Annotations: 8RBZ

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
R [auth p]	SCOP2B Superfamily	ARM repeat-like	8038568	3000116	SCOP2B (2022-06-29)
S [auth q]	SCOP2B Superfamily	Metallo-dependent phosphatases	8039778	3001067	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleic acid-binding proteins	8065300	3000135	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SOSSC C-terminal motif-like	8052447	3002118	SCOP2B (2022-06-29)
G [auth c]	SCOP2B Superfamily	ARM repeat-like	8052459	3000116	SCOP2B (2022-06-29)
G [auth c]	SCOP2B Superfamily	ARM repeat-like	8052456	3000116	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF21473	Single-stranded DNA binding protein Ssb-like, OB fold (Ssb-like_OB)	Single-stranded DNA binding protein Ssb-like, OB fold	This entry represents the OB fold of single-stranded DNA binding protein Ssb from archaea and its homologues from mammals and plants. Members of this entry have a simple domain organisation consisting of a single DNA-binding OB fold coupled to a flex ...	This entry represents the OB fold of single-stranded DNA binding protein Ssb from archaea and its homologues from mammals and plants. Members of this entry have a simple domain organisation consisting of a single DNA-binding OB fold coupled to a flexible C-terminal tail [1-3]. The ssDNA recognition is modulated by base-stacking of three key aromatic residues in archaeal Ssb, in contrast with the OB domain of the human homologue hSSB1 [3].	Domain
B	PF14750	Integrator complex subunit 2 (INTS2)	Integrator complex subunit 2	-	Family
C	PF10189	Integrator complex subunit 3 N-terminal (Ints3_N)	Integrator complex subunit 3 N-terminal	-	Repeat
D [auth Y]	PF05001	RNA polymerase Rpb1 C-terminal repeat (RNA_pol_Rpb1_R)	RNA polymerase Rpb1 C-terminal repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 1]	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK	-	-	-
J [auth f]	Integrator complex subunit 6	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytoskeleton membraneless organelle intracellular membraneless organelle actin cytoskeleton
K [auth g]	Integrator complex subunit 7	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA 3'-end processing macromolecule metabolic process RNA processing cellular response to stimulus response to ionizing radiation response to stimulus cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication cellular response to stress response to stress negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling DNA damage response signal transduction in response to DNA damage	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome membrane-bounded organelle protein-containing complex integrator complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome membrane-bounded organelle protein-containing complex integrator complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
L [auth h]	Integrator complex subunit 8	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
M [auth i]	Integrator complex subunit 9	-	cellular response to stimulus negative regulation of transforming growth factor beta receptor signaling pathway regulation of cellular process cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus response to stimulus negative regulation of signaling signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to stimulus negative regulation of transforming growth factor beta receptor signaling pathway regulation of cellular process cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus response to stimulus negative regulation of signaling signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling regulation of biological process cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus biological regulation negative regulation of signal transduction response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication cellular process response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA 3'-end processing macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
N [auth j]	Integrator complex subunit 10	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
O [auth k]	Integrator complex subunit 11	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure extracellular region extracellular space blood microparticle intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex cellular anatomical structure extracellular region extracellular space blood microparticle intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
P [auth n]	Integrator complex subunit 14	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
Q [auth o]	Integrator complex subunit 15	-	-	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle
R [auth p]	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	protein antigen binding protein binding binding antigen binding phosphoric ester hydrolase activity enzyme regulator activity catalytic activity, acting on a protein phosphatase regulator activity phosphatase activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity protein antigen binding protein binding binding antigen binding phosphoric ester hydrolase activity enzyme regulator activity catalytic activity, acting on a protein phosphatase regulator activity phosphatase activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity catalytic activity protein serine/threonine phosphatase activity protein heterodimerization activity protein dimerization activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis meiotic spindle elongation meiotic chromosome segregation sexual reproduction spindle elongation reproductive process microtubule cytoskeleton organization meiotic cell cycle process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis meiotic spindle elongation meiotic chromosome segregation sexual reproduction spindle elongation reproductive process microtubule cytoskeleton organization meiotic cell cycle process meiotic nuclear division cell cycle chromosome segregation spindle organization cell cycle process meiotic cell cycle organelle fission meiotic spindle organization organelle organization nuclear division nuclear chromosome segregation microtubule-based process cytoskeleton organization mitotic nuclear division chromosome organization sister chromatid segregation mitotic cell cycle mitotic cell cycle process chromosome separation mitotic sister chromatid segregation mitotic sister chromatid separation sister chromatid cohesion meiotic sister chromatid cohesion, centromeric centromeric sister chromatid cohesion meiotic sister chromatid cohesion cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signal transduction in absence of ligand signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus extrinsic apoptotic signaling pathway in absence of ligand signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of programmed cell death cell surface receptor signaling pathway regulation of apoptotic process biological regulation positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling regulation of growth growth multicellular organismal process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis multicellular organismal reproductive process female gamete generation gamete generation female meiotic nuclear division hippo signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction negative regulation of cellular process negative regulation of response to stimulus negative regulation of hippo signaling negative regulation of signal transduction regulation of hippo signaling regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction meiotic cell cycle process involved in oocyte maturation cellular developmental process regulation of reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction oocyte development cell differentiation anatomical structure development cell maturation regulation of cell cycle developmental process regulation of cell cycle process oogenesis regulation of meiotic cell cycle process involved in oocyte maturation developmental maturation anatomical structure maturation germ cell development oocyte maturation oocyte differentiation regulation of developmental process regulation of cell differentiation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol membraneless organelle chromosome, centromeric region intracellular membraneless organelle chromosome chromosomal region somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection synapse cell junction glutamatergic synapse cytoskeleton microtubule cytoskeleton cell body neuronal cell body cell periphery plasma membrane lateral plasma membrane FAR/SIN/STRIPAK complex nucleus
S [auth q]	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXS140 phosphatase activity myosin phosphatase activity cytoskeletal protein binding protein binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXS140 phosphatase activity myosin phosphatase activity cytoskeletal protein binding protein binding binding tau protein binding RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity RNA polymerase II CTD heptapeptide repeat modifying activity RNA polymerase II CTD heptapeptide repeat phosphatase activity RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity cation binding ion binding metal ion binding small molecule binding calmodulin-dependent protein phosphatase activity calcium-dependent protein serine/threonine phosphatase activity RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity protein heterodimerization activity protein dimerization activity signaling receptor binding GABA receptor binding protein tyrosine phosphatase activity RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity MAP kinase serine/threonine phosphatase activity MAP kinase phosphatase activity	developmental process anatomical structure development tissue development mesoderm development protein dephosphorylation dephosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process developmental process anatomical structure development tissue development mesoderm development protein dephosphorylation dephosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process regulation of growth regulation of biological process biological regulation growth cellular response to stimulus hippo signaling regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction negative regulation of cellular process signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of hippo signaling negative regulation of signal transduction regulation of response to stimulus regulation of cell communication regulation of hippo signaling regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of epithelial to mesenchymal transition multicellular organismal process regulation of developmental process cellular developmental process regulation of cell differentiation mesenchyme development cell differentiation negative regulation of cell differentiation regulation of multicellular organismal process negative regulation of developmental process animal organ development negative regulation of epithelial to mesenchymal transition epithelial to mesenchymal transition mesenchymal cell differentiation negative regulation of multicellular organismal process peptidyl-serine dephosphorylation regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process positive regulation of macromolecule metabolic process positive regulation of protein kinase activity positive regulation of protein phosphorylation positive regulation of cellular process protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorylation regulation of phosphorus metabolic process regulation of metabolic process regulation of protein binding positive regulation of protein binding regulation of binding positive regulation of microtubule binding regulation of microtubule binding positive regulation of binding cell cycle mitotic cell cycle multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly response to biotic stimulus cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus positive regulation of intracellular signal transduction positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway defense response to other organism regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly positive regulation of defense response activation of innate immune response regulation of immune response inflammatory response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular component organization positive regulation of cellular component organization regulation of response to external stimulus intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to stimulus cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response protein-containing complex assembly response to external biotic stimulus cellular component organization or biogenesis positive regulation of innate immune response defense response protein-containing complex organization positive regulation of cellular component biogenesis defense response to symbiont regulation of cellular component biogenesis positive regulation of signaling response to metal ion response to chemical response to lead ion ribonucleotide catabolic process pyridine nucleotide catabolic process negative regulation of small molecule metabolic process negative regulation of glycolytic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process negative regulation of ATP metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process pyridine-containing compound metabolic process small molecule metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process negative regulation of metabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process regulation of glycolytic process through fructose-6-phosphate ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process negative regulation of phosphorus metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process negative regulation of glycolytic process through fructose-6-phosphate glycolytic process through fructose-6-phosphate regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle regulation of G1/S transition of mitotic cell cycle mitotic cell cycle process regulation of cell cycle G1/S transition of mitotic cell cycle cell cycle process mitotic cell cycle phase transition sexual reproduction reproductive process meiotic cell cycle peptidyl-threonine dephosphorylation	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane extracellular exosome membrane-bounded organelle extracellular vesicle intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein serine/threonine phosphatase complex cytoplasm cytosol FAR/SIN/STRIPAK complex mitochondrion intracellular membrane-bounded organelle protein phosphatase type 2A complex cell periphery plasma membrane chromosome, centromeric region chromosome chromosomal region membrane microdomain membrane raft synapse cell junction nucleus
B	SOSS complex subunit B1	DNA binding binding nucleic acid binding sequence-specific DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding telomeric DNA binding protein binding DNA polymerase binding enzyme binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process establishment of protein localization to telomere protein localization establishment of protein localization cellular localization protein localization to chromosome, telomeric region establishment of localization localization establishment of protein localization to organelle cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process establishment of protein localization to telomere protein localization establishment of protein localization cellular localization protein localization to chromosome, telomeric region establishment of localization localization establishment of protein localization to organelle protein localization to chromosome cellular macromolecule localization macromolecule localization protein localization to organelle establishment of protein localization to chromosome response to ionizing radiation response to radiation response to abiotic stimulus double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process recombinational repair metabolic process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair regulation of cellular process regulation of cell cycle phase transition signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint cell communication regulation of mitotic cell cycle negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition positive regulation of organelle organization regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process telomere organization regulation of primary metabolic process cellular component organization positive regulation of metabolic process positive regulation of macromolecule metabolic process cellular component organization or biogenesis regulation of nucleobase-containing compound metabolic process positive regulation of telomere capping positive regulation of cellular process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process chromosome organization regulation of chromosome organization regulation of macromolecule metabolic process regulation of organelle organization positive regulation of chromosome organization telomere maintenance organelle organization positive regulation of DNA metabolic process telomere capping regulation of telomere capping regulation of metabolic process regulation of DNA metabolic process	membrane-bounded organelle intracellular organelle protein-containing complex SOSS complex cellular anatomical structure intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm cytosol site of double-strand break membraneless organelle membrane-bounded organelle intracellular organelle protein-containing complex SOSS complex cellular anatomical structure intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm cytosol site of double-strand break membraneless organelle site of DNA damage intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
T [auth r]	DSS1	-	-	-
U [auth m]	Integrator complex subunit 13	-	regulation of biological process sexual reproduction regulation of reproductive process reproductive process fertilization biological regulation regulation of fertilization regulation of mitotic cell cycle regulation of cellular process cellular process cell cycle regulation of cell cycle mitotic cell cycle localization regulation of biological process sexual reproduction regulation of reproductive process reproductive process fertilization biological regulation regulation of fertilization regulation of mitotic cell cycle regulation of cellular process cellular process cell cycle regulation of cell cycle mitotic cell cycle localization centrosome localization microtubule organizing center localization cell division microtubule cytoskeleton organization mitotic spindle organization cellular component organization organelle organization mitotic cell cycle process microtubule-based process cellular component organization or biogenesis cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process macromolecule metabolic process RNA processing protein localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to nucleus protein localization to nuclear envelope transcription elongation by RNA polymerase II regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process sperm motility cilium movement involved in cell motility cilium or flagellum-dependent cell motility cilium-dependent cell motility flagellated sperm motility microtubule-based movement cilium movement cell motility	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm membrane-enclosed lumen intracellular organelle lumen nuclear body membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
C	SOSS complex subunit C	-	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to ionizing radiation response to radiation response to abiotic stimulus regulation of cellular process regulation of cell cycle phase transition signaling G2/M transition of mitotic cell cycle negative regulation of biological process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to ionizing radiation response to radiation response to abiotic stimulus regulation of cellular process regulation of cell cycle phase transition signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint cell communication regulation of mitotic cell cycle negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process recombinational repair metabolic process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair	intracellular organelle site of double-strand break cellular anatomical structure intracellular anatomical structure organelle membraneless organelle site of DNA damage intracellular membraneless organelle chromosome membrane-bounded organelle protein-containing complex SOSS complex nucleus nuclear protein-containing complex intracellular organelle site of double-strand break cellular anatomical structure intracellular anatomical structure organelle membraneless organelle site of DNA damage intracellular membraneless organelle chromosome membrane-bounded organelle protein-containing complex SOSS complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
D [auth Y]	DNA-directed RNA polymerase subunit	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding core promoter sequence-specific DNA binding nucleic acid binding transcription regulatory region nucleic acid binding cation binding ion binding metal ion binding small molecule binding	-	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen euchromatin membraneless organelle intracellular membraneless organelle chromatin chromosome
E [auth a]	Integrator complex subunit 1	-	regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death RNA metabolic process regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process U2 snRNA 3'-end processing snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA 3'-end processing macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process developmental process multicellular organismal process inner cell mass cell proliferation cell population proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development multicellular organism development embryo development ending in birth or egg hatching anatomical structure development blastocyst growth blastocyst development multi-multicellular organism process reproductive process female pregnancy embryo implantation multi-organism reproductive process	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane protein-containing complex cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane protein-containing complex integrator complex nuclear protein-containing complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
F [auth b]	Integrator complex subunit 2	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane cytoplasm nuclear membrane endomembrane system membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane cytoplasm nuclear membrane endomembrane system organelle envelope nuclear envelope organelle membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
G [auth c]	Integrator complex subunit 3	-	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to ionizing radiation response to radiation response to abiotic stimulus double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to ionizing radiation response to radiation response to abiotic stimulus double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process recombinational repair metabolic process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair RNA metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing RNA processing regulation of cellular process regulation of cell cycle phase transition signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint cell communication regulation of mitotic cell cycle negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition transcription elongation by RNA polymerase II regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle intracellular organelle protein-containing complex SOSS complex cellular anatomical structure intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle integrator complex cytoplasm site of double-strand break membraneless organelle membrane-bounded organelle intracellular organelle protein-containing complex SOSS complex cellular anatomical structure intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle integrator complex cytoplasm site of double-strand break membraneless organelle site of DNA damage intracellular membraneless organelle chromosome membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
H [auth d]	Integrator complex subunit 4	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex integrator complex nuclear protein-containing complex nucleoplasm
I [auth e]	Integrator complex subunit 5	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA 3'-end processing macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cytosol protein-containing complex integrator complex nuclear protein-containing complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
J [auth f]	IPR002035	von Willebrand factor, type A	Domain
J [auth f]	IPR029307	INTS6/SAGE1/DDX26B/CT45, C-terminal	Domain
J [auth f]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
J [auth f]	IPR051113	Integrator complex subunit 6	Family
K [auth g]	IPR016024	Armadillo-type fold	Homologous Superfamily
K [auth g]	IPR033060	Integrator complex subunit 7	Family
K [auth g]	IPR054519	Integrator complex subunit 7, C-terminal domain	Domain
L [auth h]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
L [auth h]	IPR038751	Integrator complex subunit 8	Family
M [auth i]	IPR027074	Integrator complex subunit 9	Family
M [auth i]	IPR001279	Metallo-beta-lactamase	Domain
M [auth i]	IPR022712	Beta-Casp domain	Domain
M [auth i]	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
M [auth i]	IPR048660	Integrator complex subunit 9-like, C-terminal domain	Domain
N [auth j]	IPR026164	Integrator complex subunit 10	Family
O [auth k]	IPR001279	Metallo-beta-lactamase	Domain
O [auth k]	IPR050698	RNA Processing Metallo-Beta-Lactamase Domain-Containing Protein	Family
O [auth k]	IPR022712	Beta-Casp domain	Domain
O [auth k]	IPR041897	Integrator complex subunit 11, MBL-fold	Domain
O [auth k]	IPR048662	Integrator complex subunit 11, C-terminal domain	Domain
O [auth k]	IPR011108	Zn-dependent metallo-hydrolase, RNA specificity domain	Domain
O [auth k]	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
P [auth n]	IPR039841	Integrator complex subunit 14	Family
P [auth n]	IPR046471	Integrator complex subunit 14, C-terminal	Domain
P [auth n]	IPR045814	Integrator complex subunit 14, beta-barrel domain	Domain
P [auth n]	IPR002035	von Willebrand factor, type A	Domain
P [auth n]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
Q [auth o]	IPR027844	Integrator complex subunit 15	Family
R [auth p]	IPR054573	Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like, HEAT repeat	Domain
R [auth p]	IPR016024	Armadillo-type fold	Homologous Superfamily
R [auth p]	IPR021133	HEAT, type 2	Repeat
R [auth p]	IPR011989	Armadillo-like helical	Homologous Superfamily
R [auth p]	IPR051023	Protein Phosphatase 2A Regulatory Subunit A	Family
R [auth p]	IPR000357	HEAT repeat	Repeat
S [auth q]	IPR047129	Serine/Threonine protein phosphatase PP2A-like	Family
S [auth q]	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
S [auth q]	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
S [auth q]	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	Domain
B	IPR051231	SOSS complex subunit B	Family
B	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
B	IPR048970	Single-stranded DNA binding protein Ssb-like, OB fold	Domain
U [auth m]	IPR019355	Cell cycle regulator Mat89Bb	Family
C	IPR031821	SOSS complex subunit C	Family
D [auth Y]	IPR007081	RNA polymerase Rpb1, domain 5	Domain
D [auth Y]	IPR045867	DNA-directed RNA polymerase, subunit beta-prime	Family
D [auth Y]	IPR007075	RNA polymerase Rpb1, domain 6	Domain
D [auth Y]	IPR000684	RNA polymerase II, heptapeptide repeat, eukaryotic	Repeat
D [auth Y]	IPR007083	RNA polymerase Rpb1, domain 4	Domain
D [auth Y]	IPR044893	RNA polymerase Rpb1, clamp domain superfamily	Homologous Superfamily
D [auth Y]	IPR006592	RNA polymerase, N-terminal	Domain
D [auth Y]	IPR007066	RNA polymerase Rpb1, domain 3	Domain
D [auth Y]	IPR007073	RNA polymerase Rpb1, domain 7	Domain
D [auth Y]	IPR042102	RNA polymerase Rpb1, domain 3 superfamily	Homologous Superfamily
D [auth Y]	IPR038593	RNA polymerase Rpb1, domain 7 superfamily	Homologous Superfamily
D [auth Y]	IPR000722	RNA polymerase, alpha subunit	Domain
D [auth Y]	IPR038120	RNA polymerase Rpb1, funnel domain superfamily	Homologous Superfamily
D [auth Y]	IPR007080	RNA polymerase Rpb1, domain 1	Domain
E [auth a]	IPR016024	Armadillo-type fold	Homologous Superfamily
E [auth a]	IPR053964	Integrator complex subunit 1, R3 domain	Domain
E [auth a]	IPR053966	Integrator complex subunit 1, INTS2-binding domain	Domain
E [auth a]	IPR022145	Integrator complex subunit 1, RPB2-binding domain	Domain
E [auth a]	IPR053965	Integrator complex subunit 1, R4 domain	Domain
E [auth a]	IPR038902	Integrator complex subunit 1	Family
F [auth b]	IPR026236	Integrator complex subunit 2, metazoa	Family
F [auth b]	IPR029321	Integrator complex subunit 2	Family
G [auth c]	IPR045334	Integrator complex subunit 3	Family
G [auth c]	IPR019333	Integrator complex subunit 3, N-terminal	Domain
H [auth d]	IPR011989	Armadillo-like helical	Homologous Superfamily
H [auth d]	IPR016024	Armadillo-type fold	Homologous Superfamily
I [auth e]	IPR040316	Integrator complex subunit 5	Family
I [auth e]	IPR029445	Integrator complex subunit 5, N-terminal	Domain
I [auth e]	IPR029444	Integrator complex subunit 5, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
J [auth f]	Pharos: Q9UL03	lung cancer ovarian cancer tuberculosis malignant mesothelioma Pick disease osteosarcoma sarcoidosis
K [auth g]	Pharos: Q9NVH2	acute myeloid leukemia ductal breast carcinoma in situ hepatocellular carcinoma lung cancer osteosarcoma atypical teratoid rhabdoid tumor gastric cancer invasive ductal breast carcinoma medulloblastoma pituitary cancer breast cancer gastric carcinoma large cell medulloblastoma nasopharyngeal carcinoma psoriasis
L [auth h]	Pharos: Q75QN2	intellectual disability lymphoplasmacytic lymphoma medulloblastoma type 2 diabetes mellitus invasive ductal breast carcinoma malignant mesothelioma non-alcoholic fatty liver disease lung cancer maturity-onset diabetes of the young ovarian cancer
M [auth i]	Pharos: Q9NV88	astrocytic tumor medulloblastoma osteosarcoma
N [auth j]	Pharos: Q9NVR2	heart disease non-alcoholic fatty liver disease metabolic syndrome X ovarian cancer myocardial infarction peripheral arterial disease
O [auth k]	Pharos: Q5TA45	astrocytic tumor ulcerative colitis inflammatory bowel disease oligodendroglioma
P [auth n]	Pharos: Q96SY0	atypical teratoid rhabdoid tumor medulloblastoma glioblastoma large cell medulloblastoma
Q [auth o]	Pharos: Q96N11	asthma inflammatory bowel disease
R [auth p]	Pharos: P30153	microcephaly-corpus callosum hypoplasia-intellectual disability-facial dysmorphism syndrome intellectual disability Disease Exacerbation gastric neoplasm osteoarthritis hereditary diffuse gastric adenocarcinoma osteoarthritis susceptibility 1 rheumatoid arthritis gastric cancer
S [auth q]	Pharos: P67775	asthma heart disease systemic lupus erythematosus adenoma astrocytic tumor coronary artery disease hereditary spastic paraplegia lymphoplasmacytic lymphoma osteosarcoma psoriasis tuberculosis allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma asthma heart disease systemic lupus erythematosus adenoma astrocytic tumor coronary artery disease hereditary spastic paraplegia lymphoplasmacytic lymphoma osteosarcoma psoriasis tuberculosis allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant glioma ovarian cancer subependymal giant cell astrocytoma breast cancer lung adenocarcinoma myocardial ischemia plasma cell myeloma
B	Pharos: Q9BQ15	atypical teratoid rhabdoid tumor psoriasis glioblastoma skin disease large cell medulloblastoma
U [auth m]	Pharos: Q9NVM9	Chloracne glioblastoma lung cancer nasopharyngeal carcinoma ovarian cancer colorectal cancer Hodgkins lymphoma malignant colon neoplasm non-small cell lung carcinoma plasma cell myeloma dermatomyositis large cell medulloblastoma medulloblastoma osteosarcoma psoriasis
C	Pharos: Q9NRY2	astrocytic tumor osteosarcoma atypical teratoid rhabdoid tumor tuberculosis large cell medulloblastoma
E [auth a]	Pharos: Q8N201	intellectual disability malignant mesothelioma psoriasis
F [auth b]	Pharos: Q9H0H0	medulloblastoma ovarian carcinoma osteosarcoma ovarian cancer
H [auth d]	Pharos: Q96HW7	prostate cancer large cell medulloblastoma medulloblastoma Prostatic Neoplasms osteosarcoma Sjogren syndrome
I [auth e]	Pharos: Q6P9B9	psoriasis