8JS5 | pdb_00008js5

Dimeric PAS domains of oxygen sensor FixL with ferric unliganded heme

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8033723	3000471	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8033723	3000471	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8033723	3000471	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8033723	3000471	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8033723	3000471	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8033723	3000471	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8033723	3000471	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8033723	3000471	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8033723	3000471	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8033723	3000471	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF00989	PAS fold (PAS)	PAS fold	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ [5 ...	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ [5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Sensor protein FixL	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding molecular sensor activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups phosphorelay sensor kinase activity molecular function regulator activity catalytic activity cation binding metal ion binding molecular transducer activity histidine phosphotransfer kinase activity	cellular response to stimulus regulation of biological process phosphorelay signal transduction system regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication cellular process signal transduction RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process cellular response to stimulus regulation of biological process phosphorelay signal transduction system regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication cellular process signal transduction RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process ammonium ion metabolic process nitrogen cycle metabolic process nitrogen fixation	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR013767	PAS fold	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR000014	PAS domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR004358	Signal transduction histidine kinase-related protein, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR036097	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR053564	Sensor kinase FixL-like	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR003661	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR035965	PAS domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR001610	PAC motif	Repeat
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR003594	Histidine kinase/HSP90-like ATPase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR000700	PAS-associated, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR005467	Histidine kinase domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.