8RCN | pdb_00008rcn

CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused region of mTOR and RAPTOR on one protomer copy.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	8036936	3001600	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth Y]	PF14538	Raptor N-terminal CASPase like domain (Raptor_N)	Raptor N-terminal CASPase like domain	This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure [1]. It conserves the characteristic cys/his dyad of the caspases suggesting it may have a peptidase activity.	Domain
A [auth B]	PF02260	FATC domain (FATC)	FATC domain	-	Family
A [auth B]	PF08771	FKBP12-rapamycin binding domain (FRB_dom)	FKBP12-rapamycin binding domain	The macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapa ...	The macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapamycin binding domain (FRB) of the TOR proteins. This entry represents the FRB domain [1, 2].	Domain
A [auth B]	PF00454	Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase)	Phosphatidylinositol 3- and 4-kinase	-	Family
A [auth B]	PF11865	Serine/threonine-protein kinase mTOR domain (mTOR_dom)	Serine/threonine-protein kinase mTOR domain	-	Repeat
A [auth B]	PF02259	FAT domain (FAT)	FAT domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth Y]	Regulatory-associated protein of mTOR	small GTPase binding protein binding binding enzyme binding GTPase binding protein-macromolecule adaptor activity molecular adaptor activity 14-3-3 protein binding protein-containing complex binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity small GTPase binding protein binding binding enzyme binding GTPase binding protein-macromolecule adaptor activity molecular adaptor activity 14-3-3 protein binding protein-containing complex binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity enzyme-substrate adaptor activity kinase binding protein kinase binding protein kinase inhibitor activity molecular function inhibitor activity enzyme inhibitor activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to oxygen levels response to abiotic stimulus cellular component organization regulation of cellular component size biological regulation cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size cellular response to nutrient levels response to nutrient levels positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth TORC1 signaling positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition regulation of amide metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleobase-containing compound metabolic process regulation of small molecule metabolic process regulation of nucleotide metabolic process regulation of pentose-phosphate shunt pentose-phosphate shunt pyridine-containing compound metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process positive regulation of nucleobase-containing compound metabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process positive regulation of pentose-phosphate shunt catabolic process positive regulation of nucleotide metabolic process glucose 6-phosphate metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process regulation of NADP metabolic process amide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process generation of precursor metabolites and energy regulation of catabolic process purine-containing compound metabolic process NADP metabolic process positive regulation of purine nucleotide metabolic process NADPH regeneration organophosphate metabolic process positive regulation of small molecule metabolic process response to starvation cellular response to starvation cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical response to amino acid negative regulation of catabolic process negative regulation of metabolic process autophagy negative regulation of biological process regulation of autophagy negative regulation of autophagy negative regulation of cellular process process utilizing autophagic mechanism response to osmotic stress cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus cellular response to abiotic stimulus cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound cellular response to L-leucine cellular response to oxygen-containing compound response to L-leucine positive regulation of cell growth positive regulation of growth ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process positive regulation of nucleotide catabolic process glycolytic process purine ribonucleotide catabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process positive regulation of carbohydrate metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process positive regulation of purine nucleotide catabolic process ribonucleotide metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process ADP catabolic process carboxylic acid metabolic process regulation of glycolytic process positive regulation of catabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process regulation of peptidyl-threonine phosphorylation peptidyl-threonine modification positive regulation of peptidyl-threonine phosphorylation peptidyl-threonine phosphorylation homeostatic process cellular response to glucose stimulus intracellular glucose homeostasis response to hexose cellular response to carbohydrate stimulus cellular homeostasis response to monosaccharide response to carbohydrate chemical homeostasis response to glucose glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus regulation of biosynthetic process regulation of lipid metabolic process lipid biosynthetic process positive regulation of lipid biosynthetic process biosynthetic process positive regulation of biosynthetic process positive regulation of lipid metabolic process regulation of lipid biosynthetic process lipid metabolic process multicellular organismal process positive regulation of odontoblast differentiation cellular developmental process regulation of developmental process regulation of cell differentiation epithelial cell differentiation regulation of epithelial cell differentiation positive regulation of developmental process multicellular organism development positive regulation of cell differentiation cell differentiation anatomical structure development neuroepithelial cell differentiation regulation of multicellular organismal process odontoblast differentiation developmental process epithelium development regulation of multicellular organismal development regulation of odontoblast differentiation tissue development positive regulation of epithelial cell differentiation columnar/cuboidal epithelial cell differentiation positive regulation of neuroepithelial cell differentiation behavior biological process involved in intraspecies interaction between organisms social behavior positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase III RNA metabolic process positive regulation of macromolecule biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase III regulation of RNA biosynthetic process regulation of transcription by RNA polymerase III nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription cell population proliferation positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation myeloid leukocyte differentiation regulation of leukocyte differentiation cell development positive regulation of osteoclast differentiation regulation of cell development regulation of osteoclast differentiation positive regulation of hemopoiesis osteoclast differentiation regulation of immune system process positive regulation of immune system process hemopoiesis regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of multicellular organismal process positive regulation of leukocyte differentiation leukocyte differentiation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection vacuolar membrane membrane-bounded organelle membrane lytic vacuole cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection vacuolar membrane membrane-bounded organelle membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle lysosomal membrane organelle membrane lysosome cell body neuronal cell body protein-containing complex TORC1 complex TOR complex intracellular protein-containing complex cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule membraneless organelle supramolecular complex cytoplasmic stress granule nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
A [auth B]	Serine/threonine-protein kinase mTOR	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T6 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity DNA binding sequence-specific DNA binding RNA polymerase III transcription regulatory region sequence-specific DNA binding RNA polymerase III type 2 promoter sequence-specific DNA binding double-stranded DNA binding nucleic acid binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding RNA polymerase III cis-regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding histone H3S57 kinase activity histone H4S1 kinase activity histone H4 kinase activity ribonucleoprotein complex binding protein-containing complex binding ribosome binding histone H3T11 kinase activity histone H3S28 kinase activity histone H2B kinase activity histone H2BS36 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity histone H2AS121 kinase activity histone H2A kinase activity AMP-activated protein kinase activity phosphoprotein binding protein binding histone H3T45 kinase activity eukaryotic translation initiation factor 2alpha kinase activity histone H3T3 kinase activity inositol hexakisphosphate binding alcohol binding rDNA binding 5S rDNA binding RNA polymerase III type 1 promoter sequence-specific DNA binding histone H2BS14 kinase activity identical protein binding transcription factor binding TFIIIC-class transcription factor complex binding RNA polymerase III general transcription initiation factor binding general transcription initiation factor binding Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity protein serine kinase activity RNA polymerase III type 3 promoter sequence-specific DNA binding 3-phosphoinositide-dependent protein kinase activity histone H2AS1 kinase activity	calcineurin-NFAT signaling cascade cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette cellular process signal transduction calcineurin-mediated signaling calcineurin-NFAT signaling cascade cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette cellular process signal transduction calcineurin-mediated signaling catabolic process macroautophagy autophagy regulation of catabolic process regulation of autophagy regulation of macroautophagy metabolic process process utilizing autophagic mechanism regulation of metabolic process regulation of cellular component organization autophagosome organization cellular component biogenesis cellular component organization cellular component assembly cellular component organization or biogenesis autophagosome assembly organelle assembly vacuole organization regulation of autophagosome assembly regulation of vacuole organization regulation of cellular component biogenesis regulation of organelle organization organelle organization regulation of organelle assembly regulation of cellular component size regulation of biological quality regulation of cell size regulation of anatomical structure size regulation of growth growth regulation of cell growth cell growth TOR signaling TORC1 signaling developmental process heart development multicellular organismal process heart valve development animal organ development circulatory system development multicellular organism development anatomical structure morphogenesis heart valve morphogenesis anatomical structure development system development behavior response to stress multicellular organismal response to stress response to pain behavioral response to pain cellular response to nutrient levels response to nutrient levels cellular response to stress response to starvation cellular response to starvation cellular developmental process regulation of developmental process positive regulation of biological process regulation of cell differentiation regulation of striated muscle cell differentiation muscle cell differentiation myotube differentiation muscle structure development positive regulation of developmental process positive regulation of myotube differentiation positive regulation of cell differentiation cell differentiation positive regulation of striated muscle cell differentiation regulation of myotube differentiation positive regulation of cellular process positive regulation of muscle cell differentiation regulation of muscle cell differentiation striated muscle cell differentiation positive regulation of locomotion regulation of cell motility regulation of keratinocyte migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration cell migration regulation of multicellular organismal process epithelial cell migration cell motility regulation of epithelial cell migration locomotion epithelium migration regulation of locomotion positive regulation of keratinocyte migration keratinocyte migration negative regulation of catabolic process negative regulation of metabolic process negative regulation of biological process negative regulation of autophagy negative regulation of cellular process response to osmotic stress cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus cellular response to chemical stimulus response to chemical response to abiotic stimulus cellular response to abiotic stimulus positive regulation of protein metabolic process positive regulation of translation positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process translational initiation protein metabolic process regulation of biosynthetic process regulation of translational initiation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process positive regulation of translational initiation macromolecule metabolic process multicellular organism growth developmental growth anoikis apoptotic process cell death programmed cell death cellular response to acid chemical cellular response to nitrogen compound cellular response to amino acid stimulus response to oxygen-containing compound response to nitrogen compound response to amino acid cellular response to L-leucine cellular response to oxygen-containing compound response to acid chemical response to L-leucine negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction negative regulation of cell communication negative regulation of calcineurin-NFAT signaling cascade regulation of intracellular signal transduction regulation of calcineurin-mediated signaling regulation of calcium-mediated signaling regulation of calcineurin-NFAT signaling cascade regulation of signaling negative regulation of response to stimulus negative regulation of calcium-mediated signaling negative regulation of signal transduction regulation of response to stimulus regulation of cell communication negative regulation of calcineurin-mediated signaling response to heat response to temperature stimulus positive regulation of cell growth positive regulation of growth ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process regulation of generation of precursor metabolites and energy positive regulation of phosphate metabolic process nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process positive regulation of nucleotide catabolic process regulation of small molecule metabolic process glycolytic process regulation of phosphate metabolic process regulation of nucleotide metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of phosphorus metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of phosphorus metabolic process regulation of nucleotide catabolic process positive regulation of carbohydrate metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process positive regulation of nucleotide metabolic process positive regulation of purine nucleotide catabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of catabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process positive regulation of small molecule metabolic process purine ribonucleoside diphosphate catabolic process voluntary musculoskeletal movement multicellular organismal movement musculoskeletal movement system process nervous system process neuromuscular process sexual reproduction reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation germ cell development rhythmic process circadian rhythm regulation of circadian rhythm negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development tissue development epithelial to mesenchymal transition positive regulation of multicellular organismal process mesenchymal cell differentiation lytic vacuole organization lysosome organization regulation of lysosome organization regulation of cytoskeleton organization regulation of actin filament-based process actin cytoskeleton organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization cellular response to methionine response to nutrient response to methionine cellular response to nutrient myeloid leukocyte differentiation regulation of leukocyte differentiation regulation of cell development regulation of osteoclast differentiation osteoclast differentiation regulation of immune system process regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation myeloid cell differentiation immune system process regulation of hemopoiesis leukocyte differentiation positive regulation of organelle organization positive regulation of cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of protein polymerization protein-containing complex assembly regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin filament polymerization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization regulation of actin polymerization or depolymerization actin filament organization positive regulation of supramolecular fiber organization regulation of protein polymerization regulation of actin filament length regulation of supramolecular fiber organization supramolecular fiber organization positive regulation of actin filament polymerization cardiac muscle cell development striated muscle tissue development striated muscle cell development muscle cell development cardiac cell development muscle tissue development cardiac muscle tissue development cardiac muscle cell differentiation cardiocyte differentiation heart process circulatory system process cardiac muscle contraction heart contraction muscle contraction muscle system process blood circulation striated muscle contraction pyrimidine-containing compound metabolic process nucleobase biosynthetic process pyrimidine nucleobase biosynthetic process pyrimidine nucleobase metabolic process nucleobase metabolic process 'de novo' pyrimidine nucleobase biosynthetic process pyrimidine-containing compound biosynthetic process defense response inflammatory response signal transduction by p53 class mediator regulation of signal transduction by p53 class mediator response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus cellular response to endogenous stimulus response to hormone response to insulin cellular response to insulin stimulus cellular response to hormone stimulus protein localization regulation of localization cellular localization regulation of protein localization regulation of protein localization to nucleus protein localization to nucleus negative regulation of protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle negative regulation of protein localization regulation of transcription of nucleolar large rRNA by RNA polymerase I positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase I rRNA transcription rRNA metabolic process positive regulation of transcription by RNA polymerase I regulation of RNA biosynthetic process regulation of transcription by RNA polymerase I nucleolar large rRNA transcription by RNA polymerase I nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process positive regulation of transcription of nucleolar large rRNA by RNA polymerase I regulation of DNA-templated transcription cell projection organization plasma membrane bounded cell projection assembly regulation of lamellipodium assembly regulation of lamellipodium organization positive regulation of cell projection organization lamellipodium assembly plasma membrane bounded cell projection organization regulation of cell projection organization regulation of cell projection assembly positive regulation of lamellipodium assembly positive regulation of lamellipodium organization regulation of plasma membrane bounded cell projection assembly lamellipodium organization cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly stress fiber assembly actomyosin structure organization regulation of stress fiber assembly contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly negative regulation of cell size regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process peptidyl-amino acid modification protein modification process positive regulation of protein phosphorylation protein phosphorylation phosphorylation regulation of peptidyl-tyrosine phosphorylation macromolecule modification regulation of phosphorylation peptidyl-tyrosine phosphorylation DNA damage response protein destabilization regulation of protein stability response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to hypoxia response to oxygen levels regulation of amide metabolic process regulation of pentose-phosphate shunt pentose-phosphate shunt positive regulation of pentose-phosphate shunt glucose 6-phosphate metabolic process regulation of NADP metabolic process amide metabolic process NADP metabolic process NADPH regeneration heart morphogenesis animal organ morphogenesis TORC2 signaling ruffle organization regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation positive regulation of leukocyte activation regulation of cell-cell adhesion positive regulation of immune system process positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation lymphocyte costimulation regulation of leukocyte cell-cell adhesion T cell costimulation regulation of lymphocyte activation cellular response to amino acid starvation response to amino acid starvation cellular response to heat regulation of cellular response to heat regulation of cellular response to stress regulation of response to stress negative regulation of lysosome organization negative regulation of cellular component organization negative regulation of organelle organization regulation of myelination nervous system development regulation of nervous system development myelination axon ensheathment ensheathment of neurons neurogenesis central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation cellular response to leucine starvation negative regulation of macroautophagy positive regulation of cytoplasmic translational initiation regulation of cytoplasmic translational initiation cytoplasmic translation cytoplasmic translational initiation regulation of cytoplasmic translation regulation of response to wounding positive regulation of response to stimulus response to wounding regulation of wound healing, spreading of epidermal cells positive regulation of response to wounding wound healing epithelium development positive regulation of wound healing, spreading of epidermal cells morphogenesis of an epithelium epiboly involved in wound healing morphogenesis of an epithelial sheet wound healing, spreading of epidermal cells tissue morphogenesis positive regulation of wound healing regulation of wound healing epiboly wound healing, spreading of cells regulation of lipid metabolic process lipid biosynthetic process positive regulation of lipid biosynthetic process positive regulation of lipid metabolic process regulation of lipid biosynthetic process lipid metabolic process positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling energy derivation by oxidation of organic compounds energy reserve metabolic process action potential transmission of nerve impulse neuronal action potential regulation of membrane potential rhythmic behavior regulation of behavior circadian behavior locomotory behavior regulation of locomotor rhythm locomotor rhythm adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains CD4-positive or CD8-positive, alpha-beta T cell lineage commitment T-helper 1 cell lineage commitment mononuclear cell differentiation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response CD4-positive, alpha-beta T cell activation leukocyte activation involved in immune response alpha-beta T cell activation T cell differentiation CD4-positive, alpha-beta T cell lineage commitment lymphocyte activation involved in immune response T-helper cell differentiation immune response alpha-beta T cell lineage commitment T cell differentiation involved in immune response T-helper 1 type immune response T-helper cell lineage commitment T cell lineage commitment adaptive immune response immune effector process positive T cell selection T-helper 1 cell differentiation T cell selection cell fate commitment positive regulation of transcription by RNA polymerase III transcription by RNA polymerase III regulation of transcription by RNA polymerase III positive regulation of nervous system development regulation of neurogenesis regulation of gliogenesis positive regulation of gliogenesis positive regulation of neurogenesis positive regulation of oligodendrocyte differentiation positive regulation of cell development regulation of glial cell differentiation positive regulation of glial cell differentiation regulation of oligodendrocyte differentiation post-embryonic development regulation of membrane permeability	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol Golgi membrane Golgi apparatus membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol Golgi membrane Golgi apparatus membrane bounding membrane of organelle organelle membrane protein-containing complex TORC1 complex TOR complex intracellular protein-containing complex intracellular vesicle phagocytic vesicle cytoplasmic vesicle vesicle endocytic vesicle cell periphery plasma membrane lytic vacuole vacuole lysosome organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection vacuolar membrane lytic vacuole membrane lysosomal membrane mitochondrial membrane mitochondrion organelle outer membrane mitochondrial envelope mitochondrial outer membrane outer membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen TORC2 complex nuclear body PML body
C [auth X]	Eukaryotic translation initiation factor 4E-binding protein 1	eukaryotic initiation factor 4E binding protein binding binding translation initiation factor binding translation regulator activity translation repressor activity	regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process translational initiation protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of translational initiation regulation of protein metabolic process regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process translational initiation protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of translational initiation regulation of protein metabolic process negative regulation of metabolic process biological regulation negative regulation of translational initiation primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process cellular response to stimulus TOR signaling response to stimulus signaling intracellular signal transduction cell communication signal transduction positive regulation of biological process positive regulation of cell cycle mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle cell cycle regulation of cell cycle positive regulation of cellular process mitotic cell cycle process cell cycle phase transition G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle phase transition cell cycle process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth Y]	IPR016024	Armadillo-type fold	Homologous Superfamily
B [auth Y]	IPR004083	Regulatory associated protein of TOR	Family
B [auth Y]	IPR029347	Raptor, N-terminal CASPase-like domain	Domain
B [auth Y]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B [auth Y]	IPR000357	HEAT repeat	Repeat
B [auth Y]	IPR011989	Armadillo-like helical	Homologous Superfamily
B [auth Y]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B [auth Y]	IPR001680	WD40 repeat	Repeat
A [auth B]	IPR016024	Armadillo-type fold	Homologous Superfamily
A [auth B]	IPR009076	FKBP12-rapamycin binding domain	Domain
A [auth B]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A [auth B]	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site	Conserved Site
A [auth B]	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Homologous Superfamily
A [auth B]	IPR014009	PIK-related kinase	Domain
A [auth B]	IPR026683	Serine/threonine-protein kinase TOR, catalytic domain	Domain
A [auth B]	IPR003151	PIK-related kinase, FAT	Domain
A [auth B]	IPR036738	FKBP12-rapamycin binding domain superfamily	Homologous Superfamily
A [auth B]	IPR003152	FATC domain	Domain
A [auth B]	IPR024585	Serine/threonine-protein kinase mTOR domain	Domain
A [auth B]	IPR011989	Armadillo-like helical	Homologous Superfamily
A [auth B]	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	Domain
A [auth B]	IPR050517	DNA Damage Response and Repair Kinase	Family
A [auth B]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
C [auth X]	IPR008606	Eukaryotic translation initiation factor 4E binding	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth Y]	Pharos: Q8N122	nicotine dependence hypertensive disorder Sjogren syndrome Tobacco Dependence
A [auth B]	Pharos: P42345	renal cell carcinoma mantle cell lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma sarcomatoid renal cell carcinoma chromophobe renal cell carcinoma macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome adenocarcinoma granular cell carcinoma hypertensive disorder intellectual disability schizophrenia tubular adenocarcinoma papillary renal cell carcinoma isolated focal cortical dysplasia type II cancer renal cell carcinoma mantle cell lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma sarcomatoid renal cell carcinoma chromophobe renal cell carcinoma macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome adenocarcinoma granular cell carcinoma hypertensive disorder intellectual disability schizophrenia tubular adenocarcinoma papillary renal cell carcinoma isolated focal cortical dysplasia type II cancer cervical cancer collecting duct carcinoma cribriform carcinoma of breast epilepsy ovarian mucinous adenocarcinoma acute T cell leukemia glioblastoma hyperglycemia bladder carcinoma in situ inborn carbohydrate metabolic disorder kidney disease small cell lung carcinoma liver disease toxic encephalopathy connective tissue disease urinary bladder neoplasm mesothelioma obesity disorder ovarian neoplasm renal carcinoma benign mesothelioma breast disease thyroid gland carcinoma cerebral cortical dysplasia lung disease clear cell renal carcinoma lymphatic system disease urinary bladder cancer major depressive disorder cribriform carcinoma metastatic melanoma neurodegenerative disease ovarian cancer hepatocellular carcinoma bladder benign neoplasm small cell carcinoma lung large cell carcinoma type 2 diabetes mellitus urinary bladder carcinoma
C [auth X]	Pharos: Q13541	acute myeloid leukemia mantle cell lymphoma HIV infectious disease Inflammation pancreatic ductal adenocarcinoma precancerous condition psoriasis adrenal cortex carcinoma kidney neoplasm lung cancer malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor glioblastoma acute myeloid leukemia mantle cell lymphoma HIV infectious disease Inflammation pancreatic ductal adenocarcinoma precancerous condition psoriasis adrenal cortex carcinoma kidney neoplasm lung cancer malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant glioma malignant pancreatic neoplasm non-small cell lung carcinoma pilocytic astrocytoma primitive neuroectodermal tumor cancer kidney cancer lung adenocarcinoma malignant colon neoplasm