Annotations: 7B2I

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth C]	SCOP2B Superfamily	tRNA-guanine transglycosylase	8094427	3000635	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth C]	TGT	e7b2iC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TGT	ECOD (1.6)
A	TGT	e7b2iA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TGT	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth C]	PF01702	Queuine tRNA-ribosyltransferase (TGT)	Queuine tRNA-ribosyltransferase	-	Family
A	PF01702	Queuine tRNA-ribosyltransferase (TGT)	Queuine tRNA-ribosyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth C]	Queuine tRNA-ribosyltransferase catalytic subunit 1	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity protein heterodimerization activity pentosyltransferase activity glycosyltransferase activity catalytic activity, acting on RNA tRNA-guanosine(34) queuine transglycosylase activity catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA transferase activity catalytic activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity protein heterodimerization activity pentosyltransferase activity glycosyltransferase activity catalytic activity, acting on RNA tRNA-guanosine(34) queuine transglycosylase activity catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA transferase activity catalytic activity cation binding ion binding metal ion binding small molecule binding	tRNA modification RNA metabolic process tRNA-guanine transglycosylation primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA processing tRNA modification RNA metabolic process tRNA-guanine transglycosylation primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA processing macromolecule modification metabolic process cellular process macromolecule metabolic process RNA processing	protein-containing complex tRNA-guanine transglycosylase complex catalytic complex transferase complex cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle mitochondrial membrane mitochondrion cytoplasmic side of membrane membrane organelle outer membrane cytoplasmic side of mitochondrial outer membrane protein-containing complex tRNA-guanine transglycosylase complex catalytic complex transferase complex cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle mitochondrial membrane mitochondrion cytoplasmic side of membrane membrane organelle outer membrane cytoplasmic side of mitochondrial outer membrane intracellular membrane-bounded organelle side of membrane intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane nucleus
A	Queuine tRNA-ribosyltransferase accessory subunit 2	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity protein heterodimerization activity pentosyltransferase activity glycosyltransferase activity catalytic activity, acting on RNA tRNA-guanosine(34) queuine transglycosylase activity catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA transferase activity catalytic activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity protein heterodimerization activity pentosyltransferase activity glycosyltransferase activity catalytic activity, acting on RNA tRNA-guanosine(34) queuine transglycosylase activity catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA transferase activity catalytic activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding RNA binding organic cyclic compound binding tRNA binding nucleic acid binding	tRNA modification RNA metabolic process tRNA-guanine transglycosylation primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA processing tRNA modification RNA metabolic process tRNA-guanine transglycosylation primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA processing macromolecule modification metabolic process cellular process macromolecule metabolic process RNA processing	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane cytoplasmic side of membrane membrane organelle outer membrane cytoplasmic side of mitochondrial outer membrane side of membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane cytoplasmic side of membrane membrane organelle outer membrane cytoplasmic side of mitochondrial outer membrane side of membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth C]	IPR036511	Queuine tRNA-ribosyltransferase-like	Homologous Superfamily
B [auth C]	IPR004803	tRNA-guanine transglycosylase	Family
B [auth C]	IPR002616	tRNA-guanine(15) transglycosylase-like	Domain
A	IPR050852	Queuine tRNA-ribosyltransferase	Family
A	IPR028592	Queuine tRNA-ribosyltransferase accessory subunit QTRTD1	Family
A	IPR036511	Queuine tRNA-ribosyltransferase-like	Homologous Superfamily
A	IPR002616	tRNA-guanine(15) transglycosylase-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.