Annotations: 8RBX

SCOP2B Superfamily

HRDC-like

8101241

3000132

SCOP2B (2022-06-29)

SCOP2B Superfamily

RNA polymerase subunit RPB10

8101287

3001213

SCOP2B (2022-06-29)

SCOP2B Superfamily

RBP11-like subunits of RNA polymerase

8080728

3001655

SCOP2B (2022-06-29)

N [auth M]

SCOP2B Superfamily

Core histone-like

8070533

SCOP2B (2022-06-29)

T [auth S]

SCOP2B Superfamily

Core histone-like

8070533

SCOP2B (2022-06-29)

P [auth O]

SCOP2B Superfamily

Core histone-like

8070545

SCOP2B (2022-06-29)

V [auth U]

SCOP2B Superfamily

Core histone-like

8070545

SCOP2B (2022-06-29)

R [auth Q]

SCOP2B Superfamily

Core histone-like

8067130

SCOP2B (2022-06-29)

W [auth V]

SCOP2B Superfamily

Core histone-like

8067130

SCOP2B (2022-06-29)

SCOP2B Superfamily

ARM repeat-like

8038568

3000116

SCOP2B (2022-06-29)

SCOP2B Superfamily

Metallo-dependent phosphatases

8039778

3001067

SCOP2B (2022-06-29)

SCOP2B Superfamily

MgtE/FliG domain-like

8102749

3000127

SCOP2B (2022-06-29)

SA [auth w]

SCOP2B Superfamily

ARM repeat-like

8102747

3000116

SCOP2B (2022-06-29)

SCOP2B Superfamily

Translation proteins SH3-like KOW motif containing domain

8039849

3000334

SCOP2B (2022-06-29)

SCOP2B Superfamily

RPB6/omega subunit-like

8106082

3000189

SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A], Y	PF00623	RNA polymerase Rpb1, domain 2 (RNA_pol_Rpb1_2)	RNA polymerase Rpb1, domain 2	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 2, contains the active site ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 2, contains the active site. The invariant motif -NADFDGD- binds the active site magnesium ion [1,2].	Domain
B [auth A], Y	PF12432	Integrator complex subunit 1, RP2B-binding domain (INTS1_RP2B-bd)	Integrator complex subunit 1, RP2B-binding domain	-	Repeat
B [auth A], Y	PF04990	RNA polymerase Rpb1, domain 7 (RNA_pol_Rpb1_7)	RNA polymerase Rpb1, domain 7	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 7, represents a mobile modu ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 7, represents a mobile module of the RNA polymerase. Domain 7 forms a substantial interaction with the lobe domain of Rpb2 (Pfam:PF04561) [1,2].	Domain
B [auth A], Y	PF05001	RNA polymerase Rpb1 C-terminal repeat (RNA_pol_Rpb1_R)	RNA polymerase Rpb1 C-terminal repeat	-	Repeat
B [auth A], Y	PF22927	Integrator complex subunit 1, R3 domain (INT1_R3)	Integrator complex subunit 1, R3 domain	-	Repeat
B [auth A], Y	PF22929	Integrator complex subunit 1, INTS2-binding domain (INTS1_INTS2-bd)	Integrator complex subunit 1, INTS2-binding domain	-	Repeat
B [auth A], Y	PF05000	RNA polymerase Rpb1, domain 4 (RNA_pol_Rpb1_4)	RNA polymerase Rpb1, domain 4	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 4, represents the funnel do ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 4, represents the funnel domain. The funnel contain the binding site for some elongation factors [1,2].	Domain
B [auth A], Y	PF04983	RNA polymerase Rpb1, domain 3 (RNA_pol_Rpb1_3)	RNA polymerase Rpb1, domain 3	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 3, represents the pore doma ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 3, represents the pore domain. The 3' end of RNA is positioned close to this domain. The pore delimited by this domain is thought to act as a channel through which nucleotides enter the active site and/or where the 3' end of the RNA may be extruded during back-tracking [1,2].	Domain
B [auth A], Y	PF04992	RNA polymerase Rpb1, domain 6 (RNA_pol_Rpb1_6)	RNA polymerase Rpb1, domain 6	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 6, represents a mobile modu ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 6, represents a mobile module of the RNA polymerase. Domain 6 forms part of the shelf module [1,2]. This family appears to be specific to the largest subunit of RNA polymerase II.	Domain
B [auth A], Y	PF04998	RNA polymerase Rpb1, domain 5 (RNA_pol_Rpb1_5)	RNA polymerase Rpb1, domain 5	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 5, represents the discontin ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 5, represents the discontinuous cleft domain that is required to from the central cleft or channel where the DNA is bound [1,2].	Domain
B [auth A], Y	PF04997	RNA polymerase Rpb1, domain 1 (RNA_pol_Rpb1_1)	RNA polymerase Rpb1, domain 1	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 1, represents the clamp dom ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 1, represents the clamp domain, which a mobile domain involved in positioning the DNA, maintenance of the transcription bubble and positioning of the nascent RNA strand [1,2].	Domain
D [auth C]	PF01193	RNA polymerase Rpb3/Rpb11 dimerisation domain (RNA_pol_L)	RNA polymerase Rpb3/Rpb11 dimerisation domain	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation do ...	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000). Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp.	Domain
D [auth C]	PF01000	RNA polymerase Rpb3/RpoA insert domain (RNA_pol_A_bac)	RNA polymerase Rpb3/RpoA insert domain	Members of this family include: alpha subunit from eubacteria alpha subunits from chloroplasts Rpb3 subunits from eukaryotes RpoD subunits from archaeal	Domain
E [auth D]	PF03874	RNA polymerase Rpb4 (RNA_pol_Rpb4)	RNA polymerase Rpb4	-	Family
H [auth G]	PF03876	SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 (SHS2_Rpb7-N)	SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397	Rpb7 bind to Rpb4 to form a heterodimer. This complex is thought to interact with the nascent RNA strand during RNA polymerase II elongation[1]. This family includes the homologs from RNA polymerase I and III. In RNA polymerase I, Rpa43 is at leas ...	Rpb7 bind to Rpb4 to form a heterodimer. This complex is thought to interact with the nascent RNA strand during RNA polymerase II elongation[1]. This family includes the homologs from RNA polymerase I and III. In RNA polymerase I, Rpa43 is at least one of the subunits contacted by the transcription factor TIF-IA [2]. The N terminus of Rpb7p/Rpc25p/MJ0397 has a SHS2 domain that is involved in protein-protein interaction [3].	Domain
H [auth G]	PF00575	S1 RNA binding domain (S1)	S1 RNA binding domain	The S1 domain occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure.	Domain
I [auth H]	PF03870	RNA polymerase Rpb8 (RNA_pol_Rpb8)	RNA polymerase Rpb8	-	Family
J [auth I]	PF02150	RNA polymerases M/15 Kd subunit (Zn_ribbon_RPB9)	RNA polymerases M/15 Kd subunit		Domain
J [auth I]	PF01096	Transcription factor S-II (TFIIS) (Zn_ribbon_TFIIS)	Transcription factor S-II (TFIIS)		Domain
J [auth I]	PF16661	Metallo-beta-lactamase superfamily domain (Lactamase_B_6)	Metallo-beta-lactamase superfamily domain	This family is part of the metallo-beta-lactamase superfamily.	Domain
K [auth J]	PF21045	Integrator subunit 10 (INT10)	Integrator subunit 10	-	Repeat
K [auth J]	PF01194	RNA polymerases N / 8 kDa subunit (RNA_pol_N)	RNA polymerases N / 8 kDa subunit		Domain
L [auth K]	PF16661	Metallo-beta-lactamase superfamily domain (Lactamase_B_6)	Metallo-beta-lactamase superfamily domain	This family is part of the metallo-beta-lactamase superfamily.	Domain
L [auth K]	PF13656	RNA polymerase Rpb3/Rpb11 dimerisation domain (RNA_pol_L_2)	RNA polymerase Rpb3/Rpb11 dimerisation domain	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation do ...	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000). Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Many of the members of this family carry only the N-terminal region of Rpb11.	Domain
M [auth L]	PF03604	DNA directed RNA polymerase, 7 kDa subunit (Zn_ribbon_RPAB4)	DNA directed RNA polymerase, 7 kDa subunit		Domain
N [auth M], T [auth S]	PF10221	Cell cycle and development regulator Mat89Bb (Mat89Bb)	Cell cycle and development regulator Mat89Bb	-	Family
O [auth N]	PF13519	von Willebrand factor type A domain (VWA_2)	von Willebrand factor type A domain		Domain
P [auth O], V [auth U]	PF15511	Centromere kinetochore component CENP-T histone fold (CENP-T_C)	Centromere kinetochore component CENP-T histone fold	CENP-T is a family of vertebral kinetochore proteins that associates directly with CENP-W. The N-terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore. Importantly, the CENP-T-W complex does not directly asso ...	CENP-T is a family of vertebral kinetochore proteins that associates directly with CENP-W. The N-terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes. This domain is the C-terminal histone fold domain of CENP-T, which associates with chromatin [2-3].	Domain
P [auth O], V [auth U]	PF14964	Integrator complex subunit 15 (INTS15)	Integrator complex subunit 15	-	Family
R [auth Q], W [auth V]	PF00149	Calcineurin-like phosphoesterase (Metallophos)	Calcineurin-like phosphoesterase	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or ...	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	Domain
R [auth Q], W [auth V]	PF16211	C-terminus of histone H2A (Histone_H2A_C)	C-terminus of histone H2A	-	Family
R [auth Q], W [auth V]	PF06209	Cofactor of BRCA1 (COBRA1) (COBRA1)	Cofactor of BRCA1 (COBRA1)	-	Family
Z	PF00467	KOW motif (KOW)	KOW motif	-	Family
C [auth B]	PF04561	RNA polymerase Rpb2, domain 2 (RNA_pol_Rpb2_2)	RNA polymerase Rpb2, domain 2	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA po ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain [1]. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble [1]. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).	Domain
C [auth B]	PF04560	RNA polymerase Rpb2, domain 7 (RNA_pol_Rpb2_7)	RNA polymerase Rpb2, domain 7	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA p ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp [1]. The clamp region (C-terminal) contains a zinc-binding motif [1]. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription [1].	Domain
C [auth B]	PF04565	RNA polymerase Rpb2, domain 3 (RNA_pol_Rpb2_3)	RNA polymerase Rpb2, domain 3	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site [1].	Domain
C [auth B]	PF04566	RNA polymerase Rpb2, domain 4 (RNA_pol_Rpb2_4)	RNA polymerase Rpb2, domain 4	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 4, is also known as the external 2 domain ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 4, is also known as the external 2 domain [1].	Domain
C [auth B]	PF14750	Integrator complex subunit 2 (INTS2)	Integrator complex subunit 2	-	Family
C [auth B]	PF04563	RNA polymerase beta subunit (RNA_pol_Rpb2_1)	RNA polymerase beta subunit	-	Family
C [auth B]	PF00562	RNA polymerase Rpb2, domain 6 (RNA_pol_Rpb2_6)	RNA polymerase Rpb2, domain 6	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain [1]. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion[1]. This domain is also involved in binding to Rpb1 and Rpb3 [1]. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).	Domain
C [auth B]	PF04567	RNA polymerase Rpb2, domain 5 (RNA_pol_Rpb2_5)	RNA polymerase Rpb2, domain 5	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 5, is also known as the external 2 domain ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 5, is also known as the external 2 domain [1].	Domain
F [auth E]	PF14837	Integrator complex subunit 5 N-terminus (INTS5_N)	Integrator complex subunit 5 N-terminus	-	Family
F [auth E]	PF01191	RNA polymerase Rpb5, C-terminal domain (RNA_pol_Rpb5_C)	RNA polymerase Rpb5, C-terminal domain	The assembly domain of Rpb5 [1]. The archaeal equivalent to this domain is subunit H. Subunit H lacks the N-terminal domain.	Domain
F [auth E]	PF03871	RNA polymerase Rpb5, N-terminal domain (RNA_pol_Rpb5_N)	RNA polymerase Rpb5, N-terminal domain	Rpb5 has a bipartite structure which includes a eukaryote-specific N-terminal domain and a C-terminal domain resembling the archaeal RNAP subunit H [1,2]. The N-terminal domain is involved in DNA binding and is part of the jaw module in the RNA p ...	Rpb5 has a bipartite structure which includes a eukaryote-specific N-terminal domain and a C-terminal domain resembling the archaeal RNAP subunit H [1,2]. The N-terminal domain is involved in DNA binding and is part of the jaw module in the RNA pol II structure [3]. This module is important for positioning the downstream DNA.	Domain
G [auth F]	PF01192	RNA polymerase Rpb6 (RNA_pol_Rpb6)	RNA polymerase Rpb6	-	Family
G [auth F]	PF13519	von Willebrand factor type A domain (VWA_2)	von Willebrand factor type A domain		Domain

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 1]	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK	-	-	-
B [auth A], Y	DNA-directed RNA polymerase subunit	DNA binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding ion binding DNA binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding ion binding metal ion binding small molecule binding	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
D [auth C]	DNA-directed RNA polymerase II subunit RPB3	DNA binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups protein binding protein dimerization activity	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen cytoplasm cytosol
E [auth D]	RNA polymerase II subunit D	protein binding binding translation initiation factor binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process transcription initiation at RNA polymerase II promoter	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen RNA polymerase II, holoenzyme protein-containing complex nuclear protein-containing complex transferase complex RNA polymerase II, core complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex
H [auth G]	DNA-directed RNA polymerase II subunit RPB7	binding nucleic acid binding	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
I [auth H]	DNA-directed RNA polymerases I, II, and III subunit RPABC3	DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
J [auth I]	DNA-directed RNA polymerase II subunit RPB9	binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding transition metal ion binding zinc ion binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process transcription initiation at RNA polymerase II promoter transcription elongation by RNA polymerase II maintenance of transcriptional fidelity during transcription elongation DNA-templated transcription elongation maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II cellular response to stimulus response to stimulus transcription-coupled nucleotide-excision repair DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen RNA polymerase II, holoenzyme protein-containing complex nuclear protein-containing complex transferase complex nucleoplasm RNA polymerase II, core complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex
K [auth J]	DNA-directed RNA polymerases I, II, and III subunit RPABC5	DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process	transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
L [auth K]	DNA-directed RNA polymerase II subunit RPB11-a	DNA binding binding nucleic acid binding protein binding protein dimerization activity	-	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
M [auth L]	RNA polymerase II subunit K	DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle
N [auth M], T [auth S]	Histone H3.3C	DNA binding protein-containing complex binding binding chromatin binding nucleic acid binding nucleosome binding nucleosomal DNA binding chromatin DNA binding protein heterodimerization activity protein binding protein dimerization activity structural molecule activity structural constituent of chromatin	regulation of growth regulation of biological process regulation of cellular process regulation of cellular component organization biological regulation growth positive regulation of biological process positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular process cellular component organization or biogenesis regulation of growth regulation of biological process regulation of cellular process regulation of cellular component organization biological regulation growth positive regulation of biological process positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular process cellular component organization or biogenesis positive regulation of cellular process	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle euchromatin membraneless organelle intracellular membraneless organelle chromatin chromosome protein-containing complex protein-DNA complex nucleosome membrane-bounded organelle nucleus intracellular organelle cellular anatomical structure intracellular anatomical structure organelle euchromatin membraneless organelle intracellular membraneless organelle chromatin chromosome protein-containing complex protein-DNA complex nucleosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
O [auth N]	non-template DNA	-	-	-
P [auth O], V [auth U]	Histone H4	DNA binding binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity RNA binding structural molecule activity structural constituent of chromatin	protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization organelle organization protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization organelle organization telomere organization chromosome organization protein localization protein localization to chromatin cellular localization protein localization to chromosome, centromeric region localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to CENP-A containing chromatin multicellular organismal process regulation of cellular process regulation of developmental process cellular developmental process regulation of megakaryocyte differentiation negative regulation of biological process cell development megakaryocyte differentiation regulation of cell differentiation regulation of cell development multicellular organism development negative regulation of megakaryocyte differentiation cell differentiation negative regulation of cellular process anatomical structure development negative regulation of cell differentiation regulation of immune system process regulation of multicellular organismal process developmental process regulation of biological process regulation of multicellular organismal development negative regulation of developmental process hemopoiesis regulation of myeloid cell differentiation biological regulation negative regulation of myeloid cell differentiation myeloid cell differentiation immune system process regulation of hemopoiesis	cellular anatomical structure membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure CENP-A containing chromatin cellular anatomical structure membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure CENP-A containing chromatin protein-DNA complex intracellular membraneless organelle nucleosome chromosome chromatin chromosomal region intracellular organelle chromosome, centromeric core domain CENP-A containing nucleosome membraneless organelle chromosome, centromeric region chromosome, telomeric region nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
Q [auth P]	RNA	-	-	-
R [auth Q], W [auth V]	Histone H2A type 1	DNA binding binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity enzyme binding structural molecule activity structural constituent of chromatin	regulation of cellular process negative regulation of biological process cellular component organization chromatin organization negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of cellular process negative regulation of biological process cellular component organization chromatin organization negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle membraneless organelle nucleus intracellular membrane-bounded organelle
S [auth R], X [auth W]	Histone H2B type 1-J	DNA binding binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity lipid binding lipopolysaccharide binding carbohydrate derivative binding structural molecule activity structural constituent of chromatin	protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization biological process involved in interspecies interaction between organisms protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization biological process involved in interspecies interaction between organisms innate immune response in mucosa response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus mucosal immune response organ or tissue specific immune response humoral immune response antimicrobial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing defense response to Gram-negative bacterium defense response to bacterium response to bacterium antibacterial humoral response protein localization protein localization to chromatin cellular localization protein localization to chromosome, centromeric region localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to CENP-A containing chromatin cellular response to stimulus regulation of cellular process negative regulation of signaling signaling negative regulation of biological process response to cytokine regulation of signal transduction negative regulation of cell communication cytokine-mediated signaling pathway cell communication cellular response to tumor necrosis factor negative regulation of cellular process tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus signal transduction regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of tumor necrosis factor-mediated signaling pathway negative regulation of response to stimulus regulation of cytokine-mediated signaling pathway biological regulation negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of signal transduction response to peptide regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus regulation of response to stimulus negative regulation of cytokine-mediated signaling pathway response to chemical regulation of cell communication response to tumor necrosis factor defense response to Gram-positive bacterium	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex CENP-A containing chromatin protein-DNA complex intracellular membraneless organelle nucleosome chromosome chromatin chromosomal region intracellular organelle chromosome, centromeric core domain cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex CENP-A containing chromatin protein-DNA complex intracellular membraneless organelle nucleosome chromosome chromatin chromosomal region intracellular organelle chromosome, centromeric core domain CENP-A containing nucleosome organelle membraneless organelle chromosome, centromeric region extracellular region extracellular space membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
U [auth T]	Template DNA	-	-	-
AA [auth a]	Integrator complex subunit 1	-	regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death RNA metabolic process regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process U2 snRNA 3'-end processing snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA 3'-end processing macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process developmental process multicellular organismal process inner cell mass cell proliferation cell population proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development multicellular organism development embryo development ending in birth or egg hatching anatomical structure development blastocyst growth blastocyst development multi-multicellular organism process reproductive process female pregnancy embryo implantation multi-organism reproductive process	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane protein-containing complex cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane protein-containing complex integrator complex nuclear protein-containing complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
BA [auth b]	Integrator complex subunit 2	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane cytoplasm nuclear membrane endomembrane system membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane cytoplasm nuclear membrane endomembrane system organelle envelope nuclear envelope organelle membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
CA [auth d]	Integrator complex subunit 4	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex integrator complex nuclear protein-containing complex nucleoplasm
DA [auth e]	Integrator complex subunit 5	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA 3'-end processing macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cytosol protein-containing complex integrator complex nuclear protein-containing complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
FA [auth g]	Integrator complex subunit 7	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA 3'-end processing macromolecule metabolic process RNA processing cellular response to stimulus response to ionizing radiation response to stimulus cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication cellular response to stress response to stress negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling DNA damage response signal transduction in response to DNA damage	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome membrane-bounded organelle protein-containing complex integrator complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome membrane-bounded organelle protein-containing complex integrator complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
GA [auth h]	Integrator complex subunit 8	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
HA [auth i]	Integrator complex subunit 9	-	cellular response to stimulus negative regulation of transforming growth factor beta receptor signaling pathway regulation of cellular process cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus response to stimulus negative regulation of signaling signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to stimulus negative regulation of transforming growth factor beta receptor signaling pathway regulation of cellular process cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus response to stimulus negative regulation of signaling signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling regulation of biological process cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus biological regulation negative regulation of signal transduction response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication cellular process response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA 3'-end processing macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
IA [auth j]	Integrator complex subunit 10	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
JA [auth k]	Integrator complex subunit 11	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure extracellular region extracellular space blood microparticle intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex cellular anatomical structure extracellular region extracellular space blood microparticle intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
KA [auth m]	Integrator complex subunit 13	-	regulation of biological process sexual reproduction regulation of reproductive process reproductive process fertilization biological regulation regulation of fertilization regulation of mitotic cell cycle regulation of cellular process cellular process cell cycle regulation of cell cycle mitotic cell cycle localization regulation of biological process sexual reproduction regulation of reproductive process reproductive process fertilization biological regulation regulation of fertilization regulation of mitotic cell cycle regulation of cellular process cellular process cell cycle regulation of cell cycle mitotic cell cycle localization centrosome localization microtubule organizing center localization cell division microtubule cytoskeleton organization mitotic spindle organization cellular component organization organelle organization mitotic cell cycle process microtubule-based process cellular component organization or biogenesis cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process macromolecule metabolic process RNA processing protein localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to nucleus protein localization to nuclear envelope transcription elongation by RNA polymerase II regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process sperm motility cilium movement involved in cell motility cilium or flagellum-dependent cell motility cilium-dependent cell motility flagellated sperm motility microtubule-based movement cilium movement cell motility	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm membrane-enclosed lumen intracellular organelle lumen nuclear body membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
LA [auth n]	Integrator complex subunit 14	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
MA [auth o]	Integrator complex subunit 15	-	-	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle
NA [auth p]	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	protein antigen binding protein binding binding antigen binding phosphoric ester hydrolase activity enzyme regulator activity catalytic activity, acting on a protein phosphatase regulator activity phosphatase activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity protein antigen binding protein binding binding antigen binding phosphoric ester hydrolase activity enzyme regulator activity catalytic activity, acting on a protein phosphatase regulator activity phosphatase activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity catalytic activity protein serine/threonine phosphatase activity protein heterodimerization activity protein dimerization activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis meiotic spindle elongation meiotic chromosome segregation sexual reproduction spindle elongation reproductive process microtubule cytoskeleton organization meiotic cell cycle process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis meiotic spindle elongation meiotic chromosome segregation sexual reproduction spindle elongation reproductive process microtubule cytoskeleton organization meiotic cell cycle process meiotic nuclear division cell cycle chromosome segregation spindle organization cell cycle process meiotic cell cycle organelle fission meiotic spindle organization organelle organization nuclear division nuclear chromosome segregation microtubule-based process cytoskeleton organization mitotic nuclear division chromosome organization sister chromatid segregation mitotic cell cycle mitotic cell cycle process chromosome separation mitotic sister chromatid segregation mitotic sister chromatid separation sister chromatid cohesion meiotic sister chromatid cohesion, centromeric centromeric sister chromatid cohesion meiotic sister chromatid cohesion cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signal transduction in absence of ligand signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus extrinsic apoptotic signaling pathway in absence of ligand signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of programmed cell death cell surface receptor signaling pathway regulation of apoptotic process biological regulation positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling regulation of growth growth multicellular organismal process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis multicellular organismal reproductive process female gamete generation gamete generation female meiotic nuclear division hippo signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction negative regulation of cellular process negative regulation of response to stimulus negative regulation of hippo signaling negative regulation of signal transduction regulation of hippo signaling regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction meiotic cell cycle process involved in oocyte maturation cellular developmental process regulation of reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction oocyte development cell differentiation anatomical structure development cell maturation regulation of cell cycle developmental process regulation of cell cycle process oogenesis regulation of meiotic cell cycle process involved in oocyte maturation developmental maturation anatomical structure maturation germ cell development oocyte maturation oocyte differentiation regulation of developmental process regulation of cell differentiation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol membraneless organelle chromosome, centromeric region intracellular membraneless organelle chromosome chromosomal region somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection synapse cell junction glutamatergic synapse cytoskeleton microtubule cytoskeleton cell body neuronal cell body cell periphery plasma membrane lateral plasma membrane FAR/SIN/STRIPAK complex nucleus
OA [auth q]	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXS140 phosphatase activity myosin phosphatase activity cytoskeletal protein binding protein binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXS140 phosphatase activity myosin phosphatase activity cytoskeletal protein binding protein binding binding tau protein binding RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity RNA polymerase II CTD heptapeptide repeat modifying activity RNA polymerase II CTD heptapeptide repeat phosphatase activity RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity cation binding ion binding metal ion binding small molecule binding calmodulin-dependent protein phosphatase activity calcium-dependent protein serine/threonine phosphatase activity RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity protein heterodimerization activity protein dimerization activity signaling receptor binding GABA receptor binding protein tyrosine phosphatase activity RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity MAP kinase serine/threonine phosphatase activity MAP kinase phosphatase activity	developmental process anatomical structure development tissue development mesoderm development protein dephosphorylation dephosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process developmental process anatomical structure development tissue development mesoderm development protein dephosphorylation dephosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process regulation of growth regulation of biological process biological regulation growth cellular response to stimulus hippo signaling regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction negative regulation of cellular process signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of hippo signaling negative regulation of signal transduction regulation of response to stimulus regulation of cell communication regulation of hippo signaling regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of epithelial to mesenchymal transition multicellular organismal process regulation of developmental process cellular developmental process regulation of cell differentiation mesenchyme development cell differentiation negative regulation of cell differentiation regulation of multicellular organismal process negative regulation of developmental process animal organ development negative regulation of epithelial to mesenchymal transition epithelial to mesenchymal transition mesenchymal cell differentiation negative regulation of multicellular organismal process peptidyl-serine dephosphorylation regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process positive regulation of macromolecule metabolic process positive regulation of protein kinase activity positive regulation of protein phosphorylation positive regulation of cellular process protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorylation regulation of phosphorus metabolic process regulation of metabolic process regulation of protein binding positive regulation of protein binding regulation of binding positive regulation of microtubule binding regulation of microtubule binding positive regulation of binding cell cycle mitotic cell cycle multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly response to biotic stimulus cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus positive regulation of intracellular signal transduction positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway defense response to other organism regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly positive regulation of defense response activation of innate immune response regulation of immune response inflammatory response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular component organization positive regulation of cellular component organization regulation of response to external stimulus intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to stimulus cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response protein-containing complex assembly response to external biotic stimulus cellular component organization or biogenesis positive regulation of innate immune response defense response protein-containing complex organization positive regulation of cellular component biogenesis defense response to symbiont regulation of cellular component biogenesis positive regulation of signaling response to metal ion response to chemical response to lead ion ribonucleotide catabolic process pyridine nucleotide catabolic process negative regulation of small molecule metabolic process negative regulation of glycolytic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process negative regulation of ATP metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process pyridine-containing compound metabolic process small molecule metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process negative regulation of metabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process regulation of glycolytic process through fructose-6-phosphate ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process negative regulation of phosphorus metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process negative regulation of glycolytic process through fructose-6-phosphate glycolytic process through fructose-6-phosphate regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle regulation of G1/S transition of mitotic cell cycle mitotic cell cycle process regulation of cell cycle G1/S transition of mitotic cell cycle cell cycle process mitotic cell cycle phase transition sexual reproduction reproductive process meiotic cell cycle peptidyl-threonine dephosphorylation	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane extracellular exosome membrane-bounded organelle extracellular vesicle intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein serine/threonine phosphatase complex cytoplasm cytosol FAR/SIN/STRIPAK complex mitochondrion intracellular membrane-bounded organelle protein phosphatase type 2A complex cell periphery plasma membrane chromosome, centromeric region chromosome chromosomal region membrane microdomain membrane raft synapse cell junction nucleus
PA [auth r]	DSS1	-	-	-
QA [auth u]	Negative elongation factor A	chromatin binding binding molecular adaptor activity	transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of DNA-templated transcription elongation negative regulation of DNA-templated transcription regulation of biological process regulation of transcription elongation by RNA polymerase II negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of DNA-templated transcription, elongation regulation of gene expression DNA-templated transcription elongation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of protein modification process positive regulation of protein metabolic process regulation of protein metabolic process positive regulation of biological process positive regulation of metabolic process positive regulation of protein modification process macromolecule modification positive regulation of macromolecule metabolic process protein metabolic process protein modification process positive regulation of cellular process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle protein-containing complex transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle protein-containing complex transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen nuclear body
RA [auth v]	NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B	RNA binding binding nucleic acid binding	cell population proliferation cellular process transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process cell population proliferation cellular process transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of DNA-templated transcription elongation negative regulation of DNA-templated transcription regulation of biological process regulation of transcription elongation by RNA polymerase II negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of DNA-templated transcription, elongation regulation of gene expression DNA-templated transcription elongation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process developmental process stem cell differentiation cellular developmental process cell differentiation negative regulation of stem cell differentiation regulation of developmental process negative regulation of developmental process regulation of cell differentiation regulation of stem cell differentiation negative regulation of cell differentiation	membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen cytoplasm
SA [auth w]	Negative elongation factor C/D	RNA binding binding nucleic acid binding	transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of DNA-templated transcription elongation negative regulation of DNA-templated transcription regulation of biological process regulation of transcription elongation by RNA polymerase II negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of DNA-templated transcription, elongation regulation of gene expression DNA-templated transcription elongation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membrane
TA [auth x]	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK	-	-	-
Z	Transcription elongation factor SPT5	chromatin binding binding protein heterodimerization activity protein binding protein dimerization activity RNA binding nucleic acid binding mRNA binding enzyme binding	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of DNA-templated transcription, elongation positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of DNA-templated transcription, elongation positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression DNA-templated transcription elongation biosynthetic process positive regulation of RNA biosynthetic process cellular process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of biological process negative regulation of RNA biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of metabolic process negative regulation of DNA-templated transcription, elongation negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process transcription elongation by RNA polymerase II transcription by RNA polymerase II regulation of transcription elongation by RNA polymerase II positive regulation of autophagy catabolic process macroautophagy autophagy regulation of catabolic process regulation of autophagy positive regulation of catabolic process regulation of macroautophagy positive regulation of macroautophagy process utilizing autophagic mechanism transcription elongation-coupled chromatin remodeling cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II	membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex DSIF complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex DSIF complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen
EA [auth f]	Integrator complex subunit 6	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytoskeleton membraneless organelle intracellular membraneless organelle actin cytoskeleton
C [auth B]	DNA-directed RNA polymerase subunit beta	RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups ribonucleoside binding binding nucleoside binding heterocyclic compound binding carbohydrate derivative binding RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups ribonucleoside binding binding nucleoside binding heterocyclic compound binding carbohydrate derivative binding small molecule binding chromatin binding DNA binding nucleic acid binding cation binding ion binding metal ion binding	-	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region
F [auth E]	DNA-directed RNA polymerase II subunit E	DNA binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process nucleolar large rRNA transcription by RNA polymerase I transcription elongation by RNA polymerase I DNA-templated transcription elongation transcription by RNA polymerase I rRNA transcription rRNA metabolic process tRNA metabolic process tRNA transcription tRNA transcription by RNA polymerase III transcription by RNA polymerase III	membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen RNA polymerase II, holoenzyme nucleoplasm RNA polymerase II, core complex RNA polymerase III complex
G [auth F]	DNA-directed RNA polymerases I, II, and III subunit RPABC2	DNA binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen fibrillar center RNA polymerase III complex RNA polymerase II, holoenzyme nucleoplasm RNA polymerase II, core complex

Chains

Polymer

Molecular Function

Biological Process

Cellular Component

A [auth 1]

UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK

DNA-directed RNA polymerase subunit

DNA binding

nucleic acid binding

nucleotidyltransferase activity

transferase activity

transferase activity, transferring phosphorus-containing groups

cation binding

ion binding

nucleobase-containing compound biosynthetic process

transferase complex, transferring phosphorus-containing groups

nuclear lumen

DNA-directed RNA polymerase II subunit RPB3

nucleobase-containing compound biosynthetic process

RNA polymerase II subunit D

nucleobase-containing compound biosynthetic process

DNA-templated transcription initiation

nuclear speck

nuclear body

DNA-directed RNA polymerase II subunit RPB7

nucleobase-containing compound biosynthetic process

DNA-templated transcription initiation

DNA-directed RNA polymerases I, II, and III subunit RPABC3

DNA-directed RNA polymerase II subunit RPB9

nucleic acid binding

nucleotidyltransferase activity

transferase activity

transferase activity, transferring phosphorus-containing groups

cation binding

transition metal ion binding

zinc ion binding

nucleobase-containing compound biosynthetic process

DNA-templated transcription initiation

nucleolus

nuclear lumen

transition metal ion binding

DNA-directed RNA polymerases I, II, and III subunit RPABC5

zinc ion binding

ion binding

metal ion binding

small molecule binding

DNA-directed RNA polymerase II subunit RPB11-a

transition metal ion binding

M [auth L]

RNA polymerase II subunit K

zinc ion binding

ion binding

metal ion binding

small molecule binding

Histone H3.3C

regulation of growth

regulation of cellular component organization

positive regulation of biological process

growth

positive regulation of cell growth

regulation of cell growth

cell growth

positive regulation of growth

euchromatin

chromatin

chromosome

protein-DNA complex

nucleosome

O [auth N]

non-template DNA

protein-containing complex organization

Histone H4

protein-DNA complex assembly

protein-DNA complex organization

cellular component biogenesis

cellular component assembly

chromatin organization

protein-containing complex assembly

chromatin remodeling

nucleosome assembly

nucleosome organization

organelle organization

extracellular region

extracellular exosome

extracellular vesicle

extracellular organelle

extracellular membrane-bounded organelle

extracellular space

vesicle

CENP-A containing chromatin

Q [auth P]

RNA

Histone H2A type 1

chromatin organization

chromatin remodeling

negative regulation of macromolecule metabolic process

regulation of biosynthetic process

heterochromatin formation

epigenetic regulation of gene expression

negative regulation of metabolic process

extracellular exosome

extracellular vesicle

extracellular membrane-bounded organelle

extracellular organelle

protein-DNA complex

nucleosome

protein-containing complex organization

Histone H2B type 1-J

protein-DNA complex assembly

protein-DNA complex organization

cellular component biogenesis

cellular component assembly

chromatin organization

protein-containing complex assembly

chromatin remodeling

biological process involved in interspecies interaction between organisms

nucleosome assembly

nucleosome organization

CENP-A containing chromatin

protein-DNA complex

chromosome, centromeric core domain

U [auth T]

Template DNA

Integrator complex subunit 1

negative regulation of programmed cell death

regulation of apoptotic process

regulation of programmed cell death

cell death

negative regulation of apoptotic process

apoptotic process

programmed cell death

nuclear membrane

endomembrane system

BA [auth b]

Integrator complex subunit 2

nucleobase-containing compound biosynthetic process

Integrator complex subunit 4

nucleobase-containing compound biosynthetic process

nucleolus

nuclear lumen

Integrator complex subunit 5

nucleobase-containing compound biosynthetic process

snRNA 3'-end processing

snRNA processing

nuclear membrane

endomembrane system

Integrator complex subunit 7

nucleobase-containing compound biosynthetic process

snRNA 3'-end processing

snRNA processing

chromosome

GA [auth h]

Integrator complex subunit 8

nucleobase-containing compound biosynthetic process

cellular response to stimulus

Integrator complex subunit 9

negative regulation of transforming growth factor beta receptor signaling pathway

cell surface receptor protein serine/threonine kinase signaling pathway

cellular response to growth factor stimulus

response to stimulus

negative regulation of signaling

signaling

cellular response to transforming growth factor beta stimulus

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

regulation of signal transduction

negative regulation of cell communication

cell communication

regulation of transforming growth factor beta receptor signaling pathway

IA [auth j]

Integrator complex subunit 10

nucleobase-containing compound biosynthetic process

Integrator complex subunit 11

nucleobase-containing compound biosynthetic process

extracellular region

extracellular space

blood microparticle

KA [auth m]

Integrator complex subunit 13

regulation of reproductive process

sexual reproduction

reproductive process

fertilization

regulation of fertilization

regulation of mitotic cell cycle

cell cycle

regulation of cell cycle

mitotic cell cycle

localization

nuclear body

Integrator complex subunit 14

nucleobase-containing compound biosynthetic process

MA [auth o]

Integrator complex subunit 15

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

protein antigen binding

protein binding

phosphoric ester hydrolase activity

antigen binding

enzyme regulator activity

catalytic activity, acting on a protein

phosphatase regulator activity

phosphatase activity

hydrolase activity

phosphoprotein phosphatase activity

hydrolase activity, acting on ester bonds

molecular function regulator activity

protein phosphatase regulator activity

cellular component biogenesis

cellular component assembly

protein-containing complex organization

protein-containing complex assembly

meiotic spindle elongation

meiotic chromosome segregation

sexual reproduction

spindle elongation

reproductive process

microtubule cytoskeleton organization

meiotic cell cycle process

mitochondrion

phosphatase complex

protein phosphatase type 2A complex

protein serine/threonine phosphatase complex

phosphoric ester hydrolase activity

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

catalytic activity, acting on a protein

hydrolase activity, acting on ester bonds

phosphatase activity

hydrolase activity

histone modifying activity

histone phosphatase activity

histone H2AXS140 phosphatase activity

myosin phosphatase activity

cytoskeletal protein binding

protein binding

developmental process

anatomical structure development

tissue development

mesoderm development

protein dephosphorylation

dephosphorylation

macromolecule modification

phosphate-containing compound metabolic process

protein metabolic process

macromolecule metabolic process

protein modification process

cytoskeleton

spindle

spindle pole

microtubule cytoskeleton

extracellular exosome

extracellular vesicle

PA [auth r]

DSS1

transcription elongation by RNA polymerase II

Negative elongation factor A

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process

NELF complex

cell population proliferation

RA [auth v]

NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B

transcription elongation by RNA polymerase II

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process

NELF complex

transcription elongation by RNA polymerase II

SA [auth w]

Negative elongation factor C/D

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process

NELF complex

TA [auth x]

UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK

Transcription elongation factor SPT5

positive regulation of DNA-templated transcription

positive regulation of biological process

positive regulation of macromolecule biosynthetic process

positive regulation of metabolic process

positive regulation of DNA-templated transcription, elongation

positive regulation of biosynthetic process

DSIF complex

Integrator complex subunit 6

nucleobase-containing compound biosynthetic process

RNA-directed RNA polymerase activity

DNA-directed RNA polymerase subunit beta

nucleotidyltransferase activity

transferase activity

transferase activity, transferring phosphorus-containing groups

ribonucleoside binding

heterocyclic compound binding

nucleoside binding

carbohydrate derivative binding

DNA-directed RNA polymerase II subunit E

nucleobase-containing compound biosynthetic process

RNA polymerase I complex

DNA-directed RNA polymerases I, II, and III subunit RPABC2

nucleobase-containing compound biosynthetic process

RNA polymerase I complex

Chains	Accession	Name	Type
B [auth A], Y	IPR007066	RNA polymerase Rpb1, domain 3	Domain
B [auth A], Y	IPR007081	RNA polymerase Rpb1, domain 5	Domain
B [auth A], Y	IPR007073	RNA polymerase Rpb1, domain 7	Domain
B [auth A], Y	IPR045867	DNA-directed RNA polymerase, subunit beta-prime	Family
B [auth A], Y	IPR042102	RNA polymerase Rpb1, domain 3 superfamily	Homologous Superfamily
B [auth A], Y	IPR007075	RNA polymerase Rpb1, domain 6	Domain
B [auth A], Y	IPR000684	RNA polymerase II, heptapeptide repeat, eukaryotic	Repeat
B [auth A], Y	IPR007083	RNA polymerase Rpb1, domain 4	Domain
B [auth A], Y	IPR038593	RNA polymerase Rpb1, domain 7 superfamily	Homologous Superfamily
B [auth A], Y	IPR000722	RNA polymerase, alpha subunit	Domain
B [auth A], Y	IPR044893	RNA polymerase Rpb1, clamp domain superfamily	Homologous Superfamily
B [auth A], Y	IPR038120	RNA polymerase Rpb1, funnel domain superfamily	Homologous Superfamily
B [auth A], Y	IPR006592	RNA polymerase, N-terminal	Domain
B [auth A], Y	IPR007080	RNA polymerase Rpb1, domain 1	Domain
D [auth C]	IPR011262	DNA-directed RNA polymerase, insert domain	Domain
D [auth C]	IPR011263	DNA-directed RNA polymerase, RpoA/D/Rpb3-type	Domain
D [auth C]	IPR050518	Archaeal Rpo3/Eukaryotic RPB3 RNA Polymerase Subunit	Family
D [auth C]	IPR022842	DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1	Family
D [auth C]	IPR036643	DNA-directed RNA polymerase, insert domain superfamily	Homologous Superfamily
D [auth C]	IPR001514	DNA-directed RNA polymerase, 30-40kDa subunit, conserved site	Conserved Site
D [auth C]	IPR036603	RNA polymerase, RBP11-like subunit	Homologous Superfamily
E [auth D]	IPR005574	RNA polymerase subunit Rpb4/RPC9	Family
E [auth D]	IPR010997	HRDC-like superfamily	Homologous Superfamily
E [auth D]	IPR006590	RNA polymerase Rpb4/RPC9, core	Domain
E [auth D]	IPR038324	Rpb4/RPC9 superfamily	Homologous Superfamily
E [auth D]	IPR045222	DNA-directed RNA polymerase II subunit Rpb4-like	Family
H [auth G]	IPR036898	RNA polymerase Rpb7-like, N-terminal domain superfamily	Homologous Superfamily
H [auth G]	IPR003029	S1 domain	Domain
H [auth G]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
H [auth G]	IPR045113	RNA polymerase subunit Rpb7-like	Family
H [auth G]	IPR005576	RNA polymerase Rpb7-like , N-terminal	Domain
I [auth H]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
I [auth H]	IPR005570	DNA-directed RNA polymerases I, II, and III subunit RPABC3	Family
J [auth I]	IPR001529	DNA-directed RNA polymerase II subunit RPB9-like, zinc ribbon	Domain
J [auth I]	IPR012164	DNA-directed RNA polymerase subunit/transcription factor S	Family
J [auth I]	IPR001222	Zinc finger, TFIIS-type	Domain
J [auth I]	IPR034012	Pol II subunit B9, C-terminal zinc ribbon	Domain
J [auth I]	IPR019761	DNA-directed RNA polymerase M, 15kDa subunit, conserved site	Conserved Site
K [auth J]	IPR023580	RNA polymerase subunit RPB10	Homologous Superfamily
K [auth J]	IPR020789	RNA polymerases, subunit N, zinc binding site	Binding Site
K [auth J]	IPR000268	DNA-directed RNA polymerase subunit RPABC5/Rpb10	Family
L [auth K]	IPR022905	DNA-directed RNA polymerase subunit Rpo11-like	Family
L [auth K]	IPR009025	DNA-directed RNA polymerase, RBP11-like dimerisation domain	Domain
L [auth K]	IPR036603	RNA polymerase, RBP11-like subunit	Homologous Superfamily
L [auth K]	IPR008193	DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site	Conserved Site
L [auth K]	IPR037685	RNA polymerase RBP11	Family
M [auth L]	IPR006591	RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4	Family
M [auth L]	IPR029040	RNA polymerase subunit RPABC4/transcription elongation factor Spt4	Homologous Superfamily
M [auth L]	IPR039747	DNA-directed RNA polymerases I, II, and III subunit RPABC4	Family
N [auth M], T [auth S]	IPR009072	Histone-fold	Homologous Superfamily
N [auth M], T [auth S]	IPR007125	Histone H2A/H2B/H3	Domain
N [auth M], T [auth S]	IPR000164	Histone H3/CENP-A	Family
P [auth O], V [auth U]	IPR009072	Histone-fold	Homologous Superfamily
P [auth O], V [auth U]	IPR035425	CENP-T/Histone H4, histone fold	Domain
P [auth O], V [auth U]	IPR001951	Histone H4	Family
P [auth O], V [auth U]	IPR019809	Histone H4, conserved site	Conserved Site
P [auth O], V [auth U]	IPR004823	TATA box binding protein associated factor (TAF), histone-like fold domain	Domain
R [auth Q], W [auth V]	IPR009072	Histone-fold	Homologous Superfamily
R [auth Q], W [auth V]	IPR007125	Histone H2A/H2B/H3	Domain
R [auth Q], W [auth V]	IPR002119	Histone H2A	Family
R [auth Q], W [auth V]	IPR032454	Histone H2A, C-terminal domain	Domain
R [auth Q], W [auth V]	IPR032458	Histone H2A conserved site	Conserved Site
S [auth R], X [auth W]	IPR009072	Histone-fold	Homologous Superfamily
S [auth R], X [auth W]	IPR007125	Histone H2A/H2B/H3	Domain
S [auth R], X [auth W]	IPR000558	Histone H2B	Family
S [auth R], X [auth W]	IPR055333	Histone H2B, conserved site	Conserved Site
AA [auth a]	IPR016024	Armadillo-type fold	Homologous Superfamily
AA [auth a]	IPR053964	Integrator complex subunit 1, R3 domain	Domain
AA [auth a]	IPR053966	Integrator complex subunit 1, INTS2-binding domain	Domain
AA [auth a]	IPR022145	Integrator complex subunit 1, RPB2-binding domain	Domain
AA [auth a]	IPR053965	Integrator complex subunit 1, R4 domain	Domain
AA [auth a]	IPR038902	Integrator complex subunit 1	Family
BA [auth b]	IPR026236	Integrator complex subunit 2, metazoa	Family
BA [auth b]	IPR029321	Integrator complex subunit 2	Family
CA [auth d]	IPR011989	Armadillo-like helical	Homologous Superfamily
CA [auth d]	IPR016024	Armadillo-type fold	Homologous Superfamily
DA [auth e]	IPR040316	Integrator complex subunit 5	Family
DA [auth e]	IPR029445	Integrator complex subunit 5, N-terminal	Domain
DA [auth e]	IPR029444	Integrator complex subunit 5, C-terminal	Domain
FA [auth g]	IPR016024	Armadillo-type fold	Homologous Superfamily
FA [auth g]	IPR033060	Integrator complex subunit 7	Family
FA [auth g]	IPR054519	Integrator complex subunit 7, C-terminal domain	Domain
GA [auth h]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
GA [auth h]	IPR038751	Integrator complex subunit 8	Family
HA [auth i]	IPR027074	Integrator complex subunit 9	Family
HA [auth i]	IPR001279	Metallo-beta-lactamase	Domain
HA [auth i]	IPR022712	Beta-Casp domain	Domain
HA [auth i]	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
HA [auth i]	IPR048660	Integrator complex subunit 9-like, C-terminal domain	Domain
IA [auth j]	IPR026164	Integrator complex subunit 10	Family
JA [auth k]	IPR001279	Metallo-beta-lactamase	Domain
JA [auth k]	IPR050698	RNA Processing Metallo-Beta-Lactamase Domain-Containing Protein	Family
JA [auth k]	IPR022712	Beta-Casp domain	Domain
JA [auth k]	IPR041897	Integrator complex subunit 11, MBL-fold	Domain
JA [auth k]	IPR048662	Integrator complex subunit 11, C-terminal domain	Domain
JA [auth k]	IPR011108	Zn-dependent metallo-hydrolase, RNA specificity domain	Domain
JA [auth k]	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
KA [auth m]	IPR019355	Cell cycle regulator Mat89Bb	Family
LA [auth n]	IPR039841	Integrator complex subunit 14	Family
LA [auth n]	IPR046471	Integrator complex subunit 14, C-terminal	Domain
LA [auth n]	IPR045814	Integrator complex subunit 14, beta-barrel domain	Domain
LA [auth n]	IPR002035	von Willebrand factor, type A	Domain
LA [auth n]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
MA [auth o]	IPR027844	Integrator complex subunit 15	Family
NA [auth p]	IPR054573	Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like, HEAT repeat	Domain
NA [auth p]	IPR016024	Armadillo-type fold	Homologous Superfamily
NA [auth p]	IPR021133	HEAT, type 2	Repeat
NA [auth p]	IPR011989	Armadillo-like helical	Homologous Superfamily
NA [auth p]	IPR051023	Protein Phosphatase 2A Regulatory Subunit A	Family
NA [auth p]	IPR000357	HEAT repeat	Repeat
OA [auth q]	IPR047129	Serine/Threonine protein phosphatase PP2A-like	Family
OA [auth q]	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
OA [auth q]	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
OA [auth q]	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	Domain
QA [auth u]	IPR037517	Hepatitis delta antigen (HDAg) domain	Domain
QA [auth u]	IPR052828	Negative elongation factor A domain-containing protein	Family
RA [auth v]	IPR010405	Cofactor of BRCA1	Family
SA [auth w]	IPR006942	TH1 protein	Family
Z	IPR041980	Spt5, KOW domain repeat 6	Domain
Z	IPR041976	Spt5, KOW domain repeat 3	Domain
Z	IPR039385	NGN domain, eukaryotic	Domain
Z	IPR014722	Large ribosomal subunit protein uL2, domain 2	Homologous Superfamily
Z	IPR022581	Spt5 transcription elongation factor, N-terminal	Domain
Z	IPR024945	Spt5 C-terminal domain	Domain
Z	IPR006645	NusG-like, N-terminal	Domain
Z	IPR041975	Spt5, KOW domain repeat 2	Domain
Z	IPR039659	Transcription elongation factor SPT5	Family
Z	IPR036735	NusG, N-terminal domain superfamily	Homologous Superfamily
Z	IPR008991	Translation protein SH3-like domain superfamily	Homologous Superfamily
Z	IPR041973	Spt5, KOW domain repeat 1	Domain
Z	IPR005100	NGN domain	Domain
Z	IPR041977	Spt5, KOW domain repeat 4	Domain
Z	IPR017071	Transcription elongation factor Spt5, eukaryote	Family
Z	IPR005824	KOW	Domain
Z	IPR041978	Spt5, KOW domain repeat 5	Domain
EA [auth f]	IPR002035	von Willebrand factor, type A	Domain
EA [auth f]	IPR029307	INTS6/SAGE1/DDX26B/CT45, C-terminal	Domain
EA [auth f]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
EA [auth f]	IPR051113	Integrator complex subunit 6	Family
C [auth B]	IPR007120	DNA-directed RNA polymerase, subunit 2, hybrid-binding domain	Domain
C [auth B]	IPR007121	RNA polymerase, beta subunit, conserved site	Conserved Site
C [auth B]	IPR007646	RNA polymerase Rpb2, domain 4	Domain
C [auth B]	IPR007647	RNA polymerase Rpb2, domain 5	Domain
C [auth B]	IPR014724	RNA polymerase Rpb2, OB-fold	Homologous Superfamily
C [auth B]	IPR007642	RNA polymerase Rpb2, domain 2	Domain
C [auth B]	IPR015712	DNA-directed RNA polymerase, subunit 2	Family
C [auth B]	IPR037033	DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily	Homologous Superfamily
C [auth B]	IPR037034	RNA polymerase Rpb2, domain 2 superfamily	Homologous Superfamily
C [auth B]	IPR007645	RNA polymerase Rpb2, domain 3	Domain
C [auth B]	IPR007644	RNA polymerase, beta subunit, protrusion	Domain
C [auth B]	IPR007641	RNA polymerase Rpb2, domain 7	Domain
F [auth E]	IPR014381	DNA-directed RNA polymerase subunit Rpo5/Rpb5	Family
F [auth E]	IPR036710	RNA polymerase Rpb5, N-terminal domain superfamily	Homologous Superfamily
F [auth E]	IPR035913	RPB5-like RNA polymerase subunit superfamily	Homologous Superfamily
F [auth E]	IPR000783	RNA polymerase, subunit H/Rpb5 C-terminal	Domain
F [auth E]	IPR020608	RNA polymerase, subunit H/Rpb5, conserved site	Conserved Site
F [auth E]	IPR005571	RNA polymerase, Rpb5, N-terminal	Domain
G [auth F]	IPR020708	DNA-directed RNA polymerase, 14-18kDa subunit, conserved site	Conserved Site
G [auth F]	IPR036161	RPB6/omega subunit-like superfamily	Homologous Superfamily
G [auth F]	IPR028363	DNA-directed RNA polymerase, subunit RPB6	Family
G [auth F]	IPR006110	RNA polymerase, subunit omega/Rpo6/RPB6	Family
G [auth F]	IPR006111	Archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit	Family

Chains

Accession

Name

Type

RNA polymerase Rpb1, domain 3

IPR007066

Domain

RNA polymerase Rpb1, domain 5

IPR007081

Domain

RNA polymerase Rpb1, domain 7

IPR007073

Domain

DNA-directed RNA polymerase, subunit beta-prime

IPR045867

Family

RNA polymerase Rpb1, domain 3 superfamily

IPR042102

Homologous Superfamily

RNA polymerase Rpb1, domain 6

IPR007075

Domain

RNA polymerase II, heptapeptide repeat, eukaryotic

IPR000684

Repeat

RNA polymerase Rpb1, domain 4

IPR007083

Domain

RNA polymerase Rpb1, domain 7 superfamily

IPR038593

Homologous Superfamily

RNA polymerase, alpha subunit

IPR000722

Domain

RNA polymerase Rpb1, clamp domain superfamily

IPR044893

Homologous Superfamily

RNA polymerase Rpb1, funnel domain superfamily

IPR038120

Homologous Superfamily

RNA polymerase, N-terminal

IPR006592

Domain

RNA polymerase Rpb1, domain 1

IPR007080

Domain

DNA-directed RNA polymerase, insert domain

IPR011262

Domain

DNA-directed RNA polymerase, RpoA/D/Rpb3-type

IPR011263

Domain

Archaeal Rpo3/Eukaryotic RPB3 RNA Polymerase Subunit

IPR050518

Family

DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1

IPR022842

Family

DNA-directed RNA polymerase, insert domain superfamily

IPR036643

Homologous Superfamily

DNA-directed RNA polymerase, 30-40kDa subunit, conserved site

IPR001514

Conserved Site

RNA polymerase, RBP11-like subunit

IPR036603

Homologous Superfamily

RNA polymerase subunit Rpb4/RPC9

IPR005574

Family

IPR010997

HRDC-like superfamily

Homologous Superfamily

RNA polymerase Rpb4/RPC9, core

IPR006590

Domain

IPR038324

Rpb4/RPC9 superfamily

Homologous Superfamily

DNA-directed RNA polymerase II subunit Rpb4-like

IPR045222

Family

RNA polymerase Rpb7-like, N-terminal domain superfamily

IPR036898

Homologous Superfamily

Domain

Nucleic acid-binding, OB-fold

Homologous Superfamily

RNA polymerase subunit Rpb7-like

IPR045113

Family

RNA polymerase Rpb7-like , N-terminal

IPR005576

Domain

I [auth H]

IPR012340

Nucleic acid-binding, OB-fold

Homologous Superfamily

I [auth H]

IPR005570

DNA-directed RNA polymerases I, II, and III subunit RPABC3

Family

DNA-directed RNA polymerase II subunit RPB9-like, zinc ribbon

IPR001529

Domain

DNA-directed RNA polymerase subunit/transcription factor S

IPR012164

Family

IPR001222

Zinc finger, TFIIS-type

Domain

Pol II subunit B9, C-terminal zinc ribbon

IPR034012

Domain

DNA-directed RNA polymerase M, 15kDa subunit, conserved site

IPR019761

Conserved Site

RNA polymerase subunit RPB10

IPR023580

Homologous Superfamily

RNA polymerases, subunit N, zinc binding site

IPR020789

Binding Site

DNA-directed RNA polymerase subunit RPABC5/Rpb10

IPR000268

Family

DNA-directed RNA polymerase subunit Rpo11-like

IPR022905

Family

DNA-directed RNA polymerase, RBP11-like dimerisation domain

IPR009025

Domain

RNA polymerase, RBP11-like subunit

IPR036603

Homologous Superfamily

DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site

IPR008193

Conserved Site

Family

RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4

Family

M [auth L]

IPR029040

RNA polymerase subunit RPABC4/transcription elongation factor Spt4

Homologous Superfamily

M [auth L]

IPR039747

DNA-directed RNA polymerases I, II, and III subunit RPABC4

Family

Homologous Superfamily

IPR007125

Histone H2A/H2B/H3

Domain

IPR000164

Histone H3/CENP-A

Family

Homologous Superfamily

CENP-T/Histone H4, histone fold

IPR035425

Domain

IPR001951

Histone H4

Family

Histone H4, conserved site

IPR019809

Conserved Site

TATA box binding protein associated factor (TAF), histone-like fold domain

IPR004823

Domain

Homologous Superfamily

IPR007125

Histone H2A/H2B/H3

Domain

IPR002119

Histone H2A

Family

Histone H2A, C-terminal domain

IPR032454

Domain

Histone H2A conserved site

IPR032458

Conserved Site

Homologous Superfamily

IPR007125

Histone H2A/H2B/H3

Domain

IPR000558

Histone H2B

Family

Histone H2B, conserved site

IPR055333

Conserved Site

Homologous Superfamily

Integrator complex subunit 1, R3 domain

IPR053964

Domain

Integrator complex subunit 1, INTS2-binding domain

IPR053966

Domain

Integrator complex subunit 1, RPB2-binding domain

IPR022145

Domain

Integrator complex subunit 1, R4 domain

IPR053965

Domain

Integrator complex subunit 1

IPR038902

Family

BA [auth b]

IPR026236

Integrator complex subunit 2, metazoa

Family

BA [auth b]

IPR029321

Integrator complex subunit 2

Family

CA [auth d]

IPR011989

Armadillo-like helical

Homologous Superfamily

CA [auth d]

Homologous Superfamily

Integrator complex subunit 5

IPR040316

Family

Integrator complex subunit 5, N-terminal

IPR029445

Domain

Integrator complex subunit 5, C-terminal

IPR029444

Domain

FA [auth g]

Integrator complex subunit 7

Homologous Superfamily

FA [auth g]

IPR033060

Family

FA [auth g]

IPR054519

Integrator complex subunit 7, C-terminal domain

Domain

GA [auth h]

IPR011990

Tetratricopeptide-like helical domain superfamily

Homologous Superfamily

GA [auth h]

IPR038751

Integrator complex subunit 8

Family

Integrator complex subunit 9

IPR027074

Family

Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

IPR001279

Metallo-beta-lactamase

Domain

Domain

Homologous Superfamily

Integrator complex subunit 9-like, C-terminal domain

IPR048660

Domain

IA [auth j]

IPR026164

Integrator complex subunit 10

Family

IPR001279

Metallo-beta-lactamase

Domain

RNA Processing Metallo-Beta-Lactamase Domain-Containing Protein

IPR050698

Family

Domain

Integrator complex subunit 11, MBL-fold

Domain

Integrator complex subunit 11, C-terminal domain

IPR048662

Domain

Zn-dependent metallo-hydrolase, RNA specificity domain

IPR011108

Domain

Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

IPR036866

Homologous Superfamily

KA [auth m]

IPR019355

Cell cycle regulator Mat89Bb

Family

Integrator complex subunit 14

IPR039841

Family

Integrator complex subunit 14, C-terminal

IPR046471

Domain

Integrator complex subunit 14, beta-barrel domain

IPR045814

Domain

von Willebrand factor, type A

IPR002035

Domain

von Willebrand factor A-like domain superfamily

IPR036465

Homologous Superfamily

MA [auth o]

IPR027844

Integrator complex subunit 15

Family

Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like, HEAT repeat

IPR054573

Domain

Homologous Superfamily

Repeat

Armadillo-like helical

Homologous Superfamily

Protein Phosphatase 2A Regulatory Subunit A

IPR051023

Family

Repeat

Serine/Threonine protein phosphatase PP2A-like

Family

Calcineurin-like phosphoesterase domain, ApaH type

IPR004843

Domain

Metallo-dependent phosphatase-like

IPR029052

Homologous Superfamily

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

IPR006186

Domain

Hepatitis delta antigen (HDAg) domain

IPR037517

Domain

Negative elongation factor A domain-containing protein

IPR052828

Family

Family

Family

Spt5, KOW domain repeat 6

Domain

IPR041976

Spt5, KOW domain repeat 3

Domain

IPR039385

NGN domain, eukaryotic

Domain

IPR014722

Large ribosomal subunit protein uL2, domain 2

Homologous Superfamily

IPR022581

Spt5 transcription elongation factor, N-terminal

Domain

IPR024945

Spt5 C-terminal domain

Domain

IPR006645

NusG-like, N-terminal

Domain

IPR041975

Spt5, KOW domain repeat 2

Domain

IPR039659

Transcription elongation factor SPT5

Family

IPR036735

NusG, N-terminal domain superfamily

Homologous Superfamily

IPR008991

Translation protein SH3-like domain superfamily

Homologous Superfamily

IPR041973

Spt5, KOW domain repeat 1

Domain

IPR005100

NGN domain

Domain

IPR041977

Spt5, KOW domain repeat 4

Domain

IPR017071

Transcription elongation factor Spt5, eukaryote

Family

IPR005824

KOW

Domain

IPR041978

Spt5, KOW domain repeat 5

Domain

von Willebrand factor, type A

IPR002035

Domain

INTS6/SAGE1/DDX26B/CT45, C-terminal

IPR029307

Domain

von Willebrand factor A-like domain superfamily

IPR036465

Homologous Superfamily

Integrator complex subunit 6

IPR051113

Family

DNA-directed RNA polymerase, subunit 2, hybrid-binding domain

IPR007120

Domain

RNA polymerase, beta subunit, conserved site

IPR007121

Conserved Site

RNA polymerase Rpb2, domain 4

IPR007646

Domain

RNA polymerase Rpb2, domain 5

IPR007647

Domain

RNA polymerase Rpb2, OB-fold

IPR014724

Homologous Superfamily

RNA polymerase Rpb2, domain 2

IPR007642

Domain

DNA-directed RNA polymerase, subunit 2

IPR015712

Family

DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily

IPR037033

Homologous Superfamily

RNA polymerase Rpb2, domain 2 superfamily

IPR037034

Homologous Superfamily

RNA polymerase Rpb2, domain 3

IPR007645

Domain

RNA polymerase, beta subunit, protrusion

IPR007644

Domain

RNA polymerase Rpb2, domain 7

IPR007641

Domain

DNA-directed RNA polymerase subunit Rpo5/Rpb5

IPR014381

Family

RNA polymerase Rpb5, N-terminal domain superfamily

IPR036710

Homologous Superfamily

RPB5-like RNA polymerase subunit superfamily

IPR035913

Homologous Superfamily

RNA polymerase, subunit H/Rpb5 C-terminal

IPR000783

Domain

RNA polymerase, subunit H/Rpb5, conserved site

IPR020608

Conserved Site

RNA polymerase, Rpb5, N-terminal

IPR005571

Domain

DNA-directed RNA polymerase, 14-18kDa subunit, conserved site

IPR020708

Conserved Site

RPB6/omega subunit-like superfamily

IPR036161

Homologous Superfamily

DNA-directed RNA polymerase, subunit RPB6

IPR028363

Family

RNA polymerase, subunit omega/Rpo6/RPB6

IPR006110

Family

Archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit

IPR006111

Family

Chains	Drug Target	Associated Disease
N [auth M], T [auth S]	Pharos: Q6NXT2	acute myeloid leukemia diabetes mellitus
P [auth O], V [auth U]	Pharos: P62805	lung carcinoma Malignant neoplasm of breast non-small cell lung carcinoma Pick disease acute myeloid leukemia squamous cell lung carcinoma atypical teratoid rhabdoid tumor breast carcinoma ductal breast carcinoma in situ exocrine pancreatic carcinoma hepatocellular carcinoma lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm osteoarthritis lung carcinoma Malignant neoplasm of breast non-small cell lung carcinoma Pick disease acute myeloid leukemia squamous cell lung carcinoma atypical teratoid rhabdoid tumor breast carcinoma ductal breast carcinoma in situ exocrine pancreatic carcinoma hepatocellular carcinoma lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm osteoarthritis pilocytic astrocytoma allergic rhinitis ulcerative colitis autism spectrum disorder cystic fibrosis endogenous depression glioblastoma hypertensive disorder lung cancer malignant mesothelioma multiple sclerosis osteosarcoma psoriasis astrocytic tumor breast cancer diabetes mellitus endometriosis gout invasive ductal breast carcinoma
R [auth Q], W [auth V]	Pharos: P0C0S8	malignant pancreatic neoplasm ovarian cancer psoriasis acne benign prostatic hyperplasia chronic obstructive pulmonary disease exocrine pancreatic carcinoma glioblastoma lung cancer malignant glioma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma squamous cell lung carcinoma atypical teratoid rhabdoid tumor breast cancer malignant pancreatic neoplasm ovarian cancer psoriasis acne benign prostatic hyperplasia chronic obstructive pulmonary disease exocrine pancreatic carcinoma glioblastoma lung cancer malignant glioma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma squamous cell lung carcinoma atypical teratoid rhabdoid tumor breast cancer cutaneous lupus erythematosus gastric cancer hepatocellular carcinoma lung carcinoma malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm autism spectrum disorder breast carcinoma endogenous depression gastric carcinoma lung adenocarcinoma malignant colon neoplasm
S [auth R], X [auth W]	Pharos: P06899	autism spectrum disorder lung adenocarcinoma breast cancer schizophrenia endogenous depression
AA [auth a]	Pharos: Q8N201	intellectual disability malignant mesothelioma psoriasis
BA [auth b]	Pharos: Q9H0H0	medulloblastoma ovarian carcinoma osteosarcoma ovarian cancer
CA [auth d]	Pharos: Q96HW7	prostate cancer large cell medulloblastoma medulloblastoma Prostatic Neoplasms osteosarcoma Sjogren syndrome
DA [auth e]	Pharos: Q6P9B9	psoriasis
FA [auth g]	Pharos: Q9NVH2	acute myeloid leukemia ductal breast carcinoma in situ hepatocellular carcinoma lung cancer osteosarcoma atypical teratoid rhabdoid tumor gastric cancer invasive ductal breast carcinoma medulloblastoma pituitary cancer breast cancer gastric carcinoma large cell medulloblastoma nasopharyngeal carcinoma psoriasis
GA [auth h]	Pharos: Q75QN2	intellectual disability lymphoplasmacytic lymphoma medulloblastoma type 2 diabetes mellitus invasive ductal breast carcinoma malignant mesothelioma non-alcoholic fatty liver disease lung cancer maturity-onset diabetes of the young ovarian cancer
HA [auth i]	Pharos: Q9NV88	astrocytic tumor medulloblastoma osteosarcoma
IA [auth j]	Pharos: Q9NVR2	heart disease non-alcoholic fatty liver disease metabolic syndrome X ovarian cancer myocardial infarction peripheral arterial disease
JA [auth k]	Pharos: Q5TA45	astrocytic tumor ulcerative colitis inflammatory bowel disease oligodendroglioma
KA [auth m]	Pharos: Q9NVM9	Chloracne glioblastoma lung cancer nasopharyngeal carcinoma ovarian cancer colorectal cancer Hodgkins lymphoma malignant colon neoplasm non-small cell lung carcinoma plasma cell myeloma dermatomyositis large cell medulloblastoma medulloblastoma osteosarcoma psoriasis
LA [auth n]	Pharos: Q96SY0	atypical teratoid rhabdoid tumor medulloblastoma glioblastoma large cell medulloblastoma
MA [auth o]	Pharos: Q96N11	asthma inflammatory bowel disease
NA [auth p]	Pharos: P30153	microcephaly-corpus callosum hypoplasia-intellectual disability-facial dysmorphism syndrome intellectual disability Disease Exacerbation gastric neoplasm osteoarthritis hereditary diffuse gastric adenocarcinoma osteoarthritis susceptibility 1 rheumatoid arthritis gastric cancer
OA [auth q]	Pharos: P67775	asthma heart disease systemic lupus erythematosus adenoma astrocytic tumor coronary artery disease hereditary spastic paraplegia lymphoplasmacytic lymphoma osteosarcoma psoriasis tuberculosis allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma asthma heart disease systemic lupus erythematosus adenoma astrocytic tumor coronary artery disease hereditary spastic paraplegia lymphoplasmacytic lymphoma osteosarcoma psoriasis tuberculosis allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant glioma ovarian cancer subependymal giant cell astrocytoma breast cancer lung adenocarcinoma myocardial ischemia plasma cell myeloma
QA [auth u]	Pharos: Q9H3P2	Wolf-Hirschhorn syndrome astrocytic tumor large cell medulloblastoma medulloblastoma atypical teratoid rhabdoid tumor lung cancer pilocytic astrocytoma glioblastoma malignant glioma primitive neuroectodermal tumor
RA [auth v]	Pharos: Q8WX92	endogenous depression ovarian cancer psoriasis
SA [auth w]	Pharos: Q8IXH7	colorectal cancer lung cancer diabetes mellitus ovarian cancer lung adenocarcinoma plasma cell myeloma
Z	Pharos: O00267	diabetes mellitus ovarian cancer
EA [auth f]	Pharos: Q9UL03	lung cancer ovarian cancer tuberculosis malignant mesothelioma Pick disease osteosarcoma sarcoidosis

Chains

Drug Target

Associated Disease

: Q6NXT2