7R3Y
The crystal structure of the V426L variant of Pol2CORE in complex with DNA and an incoming nucleotide
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | KOG1798 | e7r3yA2 | A: beta barrels | X: OB-fold | H: Nucleic acid-binding proteins (From Topology) | T: Nucleic acid-binding proteins | F: KOG1798 | ECOD (1.6) |
A | POLBc_epsilon_2nd | e7r3yA4 | A: alpha bundles | X: thumb domain in bacteriophage RB69-like DNA polymerase I (From Topology) | H: thumb domain in bacteriophage RB69-like DNA polymerase I (From Topology) | T: thumb domain in bacteriophage RB69-like DNA polymerase I | F: POLBc_epsilon_2nd | ECOD (1.6) |
A | POLBc_epsilon_1st | e7r3yA1 | A: alpha bundles | X: fingers domain in bacteriophage RB69-like DNA polymerase I (From Topology) | H: fingers domain in bacteriophage RB69-like DNA polymerase I (From Topology) | T: fingers domain in bacteriophage RB69-like DNA polymerase I | F: POLBc_epsilon_1st | ECOD (1.6) |
A | DNA_pol_B_1st | e7r3yA3 | A: a+b two layers | X: Alpha-beta plaits | H: Adenylyl and guanylyl cyclase catalytic domain-like | T: Adenylyl and guanylyl cyclase catalytic domain-like | F: DNA_pol_B_1st | ECOD (1.6) |
A | DNA_pol_B_exo1_1st | e7r3yA6 | A: a+b two layers | X: Alpha-beta plaits | H: Family B DNA polymerase insertion domain (From Topology) | T: Family B DNA polymerase insertion domain | F: DNA_pol_B_exo1_1st | ECOD (1.6) |
A | DNA_pol_B_exo1_3rd | e7r3yA5 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: DNA_pol_B_exo1_3rd | ECOD (1.6) |
D [auth B] | KOG1798 | e7r3yB2 | A: beta barrels | X: OB-fold | H: Nucleic acid-binding proteins (From Topology) | T: Nucleic acid-binding proteins | F: KOG1798 | ECOD (1.6) |
D [auth B] | POLBc_epsilon_2nd | e7r3yB1 | A: alpha bundles | X: thumb domain in bacteriophage RB69-like DNA polymerase I (From Topology) | H: thumb domain in bacteriophage RB69-like DNA polymerase I (From Topology) | T: thumb domain in bacteriophage RB69-like DNA polymerase I | F: POLBc_epsilon_2nd | ECOD (1.6) |
D [auth B] | POLBc_epsilon_1st | e7r3yB4 | A: alpha bundles | X: fingers domain in bacteriophage RB69-like DNA polymerase I (From Topology) | H: fingers domain in bacteriophage RB69-like DNA polymerase I (From Topology) | T: fingers domain in bacteriophage RB69-like DNA polymerase I | F: POLBc_epsilon_1st | ECOD (1.6) |
D [auth B] | DNA_pol_B_1st | e7r3yB6 | A: a+b two layers | X: Alpha-beta plaits | H: Adenylyl and guanylyl cyclase catalytic domain-like | T: Adenylyl and guanylyl cyclase catalytic domain-like | F: DNA_pol_B_1st | ECOD (1.6) |
D [auth B] | DNA_pol_B_exo1_1st | e7r3yB5 | A: a+b two layers | X: Alpha-beta plaits | H: Family B DNA polymerase insertion domain (From Topology) | T: Family B DNA polymerase insertion domain | F: DNA_pol_B_exo1_1st | ECOD (1.6) |
D [auth B] | DNA_pol_B_exo1_3rd | e7r3yB3 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: DNA_pol_B_exo1_3rd | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, D [auth B] | PF22634 | DNA polymerase epsilon catalytic subunit A, thumb domain (POL2_thumb) | DNA polymerase epsilon catalytic subunit A, thumb domain | This entry represents the thumb domain of DNA polymerase epsilon catalytic subunit A from Saccharomyces cerevisiae (POL2), the catalytic component of this complex involved in chromosomal DNA replication. This domain, which makes contacts in the DNA m ... | Domain |
A, D [auth B] | PF03104 | DNA polymerase family B, exonuclease domain (DNA_pol_B_exo1) | DNA polymerase family B, exonuclease domain | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A, D [auth B] | IPR036397 | Ribonuclease H superfamily | Homologous Superfamily |
A, D [auth B] | IPR054475 | DNA polymerase-epsilon, zinc finger domain | Domain |
A, D [auth B] | IPR012337 | Ribonuclease H-like superfamily | Homologous Superfamily |
A, D [auth B] | IPR023211 | DNA polymerase, palm domain superfamily | Homologous Superfamily |
A, D [auth B] | IPR006172 | DNA-directed DNA polymerase, family B | Family |
A, D [auth B] | IPR029703 | DNA polymerase epsilon catalytic subunit | Family |
A, D [auth B] | IPR043502 | DNA/RNA polymerase superfamily | Homologous Superfamily |
A, D [auth B] | IPR013697 | DNA polymerase epsilon, catalytic subunit A, C-terminal | Domain |
A, D [auth B] | IPR006133 | DNA-directed DNA polymerase, family B, exonuclease domain | Domain |
A, D [auth B] | IPR042087 | DNA polymerase family B, thumb domain | Homologous Superfamily |
A, D [auth B] | IPR055191 | DNA polymerase epsilon ,catalytic subunit A, thumb domain | Domain |