7DF6

Mouse Galectin-3 CRD in complex with novel tetrahydropyran-based thiodisaccharide mimic inhibitor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d7df6a_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Galectin (animal S-lectin)	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d7df6b_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Galectin (animal S-lectin)	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Galectin (animal S-lectin)	8103379	4002674	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Concanavalin A-like lectins/glucanases	8103380	3000120	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8103380	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Gal-bind_lectin	e7df6A1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Gal-bind_lectin	ECOD (1.6)
B	Gal-bind_lectin	e7df6B1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Gal-bind_lectin	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00337	Galactoside-binding lectin (Gal-bind_lectin)	Galactoside-binding lectin	This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (Swiss:Q05315, EC:3.1.1.5).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Galectin-3	IgE binding protein-containing complex binding binding immunoglobulin binding carbohydrate binding	developmental process cellular developmental process cell differentiation cellular process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development cellular component organization extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization developmental process cellular developmental process cell differentiation cellular process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development cellular component organization extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process metabolic process macromolecule metabolic process RNA processing RNA splicing cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process signaling negative regulation of signaling positive regulation of biological process negative regulation of biological process regulation of signal transduction regulation of antigen receptor-mediated signaling pathway negative regulation of antigen receptor-mediated signaling pathway negative regulation of cell communication cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response negative regulation of cellular process regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process regulation of signaling cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway negative regulation of response to stimulus biological regulation regulation of T cell receptor signaling pathway T cell receptor signaling pathway negative regulation of signal transduction negative regulation of T cell receptor signaling pathway regulation of response to stimulus negative regulation of immune system process regulation of immune response regulation of cell communication antigen receptor-mediated signaling pathway activation of immune response immunological synapse formation negative regulation of immunological synapse formation regulation of immunological synapse formation regulation of leukocyte activation regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation leukocyte activation regulation of multicellular organismal process cell recognition cell-cell recognition cell activation negative regulation of cell activation negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of lymphocyte activation regulation of localization import into cell regulation of cellular component organization negative regulation of cellular component organization regulation of transport transport negative regulation of transport negative regulation of endocytosis regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport localization endocytosis regulation of endocytosis regulation of immune effector process cell activation involved in immune response negative regulation of cell adhesion T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell T cell activation negative regulation of immune response negative regulation of immune effector process immune effector process negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell adhesion cell-cell adhesion T cell activation involved in immune response leukocyte activation involved in immune response regulation of cell-cell adhesion lymphocyte activation involved in immune response regulation of cell adhesion regulation of T cell activation regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	cell periphery cellular anatomical structure plasma membrane membrane cornified envelope cell surface external side of plasma membrane side of membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix glial cell projection cell projection plasma membrane bounded cell projection cell periphery cellular anatomical structure plasma membrane membrane cornified envelope cell surface external side of plasma membrane side of membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix glial cell projection cell projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm immunological synapse extracellular region membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR044156	Galectin-like	Family
A, B	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B	IPR001079	Galectin, carbohydrate recognition domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.