8S7C

Ternary Complex of Cachd1, FZD5 and LRP6

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, E, H	PF01392	Fz domain (Fz)	Fz domain	Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups [1,2,3,4]. The domain contains 10 conserved cysteines.	Domain
C, F, I	PF14670	Coagulation Factor Xa inhibitory site (FXa_inhibition)	Coagulation Factor Xa inhibitory site	This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442 [1].	Domain
C, F, I	PF00058	Low-density lipoprotein receptor repeat class B (Ldl_recept_b)	Low-density lipoprotein receptor repeat class B	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D, G	VWFA and cache domain-containing protein 1	-	localization transport monoatomic ion transport monoatomic cation transport establishment of localization calcium ion transport metal ion transport	cellular anatomical structure membrane
B, E, H	Frizzled-5	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity Wnt receptor activity amide binding amyloid-beta binding binding peptide binding protein-containing complex binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding Wnt-protein binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity Wnt receptor activity amide binding amyloid-beta binding binding peptide binding protein-containing complex binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding Wnt-protein binding G protein-coupled receptor activity kinase binding protein kinase binding lipid binding	developmental process multicellular organismal process sensory organ development post-embryonic camera-type eye development eye development animal organ development visual system development multicellular organism development camera-type eye development anatomical structure development post-embryonic development sensory system development system development adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains developmental process multicellular organismal process sensory organ development post-embryonic camera-type eye development eye development animal organ development visual system development multicellular organism development camera-type eye development anatomical structure development post-embryonic development sensory system development system development adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response cytokine production leukocyte mediated immunity regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of adaptive immune response positive regulation of T cell cytokine production positive regulation of immune system process regulation of T cell mediated immunity regulation of biological process regulation of cytokine production involved in immune response immune response regulation of adaptive immune response immune effector process regulation of gene expression regulation of leukocyte mediated immunity biosynthetic process regulation of response to stimulus positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of immune response metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus regulation of T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of biosynthetic process regulation of cytokine production positive regulation of immune effector process regulation of multicellular organismal process cytokine production involved in immune response positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process adaptive immune response regulation of lymphocyte mediated immunity positive regulation of gene expression immune system process positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response cellular process cellular response to stimulus cell surface receptor signaling pathway signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway cell differentiation involved in embryonic placenta development cellular developmental process placenta development reproductive process syncytiotrophoblast cell differentiation involved in labyrinthine layer development chordate embryonic development labyrinthine layer development developmental process involved in reproduction embryo development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching cell differentiation embryonic organ development cell development epithelial cell differentiation intestinal epithelial cell maturation columnar/cuboidal epithelial cell development cell maturation epithelium development digestive system development intestinal epithelial cell differentiation tube development intestinal epithelial cell development developmental maturation tissue development digestive tract development epithelial cell development anatomical structure maturation columnar/cuboidal epithelial cell differentiation epithelial cell maturation columnar/cuboidal epithelial cell maturation embryonic morphogenesis morphogenesis of an epithelium branching involved in labyrinthine layer morphogenesis embryonic placenta morphogenesis anatomical structure morphogenesis labyrinthine layer morphogenesis tissue morphogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production hemopoiesis cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation T cell differentiation leukocyte differentiation glandular epithelial cell development glandular epithelial cell maturation glandular epithelial cell differentiation embryonic eye morphogenesis embryonic camera-type eye development eye morphogenesis animal organ morphogenesis embryonic organ morphogenesis camera-type eye morphogenesis embryonic camera-type eye morphogenesis sensory organ morphogenesis vasculature development circulatory system development positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription apoptotic process involved in development apoptotic process involved in morphogenesis apoptotic process cell death programmed cell death labyrinthine layer blood vessel development placenta blood vessel development blood vessel development blood vessel morphogenesis angiogenesis tube morphogenesis anatomical structure formation involved in morphogenesis cell population proliferation regulation of cell population proliferation regulation of chorionic trophoblast cell proliferation chorionic trophoblast cell proliferation non-canonical Wnt signaling pathway blastoderm segmentation embryonic pattern specification anterior/posterior axis specification, embryo anterior/posterior pattern specification segmentation pattern specification process regionalization tripartite regional subdivision embryonic axis specification anterior/posterior axis specification axis specification extraembryonic membrane development chorion development chorionic trophoblast cell differentiation bicellular tight junction assembly regulation of bicellular tight junction assembly regulation of cellular component organization tight junction organization apical junction assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis regulation of cell junction assembly cell junction organization cellular component assembly cell junction assembly tight junction assembly cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization biological process involved in interspecies interaction between organisms response to other organism response to external stimulus cellular response to molecule of bacterial origin response to biotic stimulus cellular response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin negative regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process Spemann organizer formation developmental induction regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of type II interferon production type II interferon production positive regulation of type II interferon production	somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle organelle membrane perinuclear region of cytoplasm axon cell surface cell periphery plasma membrane synapse cell junction cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction
C, F, I	Low-density lipoprotein receptor-related protein 6	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity Wnt receptor activity coreceptor activity enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity kinase inhibitor activity kinase regulator activity protein binding binding signaling receptor binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity Wnt receptor activity coreceptor activity enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity kinase inhibitor activity kinase regulator activity protein binding binding signaling receptor binding G protein-coupled receptor binding frizzled binding identical protein binding Wnt-protein binding toxin transmembrane transporter activity transporter activity transmembrane transporter activity lipoprotein particle receptor activity low-density lipoprotein particle receptor activity cargo receptor activity protein homodimerization activity protein dimerization activity	cellular response to stimulus response to sterol response to stimulus response to lipid response to alcohol cellular response to organic cyclic compound response to oxygen-containing compound response to cholesterol cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to chemical cellular response to lipid cellular process cellular response to stimulus response to sterol response to stimulus response to lipid response to alcohol cellular response to organic cyclic compound response to oxygen-containing compound response to cholesterol cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to chemical cellular response to lipid cellular process cellular response to sterol cellular response to cholesterol response to organic cyclic compound developmental process neural crest cell differentiation cellular developmental process animal organ development mesenchyme development tissue development stem cell differentiation cell differentiation anatomical structure development mesenchymal cell differentiation regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling canonical Wnt signaling pathway biological regulation cell communication signal transduction Wnt signaling pathway positive regulation of DNA-binding transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane multicellular organism development multicellular organismal process nervous system development system development trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process cell cycle regulation of cell cycle positive regulation of cell cycle positive regulation of cytosolic calcium ion concentration regulation of biological quality response to hormone response to endogenous stimulus response to peptide hormone response to nitrogen compound import into cell transport endocytosis establishment of localization vesicle-mediated transport chordate embryonic development embryo development neural crest formation epithelial to mesenchymal transition anatomical structure morphogenesis embryo development ending in birth or egg hatching anatomical structure formation involved in morphogenesis regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process negative regulation of protein serine/threonine kinase activity phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process phosphorus metabolic process protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of protein serine/threonine kinase activity negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation head development dopaminergic neuron differentiation brain development generation of neurons neurogenesis central nervous system neuron differentiation central nervous system development neuron differentiation midbrain development midbrain dopaminergic neuron differentiation cell adhesion cell-cell adhesion muscle cell apoptotic process smooth muscle cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death regulation of smooth muscle cell apoptotic process negative regulation of smooth muscle cell apoptotic process negative regulation of apoptotic process negative regulation of muscle cell apoptotic process apoptotic process programmed cell death	cell periphery protein-containing complex cellular anatomical structure Wnt-Frizzled-LRP5/6 complex plasma membrane protein complex membrane plasma membrane membrane protein complex somatodendritic compartment cell body neuronal cell body cell surface membrane microdomain membrane raft cell periphery protein-containing complex cellular anatomical structure Wnt-Frizzled-LRP5/6 complex plasma membrane protein complex membrane plasma membrane membrane protein complex somatodendritic compartment cell body neuronal cell body cell surface membrane microdomain membrane raft Wnt signalosome membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm intracellular membrane-bounded organelle vesicle extracellular region endosome membrane early endosome endosome early endosome membrane endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane synapse cell junction endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D, G	IPR051173	Voltage-dependent calcium channel subunit alpha-2/delta	Family
A, D, G	IPR002035	von Willebrand factor, type A	Domain
A, D, G	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
A, D, G	IPR029151	Periplasmic sensor-like domain superfamily	Homologous Superfamily
B, E, H	IPR036790	Frizzled cysteine-rich domain superfamily	Homologous Superfamily
B, E, H	IPR017981	GPCR, family 2-like, 7TM	Domain
B, E, H	IPR000539	Frizzled/Smoothened, 7TM	Domain
B, E, H	IPR020067	Frizzled domain	Domain
B, E, H	IPR037441	Frizzled-5, CRD domain	Domain
B, E, H	IPR015526	Frizzled/secreted frizzled-related protein	Family
C, F, I	IPR036055	LDL receptor-like superfamily	Homologous Superfamily
C, F, I	IPR000033	LDLR class B repeat	Repeat
C, F, I	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site	Conserved Site
C, F, I	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
C, F, I	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat	Repeat
C, F, I	IPR000742	EGF-like domain	Domain
C, F, I	IPR050778	Cueball/EGF/LRP/Nidogen	Family
C, F, I	IPR017049	Low density lipoprotein receptor-related protein 5/6	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C, F, I	Pharos: O75581	coronary artery disease, autosomal dominant 2 tooth agenesis, selective, 7 triple-negative breast carcinoma acute myeloid leukemia atypical teratoid rhabdoid tumor hereditary spastic paraplegia lung cancer Oligodontia Pick disease tooth agenesis adrenal cortex carcinoma malignant ependymoma osteogenesis imperfecta primitive neuroectodermal tumor astrocytic tumor coronary artery disease, autosomal dominant 2 tooth agenesis, selective, 7 triple-negative breast carcinoma acute myeloid leukemia atypical teratoid rhabdoid tumor hereditary spastic paraplegia lung cancer Oligodontia Pick disease tooth agenesis adrenal cortex carcinoma malignant ependymoma osteogenesis imperfecta primitive neuroectodermal tumor astrocytic tumor glioblastoma large cell medulloblastoma medulloblastoma osteosarcoma progressive supranuclear palsy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.