6EA3 | pdb_00006ea3

Thermobifida fusca FscH adenylation domain complexed with MbtH-like protein FscK and Ser-AMP

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6ea3a_	Alpha and beta proteins (a+b)	MbtH/L9 domain-like	MbtH-like	automated matches	automated matches	(Thermobifida fusca YX ) [TaxId: 269800 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	MbtH-like	8095436	4002237	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	MbtH-like	8095437	3000984	SCOP2 (2022-06-29)
B	SCOP2 Family	AMP-binding enzyme-like	8099447	4002922	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	AMP-binding enzyme-like	8099448	3001902	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MbtH	e6ea3A1	A: a+b two layers	X: L9 N-domain-like	H: MbtH-like (From Topology)	T: MbtH-like	F: MbtH	ECOD (1.6)
B	AMP-binding_3rd	e6ea3B3	A: beta barrels	X: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)	H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)	T: beta-barrel domain in acetyl-CoA synthetase-like proteins	F: AMP-binding_3rd	ECOD (1.6)
B	AMP-binding_1st	e6ea3B1	A: a/b three-layered sandwiches	X: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)	H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)	T: Rossmann-like domain in Acetyl-CoA synthetase-like proteins	F: AMP-binding_1st	ECOD (1.6)
B	AMP-binding_2nd	e6ea3B2	A: a/b three-layered sandwiches	X: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)	H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)	T: Rossmann-like domain in Acetyl-CoA synthetase-like proteins	F: AMP-binding_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.820.10	Alpha Beta	Alpha-Beta Complex	Rubredoxin-like	Structural Genomics, Unknown Function 30-nov-00 1gh9 Mol_id	CATH (utative)
B	3.40.50.12780	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	ANL, N-terminal domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00501	AMP-binding enzyme (AMP-binding)	AMP-binding enzyme	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	MbtH-like protein	-	siderophore biosynthetic process peptide biosynthetic process biosynthetic process secondary metabolite biosynthetic process siderophore metabolic process metabolic process cellular process nonribosomal peptide biosynthetic process peptide metabolic process secondary metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol
B	adenylation domain of Fuscachelin synthetase component H	vitamin binding amide binding modified amino acid binding binding phosphopantetheine binding small molecule binding catalytic activity	secondary metabolite biosynthetic process biosynthetic process metabolic process cellular process secondary metabolic process lipid biosynthetic process primary metabolic process lipid metabolic process amino acid activation peptide biosynthetic process amino acid activation for nonribosomal peptide biosynthetic process amino acid metabolic process nonribosomal peptide biosynthetic process peptide metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038020	MbtH-like domain superfamily	Homologous Superfamily
A	IPR037407	MbtH-like protein	Family
A	IPR005153	MbtH-like domain	Domain
B	IPR006162	Phosphopantetheine attachment site	PTM
B	IPR009081	Phosphopantetheine binding ACP domain	Domain
B	IPR020806	Polyketide synthase-like, phosphopantetheine-binding domain	Domain
B	IPR010071	Amino acid adenylation domain	Domain
B	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
B	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily	Homologous Superfamily
B	IPR045851	AMP-binding enzyme, C-terminal domain superfamily	Homologous Superfamily
B	IPR001242	Condensation domain	Domain
B	IPR036736	ACP-like superfamily	Homologous Superfamily
B	IPR025110	AMP-binding enzyme, C-terminal domain	Domain
B	IPR000873	AMP-dependent synthetase/ligase domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.