8A38 | pdb_00008a38

RING domain of human TRIM2

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF13445	RING-type zinc-finger (zf-RING_UBOX)	RING-type zinc-finger	This zinc-finger is a typical RING-type of plant ubiquitin ligases [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Tripartite motif-containing protein 2	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity translation regulator activity translation repressor activity cation binding transition metal ion binding zinc ion binding ion binding binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity translation regulator activity translation repressor activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding ubiquitin-like protein ligase activity ubiquitin protein ligase activity	protein polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of cellular process negative regulation of biological process protein polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process neuron apoptotic process regulation of apoptotic process regulation of programmed cell death cell death apoptotic process programmed cell death regulation of neuron apoptotic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
A, B, C	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
A, B, C	IPR001258	NHL repeat	Repeat
A, B, C	IPR050952	Tripartite Motif and NHL Repeat Containing E3 Ligases	Family
A, B, C	IPR000315	B-box-type zinc finger	Domain
A, B, C	IPR027370	Zinc finger, RING-type, eukaryotic	Domain
A, B, C	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B, C	IPR017868	Filamin/ABP280 repeat-like	Repeat
A, B, C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, B, C	IPR003649	B-box, C-terminal	Domain
A, B, C	IPR001841	Zinc finger, RING-type	Domain
A, B, C	IPR001298	Filamin/ABP280 repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q9C040	Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease type 2R peripheral neuropathy Osteoarthrosis Deformans pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease pilocytic astrocytoma atypical teratoid rhabdoid tumor spina bifida glioblastoma large cell medulloblastoma malignant glioma motor peripheral neuropathy osteoarthritis osteosarcoma Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease type 2R peripheral neuropathy Osteoarthrosis Deformans pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease pilocytic astrocytoma atypical teratoid rhabdoid tumor spina bifida glioblastoma large cell medulloblastoma malignant glioma motor peripheral neuropathy osteoarthritis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm progressive supranuclear palsy breast cancer ulcerative colitis interstitial cystitis lung adenocarcinoma malignant mesothelioma neurodegenerative disease osteoarthritis susceptibility 1 ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Pick disease psoriasis breast carcinoma cystic fibrosis invasive ductal breast carcinoma lung carcinoma medulloblastoma non-small cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.