, M., Conti, E.

(2009) Nature 461: 60-65

Released	2009-08-25
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Saccharomyces cerevisiae Schizosaccharomyces pombe
Macromolecule	Exportin-T (protein) GTP-binding nuclear protein GSP1/CNR1 (protein) RNA (62-MER) (nucleic acid)
Unique Ligands	GTP, MG

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3P2Q \| pdb_00003p2q	Download File View File

Crystal structure of the fluoroacetyl-CoA-specific thioesterase, FlK

Weeks, A.M., Coyle, S.M., Jinek, M., Doudna, J.A., Chang, M.C.Y.

(2010) Biochemistry 49: 9269-9279

Released	2010-10-20
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Streptantibioticus cattleyicolor
Macromolecule	Fluoroacetyl coenzyme A thioesterase (protein)

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3P2R \| pdb_00003p2r	Download File View File

Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate

Weeks, A.M., Coyle, S.M., Jinek, M., Doudna, J.A., Chang, M.C.Y.

(2010) Biochemistry 49: 9269-9279

Released	2010-10-20
Method	X-RAY DIFFRACTION 2.46 Å
Organisms	Streptantibioticus cattleyicolor
Macromolecule	Fluoroacetyl coenzyme A thioesterase (protein)
Unique Ligands	FAH

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3P2S \| pdb_00003p2s	Download File View File

Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in an open conformation

Weeks, A.M., Coyle, S.M., Jinek, M., Doudna, J.A., Chang, M.C.Y.

(2010) Biochemistry 49: 9269-9279

Released	2010-10-20
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Streptantibioticus cattleyicolor
Macromolecule	Fluoroacetyl coenzyme A thioesterase (protein)

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3P3F \| pdb_00003p3f	Download File View File

Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK

Weeks, A.M., Coyle, S.M., Jinek, M., Doudna, J.A., Chang, M.C.Y.

(2010) Biochemistry 49: 9269-9279

Released	2010-10-20
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Streptantibioticus cattleyicolor
Macromolecule	Fluoroacetyl coenzyme A thioesterase (protein)

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3P3I \| pdb_00003p3i	Download File View File

Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate and CoA

Weeks, A.M., Coyle, S.M., Jinek, M., Doudna, J.A., Chang, M.C.Y.

(2010) Biochemistry 49: 9269-9279

Released	2010-10-20
Method	X-RAY DIFFRACTION 2 Å
Organisms	Streptantibioticus cattleyicolor
Macromolecule	Fluoroacetyl coenzyme A thioesterase (protein)
Unique Ligands	COA, FAH

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4BK0 \| pdb_00004bk0	Download File View File

Crystal structure of the KIX domain of human RECQL5 (domain-swapped dimer)

Kassube, S.A., Jinek, M., Fang, J., Tsutakawa, S., Nogales, E.

(2013) Nat Struct Mol Biol 20: 892

Released	2013-06-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	ATP-DEPENDENT DNA HELICASE Q5 (protein)
Unique Ligands	PEG

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4C8Y \| pdb_00004c8y	Download File View File

Cas6 (TTHA0078) substrate mimic complex

Jinek, M., Niewoehner, O., Doudna, J.A.

(2014) Nucleic Acids Res 42: 1341

Released	2013-11-06
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Thermus thermophilus HB8
Macromolecule	CAS6A (protein) R1 REPEAT RNA SUBSTRATE MIMIC (nucleic acid)
Unique Ligands	SO4

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4C8Z \| pdb_00004c8z	Download File View File

Cas6 (TTHA0078) product complex

Jinek, M., Niewoehner, O., Doudna, J.A.

(2014) Nucleic Acids Res 42: 1341

Released	2013-11-06
Method	X-RAY DIFFRACTION 2.503 Å
Organisms	Thermus thermophilus HB8
Macromolecule	CAS6A (protein) R1 REPEAT RNA CLEAVAGE PRODUCT (nucleic acid)
Unique Ligands	K, SO4

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4C97 \| pdb_00004c97	Download File View File

Cas6 (TTHA0078) H37A mutant

Jinek, M., Niewoehner, O., Doudna, J.A.

(2014) Nucleic Acids Res 42: 1341

Released	2013-11-06
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Thermus thermophilus HB8
Macromolecule	CAS6A (protein)
Unique Ligands	SO4

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4C98 \| pdb_00004c98	Download File View File

Thermus thermophilus Cas6 (TTHB231)

Jinek, M., Niewoehner, O., Doudna, J.A.

(2014) Nucleic Acids Res 42: 1341

Released	2013-11-06
Method	X-RAY DIFFRACTION 2.001 Å
Organisms	Thermus thermophilus HB8
Macromolecule	CAS6B (protein)
Unique Ligands	ZN

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4C9D \| pdb_00004c9d	Download File View File

Cas6 (TTHB231) product complex

Jinek, M., Niewoehner, O., Doudna, J.A.

(2014) Nucleic Acids Res 42: 1341-1353

Released	2013-11-06
Method	X-RAY DIFFRACTION 3 Å
Organisms	Thermus thermophilus HB8
Macromolecule	CAS6B (protein) R3 REPEAT RNA CLEAVAGE PRODUCT (nucleic acid)

1 to 25 of 123 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1W3B | pdb_00001w3b

2J0A | pdb_00002j0a

2J0B | pdb_00002j0b

2VXG | pdb_00002vxg

2X04 | pdb_00002x04

2XLI | pdb_00002xli

2XLJ | pdb_00002xlj

2XLK | pdb_00002xlk

2Y35 | pdb_00002y35

2Y8W | pdb_00002y8w

2Y8Y | pdb_00002y8y

2Y9H | pdb_00002y9h

3IBV | pdb_00003ibv

3ICQ | pdb_00003icq

3P2Q | pdb_00003p2q

3P2R | pdb_00003p2r

3P2S | pdb_00003p2s

3P3F | pdb_00003p3f

3P3I | pdb_00003p3i

4BK0 | pdb_00004bk0

4C8Y | pdb_00004c8y

4C8Z | pdb_00004c8z

4C97 | pdb_00004c97

4C98 | pdb_00004c98

4C9D | pdb_00004c9d