Annotations: 7KIL

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16876	Lipin/Ned1/Smp2 multi-domain protein middle domain (Lipin_mid)	Lipin/Ned1/Smp2 multi-domain protein middle domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Isoform 2 of Phosphatidate phosphatase LPIN1	protein binding binding signaling receptor binding peroxisome proliferator activated receptor binding histone deacetylase binding enzyme binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding signaling receptor binding peroxisome proliferator activated receptor binding histone deacetylase binding enzyme binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds lipid phosphatase activity phosphatase activity hydrolase activity phosphatidate phosphatase activity catalytic activity	phosphatidic acid metabolic process glycerophospholipid metabolic process primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process glycerolipid metabolic process metabolic process cellular process phosphorus metabolic process lipid metabolic process neutral lipid metabolic process triglyceride metabolic process triglyceride mobilization phosphatidic acid metabolic process glycerophospholipid metabolic process primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process glycerolipid metabolic process metabolic process cellular process phosphorus metabolic process lipid metabolic process neutral lipid metabolic process triglyceride metabolic process triglyceride mobilization acylglycerol metabolic process response to stimulus immune response immune system process fatty acid metabolic process lipid catabolic process catabolic process oxoacid metabolic process carboxylic acid metabolic process organic acid metabolic process organic acid catabolic process fatty acid catabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process small molecule metabolic process monocarboxylic acid metabolic process small molecule catabolic process cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization neutral lipid biosynthetic process lipid biosynthetic process acylglycerol biosynthetic process biosynthetic process glycerolipid biosynthetic process triglyceride biosynthetic process multicellular organismal process regulation of biological process regulation of cellular process homeostatic process biological regulation positive regulation of biological process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of metabolic process positive regulation of cellular process phosphatidylethanolamine metabolic process developmental process fat cell differentiation regulation of developmental process cellular developmental process regulation of cell differentiation cell differentiation regulation of fat cell differentiation plasma membrane bounded cell projection organization ruffle organization cell projection organization cellular response to stimulus cellular response to nitrogen compound response to endogenous stimulus response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical response to insulin cellular response to insulin stimulus cellular response to hormone stimulus negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription negative regulation of RNA metabolic process organelle fission mitochondrial fission mitochondrion organization positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope organelle membrane cytoplasm membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope organelle membrane cytoplasm cytosol protein-containing complex transcription regulator complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane mitochondrial membrane mitochondrion organelle outer membrane bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR031315	LNS2/PITP	Domain
A, B	IPR007651	Lipin, N-terminal	Domain
A, B	IPR026058	LIPIN family	Family
A, B	IPR013209	Lipin/Ned1/Smp2 (LNS2)	Domain
A, B	IPR031703	Lipin, middle domain	Domain
A, B	IPR036412	HAD-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.