E3 ubiquitin-protein ligase SopA

UniProtKB accession:  Q8ZNR3

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UniProtKB description:  Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway (PubMed:28084320). For instance, prevents host innate immune response by ubiquitinating and thus sending to degradation host E3 ubiquitin ligases TRIM56 and TRIM65 (PubMed:28084320). Required for inducing polymorphonuclear leukocytes migration across the intestinal epithelium. Preferentially uses host UBE2D1 (UBCH5A), UBE2D2 (UBCH5B) and UBE2L3 (UBCH7) as E2 ubiquitin-conjugating enzymes.