7N0A

Structure of Human Leukaemia Inhibitory Factor with Fab MSC1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
SAbDab Antibody Annotation
Thera-SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth C]	SCOP2B Superfamily	4-helical cytokines	8039173	3001717	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	LIF_OSM	e7n0aC1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: LIF_OSM	ECOD (1.6)
B [auth A]	C1-set_4	e7n0aA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
B [auth A]	V-set	e7n0aA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
C [auth B]	V-set_8	e7n0aB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
C [auth B]	C1-set_1	e7n0aB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth A]	Light Chain	IGKV2	Kappa	leukemia inhibitory factor	SAbDab (2024-12-20)
C [auth B]	Heavy Chain	IGHV3	-	leukemia inhibitory factor	SAbDab (2024-12-20)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

Chain	Name	Target	Provenance Source
B [auth A]	Falbikitug	LIF	Therapeutic SAbDab (2024-12-20)
C [auth B]	Falbikitug	LIF	Therapeutic SAbDab (2024-12-20)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C]	PF01291	LIF / OSM family (LIF_OSM)	LIF / OSM family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	Leukemia inhibitory factor	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity cytokine activity cytokine receptor binding leukemia inhibitory factor receptor binding	regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process cellular response to stimulus cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction developmental process cell differentiation involved in embryonic placenta development multicellular organismal process cellular developmental process placenta development reproductive process chordate embryonic development animal organ development developmental process involved in reproduction embryo development tissue development in utero embryonic development spongiotrophoblast differentiation multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching cell differentiation anatomical structure development spongiotrophoblast layer development embryonic organ development positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process regulation of signaling negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade leukemia inhibitory factor signaling pathway enzyme-linked receptor protein signaling pathway fibroblast proliferation cell population proliferation muscle structure development anatomical structure morphogenesis animal organ morphogenesis muscle organ development muscle organ morphogenesis cell morphogenesis response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus sexual reproduction organelle fission meiotic cell cycle meiotic cell cycle process cellular component organization nuclear division organelle organization meiotic nuclear division cellular component organization or biogenesis cell cycle cell cycle process kidney epithelium development renal vesicle morphogenesis regulation of cell differentiation epithelial cell differentiation regulation of epithelial cell differentiation positive regulation of developmental process metanephros development metanephros morphogenesis regulation of epithelial cell differentiation involved in kidney development nephron development system development epithelium development positive regulation of epithelial cell differentiation regulation of developmental process nephron morphogenesis nephron epithelium morphogenesis regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric renal vesicle morphogenesis renal vesicle development renal system development positive regulation of epithelial cell differentiation involved in kidney development positive regulation of cell differentiation positive regulation of morphogenesis of an epithelium regulation of morphogenesis of an epithelium regulation of multicellular organismal process metanephric nephron development regulation of anatomical structure morphogenesis mesenchymal to epithelial transition involved in metanephros morphogenesis epithelial cell differentiation involved in kidney development nephron epithelium development regulation of multicellular organismal development morphogenesis of an epithelium mesenchymal to epithelial transition positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric nephron morphogenesis cell differentiation involved in metanephros development tissue morphogenesis kidney morphogenesis cell differentiation involved in kidney development kidney development myeloid leukocyte differentiation regulation of leukocyte differentiation cell development mononuclear cell differentiation regulation of cell development positive regulation of hemopoiesis regulation of immune system process regulation of macrophage differentiation positive regulation of immune system process hemopoiesis regulation of myeloid cell differentiation positive regulation of cell development macrophage differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation positive regulation of macrophage differentiation myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of multicellular organismal process positive regulation of leukocyte differentiation leukocyte differentiation somatic stem cell population maintenance maintenance of cell number stem cell population maintenance positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription tube development lung lobe morphogenesis respiratory tube development lung lobe development lung development respiratory system development lung morphogenesis immune response positive regulation of cell communication positive regulation of signal transduction positive regulation of receptor signaling pathway via STAT positive regulation of response to stimulus regulation of receptor signaling pathway via STAT positive regulation of signaling positive regulation of cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation metanephric nephron tubule epithelial cell differentiation metanephric epithelium development nephron tubule development renal tubule development regulation of nephron tubule epithelial cell differentiation regulation of metanephric nephron tubule epithelial cell differentiation metanephric nephron epithelium development metanephric nephron tubule development nephron tubule epithelial cell differentiation metanephric tubule development regulation of localization regulation of hormone secretion transport negative regulation of transport hormone secretion localization negative regulation of secretion regulation of secretion by cell secretion by cell signal release negative regulation of hormone secretion negative regulation of secretion by cell regulation of biological quality regulation of transport secretion regulation of hormone levels export from cell cell-cell signaling establishment of localization regulation of secretion hormone transport trophoblast giant cell differentiation multi-multicellular organism process female pregnancy embryo implantation multi-organism reproductive process positive regulation of cell adhesion mediated by integrin positive regulation of cell adhesion regulation of cell adhesion mediated by integrin regulation of cell adhesion cell adhesion cell adhesion mediated by integrin positive regulation of MAPK cascade positive regulation of intracellular signal transduction blood vessel remodeling tissue remodeling negative regulation of cell population proliferation maternal process involved in female pregnancy multicellular organismal reproductive process maternal placenta development decidualization regulation of cellular component organization regulation of reproductive process negative regulation of cell cycle regulation of cell cycle negative regulation of meiotic nuclear division regulation of meiotic cell cycle negative regulation of cellular component organization regulation of cell cycle process negative regulation of cell cycle process regulation of organelle organization regulation of meiotic nuclear division negative regulation of nuclear division negative regulation of organelle organization negative regulation of reproductive process regulation of nuclear division negative regulation of meiotic cell cycle stem cell differentiation vasculature development circulatory system development lung vasculature development nervous system development generation of neurons neurogenesis neuron differentiation neuron development lung alveolus development positive regulation of nervous system development astrocyte differentiation regulation of neurogenesis regulation of gliogenesis regulation of astrocyte differentiation positive regulation of gliogenesis regulation of nervous system development gliogenesis positive regulation of neurogenesis positive regulation of astrocyte differentiation regulation of glial cell differentiation positive regulation of glial cell differentiation central nervous system development glial cell differentiation peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol extracellular region extracellular space
B [auth A]	MSC-1 Fab Light chain	-	-	-
C [auth B]	MSC-1 Fab Heavy chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR001581	Leukemia inhibitory factor /oncostatin	Family
A [auth C]	IPR019827	Leukemia inhibitory factor /oncostatin, conserved site	Conserved Site
A [auth C]	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily
A [auth C]	IPR003624	Leukemia inhibitory factor	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C]	Pharos: P15018	polycystic ovary syndrome Cardiomegaly female infertility non-alcoholic fatty liver disease malignant ependymoma malignant pancreatic neoplasm pilocytic astrocytoma psoriasis sinusitis subependymal giant cell astrocytoma depressive disorder glioblastoma interstitial cystitis malignant glioma pancreatic ductal adenocarcinoma polycystic ovary syndrome Cardiomegaly female infertility non-alcoholic fatty liver disease malignant ependymoma malignant pancreatic neoplasm pilocytic astrocytoma psoriasis sinusitis subependymal giant cell astrocytoma depressive disorder glioblastoma interstitial cystitis malignant glioma pancreatic ductal adenocarcinoma pituitary cancer rheumatoid arthritis breast cancer Crohn disease heart disease lung cancer malignant mesothelioma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor delirium IgA glomerulonephritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.