Hemagglutinin glycoprotein

UniProtKB accession:  P08362

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Attaches the virus to the human SLAMF1/CD150 receptor for entry into host dendritic cells, macrophages, activated memory T cells and naive or memory B cells, thereby explaining the long immunosuppression that follows infection (PubMed:10972291). In the respiratory airways, binds to the NECTIN4 receptor for entry into the host cell. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). The vaccine and laboratory-adapted strains use host CD46 as an alternate receptor (Probable). The high degree of interaction between H and CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis (PubMed:9811778).