Embryonic developmental protein tofu-6

UniProtKB accession:  Q09293

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475). Promotes the biogenesis of 21U-RNAs (PubMed:31216475). Mediates the interaction between the PETISCO complex and the PUCH complex, the endoribonuclease complex processing the 5'-end of precursor piRNAs, thereby enhancing mature piRNA production (PubMed:37758951). Required for chromosome segregation and cell division in early embryos (PubMed:17171368, PubMed:31216475). May have a role in DNA replication (PubMed:17171368).