7QWM | pdb_00007qwm

TMEM106B filaments with Fold III from Multiple system atrophy (case 17)

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Transmembrane protein 106B	ATPase binding protein binding binding enzyme binding	homeostatic process intracellular pH reduction regulation of intracellular pH cellular component organization lysosome organization vacuolar acidification lysosomal lumen acidification intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality monoatomic cation homeostasis homeostatic process intracellular pH reduction regulation of intracellular pH cellular component organization lysosome organization vacuolar acidification lysosomal lumen acidification intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality monoatomic cation homeostasis regulation of lysosomal lumen pH regulation of cellular pH intracellular monoatomic ion homeostasis vacuole organization lytic vacuole organization biological regulation organelle organization cellular homeostasis chemical homeostasis cellular process localization cellular localization transport establishment of localization in cell vacuolar transport intracellular transport lysosomal transport establishment of localization organelle localization lysosome localization vacuolar localization regulation of biological process regulation of cellular component organization regulation of cellular process regulation of vacuole organization regulation of organelle organization regulation of lysosome organization catabolic process protein catabolic process in the vacuole lysosomal protein catabolic process metabolic process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process regulation of neuron projection development multicellular organismal process positive regulation of cellular component organization regulation of developmental process cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation dendrite development positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization positive regulation of cellular process system development developmental process plasma membrane bounded cell projection organization regulation of cell projection organization positive regulation of dendrite development nervous system development generation of neurons regulation of dendrite development neuron development regulation of plasma membrane bounded cell projection organization plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron cellular homeostasis	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle cell periphery plasma membrane endosome membrane late endosome membrane cytoplasmic vesicle membrane vesicle membrane late endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR048511	Transmembrane protein 106, N-terminal	Domain
A, B, C	IPR009790	Transmembrane protein 106	Family
A, B, C	IPR048509	Transmembrane protein 106, C-terminal domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q9NUM4	amyotrophic lateral sclerosis leukodystrophy Frontotemporal Lobar Degeneration ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell myeloma Sjogren syndrome bipolar disorder frontotemporal dementia glioblastoma malignant ependymoma neurodegenerative disease pancreatic intraductal papillary-mucinous carcinoma Pick disease spina bifida amyotrophic lateral sclerosis leukodystrophy Frontotemporal Lobar Degeneration ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell myeloma Sjogren syndrome bipolar disorder frontotemporal dementia glioblastoma malignant ependymoma neurodegenerative disease pancreatic intraductal papillary-mucinous carcinoma Pick disease spina bifida anxiety disorder cystic fibrosis frontotemporal dementia and/or amyotrophic lateral sclerosis 1 Grn-related frontotemporal lobar degeneration with Tdp43 inclusions leukodystrophy, hypomyelinating, 16 malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma semantic dementia behavioral variant of frontotemporal dementia endogenous depression heart disease lung adenocarcinoma myopathy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.