7EJ2 | pdb_00007ej2

human voltage-gated potassium channel KV1.3 H451N mutant

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	POZ domain	8067483	3000894	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	POZ domain	8067483	3000894	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	POZ domain	8067483	3000894	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	POZ domain	8067483	3000894	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aldo_ket_red	e7ej2A1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
C	Aldo_ket_red	e7ej2C1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
E	Aldo_ket_red	e7ej2E1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
G	Aldo_ket_red	e7ej2G1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
B	Ion_trans	e7ej2B2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
B	BTB_2	e7ej2B3	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: BTB_2	ECOD (1.6)
D	Ion_trans	e7ej2D2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
D	BTB_2	e7ej2D3	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: BTB_2	ECOD (1.6)
F	Ion_trans	e7ej2F2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
F	BTB_2	e7ej2F1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: BTB_2	ECOD (1.6)
H	Ion_trans	e7ej2H2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
H	BTB_2	e7ej2H3	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: BTB_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF00248	Aldo/keto reductase family (Aldo_ket_red)	Aldo/keto reductase family	This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2].	Domain
B, D, F, H	PF07885	Ion channel (Ion_trans_2)	Ion channel	-	Family
B, D, F, H	PF02214	BTB/POZ domain (BTB_2)	BTB/POZ domain	In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels [1]. In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor [2]. It also mediates homo ...	In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels [1]. In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor [2]. It also mediates homomultimerisation of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha [2-3].	Domain
B, D, F, H	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Voltage-gated potassium channel subunit beta-2	methylglyoxal reductase (NADPH) (acetol producing) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity methylglyoxal reductase (NADPH) (acetol producing) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity protein binding binding transmembrane transporter binding aldo-keto reductase (NADPH) activity alcohol dehydrogenase [NAD(P)+] activity channel regulator activity ion channel regulator activity potassium channel regulator activity molecular function regulator activity transporter regulator activity	protein localization regulation of localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization biological regulation localization protein localization to cell surface regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to cell surface cellular process protein localization regulation of localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization biological regulation localization protein localization to cell surface regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to cell surface cellular process regulation of action potential action potential regulation of biological quality regulation of membrane potential regulation of potassium ion transport transport monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport metal ion transport monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of transport regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport	membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane axon cell projection main axon juxtaparanode region of axon neuron projection plasma membrane bounded cell projection specific granule membrane specific granule cytosol cell periphery plasma membrane voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex potassium channel complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex cytoskeleton membraneless organelle intracellular membraneless organelle synapse cell junction pinceau fiber cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane
B, D, F, H	Potassium voltage-gated channel subfamily A member 3	monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity delayed rectifier potassium channel activity outward rectifier potassium channel activity	developmental process corpus callosum development multicellular organismal process head development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development anatomical structure development telencephalon development system development nerve development developmental process corpus callosum development multicellular organismal process head development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development anatomical structure development telencephalon development system development nerve development cranial nerve development optic nerve development transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport biological regulation action potential regulation of biological quality regulation of membrane potential cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane presynapse presynaptic membrane membrane microdomain membrane raft cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane presynapse presynaptic membrane membrane microdomain membrane raft glutamatergic synapse voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex potassium channel complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex axon neuron projection axon terminus plasma membrane bounded cell projection cell projection distal axon calyx of Held neuron projection terminus intracellular anatomical structure perinuclear region of cytoplasm cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR005399	Potassium channel, voltage-dependent, beta subunit, KCNAB-related	Family
A, C, E, G	IPR036812	NADP-dependent oxidoreductase domain superfamily	Homologous Superfamily
A, C, E, G	IPR005401	Potassium channel, voltage-dependent, beta subunit, KCNAB2	Family
A, C, E, G	IPR023210	NADP-dependent oxidoreductase domain	Domain
A, C, E, G	IPR005983	Potassium channel, voltage-dependent, beta subunit, KCNAB	Family
B, D, F, H	IPR003972	Potassium channel, voltage dependent, Kv1	Family
B, D, F, H	IPR004050	Potassium channel, voltage dependent, Kv1.3	Family
B, D, F, H	IPR028325	Voltage-gated potassium channel	Family
B, D, F, H	IPR000210	BTB/POZ domain	Domain
B, D, F, H	IPR003968	Potassium channel, voltage dependent, Kv	Family
B, D, F, H	IPR005821	Ion transport domain	Domain
B, D, F, H	IPR003131	Potassium channel tetramerisation-type BTB domain	Domain
B, D, F, H	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily
B, D, F, H	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G	Pharos: Q13303	chromosome 1p36 deletion syndrome epilepsy pilocytic astrocytoma acute myeloid leukemia Aura interstitial cystitis malignant ependymoma medulloblastoma osteosarcoma primitive neuroectodermal tumor astrocytic tumor large cell medulloblastoma malignant glioma non-small cell lung carcinoma Pick disease chromosome 1p36 deletion syndrome epilepsy pilocytic astrocytoma acute myeloid leukemia Aura interstitial cystitis malignant ependymoma medulloblastoma osteosarcoma primitive neuroectodermal tumor astrocytic tumor large cell medulloblastoma malignant glioma non-small cell lung carcinoma Pick disease atypical teratoid rhabdoid tumor glioblastoma lung cancer malignant mesothelioma oligodendroglioma
B, D, F, H	Pharos: P22001	interstitial cystitis lung carcinoma Lambert-Eaton myasthenic syndrome multiple sclerosis lung cancer pituitary cancer

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	KvAP voltage-regulated K channels

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F, G, H	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Potassium, Sodium, & Proton Ion-Selective	K_v1.3 lymphocyte Voltage-gated potassium Channel

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.