Annotations: 7PED

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	DEP	e7pedB1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: DEP	ECOD (1.6)
B [auth A]	DEP	e7pedA1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: DEP	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF00610	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (DEP)	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	The DEP domain [1] is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell [2-3]. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) prot ...	The DEP domain [1] is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell [2-3]. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting [4-5]. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit [6-7].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	DEP domain-containing mTOR-interacting protein	enzyme regulator activity catalytic activity, acting on a protein kinase activity protein kinase activity enzyme inhibitor activity transferase activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity catalytic activity kinase inhibitor activity enzyme regulator activity catalytic activity, acting on a protein kinase activity protein kinase activity enzyme inhibitor activity transferase activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity catalytic activity kinase inhibitor activity kinase regulator activity ion binding binding anion binding phosphatidic acid binding phospholipid binding lipid binding small molecule binding protein serine/threonine kinase activity protein serine/threonine kinase inhibitor activity	regulation of cellular process regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process regulation of cellular process regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process phosphorus metabolic process protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process biological regulation negative regulation of molecular function primary metabolic process negative regulation of protein kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process cellular process metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process cellular response to stimulus response to stimulus negative regulation of TORC2 signaling signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction negative regulation of TOR signaling signal transduction TOR signaling regulation of signaling regulation of TOR signaling regulation of TORC2 signaling negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus TORC2 signaling regulation of cell communication negative regulation of TORC1 signaling regulation of TORC1 signaling TORC1 signaling regulation of programmed cell death extrinsic apoptotic signaling pathway cell surface receptor signaling pathway regulation of apoptotic process cell death regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of autophagy catabolic process autophagy positive regulation of biological process regulation of catabolic process regulation of autophagy positive regulation of catabolic process positive regulation of metabolic process process utilizing autophagic mechanism positive regulation of cellular process cellular component organization negative regulation of cell size regulation of cellular component size cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR000591	DEP domain	Domain
A [auth B], B [auth A]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR037336	DEP domain-containing mTOR-interacting protein, DEP domain 2	Domain
A [auth B], B [auth A]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR036034	PDZ superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR037335	DEP domain-containing mTOR-interacting protein, DEP domain 1	Domain
A [auth B], B [auth A]	IPR051832	Regulators of mTOR signaling and Rac activation	Family
A [auth B], B [auth A]	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A]	Pharos: Q8TB45	adenoma breast cancer idiopathic pulmonary fibrosis lung adenocarcinoma medulloblastoma ovarian cancer adrenal cortex carcinoma cystic fibrosis interstitial cystitis lung carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor Duchenne muscular dystrophy interstitial lung disease adenoma breast cancer idiopathic pulmonary fibrosis lung adenocarcinoma medulloblastoma ovarian cancer adrenal cortex carcinoma cystic fibrosis interstitial cystitis lung carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor Duchenne muscular dystrophy interstitial lung disease malignant mesothelioma osteosarcoma pituitary cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.