L-amino acid oxidase 4

UniProtKB accession:  S4S6Z0

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UniProtKB description:  Catalyzes the oxidative deamination of L-amino acids with molecular oxygen to the corresponding alpha-keto acids and ammonia (PubMed:32653636, PubMed:33580695, PubMed:34459552, PubMed:39152524). L-glutamine shows the highest relative activity but LAAO4 has a broad substrate specificity, including L-amino acids with big aromatic, acidic and basic side chains (PubMed:33580695, PubMed:39152524). No reaction is detected for small polar amino acids such as L-cysteine or L-aspartate, and very little for small, branched hydrophobic amino acids like L-valine (PubMed:39152524).