7A0W

Structure of dimeric sodium proton antiporter NhaA, at pH 8.5, crystallized with chimeric Fab antibodies

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Na_H_antiport_1	e7a0wB1	A: alpha complex topology	X: Cation-proton antiporter	H: Cation-proton antiporter (CPA) (From Topology)	T: Cation-proton antiporter (CPA)	F: Na_H_antiport_1	ECOD (1.6)
A	Na_H_antiport_1	e7a0wA1	A: alpha complex topology	X: Cation-proton antiporter	H: Cation-proton antiporter (CPA) (From Topology)	T: Cation-proton antiporter (CPA)	F: Na_H_antiport_1	ECOD (1.6)
C	C1-set_1	e7a0wC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
C	V-set_12	e7a0wC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
E	C1-set_1	e7a0wE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
E	V-set_12	e7a0wE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
D	C1-set_4	e7a0wD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
D	V-set_3	e7a0wD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
F	C1-set_4	e7a0wF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
F	V-set_3	e7a0wF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Na(+)/H(+) antiporter NhaA	monoatomic cation transmembrane transporter activity metal cation:monoatomic cation antiporter activity proton transmembrane transporter activity sodium:proton antiporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity metal cation:proton antiporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity monoatomic cation transmembrane transporter activity metal cation:monoatomic cation antiporter activity proton transmembrane transporter activity sodium:proton antiporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity metal cation:proton antiporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity	chemical homeostasis homeostatic process regulation of pH biological regulation monoatomic ion homeostasis monoatomic cation homeostasis	cell periphery cellular anatomical structure plasma membrane membrane
C, E	chimeric antibody Fab-F6, heavy chain,chimeric antibody Fab-F6, heavy chain	-	-	-
D, F	chimeric antibody Fab-F6, light chain,chimeric antibody Fab-F6, light chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004670	Na+/H+ antiporter NhaA	Family
A, B	IPR023171	Na+/H+ antiporter domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Monovalent cation-proton antiporter	Sodium-proton antiporter NhaA

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.