9F2P

Crystal structure of Keap1 kelch domain in complex with a fluorenone-based small molecule inhibitor at 1.36A resolution

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Kelch motif	8033564	3000448	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01344	Kelch motif (Kelch_1)	Kelch motif	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Kelch-like ECH-associated protein 1	molecular function inhibitor activity molecular function regulator activity transcription regulator inhibitor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity disordered domain specific binding protein domain specific binding molecular function inhibitor activity molecular function regulator activity transcription regulator inhibitor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity disordered domain specific binding protein domain specific binding identical protein binding	developmental process multicellular organismal process epithelium development regulation of biological process regulation of multicellular organismal development regulation of cellular process cellular developmental process regulation of developmental process epidermal cell differentiation regulation of epidermal cell differentiation epidermis development biological regulation regulation of cell differentiation tissue development epithelial cell differentiation developmental process multicellular organismal process epithelium development regulation of biological process regulation of multicellular organismal development regulation of cellular process cellular developmental process regulation of developmental process epidermal cell differentiation regulation of epidermal cell differentiation epidermis development biological regulation regulation of cell differentiation tissue development epithelial cell differentiation regulation of epithelial cell differentiation multicellular organism development cell differentiation anatomical structure development cellular process regulation of multicellular organismal process regulation of epidermis development response to interleukin-4 response to peptide response to stimulus response to chemical response to cytokine cellular response to cytokine stimulus cellular response to interleukin-4 primary metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal negative regulation of response to stimulus negative regulation of biological process response to oxidative stress regulation of response to stimulus response to stress regulation of response to stress regulation of response to oxidative stress negative regulation of response to oxidative stress cellular response to stimulus cellular response to chemical stimulus cellular response to stress cellular response to oxidative stress cellular response to chemical stress embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development catabolic process proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process autophagy regulation of catabolic process regulation of autophagy process utilizing autophagic mechanism negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process	midbody cellular anatomical structure intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome microtubule organizing center cytoskeleton centriolar satellite organelle membraneless organelle microtubule cytoskeleton cytoplasm cytosol midbody cellular anatomical structure intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome microtubule organizing center cytoskeleton centriolar satellite organelle membraneless organelle microtubule cytoskeleton cytoplasm cytosol inclusion body membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex polymeric cytoskeletal fiber actin filament actin cytoskeleton supramolecular fiber supramolecular polymer supramolecular complex cullin-RING ubiquitin ligase complex ubiquitin ligase complex catalytic complex transferase complex Cul3-RING ubiquitin ligase complex intracellular protein-containing complex endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000210	BTB/POZ domain	Domain
A	IPR015915	Kelch-type beta propeller	Homologous Superfamily
A	IPR006652	Kelch repeat type 1	Repeat
A	IPR011705	BTB/Kelch-associated	Domain
A	IPR017096	BTB-kelch protein	Family
A	IPR030563	Kelch-like ECH-associated protein 1, BTB/POZ domain	Domain
A	IPR047098	Kelch-like ECH-associated protein 1, BACK domain	Domain
A	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.