6XA9

SARS CoV-2 PLpro in complex with ISG15 C-terminal domain propargylamide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6xa9a2	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like viral protease catalytic domain	automated matches	2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ],	SCOPe (2.08)
A	d6xa9a1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Ubiquitin-like	automated matches	automated matches	2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ],	SCOPe (2.08)
C	d6xa9c2	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like viral protease catalytic domain	automated matches	2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ],	SCOPe (2.08)
C	d6xa9c1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Ubiquitin-like	automated matches	automated matches	2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ],	SCOPe (2.08)
E	d6xa9e2	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like viral protease catalytic domain	automated matches	2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ],	SCOPe (2.08)
E	d6xa9e1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Ubiquitin-like	automated matches	automated matches	2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ],	SCOPe (2.08)
B	d6xa9b_	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Ubiquitin-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6xa9d_	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Ubiquitin-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d6xa9f_	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Ubiquitin-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cysteine proteinases	8092567	3001808	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ubiquitin-like	8092569	3000157	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Cysteine proteinases	8092567	3001808	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PLpro Zn-binding domain-like	8092568	3002538	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PLpro Zn-binding domain-like	8092568	3002538	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cysteine proteinases	8092567	3001808	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ubiquitin-like	8092569	3000157	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cysteine proteinases	8092567	3001808	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ubiquitin-like	8092569	3000157	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PLpro Zn-binding domain-like	8092568	3002538	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Cysteine proteinases	8092567	3001808	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Cysteine proteinases	8092567	3001808	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ubiquitin-like	8035116	3000157	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ubiquitin-like	8035116	3000157	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Ubiquitin-like	8035116	3000157	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Viral_protease_N	e6xa9A2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Viral_protease_N	ECOD (1.6)
A	Viral_protease_C	e6xa9A1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Viral_protease_C	ECOD (1.6)
C	Viral_protease_N	e6xa9C2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Viral_protease_N	ECOD (1.6)
C	Viral_protease_C	e6xa9C1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Viral_protease_C	ECOD (1.6)
E	Viral_protease_N	e6xa9E1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Viral_protease_N	ECOD (1.6)
E	Viral_protease_C	e6xa9E2	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Viral_protease_C	ECOD (1.6)
B	ubiquitin_2	e6xa9B1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: ubiquitin_2	ECOD (1.6)
D	ubiquitin_2	e6xa9D1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: ubiquitin_2	ECOD (1.6)
F	ubiquitin_2	e6xa9F1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: ubiquitin_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.540	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Papain-like viral protease, N-terminal domain	CATH (utative)
A	1.10.8.1190	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (utative)
A	2.60.120.1680	Mainly Beta	Sandwich	Jelly Rolls		CATH (utative)
C	3.10.20.540	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Papain-like viral protease, N-terminal domain	CATH (utative)
C	1.10.8.1190	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (utative)
C	2.60.120.1680	Mainly Beta	Sandwich	Jelly Rolls		CATH (utative)
E	3.10.20.540	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Papain-like viral protease, N-terminal domain	CATH (utative)
E	1.10.8.1190	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (utative)
E	2.60.120.1680	Mainly Beta	Sandwich	Jelly Rolls		CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D, F	PF00240	Ubiquitin family (ubiquitin)	Ubiquitin family	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E	Non-structural protein 3	protein guanylyltransferase activity guanylyltransferase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups 3'-5'-RNA exonuclease activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity RNA exonuclease activity RNA nuclease activity hydrolase activity protein guanylyltransferase activity guanylyltransferase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups 3'-5'-RNA exonuclease activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity RNA exonuclease activity RNA nuclease activity hydrolase activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exonuclease activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA 5'-3' DNA helicase activity helicase activity ATP-dependent activity RNA methyltransferase activity transferase activity, transferring one-carbon groups S-adenosylmethionine-dependent methyltransferase activity mRNA 5'-cap (guanine-N7-)-methyltransferase activity N-methyltransferase activity methyltransferase activity mRNA methyltransferase activity lipid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters endonuclease activity RNA endonuclease activity, producing 3'-phosphomonoesters RNA endonuclease activity peptidase activity omega peptidase activity catalytic activity, acting on a protein cation binding transition metal ion binding copper ion binding metal ion binding O-methyltransferase activity mRNA (nucleoside-2'-O-)-methyltransferase activity 5'-3' RNA polymerase activity RNA polymerase activity RNA-dependent RNA polymerase activity mRNA guanylyltransferase activity RNA guanylyltransferase activity cysteine-type peptidase activity ubiquitin-like protein peptidase activity ISG15-specific peptidase activity cysteine-type endopeptidase activity endopeptidase activity lyase activity RNA binding nucleic acid binding single-stranded RNA binding cysteine-type deubiquitinase activity deubiquitinase activity G-quadruplex RNA binding 5'-3' RNA helicase activity RNA helicase activity ATP-dependent activity, acting on RNA zinc ion binding	RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process viral genome replication biosynthetic process viral RNA genome replication viral process metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process viral genome replication biosynthetic process viral RNA genome replication viral process metabolic process cellular process macromolecule metabolic process symbiont-mediated suppression of host signal transduction pathway symbiont-mediated perturbation of host NF-kappaB cascade symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host signal transduction pathway symbiont-mediated suppression of host NF-kappaB cascade modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host defense response symbiont-mediated suppression of host ISG15-protein conjugation response to host defenses response to stimulus response to other organism symbiont-mediated perturbation of host immune response symbiont-mediated perturbation of host defenses response to defenses of other organism response to external stimulus response to biotic stimulus symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus viral gene expression viral protein processing symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway modulation by virus of host process virus-mediated perturbation of host defense response modulation by virus of host cellular process symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity gene expression DNA-templated transcription symbiont-mediated degradation of host mRNA symbiont-mediated perturbation of host ubiquitin-like protein modification catabolic process regulation of cellular process autophagy positive regulation of biological process regulation of autophagy positive regulation of metabolic process induction by virus of host autophagy process utilizing autophagic mechanism positive regulation of cellular process positive regulation of autophagy regulation of biological process modulation by virus of host autophagy biological regulation regulation of catabolic process positive regulation of catabolic process regulation of metabolic process symbiont-mediated suppression of host toll-like receptor signaling pathway viral translational frameshifting viral translation proteolysis protein metabolic process	host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum-Golgi intermediate compartment cellular anatomical structure host cell cytoplasm host cell part host intracellular region host cell cytoplasm part host intracellular organelle cytoplasmic viral factory double membrane vesicle viral factory membrane host cell membrane host cell cytoplasmic vesicle membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum-Golgi intermediate compartment cellular anatomical structure host cell cytoplasm host cell part host intracellular region host cell cytoplasm part host intracellular organelle cytoplasmic viral factory double membrane vesicle viral factory membrane host cell membrane host cell cytoplasmic vesicle membrane host cell cytoplasmic vesicle viral factory double membrane vesicle viral factory outer membrane double membrane vesicle viral factory host cell perinuclear region of cytoplasm host cell endosome host cell nucleus membrane host cell endoplasmic reticulum host cell endomembrane system host cell endoplasmic reticulum membrane host cell Golgi apparatus
B, D, F	ISG15 CTD-propargylamide	cell adhesion molecule binding protein-containing complex binding protein binding binding integrin binding signaling receptor binding protein tag activity molecular tag activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding	negative regulation of post-translational protein modification regulation of cellular process regulation of protein modification process negative regulation of biological process regulation of protein ubiquitination regulation of primary metabolic process protein ubiquitination negative regulation of protein modification process negative regulation of cellular process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of post-translational protein modification regulation of cellular process regulation of protein modification process negative regulation of biological process regulation of protein ubiquitination regulation of primary metabolic process protein ubiquitination negative regulation of protein modification process negative regulation of cellular process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process cellular process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular response to stimulus response to stimulus regulation of type I interferon-mediated signaling pathway response to cytokine regulation of signal transduction response to biotic stimulus cell communication interferon-mediated signaling pathway cellular response to type I interferon cellular response to cytokine stimulus regulation of immune system process signal transduction immune response response to other organism regulation of innate immune response negative regulation of immune response response to external stimulus regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus regulation of response to stimulus response to chemical defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response response to type I interferon regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus negative regulation of response to biotic stimulus negative regulation of signaling signaling negative regulation of cell communication cytokine-mediated signaling pathway response to stress regulation of response to stress innate immune response response to external biotic stimulus regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus defense response regulation of cytokine-mediated signaling pathway defense response to symbiont negative regulation of signal transduction response to peptide negative regulation of immune system process negative regulation of cytokine-mediated signaling pathway immune system process type I interferon-mediated signaling pathway regulation of cell communication negative regulation of type I interferon-mediated signaling pathway negative regulation of innate immune response catabolic process proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis integrin-mediated signaling pathway regulation of biosynthetic process multicellular organismal process regulation of type II interferon production type II interferon production gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process cytokine production regulation of cytokine production regulation of macromolecule biosynthetic process regulation of multicellular organismal process ISG15-protein conjugation regulation of developmental process positive regulation of biological process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process multicellular organism development positive regulation of biomineral tissue development ossification anatomical structure development biomineral tissue development developmental process regulation of multicellular organismal development bone mineralization animal organ development tissue development positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification defense response to bacterium response to bacterium positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of interferon-beta production interferon-beta production positive regulation of cellular process positive regulation of type I interferon production type I interferon production positive regulation of gene expression positive regulation of interferon-beta production positive regulation of cytokine production regulation of type I interferon production regulation of cellular component organization positive regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of protein oligomerization regulation of cellular component biogenesis cellular component biogenesis cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly positive regulation of protein oligomerization protein complex oligomerization protein-containing complex assembly cellular component organization or biogenesis cellular developmental process homeostatic process cell development regulation of cell differentiation regulation of cell development positive regulation of cell differentiation cell differentiation myeloid cell homeostasis erythrocyte homeostasis hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells interleukin-10 production regulation of interleukin-10 production positive regulation of interleukin-10 production protein localization localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to mitochondrion negative regulation of viral genome replication viral life cycle negative regulation of viral process regulation of viral process regulation of viral life cycle viral genome replication viral process regulation of viral genome replication response to virus defense response to virus positive regulation of type II interferon production	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E	IPR022733	DPUP/SUD, C-terminal, betacoronavirus	Domain
A, C, E	IPR042515	Non-structural protein NSP15, N-terminal domain superfamily, coronavirus	Homologous Superfamily
A, C, E	IPR043174	Non-structural protein NSP15, middle domain superfamily	Homologous Superfamily
A, C, E	IPR044315	Nonstructural protein 14, betacoronavirus	Domain
A, C, E	IPR038123	Non-structural protein NSP4, C-terminal superfamily, coronavirus	Homologous Superfamily
A, C, E	IPR042570	Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirus	Homologous Superfamily
A, C, E	IPR043178	Papain-like protease, thumb domain superfamily, coronavirus	Homologous Superfamily
A, C, E	IPR046441	RNA-dependent RNA polymerase, coronavirus	Domain
A, C, E	IPR044863	Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domain	Domain
A, C, E	IPR044343	Nonstructural protein 13, 1B domain, coronavirus	Domain
A, C, E	IPR038166	Polyprotein cleavage domain PL2pro superfamily, betacoronavirus	Homologous Superfamily
A, C, E	IPR037227	Endoribonuclease EndoU-like	Homologous Superfamily
A, C, E	IPR027352	Nonstructural protein 13, zinc-binding domain, coronavirus-like	Domain
A, C, E	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, C, E	IPR013016	Peptidase C16, coronavirus	Domain
A, C, E	IPR009466	Non-structural protein 14, coronavirus	Domain
A, C, E	IPR044357	NSP3, first ubiquitin-like (Ubl) domain, coronavirus	Domain
A, C, E	IPR046436	Nidovirus 3'-5' exoribonuclease domain	Domain
A, C, E	IPR047570	NSP12, interface domain, coronavirus	Domain
A, C, E	IPR018995	RNA synthesis protein NSP10, coronavirus	Domain
A, C, E	IPR043615	Nonstructural protein 2, N-terminal domain, coronavirus	Domain
A, C, E	IPR050534	Coronaviruses polyprotein 1ab	Family
A, C, E	IPR043177	Papain-like protease, N-terminal domain superfamily, coronavirus	Homologous Superfamily
A, C, E	IPR043606	Coronavirus replicase NSP15, N-terminal oligomerization	Domain
A, C, E	IPR044330	Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirus	Domain
A, C, E	IPR041679	DNA2/NAM7 helicase-like, C-terminal	Domain
A, C, E	IPR024375	Non-structural protein NSP3, SUD-M domain, betacoronavirus	Domain
A, C, E	IPR014828	Non-structural protein NSP7, coronavirus	Domain
A, C, E	IPR043503	Papain-like viral protease, palm and finger domains, coronavirus	Homologous Superfamily
A, C, E	IPR014829	Non-structural protein NSP8, coronavirus	Domain
A, C, E	IPR036499	Non-structural protein NSP9 superfamily, coronavirus	Homologous Superfamily
A, C, E	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A, C, E	IPR044389	Non-structural protein 2, SARS-CoV-like	Domain
A, C, E	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
A, C, E	IPR008740	Peptidase C30, coronavirus	Domain
A, C, E	IPR036333	RNA synthesis protein NSP10 superfamily, coronavirus	Homologous Superfamily
A, C, E	IPR047573	Non-structural protein 2, middle domain, coronavirus	Domain
A, C, E	IPR049894	Coronavirus NSP3, 3Ecto domain	Domain
A, C, E	IPR043472	Macro domain-like	Homologous Superfamily
A, C, E	IPR043609	NendoU domain, nidovirus	Domain
A, C, E	IPR032592	Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirus	Domain
A, C, E	IPR043613	Non-structural protein 2, C-terminal domain, coronavirus	Domain
A, C, E	IPR038083	Non-structural protein NSP3A domain-like superfamily	Homologous Superfamily
A, C, E	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A, C, E	IPR044351	RNA-dependent RNA polymerase, SARS-CoV-like	Domain
A, C, E	IPR024358	Non-structural protein NSP3, N-terminal, betacoronavirus	Domain
A, C, E	IPR048673	Nonstructural protein 13, stalk domain, coronavirus	Domain
A, C, E	IPR046435	NSP14, guanine-N7-methyltransferase domain, coronavirus	Domain
A, C, E	IPR009469	RNA-dependent RNA polymerase, N-terminal, coronavirus	Domain
A, C, E	IPR043611	Coronavirus replicase NSP3, C-terminal	Domain
A, C, E	IPR044864	Non-structural protein NSP3, SUD-N (Mac2) domain, betacoronavirus	Domain
A, C, E	IPR047566	Coronavirus replicase NSP3, Y domain	Domain
A, C, E	IPR048672	Nonstructural protein 13, zinc-binding domain, coronavirus	Domain
A, C, E	IPR043612	Non-structural protein NSP4, N-terminal, coronavirus	Domain
A, C, E	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, C, E	IPR043608	Nonstructural protein 15, middle domain, coronavirus	Domain
A, C, E	IPR044353	NSP3, second ubiquitin-like (Ubl) domain, coronavirus	Domain
A, C, E	IPR037204	Non-structural protein NSP7 superfamily, coronavirus	Homologous Superfamily
A, C, E	IPR046443	NSP1, globular domain, alpha/betacoronavirus	Domain
A, C, E	IPR043610	Non-structural protein 6, coronavirus	Domain
A, C, E	IPR027351	(+) RNA virus helicase core domain	Domain
A, C, E	IPR044322	Nonstructural protein 15, middle domain, alpha/betacoronavirus	Domain
A, C, E	IPR009461	Non-structural protein NSP16, coronavirus-like	Domain
A, C, E	IPR043477	Peptidase C30, domain 3, coronavirus	Homologous Superfamily
A, C, E	IPR043478	Non-structural protein NSP3, SUD-N (Mac2) domain superfamily, betacoronavirus	Homologous Superfamily
A, C, E	IPR038400	Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirus	Homologous Superfamily
A, C, E	IPR046442	NSP1, C-terminal domain, betacoronavirus	Domain
A, C, E	IPR001205	RNA-directed RNA polymerase, C-terminal domain	Domain
A, C, E	IPR044401	NSP15, NendoU domain, coronavirus	Domain
A, C, E	IPR014822	Non-structural protein NSP9, coronavirus	Domain
A, C, E	IPR038030	NSP1 globular domain superfamily, betacoronavirus	Homologous Superfamily
A, C, E	IPR021590	NSP1, globular domain, betacoronavirus	Domain
A, C, E	IPR044367	Non-structural protein 6, betacoronavirus	Domain
A, C, E	IPR037230	Non-structural protein NSP8 superfamily, coronavirus	Homologous Superfamily
A, C, E	IPR046440	Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domain	Domain
A, C, E	IPR032505	Non-structural protein NSP4, C-terminal, coronavirus	Domain
A, C, E	IPR046438	Nidovirus 2-O-methyltransferase	Domain
A, C, E	IPR002589	Macro domain	Domain
A, C, E	IPR047567	Non-structural protein NSP3, group 2-specific marker domain, betacoronavirus	Domain
A, C, E	IPR044371	Non-structural protein 3, X-domain-like	Domain
A, C, E	IPR007094	RNA-directed RNA polymerase, catalytic domain	Domain
B, D, F	IPR000626	Ubiquitin-like domain	Domain
B, D, F	IPR015496	Ubiquilin	Family
B, D, F	IPR019956	Ubiquitin domain	Domain
B, D, F	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D, F	Pharos: P05161	mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiency influenza malignant mesothelioma ovarian cancer pilocytic astrocytoma Sjogren syndrome atopic eczema tuberculosis breast carcinoma cystic fibrosis exocrine pancreatic carcinoma juvenile dermatomyositis lung adenocarcinoma malignant pancreatic neoplasm microphthalmia with limb anomalies mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiency influenza malignant mesothelioma ovarian cancer pilocytic astrocytoma Sjogren syndrome atopic eczema tuberculosis breast carcinoma cystic fibrosis exocrine pancreatic carcinoma juvenile dermatomyositis lung adenocarcinoma malignant pancreatic neoplasm microphthalmia with limb anomalies pancreatic ductal adenocarcinoma plasma cell myeloma subependymal giant cell astrocytoma Barrett esophagus ulcerative colitis Crohn disease dermatomyositis glioblastoma interstitial cystitis large cell medulloblastoma malignant ependymoma medulloblastoma multiple sclerosis pancreatic intraductal papillary-mucinous neoplasm psoriasis systemic lupus erythematosus breast cancer cutaneous lupus erythematosus esophageal adenocarcinoma hepatocellular carcinoma invasive ductal breast carcinoma Liver carcinoma