7NZB

Mutant V517L of the SH3 domain of JNK-interacting protein 1 (JIP1)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D [auth DDD]	SCOP2B Superfamily	SH3-domain	8106342	3000153	SCOP2B (2022-06-29)
H [auth HHH]	SCOP2B Superfamily	SH3-domain	8106342	3000153	SCOP2B (2022-06-29)
L [auth LLL]	SCOP2B Superfamily	SH3-domain	8106342	3000153	SCOP2B (2022-06-29)
A [auth AAA]	SCOP2B Superfamily	SH3-domain	8106342	3000153	SCOP2B (2022-06-29)
B [auth BBB]	SCOP2B Superfamily	SH3-domain	8106342	3000153	SCOP2B (2022-06-29)
C [auth CCC]	SCOP2B Superfamily	SH3-domain	8106342	3000153	SCOP2B (2022-06-29)
E [auth EEE]	SCOP2 Family	SH3-domain	8106341	4000369	SCOP2 (2022-06-29)
E [auth EEE]	SCOP2 Superfamily	SH3-domain	8106342	3000153	SCOP2 (2022-06-29)
F [auth FFF]	SCOP2B Superfamily	SH3-domain	8106342	3000153	SCOP2B (2022-06-29)
G [auth GGG]	SCOP2B Superfamily	SH3-domain	8106342	3000153	SCOP2B (2022-06-29)
I [auth III]	SCOP2B Superfamily	SH3-domain	8106342	3000153	SCOP2B (2022-06-29)
J [auth JJJ]	SCOP2B Superfamily	SH3-domain	8106342	3000153	SCOP2B (2022-06-29)
K [auth KKK]	SCOP2B Superfamily	SH3-domain	8106342	3000153	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth DDD]	SH3_1	e7nzbDDD1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
H [auth HHH]	SH3_1	e7nzbHHH1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
L [auth LLL]	SH3_1	e7nzbLLL1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
A [auth AAA]	SH3_1	e7nzbAAA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
B [auth BBB]	SH3_1	e7nzbBBB1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
C [auth CCC]	SH3_1	e7nzbCCC1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
E [auth EEE]	SH3_1	e7nzbEEE1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
F [auth FFF]	SH3_1	e7nzbFFF1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
G [auth GGG]	SH3_1	e7nzbGGG1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
I [auth III]	SH3_1	e7nzbIII1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
J [auth JJJ]	SH3_1	e7nzbJJJ1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
K [auth KKK]	SH3_1	e7nzbKKK1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], F [auth FFF], G [auth GGG], H [auth HHH], I [auth III], J [auth JJJ], K [auth KKK], L [auth LLL]	PF14604	Variant SH3 domain (SH3_9)	Variant SH3 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], F [auth FFF], G [auth GGG], H [auth HHH], I [auth III], J [auth JJJ], K [auth KKK], L [auth LLL]	SH3 domain of JNK-interacting protein 1 (JIP1)	JUN kinase binding protein binding binding kinase binding enzyme binding protein kinase binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity JUN kinase binding protein binding binding kinase binding enzyme binding protein kinase binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity cytoskeletal protein binding kinesin binding MAP-kinase scaffold activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity	cellular response to stimulus regulation of cellular process response to stimulus regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of signal transduction regulation of transferase activity regulation of MAP kinase activity intracellular signal transduction regulation of primary metabolic process cell communication negative regulation of kinase activity negative regulation of transferase activity negative regulation of JNK cascade cellular response to stimulus regulation of cellular process response to stimulus regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of signal transduction regulation of transferase activity regulation of MAP kinase activity intracellular signal transduction regulation of primary metabolic process cell communication negative regulation of kinase activity negative regulation of transferase activity negative regulation of JNK cascade regulation of phosphate metabolic process JNK cascade phosphate-containing compound metabolic process intracellular signaling cassette negative regulation of protein modification process signal transduction phosphorus metabolic process protein modification process negative regulation of protein metabolic process regulation of biological process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process regulation of JNK cascade primary metabolic process regulation of MAPK cascade regulation of molecular function regulation of kinase activity regulation of response to stimulus negative regulation of protein phosphorylation regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphate metabolic process negative regulation of cell communication regulation of intracellular signal transduction negative regulation of protein serine/threonine kinase activity negative regulation of cellular process protein metabolic process negative regulation of JUN kinase activity negative regulation of macromolecule metabolic process regulation of signaling negative regulation of response to stimulus biological regulation negative regulation of molecular function negative regulation of MAP kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of protein kinase activity negative regulation of signal transduction negative regulation of phosphorus metabolic process regulation of JUN kinase activity MAPK cascade regulation of cell communication regulation of phosphorylation cellular process negative regulation of phosphorylation negative regulation of MAPK cascade regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of intrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process positive regulation of response to stimulus positive regulation of JNK cascade positive regulation of cellular process positive regulation of MAPK cascade positive regulation of intracellular signal transduction positive regulation of signaling RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription localization transport establishment of localization vesicle-mediated transport multicellular organismal process CD8-positive, alpha-beta T cell activation regulation of alpha-beta T cell activation regulation of leukocyte activation CD8-positive, alpha-beta T cell proliferation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation regulation of alpha-beta T cell proliferation T cell activation alpha-beta T cell proliferation lymphocyte proliferation alpha-beta T cell activation regulation of multicellular organismal process regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of CD8-positive, alpha-beta T cell proliferation cell population proliferation cell activation regulation of T cell activation regulation of T cell proliferation immune system process mononuclear cell proliferation regulation of cell population proliferation regulation of mononuclear cell proliferation regulation of CD8-positive, alpha-beta T cell activation regulation of lymphocyte activation	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane cytosol membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane cytosol cell periphery plasma membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane synapse cell junction perinuclear region of cytoplasm cell body neuronal cell body axon dentate gyrus mossy fiber hippocampal mossy fiber nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], F [auth FFF], G [auth GGG], H [auth HHH], I [auth III], J [auth JJJ], K [auth KKK], L [auth LLL]	IPR035638	JIP1, SH3 domain	Domain
A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], F [auth FFF], G [auth GGG], H [auth HHH], I [auth III], J [auth JJJ], K [auth KKK], L [auth LLL]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], F [auth FFF], G [auth GGG], H [auth HHH], I [auth III], J [auth JJJ], K [auth KKK], L [auth LLL]	IPR011993	PH-like domain superfamily	Homologous Superfamily
A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], F [auth FFF], G [auth GGG], H [auth HHH], I [auth III], J [auth JJJ], K [auth KKK], L [auth LLL]	IPR047178	JNK-interacting protein 1	Family
A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], F [auth FFF], G [auth GGG], H [auth HHH], I [auth III], J [auth JJJ], K [auth KKK], L [auth LLL]	IPR006020	PTB/PI domain	Domain
A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], F [auth FFF], G [auth GGG], H [auth HHH], I [auth III], J [auth JJJ], K [auth KKK], L [auth LLL]	IPR001452	SH3 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], A [auth AAA], B [auth BBB], C [auth CCC], D [auth DDD], E [auth EEE], F [auth FFF], G [auth GGG], H [auth HHH], I [auth III], J [auth JJJ], K [auth KKK], L [auth LLL]	Pharos: Q9UQF2	type 2 diabetes mellitus acquired metabolic disease diabetes mellitus INSULIN RESISTANCE, SUSCEPTIBILITY TO maturity-onset diabetes of the young attention deficit hyperactivity disorder, inattentive type lung carcinoma oligodendroglioma vascular disease cervical cancer malignant glioma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.