8WCI

Cryo-EM structure of the inhibitor-bound Vo complex from Enterococcus hirae

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
K [auth P]	PF01496	V-type ATPase 116kDa subunit family (V_ATPase_I)	V-type ATPase 116kDa subunit family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	V-type sodium ATPase subunit K	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity identical protein binding protein binding binding	localization transport monoatomic ion transport monoatomic cation transport establishment of localization sodium ion transport metal ion transport	ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain cell periphery plasma membrane
K [auth P]	V-type sodium ATPase subunit I	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity ATPase binding protein binding binding enzyme binding	localization transport monoatomic ion transport monoatomic cation transport establishment of localization sodium ion transport metal ion transport homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vacuolar acidification cellular homeostasis chemical homeostasis localization transport monoatomic ion transport monoatomic cation transport establishment of localization sodium ion transport metal ion transport homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vacuolar acidification cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis	ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain cell periphery plasma membrane membrane-bounded organelle intracellular anatomical structure intracellular organelle bounding membrane of organelle vacuolar membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex organelle cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR000245	V-ATPase proteolipid subunit	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
K [auth P]	IPR002490	V-type ATPase, V0 complex, 116kDa subunit family	Family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K [auth P]	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.