Annotations: 6WUL

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Bac_surface_Ag	e6wulB1	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Porin	F: Bac_surface_Ag	ECOD (1.6)
B	UNK_F_TYPE	e6wulB2	A: a+b duplicates or obligate multimers	X: Polypeptide transport-associated (POTRA) domain (From Topology)	H: Polypeptide transport-associated (POTRA) domain (From Topology)	T: Polypeptide transport-associated (POTRA) domain	F: UNK_F_TYPE	ECOD (1.6)
E	Bac_surface_Ag	e6wulE1	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Porin	F: Bac_surface_Ag	ECOD (1.6)
E	UNK_F_TYPE	e6wulE2	A: a+b duplicates or obligate multimers	X: Polypeptide transport-associated (POTRA) domain (From Topology)	H: Polypeptide transport-associated (POTRA) domain (From Topology)	T: Polypeptide transport-associated (POTRA) domain	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.40.160.50	Mainly Beta	Beta Barrel	Porin	membrane protein fhac: a member of the omp85/tpsb transporter family	CATH (utative)
E	2.40.160.50	Mainly Beta	Beta Barrel	Porin	membrane protein fhac: a member of the omp85/tpsb transporter family	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF17172	Glutathione S-transferase N-terminal domain (GST_N_4)	Glutathione S-transferase N-terminal domain	This domain is homologous to Pfam:PF02798.	Domain
A, D	PF17171	Glutathione S-transferase, C-terminal domain (GST_C_6)	Glutathione S-transferase, C-terminal domain	This domain is closely related to PF00043.	Domain
B, E	PF01103	Omp85 superfamily domain (Omp85)	Omp85 superfamily domain	The Omp85 protein superfamily contains bacterial outer membrane proteins, which can function as protein translocases or as membrane protein assembly factors [1]. The family includes the membrane bound beta barrel of proteins such as BamA and TamA fro ...	The Omp85 protein superfamily contains bacterial outer membrane proteins, which can function as protein translocases or as membrane protein assembly factors [1]. The family includes the membrane bound beta barrel of proteins such as BamA and TamA from E. coli.	Domain
C, F	PF10568	Outer mitochondrial membrane transport complex protein (Tom37)	Outer mitochondrial membrane transport complex protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Sam35	-	cellular component organization organelle organization cellular process cellular component organization or biogenesis mitochondrion organization	membrane-bounded organelle protein-containing complex intracellular anatomical structure mitochondrial membrane mitochondrion membrane protein complex organelle outer membrane intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle mitochondrial protein-containing complex outer mitochondrial membrane protein complex membrane membrane-bounded organelle protein-containing complex intracellular anatomical structure mitochondrial membrane mitochondrion membrane protein complex organelle outer membrane intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle mitochondrial protein-containing complex outer mitochondrial membrane protein complex membrane intracellular membrane-bounded organelle SAM complex organelle mitochondrial envelope mitochondrial outer membrane mitochondrial outer membrane translocase complex outer membrane cytoplasm organelle membrane
B, E	Bac_surface_Ag domain-containing protein	-	protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis mitochondrial transport mitochondrion organization membrane organization establishment of protein localization to membrane protein insertion into mitochondrial outer membrane intracellular transport localization within membrane protein localization to membrane establishment of localization organelle organization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion intracellular protein transport	membrane-bounded organelle intracellular anatomical structure mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane membrane-bounded organelle intracellular anatomical structure mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane outer membrane cytoplasm organelle membrane
C, F	Tom37 domain-containing protein	-	cellular component organization organelle organization cellular process cellular component organization or biogenesis mitochondrion organization protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of localization localization protein transport cellular macromolecule localization cellular component organization organelle organization cellular process cellular component organization or biogenesis mitochondrion organization protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization	membrane-bounded organelle protein-containing complex intracellular anatomical structure mitochondrial membrane mitochondrion membrane protein complex organelle outer membrane intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle mitochondrial protein-containing complex outer mitochondrial membrane protein complex membrane membrane-bounded organelle protein-containing complex intracellular anatomical structure mitochondrial membrane mitochondrion membrane protein complex organelle outer membrane intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle mitochondrial protein-containing complex outer mitochondrial membrane protein complex membrane intracellular membrane-bounded organelle SAM complex organelle mitochondrial envelope mitochondrial outer membrane mitochondrial outer membrane translocase complex outer membrane cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR012336	Thioredoxin-like fold	Domain
A, D	IPR033468	Metaxin, glutathione S-transferase domain	Domain
A, D	IPR050931	Mitochondrial Protein Transport Metaxin	Family
B, E	IPR039910	Surface antigen D15-like	Family
B, E	IPR000184	Bacterial surface antigen (D15)	Domain
C, F	IPR050931	Mitochondrial Protein Transport Metaxin	Family
C, F	IPR019564	Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain	Domain

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
B, C, E, F	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
B, C, E, F	mpstruc	TRANSMEMBRANE PROTEINS: BETA-BARREL	Mitochondrial Outer Membrane Beta Barrel Proteins	Sorting & assembly Machinery (SAM) complex (Sam35, Sam37, Sam50) in nanodiscs (monomer)

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.