Annotations: 8EB1

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Unconventional myosin-Ih, Transcription activator BRG1 intragenic antimicrobial chimeric peptide	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity microfilament motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity histone binding hydrolase activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid transcription factor binding transcription coregulator binding DNA binding nucleic acid binding p53 binding nucleic acid conformation isomerase activity helicase activity chromatin binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding Tat protein binding RNA binding ATP-dependent chromatin remodeler activity nuclear receptor binding nuclear androgen receptor binding transcription corepressor activity nucleosome array spacer activity histone octamer slider activity DNA polymerase binding enzyme binding	localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular component organization or biogenesis supramolecular fiber organization localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization actin filament-based movement regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle regulation of mitotic cell cycle cell cycle regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition developmental process regulation of developmental process cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development regulation of myoblast differentiation myoblast differentiation positive regulation of cellular process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process transcription initiation at RNA polymerase II promoter regulation of biosynthetic process epigenetic regulation of gene expression primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of DNA-binding transcription factor activity regulation of primary metabolic process positive regulation of molecular function regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of molecular function regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of growth negative regulation of biological process growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth negative regulation of cellular process cellular component disassembly protein-containing complex organization protein-DNA complex disassembly protein-containing complex disassembly protein-DNA complex organization nucleosome disassembly nucleosome organization positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of miRNA metabolic process miRNA transcription regulation of miRNA metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of miRNA transcription cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling viral gene expression biological process involved in interspecies interaction between organisms viral process modulation of process of another organism viral transcription positive regulation by host of viral transcription host-mediated perturbation of symbiont process multicellular organism development multicellular organismal process nervous system development system development negative regulation of developmental process negative regulation of cell differentiation negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process sensory organ development eye development animal organ development retina development in camera-type eye visual system development neural retina development camera-type eye development sensory system development positive regulation of transcription by RNA polymerase II regulation of double-strand break repair regulation of cellular response to stress positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress DNA repair double-strand break repair DNA metabolic process positive regulation of double-strand break repair regulation of DNA repair positive regulation of DNA metabolic process DNA damage response regulation of DNA metabolic process regulation of stem cell population maintenance stem cell population maintenance positive regulation of stem cell population maintenance positive regulation of multicellular organismal process regulation of multicellular organismal process maintenance of cell number hexose mediated signaling homeostatic process regulation of glucose mediated signaling pathway response to monosaccharide response to carbohydrate positive regulation of glucose mediated signaling pathway carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose sugar mediated signaling pathway glucose mediated signaling pathway cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis chemical homeostasis response to glucose response to chemical glucose homeostasis carbohydrate mediated signaling cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis nucleotide-excision repair regulation of nucleotide-excision repair heterochromatin formation negative regulation of gene expression negative regulation of gene expression, epigenetic regulation of G0 to G1 transition G0 to G1 transition transcription preinitiation complex assembly RNA polymerase I preinitiation complex assembly cellular component biogenesis transcription initiation at RNA polymerase I promoter cellular component assembly transcription by RNA polymerase I protein-containing complex assembly protein-DNA complex assembly intracellular receptor signaling pathway response to lipid negative regulation of signaling negative regulation of intracellular signal transduction hormone-mediated signaling pathway intracellular signal transduction negative regulation of cell communication negative regulation of intracellular steroid hormone receptor signaling pathway cellular response to endogenous stimulus response to hormone regulation of intracellular signal transduction response to steroid hormone regulation of intracellular steroid hormone receptor signaling pathway androgen receptor signaling pathway nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus steroid hormone receptor signaling pathway cellular response to hormone stimulus negative regulation of response to stimulus response to endogenous stimulus negative regulation of signal transduction regulation of androgen receptor signaling pathway cellular response to lipid negative regulation of androgen receptor signaling pathway nuclear receptor-mediated signaling pathway regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle regulation of transcription of nucleolar large rRNA by RNA polymerase I rRNA transcription rRNA metabolic process positive regulation of transcription by RNA polymerase I regulation of transcription by RNA polymerase I nucleolar large rRNA transcription by RNA polymerase I positive regulation of transcription of nucleolar large rRNA by RNA polymerase I regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of cell activation T cell activation positive regulation of leukocyte activation T cell differentiation regulation of immune system process positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development regulation of leukocyte cell-cell adhesion leukocyte differentiation cell development positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of hemopoiesis regulation of cell-cell adhesion regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation immune system process regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cell projection actin-based cell projection microvillus plasma membrane bounded cell projection cell periphery plasma membrane intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cell projection actin-based cell projection microvillus plasma membrane bounded cell projection cell periphery plasma membrane membrane cytoplasm protein-containing complex myosin complex membrane-bounded organelle ATPase complex catalytic complex GBAF complex nucleus nuclear protein-containing complex chromatin chromosome intracellular membrane-bounded organelle SWI/SNF superfamily-type complex SWI/SNF complex nBAF complex npBAF complex extracellular region extracellular space membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear lumen nuclear matrix nucleolus RSC-type complex nucleoplasm bBAF complex chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome fibrillar center

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR001609	Myosin head, motor domain-like	Domain
A	IPR010926	Class I myosin tail homology domain	Domain
A	IPR036072	Class I myosin, motor domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR030100	SWI/SNF complex subunit BRG1, ATP-binding	Domain
A	IPR018359	Bromodomain, conserved site	Conserved Site
A	IPR049730	SNF2/RAD5-like, C-terminal helicase domain	Domain
A	IPR014978	Glutamine-Leucine-Glutamine, QLQ	Domain
A	IPR006576	BRK domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR037259	BRK domain superfamily	Homologous Superfamily
A	IPR001650	Helicase, C-terminal domain-like	Domain
A	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
A	IPR029295	Snf2, ATP coupling domain	Domain
A	IPR000330	SNF2, N-terminal	Domain
A	IPR001487	Bromodomain	Domain
A	IPR038718	SNF2-like, N-terminal domain superfamily	Homologous Superfamily
A	IPR014012	Helicase/SANT-associated domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P51532	congenital central hypoventilation syndrome psoriasis endogenous depression heart disease Coffin-Siris syndrome rhabdoid tumor predisposition syndrome 2 small cell lung carcinoma Burkitt lymphoma intellectual disability, autosomal dominant 16 sarcoma spindle cell sarcoma atypical teratoid rhabdoid tumor cocaine dependence intellectual disability Sezary syndrome congenital central hypoventilation syndrome psoriasis endogenous depression heart disease Coffin-Siris syndrome rhabdoid tumor predisposition syndrome 2 small cell lung carcinoma Burkitt lymphoma intellectual disability, autosomal dominant 16 sarcoma spindle cell sarcoma atypical teratoid rhabdoid tumor cocaine dependence intellectual disability Sezary syndrome lung cancer ovarian cancer small cell carcinoma cocaine abuse Precursor T-Cell Lymphoblastic Leukemia-Lymphoma invasive ductal breast carcinoma lung adenocarcinoma lymphoplasmacytic lymphoma abdominal aortic aneurysm medulloblastoma neoplasm of thorax osteosarcoma ovarian neoplasm congenital anomaly of kidney and urinary tract peripheral arterial disease ductal breast carcinoma in situ primitive neuroectodermal tumor rhabdoid tumor juvenile dermatomyositis thoracic cancer malignant colon neoplasm myocardial infarction carotid artery disease ovarian small cell carcinoma dermatomyositis plasma cell myeloma epithelioid sarcoma progressive supranuclear palsy large cell medulloblastoma spina bifida astrocytic tumor myopathy cancer non-small cell lung carcinoma ovarian carcinoma pancreatic ductal adenocarcinoma diabetes mellitus heart disease psoriasis